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Serine/threonine-protein kinase WEE1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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9-Hydroxy-4-phenyl-6H-pyrrolo[3,4-C]carbazole-1,3-dioneIC5097.0 [1], 97.72 [2]
Wee1 InhibitorIC5011.0 [1]
4-(2,6-Dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5028.0 [1]
4-(2-Chlorophenyl)-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5057.0 [1]
Wee1 Inhibitor IIIC5059.0 [1]
9-Hydroxy-6-methyl-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50140.0 [1], 257.04 [2], 260.0 [3]
4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC509.0 [1]
4-(2-Bromophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2h,6h)-dioneIC5022.91 [1], 23.0 [2]
9-Hydroxy-4-[2-(methylsulfanyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5033.0 [1]
4-(2-Chlorophenyl)-6-ethyl-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5050.0 [1]
4-(2-Chlorophenyl)-9-hydroxy-6-isopropylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5053.0 [1]
4-(2,6-Dibromophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5035.0 [1]
4-(2-Chloro-5-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5041.69 [1], 42.0 [2]
9-Hydroxy-4-(2-methoxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5023.99 [1], 24.0 [2]
9-Hydroxy-4-(2-thienyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50140.0 [1]
4-(2-Chloro-6-methoxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5015.0 [1]
4-(2,3-Dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5028.0 [1]
4-(2,6-Dichloro-4-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5048.98 [1], 49.0 [2]
4-(2-Aminophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2h,6h)-dioneIC50210.0 [1]
4-(2-Iodophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5013.0 [1]
4-(2-Chloro-6-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5045.0 [1]
9-Hydroxy-4-(4-hydroxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5067.0 [1]
9-Hydroxy-4-(2-nitrophenyl)pyrrolo[3,4-c]carbazole-1,3(2h,6h)-dioneIC5047.0 [1]
4-(2,6-Dichloro-3-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5018.0 [1]
4-(2,6-Dimethylphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5075.0 [1]
4-(2-Acetylphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50830.0 [1]
9-Hydroxy-4-(2-hydroxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2h,6h)-dioneIC5060.0 [1], 60.26 [2]
4-(2,6-Dimethoxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5027.0 [1]
4-(4-Amino-2-bromophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5020.0 [1]
4-(2,6-Dichlorophenyl)-9-hydroxy-6-[3-(methylamino)propyl]pyrrolo[3,4-c]carbazole-1,3-dioneIC50110.0 [1]
4-(2-Chloro-3-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5012.0 [1]
9-Hydroxy-4-iodopyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC502300.0 [1]
9-Hydroxy-4-phenyl-6-thia-2-aza-cyclopenta[c]fluorene-1,3-dioneIC5078.0 [1]
5-Ethyl-9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC501600.0 [1]
9-Hydroxy-4,5-diphenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC502300.0 [1]
9-Hydroxy-4-(4-(methylthio)phenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5029000.0 [1], 31622.78 [2]
4-(2,3-Dimethylphenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dioneIC50270.0 [1]
4-(5-Amino-2-methoxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50110.0 [1]
4-(2-Fluoro-6-methoxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5029.0 [1]
9-Hydroxy-4-(1H-pyrrol-2-yl)-6H-pyrrolo[3,4-c]carbazole-1,3-dioneIC50180.0 [1]
9-Hydroxy-4-(3-pyridinyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50575.44 [1], 580.0 [2]
9-Hydroxy-4-phenyl-1,2-dihydropyrrolo[3,4-c]carbazol-3(6H)-oneIC5037000.0 [1]
4-(2-Fluorophenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dioneIC50330.0 [1]
4-(2-Ethylphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50510.0 [1]
9-Hydroxy-4-[2-(hydroxymethyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50450.0 [1]
4-(2-Ethoxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50260.0 [1]
4-(2-Chlorophenyl)-9-hydroxy-6-propylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5063.0 [1]
4-(2-Chlorophenyl)-9-hydroxy-6-pentylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50170.0 [1]
9-Hydroxy-4-[2-(methylsulfinyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50220.0 [1]
9-Hydroxy-4-m-tolylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50230.0 [1]
9-Hydroxy-4-(3-(hydroxymethyl)phenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50870.0 [1]
9-Hydroxy-4-(3-methoxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50620.0 [1]
4-(4-Fluorophenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dioneIC5016000.0 [1]
9-Hydroxy-4-p-tolylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC503300.0 [1], 3311.31 [2]
9-Hydroxy-4-(4-(hydroxymethyl)phenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC501200.0 [1], 1202.26 [2]
4-(4-Acetylphenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dioneIC503600.0 [1]
9-Hydroxy-4-(4-methoxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5012000.0 [1]
4-(4-Aminophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50150.0 [1]
4-(2,5-Dichlorophenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dioneIC50490.0 [1]
4-(5-Amino-2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5020.0 [1]
4-(2,5-Dimethylphenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dioneIC50960.0 [1]
4-(4-Amino-2-methoxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5019.0 [1]
9-Hydroxy-4-(3-thienyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5042.0 [1]
9-Hydroxy-4-(1H-pyrrol-3-yl)-6H-pyrrolo[3,4-c]carbazole-1,3-dioneIC5038.0 [1]
9-Hydroxy-4-(4-pyridinyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50812.83 [1], 820.0 [2]
4-(2-Chlorophenyl)-9-hydroxy-6-isopentylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50150.0 [1]
9-Hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5097.0 [1], 4000.0 [2]
8-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50310.0 [1]
9-Hydroxy-4-phenyl-1H-benzofuro[3,2-e]isoindole-1,3(2H)-dioneIC50430.0 [1]
9-Hydroxy-5-methyl-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50130.0 [1]
9-Hydroxy-4-methyl-5-phenylpyrrolo[3,4-c]carbazole-1,3(2h,6h)-dioneIC509700.0 [1]
9-Hydroxy-5-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC504000.0 [1]
2-Amino-9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC503900.0 [1]
4-(2-Chlorophenyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50640.0 [1]
4-(2-Chlorophenyl)-9-hydroxy-1H-benzofuro[3,2-e]isoindole-1,3(2H)-dioneIC5033.0 [1], 33.11 [2]
9-Hydroxy-4-o-tolylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50150.0 [1]
9-Hydroxy-4-(2-(trifluoromethyl)phenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50580.0 [1]
2-(9-Hydroxy-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-c]carbazol-4-yl)benzonitrileIC50190.0 [1]
4-(Biphenyl-2-yl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50570.0 [1]
4-(3-Fluorophenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dioneIC50220.0 [1]
4-(3-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5055.0 [1]
4-(3-(Aminomethyl)phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC504400.0 [1]
4-(3-Acetylphenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dioneIC504300.0 [1]
9-Hydroxy-4-(3-hydroxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5089.0 [1], 89.13 [2]
9-Hydroxy-4-(3-nitrophenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50300.0 [1]
4-(4-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50730.0 [1]
4-(9-Hydroxy-1,3-dioxo-6H-pyrrolo[3,4-c]carbazol-4-yl)benzonitrileIC501800.0 [1]
4-(2-Chlorophenyl)-8-[3-(dimethylamino)propoxy]-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3-dioneIC5057.54 [1], 58.0 [2]
3-(9-Hydroxy-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-c]carbazol-4-yl)benzonitrileIC50180.0 [1]
4-(3-Amino-2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5021.0 [1]
4-(3-Aminophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5070.0 [1]
4-(2-Chlorophenyl)-6-(2-hydroxyethyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5045.0 [1]
N-(Benzenesulfonyl)-3-[4-(2-chlorophenyl)-9-hydroxy-1,3-dioxopyrrolo[3,4-c]carbazol-6-yl]propanamideIC507.0 [1], 7.08 [2]
4-(2-Chloro-4-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5023.0 [1]
3-[4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxopyrrolo[3,4-c]carbazol-6-yl]-N-[2-(dimethylamino)ethyl]propanamideIC5035.0 [1]
4-(2,6-Dichlorophenyl)-9-hydroxy-6-(2-hydroxyethyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC507.94 [1], 8.0 [2]
3-[4-(2,6-Dichlorophenyl)-9-hydroxy-1,3-dioxopyrrolo[3,4-c]carbazol-6-yl]-N-[2-(dimethylamino)ethyl]propanamideIC5014.0 [1]
4-(2-Chlorophenyl)-9-hydroxy-6-[2-(1H-tetraazol-5-yl)ethyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5020.89 [1], 21.0 [2]
3-(4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihydropyrrolo[3,4-c]carbazol-6(1h)-yl)propanoic acidIC509.0 [1]
9-Hydroxy-6-(3-hydroxypropyl)-4-(2-methoxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5030.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase WEE1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-wee1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Serine/threonine-protein kinase WEE1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-wee1-inhibitors-ic50-ki.
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