Serotonin 1d (5-HT1d) receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Sumatriptan	Ki	8.5 [1]
	Serotonin	IC50	3.0 [1]
	Serotonin	Ki	5.06 [1]
	GR-127935	IC50	52.0 [1]
	Rizatriptan	IC50	11.0 [1], 79.43 [2]
	Rizatriptan	Ki	4.3 [1], 13.5 [2], 40.0 [3]
	6-((1-(2-((2-Methylquinolin-5-yl)oxy)ethyl)piperidin-4-yl)methyl)-2H-1,4-benzoxazin-3(4H)-one	Ki	1.58 [1]
	3-(2-Pyrrolidin-1-ylethyl)-5-(1,2,4-triazol-4-yl)-1H-indole	IC50	3.1 [1], 3.4 [2]
	3-[3-(4-Benzylpiperazino)propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	0.1 [1], 0.14 [2], 0.2 [3]
	N-Benzyl-1-[(3S)-1-[2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethyl]pyrrolidin-3-yl]methanamine	IC50	0.5 [1], 0.6 [2]
	Ergotamine	Ki	0.8 [1], 2.2 [2], 4.3 [3], 6.0 [4]
	Zolmitriptan	IC50	2.82 [1]
	Zolmitriptan	Ki	0.76 [1], 0.92 [2], 4.0 [3]
	CID 9847194	IC50	0.9 [1]
	CID 9847194	Ki	0.9 [1]
	6-[2-[4-(2-Methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one	Ki	0.16 [1], 0.2 [2], 0.5 [3]
	5-(4H-1,2,4-Triazole-4-yl)-3-[3-[4-(methylbenzylamino)piperidino]propyl]-1H-indole	IC50	2.1 [1], 2.2 [2]
	1-[4-[2-Methylphenyl]piperazin-1-yl]-2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]ethanone	Ki	0.8 [1], 0.87 [2], 2.08 [3], 2.1 [4]
	1-(4-Phenylpiperazin-1-yl)-2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]ethanone	Ki	0.4 [1], 0.6 [2], 1.2 [3]
	SB 224289	IC50	1000.0 [1]
	SB 224289	Ki	260.0 [1], 501.19 [2]
	4-Fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]benzamide	Ki	137.0 [1], 430.0 [2]
	5-(4H-1,2,4-Triazole-4-yl)-3-[3-(4-benzylpiperidino)propyl]-1H-indole	IC50	0.3 [1], 0.35 [2]
	3-[3-(4-Fluoro-4-benzylpiperidino)propyl]-5-(4H-1,2,4-triazole-4-yl)-1H-indole	IC50	0.9 [1], 1.0 [2]
	N,N-Dimethyl-1-(3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7,9,11,14,16-hexaen-4-yl)methanamine	IC50	660.69 [1]
	N-(3-(1-(2-(2-Methylquinolin-5-yloxy)ethyl)piperidin-4-ylmethyl)phenyl)methanesulfonamide	Ki	0.5 [1]
	8-[2-[4-(2-Methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one	Ki	0.05 [1]
	4-Methyl-8-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1,4-benzoxazin-3-one	Ki	0.1 [1], 0.32 [2]
	1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-3,4-dihydro-1H-isochromene-6-carboxamide	Ki	8.0 [1], 56.0 [2]
	N,N-Dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethanamine	IC50	0.3 [1]
	4-Methyl-6-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1,4-benzoxazin-3-one	Ki	0.1 [1], 0.32 [2]
	1-[4-[4-(Acetylamino)phenyl]piperazin-1-yl]-2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]ethanone	Ki	1.4 [1], 1.7 [2], 2.8 [3]
	Trifluoro-methanesulfonic acid 3-(2-dimethylamino-ethyl)-1H-indol-5-yl ester	IC50	8.4 [1]
	Trifluoro-methanesulfonic acid 3-(2-dimethylamino-ethyl)-1H-indol-5-yl ester	Ki	3.2 [1], 30.0 [2]
	Trifluoro-methanesulfonic acid 3-(2-diethylamino-ethyl)-1H-indol-5-yl ester	IC50	21.0 [1]
	Trifluoro-methanesulfonic acid 3-(2-diethylamino-ethyl)-1H-indol-5-yl ester	Ki	12.0 [1], 29.0 [2]
	Trifluoro-methanesulfonic acid 3-(2-dipropylamino-ethyl)-1H-indol-5-yl ester	IC50	170.0 [1]
	Trifluoro-methanesulfonic acid 3-(2-dipropylamino-ethyl)-1H-indol-5-yl ester	Ki	36.0 [1], 190.0 [2]
	8-OH-Dpat	Ki	115.0 [1], 164.0 [2]
	Ketanserin	IC50	260.0 [1], 270.0 [2]
	Mianserin	IC50	380.19 [1]
	Tryptamine	Ki	23.0 [1], 61.0 [2]
	Tolazoline	Ki	10000.0 [1]
	5-Methoxytryptamine	Ki	4.1 [1], 5.4 [2]
	N,N-Dimethyl-5-methoxytryptamine	IC50	49.0 [1]
	N,N-Dimethyl-5-methoxytryptamine	Ki	20.0 [1]
	Xylometazoline	Ki	0.7 [1]
	1-Naphthylpiperazine	Ki	6.18 [1], 6.2 [2]
	(7R)-7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol	Ki	164.0 [1], 638.0 [2]
	3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide	Ki	0.3 [1], 104.0 [2]
	2-Ethyl-5-methoxy-N,N-dimethyltryptamine	IC50	1400.0 [1]
	2-Ethyl-5-methoxy-N,N-dimethyltryptamine	Ki	290.0 [1]
	N,N-Diallyl-5-methoxytryptamine	Ki	158.49 [1], 10000.0 [2]
	(1S)-1-[2-[4-(4-Methoxyphenyl)piperazin-1-yl]ethyl]-N-methyl-3,4-dihydro-1H-isochromene-6-carboxamide	Ki	0.9 [1]
	CID 9870500	Ki	1.0 [1], 2.0 [2]
	N,N-Di-n-propylserotonin	IC50	820.0 [1]
	N,N-Dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine	Ki	39.0 [1], 40.0 [2]
	Dipropyl-(S)-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl-amine	Ki	440.0 [1], 441.0 [2]
	Dipropyl-(R)-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl-amine	Ki	16.0 [1]
	5-Chloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide	Ki	199.53 [1]
	2-Methyl-5-(2-(4-(quinolin-8-ylmethyl)piperazin-1-yl)ethoxy)quinoline	Ki	0.79 [1]
	3-[2-Fluoro-3-(4-benzylpiperidino)propyl]-5-(4H-1,2,4-triazole-4-yl)-1H-indole	IC50	0.9 [1], 0.95 [2]
	2-(Dipropylamino)-8-[(trifluoromethylsulfonyl)-oxy]tetralin	Ki	12.0 [1], 127.0 [2]
	Trifluoro-methanesulfonic acid 7-propylamino-5,6,7,8-tetrahydro-naphthalen-1-yl ester	Ki	15.0 [1], 169.0 [2]
	2-(2,6-Dimethyl-benzyl)-4,5-dihydro-1H-imidazole	Ki	2210.0 [1]
	4-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile	Ki	120.0 [1]
	2-(Dimethylamino)-N-[3-[[1-[2-(2-methylquinolin-5-yl)oxyethyl]piperidin-4-yl]methyl]phenyl]acetamide	Ki	1.0 [1]
	Methyl 1-[3-[[2,6-dimethyl-5-(methylcarbamoyl)-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate	Ki	5000.0 [1], 8840.0 [2]
	1-(17-Chloro-3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(14),7,9,11,15,17-hexaen-4-yl)-N,N-dimethylmethanamine	IC50	134.9 [1]
	N-Benzyl-N-methyl-1-[(3S)-1-[2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethyl]pyrrolidin-3-yl]methanamine	IC50	0.7 [1]
	3-[3-[4-Fluoro-4-(3-fluorophenethyl)piperidino]propyl]-5-(4H-1,2,4-triazole-4-yl)-1H-indole	IC50	0.7 [1], 0.75 [2]
	3-[3-[4-(2-Fluorophenethyl)piperazino]propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	0.5 [1], 0.6 [2]
	3-[3-[4-(4-Fluorophenethyl)piperazino]propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	0.8 [1]
	3-[2-Fluoro-3-[4-(3-fluorophenethyl)piperazino]propyl]-5-(4H-1,2,4-triazole-4-yl)-1H-indole	IC50	3.5 [1], 3.7 [2]
	Benzyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-propyl]-piperidin-4-yl}-amine	IC50	4.6 [1], 4.8 [2]
	3-[2-(4-Methylpiperazino)ethyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	134.0 [1], 140.0 [2]
	(3R)-N-Benzyl-N-methyl-1-[2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethyl]pyrrolidin-3-amine	IC50	37.0 [1], 38.0 [2]
	3-[3-(4-Phenethylpiperazino)propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	1.4 [1]
	(R)-beta-[[1-[3-[5-(4H-1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl]piperidin-4-yl]amino]benzeneethanol	IC50	1.3 [1]
	3-(3-Piperidinopropyl)-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	24.0 [1]
	3-[2-((R)-3-Benzyloxymethyl-pyrrolidin-1-yl)-ethyl]-5-[1,2,4]triazol-4-yl-1H-indole	IC50	2.3 [1]
	N-[(1R)-1-Phenylethyl]-1-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperidin-4-amine	IC50	0.35 [1], 0.4 [2]
	N-Benzyl-N-methyl-1-[1-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperidin-4-yl]methanamine	IC50	0.9 [1], 0.95 [2]
	Benzyl-{(R)-1-[2-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-ethyl]-pyrrolidin-3-ylmethyl}-amine	IC50	1.6 [1]
	N-[4-[2-[4-[3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl]piperazin-1-yl]ethyl]phenyl]acetamide	IC50	1.3 [1]
	2-(5-((4-((3-(2-Aminoethyl)-1H-indol-5-yloxy)methyl)phenyl)methoxy)-1H-indol-3-yl)ethanamine	Ki	0.11 [1]
	2-(5-(2-(8-(4-Methylpiperazin-1-yl)naphthalen-2-yloxy)ethoxy)-1H-indol-3-yl)ethanamine	Ki	0.4 [1]
	(3R,4S)-N-Benzyl-3-fluoro-N-methyl-1-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperidin-4-amine	IC50	2.2 [1], 12.0 [2]
	3-(2-Piperidinoethyl)-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	200.0 [1]
	1H-Indole-3-ethanamine, N,N'-dimethyl-5-(phenylmethoxy)-	IC50	25.0 [1], 76.0 [2]
	3-[3-[4-(3,4-Difluorophenethyl)piperazino]propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	0.9 [1], 1.0 [2]
	2-(4-Bromo-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazole	Ki	74.0 [1]
	3-[2-Fluoro-3-[4-(methylbenzylamino)piperidino]propyl]-5-(4H-1,2,4-triazole-4-yl)-1H-indole	IC50	5.4 [1]
	1-Methyl-2-(2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline	Ki	86.0 [1]
	1-[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]-N-[[4-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methylsulfonyl-methylamino]methyl]phenyl]methyl]-N-methylmethanesulfonamide	Ki	0.89 [1]
	N,N-Dimethyl-2-(5-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-3-yl)ethanamine	Ki	8.0 [1]
	3-[2-((R)-3-Benzyloxy-pyrrolidin-1-yl)-ethyl]-5-[1,2,4]triazol-4-yl-1H-indole	IC50	6.3 [1], 23.0 [2]
	3-[3-(4-Methylpiperazino)propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	33.0 [1], 35.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serotonin 1d (5-HT1d) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/serotonin-1d-5-ht1d-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 21). Quest Database™ Serotonin 1d (5-HT1d) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-1d-5-ht1d-receptor-inhibitors-ic50-ki.
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