Serine/threonine-protein kinase PLK1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	BI-2536	IC50	0.83 [1]
	BI-2536	Ki	0.22 [1], 3.0 [2]
	[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-(8-phenyloctyl)imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphate	IC50	25.0 [1]
	Staurosporine	IC50	540.0 [1]
	[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphate	IC50	300.0 [1], 16000.0 [2], 21500.0 [3], 300000.0 [4]
	Wortmannin	IC50	5.8 [1], 24.0 [2], 1300.0 [3]
	Volasertib	IC50	0.87 [1]
	Gsk-461364	IC50	100.0 [1]
	Gsk-461364	Ki	2.2 [1]
	[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-(2-fluoro-6-phenoxyphenyl)octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphate	IC50	6.6 [1], 66.0 [2], 127.0 [3]
	1-Methyl-8-[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	1.0 [1], 3.0 [2]
	1-Methyl-8-(2-methylanilino)-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	14.0 [1], 15.0 [2]
	4-[2-(2-Hydroxyethoxy)-5-methyl-3-[4-(2H-tetrazol-5-yl)phenyl]phenyl]benzonitrile	IC50	139000.0 [1], 146000.0 [2], 151000.0 [3]
	Quercetin	IC50	5750.0 [1], 64000.0 [2]
	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	IC50	2000.0 [1], 2100.0 [2]
	4-[[(7S)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide	IC50	32.5 [1]
	4-[[(7S)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide	Ki	0.42 [1]
	5-(5,6-Dimethoxy-1-benzimidazolyl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide	IC50	2.0 [1]
	5-Cyano-7-nitro-3-oxido-1,3-benzothiazol-3-ium-2-carboxamide	IC50	8000.0 [1], 10000.0 [2]
	Nms-P937 (nms1286937)	IC50	2.0 [1], 3.0 [2]
	8-[2-Methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	7.0 [1], 10.0 [2]
	3-[(2-Chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide	IC50	2.0 [1]
	8-Anilino-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	68.0 [1]
	8-Anilino-N,1-dimethyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	4215.0 [1]
	4-[4-(4-Methyl-2-methylamino-thiazol-5-YL)-pyrimidin-2-ylamino]-phenol	IC50	10000.0 [1]
	4-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]phenol	IC50	5000.0 [1]
	5-(1H-Benzimidazol-1-yl)-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide	IC50	15.0 [1], 35.0 [2]
	3-[[(2R)-3,3-Dimethylbutan-2-yl]amino]-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione	Ki	2000.0 [1], 2200.0 [2]
	8-Anilino-1-methyl-N-phenyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	10000.0 [1]
	Cyclapolin 9	IC50	500.0 [1], 2400.0 [2]
	3-[(E)-[3-[(E)-2-Pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-ol	IC50	10000.0 [1], 100000.0 [2]
	2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydropyrimido[5,4-d][1]benzazepin-6-one	IC50	5700.0 [1]
	3-Methyl-1-phenyl-N-[(1S)-1-phenylethyl]pyrazolo[4,3-c]pyridin-6-amine	IC50	1301.0 [1]
	1-(3-Chlorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]pyrazolo[4,3-c]pyridin-6-amine	IC50	121.0 [1]
	5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide	IC50	75.0 [1], 125.89 [2]
	(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-phosphonooxybutanoic acid	IC50	5270.0 [1], 32030.0 [2]
	8-(2-Methoxyanilino)-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	42.0 [1]
	8-[5-Amino-2-(trifluoromethoxy)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	60.0 [1], 87.0 [2]
	1-Methyl-8-[5-[2-(1-methylpyrrolidin-2-yl)ethylamino]-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	123.0 [1], 149.0 [2]
	1-Methyl-8-(2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	117.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	N-[(2,6-Dibromo-4-sulfamoylphenyl)carbamothioyl]benzamide	IC50	39800.0 [1], 95000.0 [2]
	[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[6-[(E)-benzylideneamino]oxyhexyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphate	IC50	558.0 [1], 5050.0 [2]
	[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[6-[(Z)-(2-fluoro-6-phenoxyphenyl)methylideneamino]oxyhexyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphate	IC50	91.0 [1], 670.0 [2]
	[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[5-[(E)-(2-fluoro-6-phenoxyphenyl)methylideneamino]oxypentyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphate	IC50	163.0 [1], 1550.0 [2]
	[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[5-[(E)-benzylideneamino]oxypentyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphate	IC50	2380.0 [1], 9000.0 [2]
	[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-[4-(2-phenylmethoxyethyl)phenyl]octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphate	IC50	9.7 [1], 152.0 [2]
	[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-[2-fluoro-6-(3-hydroxyphenoxy)phenyl]octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphate	IC50	5.5 [1], 188.0 [2]
	[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-[2-fluoro-6-(3-phenylmethoxyphenoxy)phenyl]octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphate	IC50	11.2 [1], 862.0 [2]
	[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-[4-(2-hydroxyethyl)phenyl]octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphate	IC50	5.5 [1], 218.0 [2]
	[(1R)-1-[(9S,12S,15S)-15-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-12-(hydroxymethyl)-8,11,14-trioxo-18-(8-phenyloctyl)-7,10,13,18-tetraza-1-azoniabicyclo[15.2.1]icosa-1(19),17(20)-dien-9-yl]ethyl] dihydrogen phosphate	IC50	6.0 [1], 45.0 [2]
	[(1R)-1-[(10S,13S,16S)-16-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-13-(hydroxymethyl)-9,12,15-trioxo-19-(8-phenyloctyl)-8,11,14,19-tetraza-1-azoniabicyclo[16.2.1]henicosa-1(20),18(21)-dien-10-yl]ethyl] dihydrogen phosphate	IC50	5.0 [1], 44.0 [2]
	[(1R)-1-[(8S,11S,14S)-14-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-11-(hydroxymethyl)-7,10,13-trioxo-17-(8-phenyloctyl)-6,9,12,17-tetraza-1-azoniabicyclo[14.2.1]nonadeca-1(18),16(19)-dien-8-yl]ethyl] dihydrogen phosphate	IC50	10.0 [1], 160.0 [2]
	[(1R)-1-[(9S,12S,15S)-15-Acetamido-12-(hydroxymethyl)-8,11,14-trioxo-18-(8-phenyloctyl)-7,10,13,18-tetraza-1-azoniabicyclo[15.2.1]icosa-1(19),17(20)-dien-9-yl]ethyl] dihydrogen phosphate	IC50	8.0 [1], 370.0 [2]
	1-Methyl-8-[5-piperazin-1-yl-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	2.0 [1]
	1-Methyl-8-[5-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	3.0 [1], 8.0 [2]
	1-Ethenyl-8-[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	1.0 [1], 6.0 [2]
	1-(2-Fluoroethyl)-8-[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	4.0 [1], 5.0 [2]
	1-(2-Chloroethyl)-8-[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	7.0 [1], 13.0 [2]
	Erlotinib	IC50	100000.0 [1]
	Sorafenib tosylate	IC50	10000.0 [1]
	Sunitinib	IC50	10000.0 [1]
	Lapatinib	IC50	100000.0 [1]
	Ellagic acid	IC50	3340.0 [1]
	Morin	IC50	12600.0 [1]
	Thymoquinone	IC50	2180.0 [1]
	Axitinib	IC50	10000.0 [1]
	Nintedanib	IC50	10000.0 [1]
	Doramapimod	IC50	30000.0 [1]
	N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide	IC50	10000.0 [1]
	Reversine	IC50	5000.0 [1]
	Kenpaullone	IC50	100000.0 [1]
	Nvp-aew541	IC50	10000.0 [1]
	Danusertib	IC50	3500.0 [1]
	Scytonemin	IC50	2000.0 [1]
	5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone	IC50	4600.0 [1]
	Rigosertib	IC50	9.0 [1]
	4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid	IC50	53000.0 [1]
	Entrectinib	IC50	10000.0 [1]
	Cfms Receptor Tyrosine Kinase Inhibitor	IC50	24000.0 [1]
	Bms-777607	IC50	2000.0 [1]
	Azd-1152hqpa	Ki	10000.0 [1]
	2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one	IC50	980.0 [1]
	Tak-285	IC50	10000.0 [1]
	Milciclib	IC50	10000.0 [1]
	4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine	Ki	10000.0 [1]
	Aminofurazanyl-azabenzimidazole 6n	IC50	10000.0 [1]
	Pha-793887	IC50	10000.0 [1]
	CFI-400945 (free base)	IC50	50000.0 [1]
	TCS JNK 5a	IC50	10000.0 [1]
	Norlichexanthone	IC50	75700.0 [1]
	CID 44556162	IC50	10000.0 [1]
	N6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine	IC50	5000.0 [1]
	CID 53357478	IC50	2.0 [1]
	Poloxin	IC50	29400.0 [1]
	JNK Inhibitor VIII	Ki	8900.0 [1]
	IKK-3 Inhibitor	IC50	794.33 [1]
	CID 11634725	Ki	4000.0 [1]
	CID 25015677	IC50	4.0 [1]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	100000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase PLK1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-plk1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Serine/threonine-protein kinase PLK1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-plk1-inhibitors-ic50-ki.
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