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Serine/threonine-protein kinase receptor R3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(4S,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-triene-2,8-dioneIC5062.0 [1], 1213.0 [2]
N-[4-[(6-Chloro-[1,3]dioxolo[4,5-B]pyridin-7-Yl)amino]-2-Pyridyl]cyclopropanecarboxamideIC501.1 [1], 4.0 [2], 45.0 [3]
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinolineIC5011.13 [1], 13.3 [2]
N-[4-(Pyridin-4-ylamino)pyridin-2-yl]cyclopropanecarboxamideIC501000.0 [1], 3800.0 [2]
N-[4-[(6-Chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)-methylamino]pyridin-2-yl]cyclopropanecarboxamideIC5026.0 [1], 320.0 [2]
N-[4-(1,3-Benzodioxol-4-ylamino)pyridin-2-yl]cyclopropanecarboxamideIC50120.0 [1], 2300.0 [2]
N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]acetamideIC5048.0 [1], 3600.0 [2]
N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]cyclopropanecarboxamideIC5017.0 [1], 240.0 [2]
N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]propanamideIC5040.0 [1], 980.0 [2]
[4-[4-Amino-7-[(3R)-piperidin-3-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2,6-difluorophenyl]methanolIC501.9 [1], 3.0 [2]
4-[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclohexan-1-olIC502.0 [1], 6.7 [2]
[4-(4-Amino-7-pyrrolidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2,6-difluorophenyl]methanolIC504.4 [1], 21.0 [2]
4-[4-Amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclohexan-1-olIC50124.0 [1], 170.0 [2]
StaurosporineIC50850.0 [1]
Staurosporine HClIC501.36 [1]
DorsomorphinIC50106.3 [1]
VactosertibIC5010000.0 [1]
(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dioneIC50125.0 [1]
5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinolineIC5014.4 [1]
1-(4-(6-Methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazineIC5027.0 [1]
5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinolineIC5046.0 [1]
4-[6-(4-Propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinolineIC5027.0 [1]
4-(6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinolineIC5026.5 [1]
4-Amino-N-[4-[(3-fluorophenyl)carbamoylamino]phenyl]pyrrolo[2,1-f][1,2,4]triazine-5-carboxamideIC5010000.0 [1]
CID 60182364IC505.0 [1]
CID 60182389IC505.0 [1]
4-(4-(3-(1H-Pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)morpholineIC5042.1 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
(4S,8R,9S,10S)-8,9,10,18-Tetrahydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-2-oneIC501785.0 [1]
(4S,9R,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-8-methylidene-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-2-oneIC501256.0 [1]
2-Amino-7-methyl-4-[(4-methylphenyl)methylamino]-9H-pyrimido[4,5-b]indol-6-olIC50100000.0 [1]
Alk2-IN-2IC5051.0 [1]
(4S,8S,9S,10S)-8,9,10,18-Tetrahydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-2-oneIC50770.0 [1]
6-(4-Methoxyphenyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidineIC5052.4 [1]
6-(4-Piperazin-1-ylphenyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidineIC5055.0 [1]
3-Methyl-6-[2-(6-methylpyridin-2-yl)pyrazol-3-yl]quinazolin-4-oneIC505000.0 [1]
[4-(4-Amino-7-morpholin-4-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluorophenyl]methanolIC5025.0 [1]
N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]benzamideIC50340.0 [1]
N-(4-Anilinopyridin-2-yl)cyclopropanecarboxamideIC502300.0 [1]
N-[4-(2-Chloroanilino)pyridin-2-yl]cyclopropanecarboxamideIC504600.0 [1]
N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]-2-methylpropanamideIC50800.0 [1]
N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]cyclobutanecarboxamideIC50230.0 [1]
N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]cyclopentanecarboxamideIC50940.0 [1]
6-(1-Methylpiperidin-4-yl)-2-[2-oxo-4-[[(2S)-1-(2,3,5,6-tetrafluorophenyl)propan-2-yl]amino]-1H-pyridin-3-yl]-3,5-dihydropyrrolo[3,4-f]benzimidazol-7-oneIC509.81 [1]
2-[4-[1-(2,5-Difluorophenyl)propan-2-ylamino]-2-oxo-1H-pyridin-3-yl]-6-(1-methylpiperidin-4-yl)-3H-pyrrolo[3,4-f]benzimidazole-5,7-dioneIC5015.11 [1]
2-[4-[1-(2,5-Difluorophenyl)propan-2-ylamino]-2-oxo-1H-pyridin-3-yl]-6-[2-(dimethylamino)ethyl]-3H-pyrrolo[3,4-f]benzimidazole-5,7-dioneIC5038.86 [1]
2-[4-[1-(2,5-Difluorophenyl)propan-2-ylamino]-2-oxo-1H-pyridin-3-yl]-6-[2-(dimethylamino)ethyl]-3,5-dihydropyrrolo[3,4-f]benzimidazol-7-oneIC509.16 [1]
8-Methyl-6-(1-methylpiperidin-4-yl)-2-[2-oxo-4-[1-(2,3,5,6-tetrafluorophenyl)propan-2-ylamino]-1H-pyridin-3-yl]-3H-pyrrolo[3,4-f]benzimidazole-5,7-dioneIC50231.3 [1]
8-Methyl-6-(1-methylpiperidin-4-yl)-2-[2-oxo-4-[1-(2,3,5,6-tetrafluorophenyl)propan-2-ylamino]-1H-pyridin-3-yl]-3,5-dihydropyrrolo[3,4-f]benzimidazol-7-oneIC5023.7 [1]
4-Methyl-6-(1-methylpiperidin-4-yl)-2-[2-oxo-4-[1-(2,3,5,6-tetrafluorophenyl)propan-2-ylamino]-1H-pyridin-3-yl]-1,5-dihydropyrrolo[3,4-f]benzimidazol-7-oneIC5014.59 [1]
6-[2-(Dimethylamino)ethyl]-2-[2-oxo-4-[[(2S)-1-(2,3,5,6-tetrafluorophenyl)propan-2-yl]amino]-1H-pyridin-3-yl]-3,5-dihydropyrrolo[3,4-f]benzimidazol-7-oneIC504.7 [1]
2-[2-Oxo-4-[[(2S)-1-(2,3,5,6-tetrafluorophenyl)propan-2-yl]amino]-1H-pyridin-3-yl]-6-pyridin-3-yl-3H-pyrrolo[3,4-f]benzimidazole-5,7-dioneIC5047.3 [1]
6-(6-Fluoropyridin-3-yl)-2-[2-oxo-4-[[(2S)-1-(2,3,5,6-tetrafluorophenyl)propan-2-yl]amino]-1H-pyridin-3-yl]-3H-pyrrolo[3,4-f]benzimidazole-5,7-dioneIC5010000.0 [1]
5-Methoxy-2-[2-oxo-4-[1-(2,3,5,6-tetrafluorophenyl)propan-2-ylamino]-1H-pyridin-3-yl]-6-pyridin-3-yl-3,5-dihydropyrrolo[3,4-f]benzimidazol-7-oneIC50174.4 [1]
5-Hydroxy-2-[2-oxo-4-[[(2S)-1-(2,3,5,6-tetrafluorophenyl)propan-2-yl]amino]-1H-pyridin-3-yl]-6-pyridin-3-yl-3,5-dihydropyrrolo[3,4-f]benzimidazol-7-oneIC5015.18 [1]
6-[2-(Dimethylamino)ethyl]-2-[2-oxo-4-[[(2S)-1-(2,3,5,6-tetrafluorophenyl)propan-2-yl]amino]-1H-pyridin-3-yl]-3H-pyrrolo[3,4-f]benzimidazole-5,7-dioneIC5014.03 [1]
[4-[4-Amino-7-[2-(aminomethyl)-1,3-thiazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2,6-difluorophenyl]methanolIC504.1 [1]
3-[4-Amino-5-[4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]propan-1-olIC504.0 [1]
1-[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]ethanolIC503.8 [1]
1-[[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]piperidin-3-olIC5070.0 [1]
[4-(4-Amino-7-propylpyrrolo[2,1-f][1,2,4]triazin-5-yl)phenyl]methanolIC502.0 [1]
[4-[4-Amino-7-(2-methyl-1,3-thiazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl]methanolIC504.0 [1]
1-[[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]piperidin-4-olIC5065.0 [1]
[4-[4-Amino-7-(2-methyl-1,3-thiazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2,6-difluorophenyl]methanolIC505.3 [1]
3-[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]piperidin-3-olIC505.7 [1]
[4-(4-Amino-7-pyrrolidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluoro-6-methylphenyl]methanolIC504.0 [1]
[4-(4-Amino-7-piperidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluoro-6-methoxyphenyl]methanolIC502.0 [1]
[4-(4-Amino-7-propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2,6-difluorophenyl]methanolIC501.9 [1]
4-[4-Amino-5-[4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]butan-1-olIC501.0 [1]
[4-(4-Amino-7-pyrrolidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-ethyl-6-fluorophenyl]methanolIC503.0 [1]
[4-[4-Amino-7-(piperazin-1-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl]methanolIC5080.0 [1]
[4-(4-Amino-7-piperidin-4-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)phenyl]methanolIC508.0 [1]
[4-(4-Amino-7-piperidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluoro-6-methylphenyl]methanolIC504.0 [1]
1-[[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]pyrrolidin-3-olIC5030.0 [1]
[4-(4-Amino-7-propylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2,6-difluorophenyl]methanolIC502.8 [1]
[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]-cyclopropylmethanolIC501.3 [1]
[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]-(oxan-4-yl)methanolIC5040.0 [1]
[4-[4-Amino-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2,6-difluorophenyl]methanolIC5030.0 [1]
[4-[4-Amino-7-(2-amino-1,3-thiazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl]methanolIC502.0 [1]
4-[4-Amino-5-[3-fluoro-4-(hydroxymethyl)-5-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclohexan-1-olIC501.0 [1]
[4-Amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]-cyclopropylmethanolIC505.7 [1]
[4-Amino-5-[4-(hydroxymethyl)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]-cyclopropylmethanolIC501.2 [1]
[4-(4-Amino-7-piperidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-ethyl-6-fluorophenyl]methanolIC504.0 [1]
[4-[4-Amino-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl]methanolIC5019.0 [1]
[5-[4-Amino-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]pyridin-2-yl]methanolIC50140.0 [1]
[4-[4-Amino-7-(2-ethyl-1,3-thiazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2,6-difluorophenyl]methanolIC502.6 [1]
[4-[4-Amino-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-methylphenyl]methanolIC5030.0 [1]
[4-[4-Amino-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-chlorophenyl]methanolIC5017.0 [1]
1-[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclohexan-1-olIC5015.0 [1]
[4-[4-Amino-7-[(3S)-piperidin-3-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2,6-difluorophenyl]methanolIC505.9 [1]
[4-[4-Amino-7-(2-ethyl-1,3-thiazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl]methanolIC5060.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase receptor R3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-receptor-r3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Serine/threonine-protein kinase receptor R3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-receptor-r3-inhibitors-ic50-ki.
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