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Serine/threonine-protein kinase PIM2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2e)-3-{3-[6-(4-Methyl-1,4-Diazepan-1-Yl)pyrazin-2-Yl]phenyl}prop-2-Enoic AcidIC50140.0 [1]
N-[(1-Methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amineIC50363.0 [1]
N-[(1-Methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amineKi610.0 [1]
(R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dioneIC505.0 [1], 150.0 [2]
(R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dioneKi0.16 [1]
1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehydeIC50510.0 [1]
CID 46179018IC501.0 [1]
CID 46179018Ki0.0 [1], 1.0 [2], 3.0 [3]
StaurosporineIC507.0 [1], 28.0 [2], 345.0 [3]
CID 44814409IC502.0 [1]
CID 44814409Ki0.02 [1], 3.0 [2]
(2e)-3-(3-{6-[(trans-4-Aminocyclohexyl)amino]pyrazin-2-Yl}phenyl)prop-2-Enoic AcidIC5012.0 [1], 19.0 [2]
5-[3-(6-Cyclopentyloxypyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5040.79 [1], 41.0 [2], 6900.0 [3]
5-[3-(6-Cyclohexyloxypyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC50114.0 [1], 114.43 [2], 31600.0 [3]
5-(3-(6-Ethoxypyrazin-2-yl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amineIC5027.79 [1], 28.0 [2], 2750.0 [3]
5-(3-Quinolin-3-yl-1H-indol-5-yl)-1,3,4-thiadiazol-2-amineIC501006.03 [1], 1010.0 [2], 31600.0 [3]
5-[3-(6-Ethoxypyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5021.56 [1], 22.0 [2], 3730.0 [3]
5-[3-[6-(Cyclopentylamino)pyrazin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC505.92 [1], 6.0 [2], 1220.0 [3]
5-(3-(6-Morpholinopyridin-2-yl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amineIC5059.0 [1], 729.8 [2], 7570.0 [3]
5-(3-(6-(1-Pyrrolidinyl)-2-pyridinyl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amineIC50104.0 [1], 104.38 [2], 31600.0 [3]
5-[3-(6-Cyclopentyloxypyrazin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5024.63 [1], 25.0 [2], 6540.0 [3]
6-[5-(5-Amino-1,3,4-Thiadiazol-2-Yl)-1h-Indol-3-Yl]-N-Cyclopentylpyridin-2-AmineIC5021.0 [1], 21.11 [2], 3090.0 [3]
5-[3-(6-Propan-2-yloxypyrazin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5017.0 [1], 1294.16 [2], 2220.0 [3]
5-[3-(6-Propan-2-yloxypyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5010.0 [1], 10.07 [2], 2220.0 [3]
5-[3-[6-(Propan-2-ylamino)pyridin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5037.0 [1], 37.16 [2], 2190.0 [3]
5-[3-[6-(Cyclohexylamino)pyrazin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5018.0 [1], 18.07 [2], 2600.0 [3]
5-[3-(6-Morpholin-4-ylpyrazin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5012.0 [1], 12.31 [2], 1900.0 [3]
5-[3-[6-(Propan-2-ylamino)pyrazin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC509.65 [1], 10.0 [2], 945.0 [3]
2-[3-[(3-Hydroxycyclobutyl)amino]-2-methylquinoxalin-5-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-oneIC501.4 [1], 1.73 [2], 1.9 [3]
(5Z)-5-[3-(Trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dioneIC50100.0 [1]
(5Z)-5-[3-(Trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dioneKi100.0 [1]
(2z)-2-(1h-Indazol-3-Ylmethylidene)-6-Methoxy-7-(Piperazin-1-Ylmethyl)-1-Benzofuran-3(2h)-OneIC501000.0 [1], 1160.0 [2]
CID 44222958IC506.0 [1]
4-Chloro-1-methyl-2-[4-(4-methylpiperazin-1-yl)phenyl]pyrrolo[2,3-b]pyridine-6-carboxamideIC5030000.0 [1]
2-(Acetylamino)-N-[2-(Piperidin-1-Yl)phenyl]-1,3-Thiazole-4-CarboxamideKi12500.0 [1]
7-[(cis-4-Aminocyclohexyl)amino]-5-Bromo-1-Benzofuran-2-Carboxylic AcidIC504.0 [1], 66.0 [2]
3-Amino-N-[4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl]-6-(2-fluorophenyl)pyridine-2-carboxamideKi1.0 [1], 3.0 [2]
(3S)-1-[6-[5-(1-Methylpyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl]pyridin-2-yl]piperidin-3-amineKi0.2 [1], 0.26 [2]
N-[6-[3-(2-Aminopyrimidin-4-yl)-1H-indol-5-yl]pyrazin-2-yl]-N',N'-dimethylethane-1,2-diamineIC50110.0 [1]
3-Chloro-4-[[7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-yl]amino]phenolIC501.0 [1], 2.0 [2]
3-Fluoro-4-[6-[6-(propan-2-ylamino)indazol-1-yl]pyrazin-2-yl]benzoic acidIC508600.0 [1], 22000.0 [2]
N'-[6-[6-(Propan-2-ylamino)indazol-1-yl]pyrazin-2-yl]propane-1,3-diamineIC50140.0 [1], 1900.0 [2]
(2E)-3-(3-{6-[(4-Aminobutyl)amino]pyrazin-2-yl}phenyl)prop-2-enoic acidIC5022.0 [1]
(2E)-3-(3-{6-[(3-Methoxypropyl)amino]pyrazin-2-yl}phenyl)prop-2-enoic acidIC50480.0 [1]
(2E)-3-{3-[6-(4-Methyl-1,4-diazepan-1-yl)pyridin-2-yl]phenyl}prop-2-enoic acidIC5046.0 [1], 50.0 [2]
N-[2-Chloro-4-(2-morpholin-4-ylethoxy)phenyl]-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC507.0 [1], 14.0 [2]
N-[4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamideIC502.0 [1]
N-[4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamideKi3.0 [1]
N-[4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamideIC507.0 [1]
N-[4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamideKi6.0 [1]
N-(2-Fluorophenyl)-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC503.0 [1], 5.0 [2]
N-[2-Fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC5012.0 [1], 28.0 [2]
(R,Z)-5-(2-(3-Aminopiperidin-1-yl)-3-chlorobenzylidene)thiazolidine-2,4-dioneIC505.0 [1], 310.0 [2]
(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]-3-methoxyphenyl]methylidene]-1,3-thiazolidine-2,4-dioneIC505.0 [1], 320.0 [2]
(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]-3-bromophenyl]methylidene]-1,3-thiazolidine-2,4-dioneIC503.0 [1], 150.0 [2]
(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]-3-ethoxyphenyl]methylidene]-1,3-thiazolidine-2,4-dioneIC504.0 [1], 160.0 [2]
(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]-3-(2-methylpropoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dioneIC504.0 [1], 140.0 [2]
(5z)-5-{2-[(3r)-3-Aminopiperidin-1-Yl]-3-(Propan-2-Yloxy)benzylidene}-1,3-Thiazolidine-2,4-DioneIC503.0 [1], 50.0 [2]
(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dioneIC5014.0 [1], 1200.0 [2]
N-[4-[(1R,3R,4R,5S)-3-Amino-4-hydroxy-5-methylcyclohexyl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamideIC503.0 [1]
N-[4-[(1R,3R,4R,5S)-3-Amino-4-hydroxy-5-methylcyclohexyl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamideKi3.0 [1]
3-Amino-N-[4-[(1R,3S)-3-aminocyclohexyl]pyridin-3-yl]-6-cyclohexylpyridine-2-carboxamideIC5022.0 [1]
3-Amino-N-[4-[(1R,3S)-3-aminocyclohexyl]pyridin-3-yl]-6-cyclohexylpyridine-2-carboxamideKi23.0 [1]
N-[4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl]-5-fluoro-6-(2-fluorophenyl)pyridine-2-carboxamideIC504.0 [1]
N-[4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl]-5-fluoro-6-(2-fluorophenyl)pyridine-2-carboxamideKi4.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamideIC508.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamideKi5.0 [1]
5-{6-[(trans-4-Aminocyclohexyl)amino]pyrazin-2-Yl}-1-Benzofuran-2-Carboxylic AcidIC5054.0 [1], 110.0 [2]
4-[[3-[3-(Trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-yl]amino]cyclohexan-1-olIC5069.0 [1], 152.0 [2]
cis-5-Bromo-7-(4-hydroxycyclohexylamino)benzofuran-2-carboxylic acidIC506100.0 [1], 6800.0 [2]
N-Phenyl-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC5010.0 [1], 15.0 [2]
N-(5-Chloro-2-fluorophenyl)-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC5010.0 [1], 12.0 [2]
5-(2-Chloroanilino)-N-methylbenzo[c][2,6]naphthyridine-7-carboxamideIC501.0 [1], 5.0 [2]
N-(2,4-Difluorophenyl)-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC506.0 [1], 15.0 [2]
N-[2-Fluoro-4-(2-methoxyethoxy)phenyl]-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC5010.0 [1], 30.0 [2]
N-[4-[(1R,3S)-3-Aminocyclohexyl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamideIC505.0 [1]
N-[4-[(1R,3S)-3-Aminocyclohexyl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamideKi5.0 [1]
3-Amino-N-[4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamideIC501.0 [1]
3-Amino-N-[4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamideKi0.0 [1]
N-[4-[(1R,3S)-3-Aminocyclohexyl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamideIC5029.0 [1]
N-[4-[(1R,3S)-3-Aminocyclohexyl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamideKi29.0 [1]
5-[3-(2,6-Difluorophenyl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC50347.65 [1], 348.0 [2]
5-[3-[6-(Cyclohexylamino)pyridin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC50226.69 [1], 227.0 [2]
5-[3-(6-Aminopyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC50977.0 [1], 977.36 [2]
6-[5-(5-Amino-1,3,4-thiadiazol-2-yl)-1H-indol-3-yl]-2-PyrazinamineIC50192.0 [1], 192.34 [2]
N-Methyl-5-(3-quinolin-3-yl-1H-indol-5-yl)-1,3,4-thiadiazol-2-amineIC501630.0 [1], 1632.17 [2]
(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]-3-pyridin-4-ylphenyl]methylidene]-1,3-thiazolidine-2,4-dioneIC5019.0 [1], 690.0 [2]
N-[4-[(3S)-3-Aminopyrrolidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC501000.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2-chlorophenyl)imidazo[1,5-b]pyridazin-7-amineIC503.0 [1], 3.4 [2]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2,4-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC503.0 [1], 3.1 [2]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2-fluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC501.6 [1], 2.0 [2]
5-[(3S)-3-Aminopiperidin-1-yl]-N-[2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl]-1,2-thiazol-4-amineIC50136.0 [1], 148.0 [2]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(1,3-thiazol-2-yl)imidazo[1,5-b]pyridazin-7-amineIC502.9 [1], 3.0 [2]
N-[4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC500.09 [1], 0.3 [2]
N-[4-[(3S,4S)-3-Amino-4-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC501.6 [1]
N-[4-[(3S,4R)-3-Amino-4-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC500.18 [1], 0.2 [2]
N-[4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(3-fluoropyridin-2-yl)imidazo[1,5-b]pyridazin-7-amineIC500.4 [1], 0.43 [2]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC500.5 [1], 35.2 [2]
(3S)-1-[3-[[2-(2,6-Difluorophenyl)imidazo[1,5-b]pyridazin-7-yl]amino]pyridin-4-yl]piperidin-3-olIC5030.0 [1]
N-[4-[(3S,5R)-3-Amino-5-fluoropiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC503.2 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase PIM2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pim2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Serine/threonine-protein kinase PIM2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pim2-inhibitors-ic50-ki.
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