![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_1d5eba4b4bb57896dda18b1604bab021.svg) | Staurosporine | IC50 | 2.5 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_c8494007663098abb5d227cb27cc738b.svg) | Sorafenib | IC50 | 3300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_18b0aaeef16b71367292d08b52874f1b.svg) | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | IC50 | 2800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_49a5495605b74208c838150d56407afb.svg) | 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene | IC50 | 290.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_27ca4e0730f60781e1d36a4449f9874b.svg) | Oroidin | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_8cc99367596a19949f2432708276e495.svg) | Hymenialdisine | IC50 | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_08965270bb20ce8e82e86d4d79e4cf20.svg) | 10Z-Hymenialdisine | IC50 | 3.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_362024bcb53c4ceee86facb85742b012.svg) | Debromohymenialdisine | IC50 | 881.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_9cf1a487e0964a270ab59f7c8543fcd7.svg) | Src Kinase Inhibitor I | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_d81eb99f16502aef19cbf74caa13a4e6.svg) | 4,5-Dibromo-1h-pyrrole-2-carboxamide | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_e49944f4b295c5c18cbcd821f1b6f457.svg) | 6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_9991016043a659640f103b51434e54d1.svg) | 7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine | IC50 | 69.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_a8ebd4976d63cfa733b87fd61eea9b5d.svg) | 4-(4-Phenoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)-3-quinolinecarbonitrile | IC50 | 2.4 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_d10507bbe5a40f1d93ef354cfb5f7cc0.svg) | 6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrile | IC50 | 9.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_7451c2acc5253d58bcf4c600fcf52ea2.svg) | 2-Bromo-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione | IC50 | 539.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_fc9f48ecabafd5f654fa856beb73ec7b.svg) | 4-(3-Phenoxyanilino)-6,7-dimethoxy-3-quinolinecarbonitrile | IC50 | 95.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_26f5955c1d6791a4269169be8dd4ea62.svg) | 4-(2-Phenoxyanilino)-6,7-dimethoxy-3-quinolinecarbonitrile | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_f216c35fc3f00580cf9c1e73745b89d8.svg) | (+/-)-Hymenin | IC50 | 1288.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_97fef8e3a5bc02f905623e41ada26cc7.svg) | N-(4-(Benzyloxy)-3-methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanamide | IC50 | 9000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_7f64eea1afb8bace80371afa0ae30f1e.svg) | 4-(4-Phenoxyanilino)-6-methoxy-7-(2-morpholinoethoxy)-3-quinolinecarbonitrile | IC50 | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_76c6b01a083bc1d78e0f6a4111273be3.svg) | 2-Chloro-N-[(3-methoxy-4-phenylmethoxyphenyl)methyl]-N-(2-pyridin-2-ylethyl)benzamide | IC50 | 20600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_b54a61edb71f49faa73ef97df8d6bda9.svg) | N-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-4-phenyl-N-(2-pyridin-2-ylethyl)pentanamide | IC50 | 11200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_34fbac06f07854f4612ed2e4273642ce.svg) | 6-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrile | IC50 | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_fbb847d6009f2e3e690ebc4a24d8ad36.svg) | 4-(4-Phenoxyanilino)-5-methoxy-3-quinolinecarbonitrile | IC50 | 98.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_27bb39b3510f37cb117083083d86f294.svg) | 4-(4-Phenoxyanilino)-6,7,8-trimethoxy-3-quinolinecarbonitrile | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_8568a31842d213773d54c4bbcf3035bf.svg) | 4-(4-Phenoxyanilino)-8-methoxy-3-quinolinecarbonitrile | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_2712dd3cc94b634d1f373ee7905ea0e4.svg) | 4-(4-Phenoxyanilino)-7-(3-morpholinopropoxy)-3-quinolinecarbonitrile | IC50 | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_617b5ac461859c9567e85534fa5a6aa2.svg) | 4-(4-Phenoxyanilino)-5,8-dimethoxy-3-quinolinecarbonitrile | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_76d8977cb8b9caf756279a4a54d4f0da.svg) | 4-(4-Phenoxyanilino)-5,7-dimethoxy-3-quinolinecarbonitrile | IC50 | 60.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_612ad63d650908709c610a14d0cc9467.svg) | 4-(4-Phenoxyanilino)-3-quinolinecarbonitrile | IC50 | 125.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_8771d85b761922406072a06ab582e363.svg) | 4-(4-Phenoxyanilino)-7-methoxy-3-quinolinecarbonitrile | IC50 | 90.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_7538c6492f7cedeed71348ed9f63d515.svg) | N-[(3-Hydroxy-4-phenylmethoxyphenyl)methyl]-5-phenyl-N-(2-pyridin-2-ylethyl)pentanamide | IC50 | 19400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_a4ffb2cf850271a1bf3f4d736a232099.svg) | N-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-2-phenyl-N-(2-pyridin-2-ylethyl)cyclopropane-1-carboxamide | IC50 | 10500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_5e3377a59a37c9a469452dd0ac048394.svg) | N-[[3-(2-Hydroxyethoxy)-4-phenylmethoxyphenyl]methyl]-5-phenyl-N-(2-pyridin-2-ylethyl)pentanamide | IC50 | 14200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_dde47520b4bf030772109e9b061631fb.svg) | N-[(2-Chlorophenyl)methyl]-3-methoxy-4-phenylmethoxy-N-(2-pyridin-2-ylethyl)benzamide | IC50 | 16200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_3dec08037634da8884db18ed784526f7.svg) | N-[(2-Chlorophenyl)methyl]-N-[(3-methoxy-4-phenylmethoxyphenyl)methyl]-2-pyridin-2-ylacetamide | IC50 | 25300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_4fac2055bdd83de78143bb1cfeef0113.svg) | N-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-N-[2-(6-oxo-1H-pyridin-2-yl)ethyl]-5-phenylpentanamide | IC50 | 12300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_10aadaf51a5da628b2b5db117d6b61e2.svg) | Thieno[3,2-b]-pyridine-6-carbonitrile 12 | IC50 | 1600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_cb909811c7dd71ebab2775ff4ca29009.svg) | 4-[7-Fluoro-8-(2-methoxy-4-pyrimidin-2-yloxyphenyl)imidazo[4,5-c]quinolin-1-yl]-4-methylpiperidine-1-carboxamide | IC50 | 4.6 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_bc990e5687d6cad62116db86ec650095.svg) | [2-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-oxoethyl] hydrogen sulfate | IC50 | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_618b6b74a947716b96eb4c930d45e067.svg) | 4-[8-[2-Chloro-4-(4-methyl-3-oxopyrazin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidine-1-carboxamide | IC50 | 4.5 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_9ef57065ab29dfffe306cadcbc1da195.svg) | 1-[4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-methoxyethanone | IC50 | 53.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_b7f4b98a8d6374cee427ef58399c9703.svg) | 1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-methoxyethanone | IC50 | 9.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_70375c6823c1717e8999829bf90ab898.svg) | 2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]acetonitrile | IC50 | 22.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_118f217ea48897f48aba5e7c91f73456.svg) | 1-[4-[7-Fluoro-2-methyl-8-[2-methyl-4-(4-methylpyrimidin-2-yl)oxyphenyl]imidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone | IC50 | 80.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_5b5b83e50357d911d73e4d6994a390ce.svg) | 1-[(3S,4S)-3-Fluoro-4-[7-fluoro-8-(2-methoxy-4-pyrimidin-2-yloxyphenyl)-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone | IC50 | 5.7 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_4b5428d01db040f7556271b340403702.svg) | 4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-N,N-dimethylpiperidine-1-sulfonamide | IC50 | 213.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_5695820454fa5ea7740092b9187cb958.svg) | 8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methyl-1-(1-methylsulfonylpiperidin-4-yl)imidazo[4,5-c]quinoline | IC50 | 40.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_279cff7d4b230d5b7beca1231664ffab.svg) | 6-[3-Chloro-4-[7-fluoro-1-[1-(2-hydroxyacetyl)-4-methylpiperidin-4-yl]imidazo[4,5-c]quinolin-8-yl]phenoxy]-3-methylpyrimidin-4-one | IC50 | 59.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_7a70d64968ddd702c86694999579b9e8.svg) | 2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]acetamide | IC50 | 515.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_9b1f3ced0fd38aa73498af7e999f79f7.svg) | 2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]ethanol | IC50 | 93.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_2db444a56f208b21a7d4863e6de962f6.svg) | 1-[4-[7-Fluoro-8-[2-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone | IC50 | 39.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_fb7dbf37b16a5b60a77ba261bd92c11c.svg) | 1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxyethanone | IC50 | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_a8435d15ff920db446b3b86b2ce0bc42.svg) | 4-[7-Fluoro-8-(2-fluoro-4-pyrimidin-2-yloxyphenyl)imidazo[4,5-c]quinolin-1-yl]-4-methylpiperidine-1-carboxamide | IC50 | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_9bf4c8b3ef07263c30d76898b7439d36.svg) | 1-[(3S,4S)-3-Fluoro-4-[7-fluoro-2-methyl-8-(2-methyl-4-pyrimidin-2-yloxyphenyl)imidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone | IC50 | 2.6 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_6fb00f31d7e662194d30b328b8003d4f.svg) | 8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-1-[1-(2-methoxyethyl)piperidin-4-yl]-2-methylimidazo[4,5-c]quinoline | IC50 | 726.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_df938146fbc9ee91779aa443d6827c49.svg) | [2-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-oxoethyl] acetate | IC50 | 232.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_0f234afb5a05f68bb8a843419a8176ce.svg) | 4-[3-Chloro-4-[1-[1-(cyanomethyl)piperidin-4-yl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-8-yl]phenoxy]-6-methylpyrimidine-2-carbonitrile | IC50 | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_2bf5217838861e0e400bf2cd37e94b3f.svg) | 2-[4-[7-Fluoro-8-(2-methoxy-4-pyrimidin-2-yloxyphenyl)imidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]ethanol | IC50 | 333.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_11ec711283766fad5caafeed3ce5efff.svg) | 2-Amino-1-[4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]ethanone | IC50 | 455.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_c4ab37d98ecd1f5a3b7d3fe20939d6de.svg) | 1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone | IC50 | 7.1 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_7f4449f28e580aad8a49feb6edf99223.svg) | 2-Amino-1-[4-[8-[2-chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]ethanone | IC50 | 186.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_5b806eb0c54ffadc9e10af21db83e70b.svg) | 1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-methoxyethanone | IC50 | 85.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_15ba0c2336369c75d80328851c95af46.svg) | 4-[8-[2-Chloro-4-(1-methyl-2-oxopyridin-3-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidine-1-carboxamide | IC50 | 3.6 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_057b64c665da30199c4ed85b59d6e997.svg) | (2S)-1-[4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxypropan-1-one | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_3ef919d3b7dd1159039a2faeaa11c608.svg) | 1-[4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxypropan-1-one | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_753823b48992391981ea4f57052148c5.svg) | 1-[(3S,4S)-4-[8-[2-Chloro-4-[4-(trifluoromethyl)pyrimidin-2-yl]oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_9acd5a5209bf71c7badfdb7d098583ca.svg) | 1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]ethanone | IC50 | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_3013ce86a65f3cd597e636d296936645.svg) | 4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-N-(2,2,2-trifluoroethyl)piperidine-1-carboxamide | IC50 | 191.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_23fa329fcdddda0cdfb11939751359ae.svg) | 4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-N,N-dimethylpiperidine-1-carboxamide | IC50 | 2350.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_f282abd6fe426e8c22b0272f2a94f175.svg) | 1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxypropan-1-one | IC50 | 73.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_18836f01c1cbd76317bb967d497f1958.svg) | 2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]propan-1-ol | IC50 | 59.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_70e6401f9952881b857a98a7174aae53.svg) | 1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-fluoroethanone | IC50 | 40.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_aed09b1fecf22e05dc63ae57efe7a433.svg) | 1-[4-[7-Fluoro-8-[2-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl]imidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxyethanone | IC50 | 47.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_e4ca86b25a67911719c636cdf00355c7.svg) | 1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-fluoroethanone | IC50 | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_9fcf9d9f5342753bc9446dbec81ecf42.svg) | 4-[8-[2-Chloro-4-(1-methyl-2-oxopyridin-3-yl)oxyphenyl]-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidine-1-carboxamide | IC50 | 3.8 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_df3c13b8e70aa924792ddd2b9ed901ca.svg) | 3-[3-Chloro-4-[7-fluoro-1-[1-(2-hydroxyacetyl)piperidin-4-yl]-2-methylimidazo[4,5-c]quinolin-8-yl]phenoxy]-1-methylpyridin-2-one | IC50 | 8.5 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_66db16c5929ddf63f31a8c10b934e6e7.svg) | 4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidine-1-carboxamide | IC50 | 3.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_69ad008c72223f6cfad5584f3634066b.svg) | 1-[4-[8-[2-Chloro-4-(4-methoxy-6-methylpyrimidin-2-yl)oxyphenyl]-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxyethanone | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_b417751e82f0bc01ed76b4978d477596.svg) | 8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-1-(3-fluorooxan-4-yl)-2-methylimidazo[4,5-c]quinoline | IC50 | 280.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_efe4d8b5eac8e19f1744677789fbb4fe.svg) | 4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidine-1-carboxamide | IC50 | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_332af249fc3bf20ed969e2d30c3f3a46.svg) | 2-[4-[8-[2-Chloro-4-(1-methyl-6-oxopyrimidin-4-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]acetonitrile | IC50 | 113.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_2e4c161e0c630beb6685344a9f11cd7f.svg) | 2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]ethanol | IC50 | 104.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_01adc428df7994927985c1236556ebcf.svg) | 1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-3-hydroxypropan-1-one | IC50 | 40.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_728d431e6a2f0862505e60089318f5d7.svg) | (2S)-1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxypropan-1-one | IC50 | 7.3 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_dd7acce33819f5ab0e1469703fe39e26.svg) | (2S)-1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxypropan-1-one | IC50 | 88.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_54b823eabc97a0ee64e66c60df29ccc4.svg) | 1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxypropan-1-one | IC50 | 62.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_3ee6275b0e8308b364396bc7262d835e.svg) | 1-[4-[8-[2-Chloro-4-[6-(hydroxymethyl)pyridin-2-yl]oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone | IC50 | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_616614a62aa0e2304c66ad6de2cddb66.svg) | 1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]propan-2-ol | IC50 | 468.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_05f92d78962d982d915fa7a0daae806c.svg) | 2-[(3S,4S)-3-Fluoro-4-[7-fluoro-8-(2-methoxy-4-pyrimidin-2-yloxyphenyl)-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]acetonitrile | IC50 | 3.7 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_4cd822a2a87c697c54fe36671e5e9b19.svg) | 6-[3-Chloro-4-[7-fluoro-1-[1-(2-hydroxyacetyl)piperidin-4-yl]-2-methylimidazo[4,5-c]quinolin-8-yl]phenoxy]-3-methylpyrimidin-4-one | IC50 | 45.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_66642ce12a19446d4a3f6cbd32e04bf3.svg) | 1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]ethanone | IC50 | 212.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_7ae7ef4cfafcb1dbbcda8e61809b3a37.svg) | 3-[3-Chloro-4-[7-fluoro-1-[1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl]-2-methylimidazo[4,5-c]quinolin-8-yl]phenoxy]-1-methylpyridin-2-one | IC50 | 7.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_a91740473e32a158279c6a80e3e18011.svg) | 1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-3-hydroxy-2-(hydroxymethyl)propan-1-one | IC50 | 1346.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_84f117f8a9f03389407dc28db66474db.svg) | 4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidine-1-carboxamide | IC50 | 5.3 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_95b31c0ab10b8250140251fc2b48f66a.svg) | 1-[(3S,4S)-3-Fluoro-4-[7-fluoro-8-(2-fluoro-4-pyrimidin-2-yloxyphenyl)-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone | IC50 | 32.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_fbd6a8c8475853e7c5ac9780e361951f.svg) | [(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-(oxetan-2-yl)methanone | IC50 | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_d3c38940126446eba62aaa7bfab222cd.svg) | 1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-fluoropropan-1-one | IC50 | 547.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_c15c8bd302c74f7b29569e7d354fca45.svg) | 1-[4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxypropan-1-one | IC50 | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek_21404bd1677f667b6f3551a3fccef260.svg) | 1-[4-[7-Fluoro-2-methyl-8-[4-(4-methylpyrimidin-2-yl)oxyphenyl]imidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone | IC50 | 179.0 [1] |