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Serine/threonine-protein kinase RIPK2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazoleIC50200.0 [1]
CID 67469084IC505.0 [1], 18.0 [2], 237.0 [3], 10000.0 [4]
4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenolIC503.0 [1], 20.0 [2], 10000.0 [3]
1-[3,5-Difluoro-4-[2-(methylamino)pyridin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]ureaIC50320.0 [1], 790.0 [2], 2000.0 [3]
1-(5-Tert-butyl-1,2-oxazol-3-YL)-3-(4-pyridin-4-yloxyphenyl)ureaIC5063.0 [1], 320.0 [2]
2-[2-Fluoro-4-[[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyphenyl]carbamoylamino]phenyl]sulfanylacetic acidIC502260.0 [1], 4870.0 [2]
N-[3-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)phenyl]acetamideIC5021.0 [1], 32.0 [2]
4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)pyridin-2-amineIC5029.0 [1]
4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)-6-chloropyridin-2-amineIC506.0 [1], 9.0 [2]
6-Tert-butylsulfonyl-3-(1H-indazol-5-yl)-7-methoxyimidazo[1,2-a]pyridineIC5020.0 [1], 130.0 [2]
N-[4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)pyridin-2-yl]acetamideIC5040.0 [1], 60.0 [2]
4-(7-Ethoxy-6-propan-2-ylsulfonylimidazo[1,2-a]pyridin-3-yl)-6-fluoropyridin-2-amineIC503.0 [1], 30.0 [2]
N-[3-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)-5-chlorophenyl]acetamideIC502.0 [1], 9.0 [2]
6-Tert-butylsulfonyl-N-(5-methyl-1H-pyrazol-3-yl)quinolin-4-amineIC50126.0 [1], 742.0 [2]
6-Tert-butylsulfonyl-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-(trifluoromethoxy)quinolin-4-amineIC506.3 [1], 446.0 [2]
6-Tert-butylsulfonyl-N-(1H-pyrazol-5-yl)quinolin-4-amineIC50794.0 [1], 3226.0 [2]
6-Tert-butylsulfonyl-N-(4,5,6,7-tetrahydro-1H-indazol-3-yl)quinolin-4-amineIC504719.0 [1], 5012.0 [2]
2-(2-(4-Chlorophenyl)-1h-Imidazol-5-Yl)-N,1-Bis(2-Methoxyethyl)-1h-Benzo[d]imidazole-5-CarboxamideIC5012.0 [1], 500.0 [2]
6-Tert-butylsulfonyl-N-(5-fluoro-2H-pyrazolo[3,4-b]pyridin-3-yl)quinolin-4-amineIC5079.0 [1], 1380.0 [2]
6-Tert-butylsulfonyl-N-(4,5-dimethyl-1H-pyrazol-3-yl)quinolin-4-amineIC506.3 [1], 100.0 [2]
RIP2 Kinase Inhibitor 3IC501.3 [1], 11.0 [2]
6-Tert-butylsulfonyl-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-ethoxyquinolin-4-amineIC501.6 [1], 41.0 [2]
6-Tert-butylsulfonyl-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-ethylquinolin-4-amineIC502.5 [1], 154.0 [2]
2-[6-Tert-butylsulfonyl-4-[(4,5-dimethyl-1H-pyrazol-3-yl)amino]quinolin-7-yl]oxyethanolIC502.5 [1], 15.0 [2]
RIP2 kinase inhibitor 2IC502.5 [1], 5.0 [2]
2,6-Difluoro-N-[3-[5-[2-(3-methylsulfonylanilino)pyrimidin-4-yl]-2-morpholin-4-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamideIC506.3 [1], 7.9 [2]
GefitinibIC503.8 [1]
SorafenibIC503600.0 [1]
DasatinibIC50109.0 [1]
1-Tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5019.0 [1]
PonatinibIC506.7 [1]
DoramapimodIC5010000.0 [1]
GalunisertibIC5044.0 [1]
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridineIC50685.0 [1]
3-(Dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamideIC50100000.0 [1]
1-(Tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5026.0 [1]
Benzamide, 3-((4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl)methyl)-IC50111.0 [1]
1-Tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50130.0 [1]
VactosertibIC5054.0 [1]
Src Kinase Inhibitor IIC5026.0 [1]
1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50120.0 [1]
CID 59604787IC5010000.0 [1]
Ripk-IN-4IC503.0 [1]
4-(4-Fluorophenyl)-5-pyridin-4-yl-2-(2,4,6-trichlorophenyl)pyrazol-3-amineIC5041.0 [1]
4-Methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}phenolIC5010.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
N-(2-Chlorophenyl)pyrazolo[1,5-a]pyridine-3-carboxamideIC501500.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5037000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
4-Methyl-3-(quinolin-4-ylamino)phenolIC50630.0 [1]
3-[(6-Methoxyquinolin-4-yl)amino]-4-methylphenolIC50250.0 [1]
4-[6-Tert-butylsulfonyl-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-6-chloropyridin-2-amineIC508.0 [1]
5-(1,3-Benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amineIC50403.1 [1]
4-[6-Tert-butylsulfonyl-7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl]-6-chloropyridin-2-amineIC505.0 [1]
2-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)benzamideIC5010000.0 [1]
6-Tert-butylsulfonyl-3-(3-chloro-5-methoxyphenyl)-7-methoxyimidazo[1,2-a]pyridineIC5045.0 [1]
3-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)phenolIC5035.0 [1]
6-Tert-butylsulfonyl-3-(1H-indazol-6-yl)-7-methoxyimidazo[1,2-a]pyridineIC50200.0 [1]
6-Tert-butylsulfonyl-7-methoxy-3-(2-methoxyphenyl)imidazo[1,2-a]pyridineIC50460.0 [1]
(2-Methylphenyl) 6-tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridine-3-carboxylateIC5038.0 [1]
6-Tert-butylsulfonyl-3-(2-chlorophenyl)-7-methoxyimidazo[1,2-a]pyridineIC5010000.0 [1]
4-(6-Tert-butylsulfonyl-7-cyclopropyloxyimidazo[1,2-a]pyridin-3-yl)-6-chloropyridin-2-amineIC5058.0 [1]
4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)-2-methoxyphenolIC5011.0 [1]
4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)benzamideIC50160.0 [1]
6-Tert-butylsulfonyl-7-methoxy-3-(4-methoxyphenyl)imidazo[1,2-a]pyridineIC50130.0 [1]
4-(6-Tert-butylsulfonyl-7-propan-2-yloxyimidazo[1,2-a]pyridin-3-yl)-6-chloropyridin-2-amineIC507.0 [1]
6-Tert-butylsulfonyl-3-(3-chlorophenyl)-7-methoxyimidazo[1,2-a]pyridineIC5090.0 [1]
3-(3H-Benzimidazol-5-yl)-6-tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridineIC50120.0 [1]
4-(6-Tert-butylsulfonyl-7-ethoxyimidazo[1,2-a]pyridin-3-yl)-6-chloropyridin-2-amineIC505.0 [1]
4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)phenolIC5016.0 [1]
3-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)-5-chlorophenolIC509.0 [1]
3-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)benzamideIC50430.0 [1]
4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)-2-chlorophenolIC505.0 [1]
6-Tert-butylsulfonyl-7-methoxy-N-(2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamideIC5024.0 [1]
4-[6-Tert-butylsulfonyl-7-(2,2,2-trifluoroethoxy)imidazo[1,2-a]pyridin-3-yl]-6-chloropyridin-2-amineIC507.0 [1]
6-Tert-butylsulfonyl-7-methoxy-3-(3-methoxyphenyl)imidazo[1,2-a]pyridineIC5040.0 [1]
4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)-2-chlorobenzamideIC5070.0 [1]
6-Tert-butylsulfonyl-3-(4-chlorophenyl)-7-methoxyimidazo[1,2-a]pyridineIC50520.0 [1]
2-[2-Fluoro-4-[(2-fluorophenyl)carbamoylamino]phenyl]sulfanylacetic acidIC5013200.0 [1]
3-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)benzonitrileIC50180.0 [1]
N-[5-(4-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamideIC5050978.0 [1]
4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-iumIC5010000.0 [1]
N-(6-Methylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amineIC506.3 [1]
N-(2H-Benzotriazol-5-yl)-6-methylsulfonylquinolin-4-amineIC5050.0 [1]
4-(5-Hydroxy-2-methylanilino)-N-(oxan-4-ylmethyl)quinoline-6-carboxamideIC5020.0 [1]
N-(5-Fluoro-1H-indazol-3-yl)-6-propan-2-ylsulfonylquinolin-4-amineIC5010.0 [1]
N-(5-Fluoro-1H-indazol-3-yl)-6-methylsulfonylquinolin-4-amineIC5050.0 [1]
1-Benzyl-3-[4-(3-bromoanilino)quinazolin-6-yl]thioureaIC5010000.0 [1]
4-Methyl-3-[[6-(trifluoromethyl)quinolin-4-yl]amino]phenolIC508.0 [1]
Items per page: 1 - 10 of 89
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase RIPK2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-ripk2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Serine/threonine-protein kinase RIPK2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-ripk2-inhibitors-ic50-ki.
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