Serotonin 1b (5-HT1b) receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Sumatriptan	Ki	23.1 [1]
	Serotonin	IC50	5.0 [1], 6.5 [2], 12.0 [3], 16.0 [4]
	Serotonin	Ki	6.76 [1]
	6-((1-(2-((2-Methylquinolin-5-yl)oxy)ethyl)piperidin-4-yl)methyl)-2H-1,4-benzoxazin-3(4H)-one	Ki	10.0 [1]
	6-[2-[4-(2-Methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one	Ki	0.2 [1], 0.5 [2], 251.19 [3]
	3-(2-Pyrrolidin-1-ylethyl)-5-(1,2,4-triazol-4-yl)-1H-indole	IC50	28.0 [1], 30.2 [2]
	GR-127935	Ki	0.14 [1], 1.0 [2], 4.31 [3]
	1-(3-(5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine	IC50	72.0 [1], 75.0 [2]
	3-[3-(4-Benzylpiperazino)propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	8.1 [1], 11.0 [2]
	N-Benzyl-1-[(3S)-1-[2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethyl]pyrrolidin-3-yl]methanamine	IC50	37.0 [1], 47.0 [2]
	SB 224289	Ki	6.31 [1], 10.0 [2]
	4-Fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]benzamide	Ki	83.0 [1], 240.0 [2]
	5-(4H-1,2,4-Triazole-4-yl)-3-[3-[4-(methylbenzylamino)piperidino]propyl]-1H-indole	IC50	140.0 [1], 145.0 [2]
	N-(3-(1-(2-(2-Methylquinolin-5-yloxy)ethyl)piperidin-4-ylmethyl)phenyl)methanesulfonamide	Ki	2.0 [1]
	8-[2-[4-(2-Methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one	Ki	1.0 [1]
	4-Methyl-8-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1,4-benzoxazin-3-one	Ki	1.58 [1], 3.98 [2]
	1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-3,4-dihydro-1H-isochromene-6-carboxamide	Ki	203.0 [1], 281.0 [2]
	N,N-Dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethanamine	IC50	1.3 [1], 1.4 [2]
	4-Methyl-6-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1,4-benzoxazin-3-one	Ki	0.5 [1], 2.0 [2]
	Trifluoro-methanesulfonic acid 3-(2-dimethylamino-ethyl)-1H-indol-5-yl ester	IC50	98.0 [1]
	Trifluoro-methanesulfonic acid 3-(2-dimethylamino-ethyl)-1H-indol-5-yl ester	Ki	28.0 [1], 32.0 [2]
	Trifluoro-methanesulfonic acid 3-(2-diethylamino-ethyl)-1H-indol-5-yl ester	IC50	530.0 [1]
	Trifluoro-methanesulfonic acid 3-(2-diethylamino-ethyl)-1H-indol-5-yl ester	Ki	37.0 [1], 171.0 [2]
	Trifluoro-methanesulfonic acid 3-(2-dipropylamino-ethyl)-1H-indol-5-yl ester	IC50	660.0 [1]
	Trifluoro-methanesulfonic acid 3-(2-dipropylamino-ethyl)-1H-indol-5-yl ester	Ki	88.0 [1], 246.0 [2]
	Propranolol	IC50	5011.87 [1]
	Propranolol	Ki	10000.0 [1]
	8-OH-Dpat	Ki	559.0 [1], 638.0 [2]
	Ketanserin	IC50	6500.0 [1], 10000.0 [2]
	Ergotamine	Ki	2.1 [1], 3.1 [2]
	Tolazoline	Ki	10000.0 [1]
	Rizatriptan	IC50	41.0 [1]
	Rizatriptan	Ki	10.1 [1]
	Zolmitriptan	IC50	6.17 [1]
	Zolmitriptan	Ki	4.2 [1]
	Xylometazoline	Ki	13.0 [1], 14.0 [2]
	1-Naphthylpiperazine	Ki	10.1 [1], 10.6 [2]
	3-[3-(Dimethylamino)propyl]-4-hydroxy-N-(4-pyridin-4-ylphenyl)benzamide	Ki	12.1 [1], 14.0 [2]
	2-[1-(Benzenesulfonyl)-5-methoxyindol-3-yl]-N,N-dimethylethanamine	Ki	2200.0 [1], 9210.0 [2]
	N,N-Diallyl-5-methoxytryptamine	Ki	128.82 [1], 741.31 [2]
	2,6,3,5-Ethanediylidenepentaleno(1,6-bc)pyrrol-2(1H)-ol, octahydro-1-(phenylmethyl)-	Ki	10000.0 [1]
	CID 9870500	Ki	3.98 [1], 7.94 [2]
	Thalictruberine	Ki	100.0 [1]
	CID 9847194	IC50	150.0 [1], 185.0 [2]
	N,N-Dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine	Ki	349.0 [1]
	Dipropyl-(S)-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl-amine	Ki	2275.0 [1]
	Dipropyl-(R)-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl-amine	Ki	139.0 [1]
	5-(4H-1,2,4-Triazole-4-yl)-3-[3-(4-benzylpiperidino)propyl]-1H-indole	IC50	19.0 [1]
	5-Chloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide	Ki	794.33 [1]
	3-[3-(4-Fluoro-4-benzylpiperidino)propyl]-5-(4H-1,2,4-triazole-4-yl)-1H-indole	IC50	15.0 [1]
	2-Methyl-5-(2-(4-(quinolin-8-ylmethyl)piperazin-1-yl)ethoxy)quinoline	Ki	199.53 [1]
	2-(2,6-Dimethyl-benzyl)-4,5-dihydro-1H-imidazole	Ki	10000.0 [1]
	3-(3-Dimethylamino-propyl)-4-methoxy-N-(4-pyridin-4-yl-phenyl)-benzamide	Ki	15.4 [1], 70.1 [2]
	2-(Dimethylamino)-N-[3-[[1-[2-(2-methylquinolin-5-yl)oxyethyl]piperidin-4-yl]methyl]phenyl]acetamide	Ki	6.31 [1]
	N-Benzyl-N-methyl-1-[(3S)-1-[2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethyl]pyrrolidin-3-yl]methanamine	IC50	32.0 [1], 33.0 [2]
	3-[3-[4-(2-Fluorophenethyl)piperazino]propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	98.0 [1], 100.0 [2]
	3-[3-[4-(4-Fluorophenethyl)piperazino]propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	120.0 [1]
	Benzyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-propyl]-piperidin-4-yl}-amine	IC50	120.0 [1], 125.0 [2]
	3-[2-(4-Methylpiperazino)ethyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	304.0 [1], 310.0 [2]
	(3R)-N-Benzyl-N-methyl-1-[2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethyl]pyrrolidin-3-amine	IC50	209.0 [1], 210.0 [2]
	3-[3-(4-Phenethylpiperazino)propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	166.0 [1], 170.0 [2]
	(R)-beta-[[1-[3-[5-(4H-1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl]piperidin-4-yl]amino]benzeneethanol	IC50	110.0 [1], 114.0 [2]
	3-(3-Piperidinopropyl)-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	15.0 [1]
	3-[2-((R)-3-Benzyloxymethyl-pyrrolidin-1-yl)-ethyl]-5-[1,2,4]triazol-4-yl-1H-indole	IC50	85.0 [1], 88.0 [2]
	N-[(1R)-1-Phenylethyl]-1-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperidin-4-amine	IC50	35.0 [1]
	N-Benzyl-N-methyl-1-[1-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperidin-4-yl]methanamine	IC50	27.0 [1], 28.0 [2]
	[2-(5-Ethyl-1H-indol-3-yl)-ethyl]-dimethyl-amine	Ki	5.5 [1], 286.0 [2]
	Benzyl-{(R)-1-[2-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-ethyl]-pyrrolidin-3-ylmethyl}-amine	IC50	47.0 [1], 50.0 [2]
	N-[4-[2-[4-[3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl]piperazin-1-yl]ethyl]phenyl]acetamide	IC50	251.0 [1], 260.0 [2]
	2-(5-((4-((3-(2-Aminoethyl)-1H-indol-5-yloxy)methyl)phenyl)methoxy)-1H-indol-3-yl)ethanamine	Ki	0.1 [1]
	2-(5-(2-(8-(4-Methylpiperazin-1-yl)naphthalen-2-yloxy)ethoxy)-1H-indol-3-yl)ethanamine	Ki	0.76 [1]
	3-(2-Piperidinoethyl)-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	568.0 [1], 570.0 [2]
	3-[3-[4-(3,4-Difluorophenethyl)piperazino]propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	83.0 [1], 98.0 [2]
	5-(2-Pyridin-2-ylethyl)-5-azahexacyclo[5.4.1.02,6.03,10.04,8.09,12]dodecan-4-ol	Ki	956.0 [1]
	2-(4-Bromo-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazole	Ki	1570.0 [1]
	1-Methyl-2-(2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline	Ki	5000.0 [1]
	1-[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]-N-[[4-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methylsulfonyl-methylamino]methyl]phenyl]methyl]-N-methylmethanesulfonamide	Ki	0.64 [1]
	N,N-Dimethyl-2-(5-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-3-yl)ethanamine	Ki	610.0 [1]
	3-[2-((R)-3-Benzyloxy-pyrrolidin-1-yl)-ethyl]-5-[1,2,4]triazol-4-yl-1H-indole	IC50	145.0 [1], 280.0 [2]
	3-[3-(4-Methylpiperazino)propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indole	IC50	309.0 [1], 430.0 [2]
	(4S)-4-[[3-[2-[(3S)-3-[(Benzylamino)methyl]pyrrolidin-1-yl]ethyl]-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one	IC50	49.0 [1]
	N-[4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-(2-methoxyphenyl)piperazine-1-carboxamide	Ki	2.0 [1], 12.4 [2]
	3-[(Z)-3-(Dimethylamino)prop-1-enyl]-4-methoxy-N-(4-pyridin-4-ylphenyl)benzamide	Ki	6.1 [1], 19.0 [2]
	Trifluoromethanesulfonic acid 3-(2-aminoethyl)-1H-indol-5-yl ester	Ki	14.0 [1], 18.0 [2]
	3-((E)-3-Dimethylamino-propenyl)-4-methoxy-N-(4-pyridin-4-yl-phenyl)-benzamide	Ki	13.6 [1], 18.8 [2]
	3-(3-Dimethylamino-prop-1-ynyl)-4-methoxy-N-(4-pyridin-4-yl-phenyl)-benzamide	Ki	16.2 [1], 22.3 [2]
	(4S)-4-[[3-[2-[(3S)-3-[[[(1S)-1-Phenylethyl]amino]methyl]pyrrolidin-1-yl]ethyl]-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one	IC50	49.0 [1], 50.0 [2]
	[(4S,5S)-2-(4-Butoxyphenyl)-5-methyl-4,5-dihydro-1,3-thiazol-4-yl]methanol	IC50	2100.0 [1]
	[(4S,5S)-2-(4-Butoxyphenyl)-5-methyl-4,5-dihydro-1,3-thiazol-4-yl]methanol	Ki	10000.0 [1]
	[(4S,5S)-2-(4-Hexoxyphenyl)-5-methyl-4,5-dihydro-1,3-thiazol-4-yl]methanol	IC50	1900.0 [1]
	[(4S,5S)-2-(4-Hexoxyphenyl)-5-methyl-4,5-dihydro-1,3-thiazol-4-yl]methanol	Ki	10000.0 [1]
	1-[3-[2-[(3S)-3-[(Benzylamino)methyl]pyrrolidin-1-yl]ethyl]-1H-indol-5-yl]-N-methylmethanesulfonamide	IC50	62.0 [1]
	8-[4-(5-Methoxyspiro[2,4-dihydrochromene-3,2'-pyrrolidine]-1'-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione	IC50	3801.89 [1], 6606.93 [2]
	Clozapine	Ki	1000.0 [1]
	Risperidone	Ki	10.0 [1]
	Olanzapine	Ki	1000.0 [1]
	Prazosin	Ki	7700.0 [1]
	Quetiapine	Ki	1000.0 [1]
	Aripiprazole	Ki	1000.0 [1]
	Pindolol	Ki	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serotonin 1b (5-HT1b) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/serotonin-1b-5-ht1b-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Serotonin 1b (5-HT1b) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-1b-5-ht1b-receptor-inhibitors-ic50-ki.
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