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Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK) Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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StaurosporineIC502.5 [1]
SorafenibIC503300.0 [1]
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-oneIC502800.0 [1]
1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadieneIC50290.0 [1]
OroidinIC502500.0 [1]
HymenialdisineIC506.0 [1]
10Z-HymenialdisineIC503.0 [1]
DebromohymenialdisineIC50881.0 [1]
Src Kinase Inhibitor IIC50100000.0 [1]
4,5-Dibromo-1h-pyrrole-2-carboxamideIC502500.0 [1]
6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dioneIC502500.0 [1]
7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC5069.0 [1]
4-(4-Phenoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)-3-quinolinecarbonitrileIC502.4 [1]
6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrileIC509.0 [1]
2-Bromo-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dioneIC50539.0 [1]
4-(3-Phenoxyanilino)-6,7-dimethoxy-3-quinolinecarbonitrileIC5095.0 [1]
4-(2-Phenoxyanilino)-6,7-dimethoxy-3-quinolinecarbonitrileIC5010000.0 [1]
(+/-)-HymeninIC501288.0 [1]
N-(4-(Benzyloxy)-3-methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanamideIC509000.0 [1]
4-(4-Phenoxyanilino)-6-methoxy-7-(2-morpholinoethoxy)-3-quinolinecarbonitrileIC508.0 [1]
2-Chloro-N-[(3-methoxy-4-phenylmethoxyphenyl)methyl]-N-(2-pyridin-2-ylethyl)benzamideIC5020600.0 [1]
N-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-4-phenyl-N-(2-pyridin-2-ylethyl)pentanamideIC5011200.0 [1]
6-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrileIC5018.0 [1]
4-(4-Phenoxyanilino)-5-methoxy-3-quinolinecarbonitrileIC5098.0 [1]
4-(4-Phenoxyanilino)-6,7,8-trimethoxy-3-quinolinecarbonitrileIC5010000.0 [1]
4-(4-Phenoxyanilino)-8-methoxy-3-quinolinecarbonitrileIC5010000.0 [1]
4-(4-Phenoxyanilino)-7-(3-morpholinopropoxy)-3-quinolinecarbonitrileIC5028.0 [1]
4-(4-Phenoxyanilino)-5,8-dimethoxy-3-quinolinecarbonitrileIC5010000.0 [1]
4-(4-Phenoxyanilino)-5,7-dimethoxy-3-quinolinecarbonitrileIC5060.0 [1]
4-(4-Phenoxyanilino)-3-quinolinecarbonitrileIC50125.0 [1]
4-(4-Phenoxyanilino)-7-methoxy-3-quinolinecarbonitrileIC5090.0 [1]
N-[(3-Hydroxy-4-phenylmethoxyphenyl)methyl]-5-phenyl-N-(2-pyridin-2-ylethyl)pentanamideIC5019400.0 [1]
N-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-2-phenyl-N-(2-pyridin-2-ylethyl)cyclopropane-1-carboxamideIC5010500.0 [1]
N-[[3-(2-Hydroxyethoxy)-4-phenylmethoxyphenyl]methyl]-5-phenyl-N-(2-pyridin-2-ylethyl)pentanamideIC5014200.0 [1]
N-[(2-Chlorophenyl)methyl]-3-methoxy-4-phenylmethoxy-N-(2-pyridin-2-ylethyl)benzamideIC5016200.0 [1]
N-[(2-Chlorophenyl)methyl]-N-[(3-methoxy-4-phenylmethoxyphenyl)methyl]-2-pyridin-2-ylacetamideIC5025300.0 [1]
N-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-N-[2-(6-oxo-1H-pyridin-2-yl)ethyl]-5-phenylpentanamideIC5012300.0 [1]
Thieno[3,2-b]-pyridine-6-carbonitrile 12IC501600.0 [1]
4-[7-Fluoro-8-(2-methoxy-4-pyrimidin-2-yloxyphenyl)imidazo[4,5-c]quinolin-1-yl]-4-methylpiperidine-1-carboxamideIC504.6 [1]
[2-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-oxoethyl] hydrogen sulfateIC5018.0 [1]
4-[8-[2-Chloro-4-(4-methyl-3-oxopyrazin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidine-1-carboxamideIC504.5 [1]
1-[4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-methoxyethanoneIC5053.0 [1]
1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-methoxyethanoneIC509.0 [1]
2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]acetonitrileIC5022.0 [1]
1-[4-[7-Fluoro-2-methyl-8-[2-methyl-4-(4-methylpyrimidin-2-yl)oxyphenyl]imidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanoneIC5080.0 [1]
1-[(3S,4S)-3-Fluoro-4-[7-fluoro-8-(2-methoxy-4-pyrimidin-2-yloxyphenyl)-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanoneIC505.7 [1]
4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-N,N-dimethylpiperidine-1-sulfonamideIC50213.0 [1]
8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methyl-1-(1-methylsulfonylpiperidin-4-yl)imidazo[4,5-c]quinolineIC5040.0 [1]
6-[3-Chloro-4-[7-fluoro-1-[1-(2-hydroxyacetyl)-4-methylpiperidin-4-yl]imidazo[4,5-c]quinolin-8-yl]phenoxy]-3-methylpyrimidin-4-oneIC5059.0 [1]
2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]acetamideIC50515.0 [1]
2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]ethanolIC5093.0 [1]
1-[4-[7-Fluoro-8-[2-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanoneIC5039.0 [1]
1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxyethanoneIC5028.0 [1]
4-[7-Fluoro-8-(2-fluoro-4-pyrimidin-2-yloxyphenyl)imidazo[4,5-c]quinolin-1-yl]-4-methylpiperidine-1-carboxamideIC5013.0 [1]
1-[(3S,4S)-3-Fluoro-4-[7-fluoro-2-methyl-8-(2-methyl-4-pyrimidin-2-yloxyphenyl)imidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanoneIC502.6 [1]
8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-1-[1-(2-methoxyethyl)piperidin-4-yl]-2-methylimidazo[4,5-c]quinolineIC50726.0 [1]
[2-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-oxoethyl] acetateIC50232.0 [1]
4-[3-Chloro-4-[1-[1-(cyanomethyl)piperidin-4-yl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-8-yl]phenoxy]-6-methylpyrimidine-2-carbonitrileIC5018.0 [1]
2-[4-[7-Fluoro-8-(2-methoxy-4-pyrimidin-2-yloxyphenyl)imidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]ethanolIC50333.0 [1]
2-Amino-1-[4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]ethanoneIC50455.0 [1]
1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanoneIC507.1 [1]
2-Amino-1-[4-[8-[2-chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]ethanoneIC50186.0 [1]
1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-methoxyethanoneIC5085.0 [1]
4-[8-[2-Chloro-4-(1-methyl-2-oxopyridin-3-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidine-1-carboxamideIC503.6 [1]
(2S)-1-[4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxypropan-1-oneIC5019.0 [1]
1-[4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxypropan-1-oneIC5019.0 [1]
1-[(3S,4S)-4-[8-[2-Chloro-4-[4-(trifluoromethyl)pyrimidin-2-yl]oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanoneIC501.0 [1]
1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]ethanoneIC5025.0 [1]
4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-N-(2,2,2-trifluoroethyl)piperidine-1-carboxamideIC50191.0 [1]
4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-N,N-dimethylpiperidine-1-carboxamideIC502350.0 [1]
1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxypropan-1-oneIC5073.0 [1]
2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]propan-1-olIC5059.0 [1]
1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-fluoroethanoneIC5040.0 [1]
1-[4-[7-Fluoro-8-[2-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl]imidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxyethanoneIC5047.0 [1]
1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-fluoroethanoneIC5011.0 [1]
4-[8-[2-Chloro-4-(1-methyl-2-oxopyridin-3-yl)oxyphenyl]-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidine-1-carboxamideIC503.8 [1]
3-[3-Chloro-4-[7-fluoro-1-[1-(2-hydroxyacetyl)piperidin-4-yl]-2-methylimidazo[4,5-c]quinolin-8-yl]phenoxy]-1-methylpyridin-2-oneIC508.5 [1]
4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidine-1-carboxamideIC503.0 [1]
1-[4-[8-[2-Chloro-4-(4-methoxy-6-methylpyrimidin-2-yl)oxyphenyl]-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxyethanoneIC5010.0 [1]
8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-1-(3-fluorooxan-4-yl)-2-methylimidazo[4,5-c]quinolineIC50280.0 [1]
4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidine-1-carboxamideIC5011.0 [1]
2-[4-[8-[2-Chloro-4-(1-methyl-6-oxopyrimidin-4-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]acetonitrileIC50113.0 [1]
2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]ethanolIC50104.0 [1]
1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-3-hydroxypropan-1-oneIC5040.0 [1]
(2S)-1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxypropan-1-oneIC507.3 [1]
(2S)-1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxypropan-1-oneIC5088.0 [1]
1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxypropan-1-oneIC5062.0 [1]
1-[4-[8-[2-Chloro-4-[6-(hydroxymethyl)pyridin-2-yl]oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanoneIC502.0 [1]
1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]propan-2-olIC50468.0 [1]
2-[(3S,4S)-3-Fluoro-4-[7-fluoro-8-(2-methoxy-4-pyrimidin-2-yloxyphenyl)-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]acetonitrileIC503.7 [1]
6-[3-Chloro-4-[7-fluoro-1-[1-(2-hydroxyacetyl)piperidin-4-yl]-2-methylimidazo[4,5-c]quinolin-8-yl]phenoxy]-3-methylpyrimidin-4-oneIC5045.0 [1]
1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]ethanoneIC50212.0 [1]
3-[3-Chloro-4-[7-fluoro-1-[1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl]-2-methylimidazo[4,5-c]quinolin-8-yl]phenoxy]-1-methylpyridin-2-oneIC507.0 [1]
1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-3-hydroxy-2-(hydroxymethyl)propan-1-oneIC501346.0 [1]
4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidine-1-carboxamideIC505.3 [1]
1-[(3S,4S)-3-Fluoro-4-[7-fluoro-8-(2-fluoro-4-pyrimidin-2-yloxyphenyl)-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanoneIC5032.0 [1]
[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-(oxetan-2-yl)methanoneIC5011.0 [1]
1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-fluoropropan-1-oneIC50547.0 [1]
1-[4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxypropan-1-oneIC5028.0 [1]
1-[4-[7-Fluoro-2-methyl-8-[4-(4-methylpyrimidin-2-yl)oxyphenyl]imidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanoneIC50179.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek-inhibitors-ic50-ki.
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