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Serine/threonine-protein kinase PIM1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-[(1-Methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amineIC507.0 [1]
N-[(1-Methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amineKi16.0 [1]
StaurosporineIC5010.0 [1]
(5Z)-5-[3-(Trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dioneIC5017.0 [1], 24.0 [2], 3000.0 [3]
(5Z)-5-[3-(Trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dioneKi24.0 [1]
(R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dioneIC500.4 [1], 3.0 [2], 5.0 [3]
(R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dioneKi0.02 [1]
(2e)-3-{3-[6-(4-Methyl-1,4-Diazepan-1-Yl)pyrazin-2-Yl]phenyl}prop-2-Enoic AcidIC5057.0 [1]
6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrileIC5050.0 [1]
QuercetinIC5043.0 [1], 500.0 [2], 1100.0 [3]
1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehydeIC50120.0 [1]
CID 46179018IC501.0 [1]
CID 46179018Ki0.0 [1], 1.0 [2]
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneIC50820.0 [1], 4000.0 [2]
QuercetagetinIC50340.0 [1]
Pim-1 inhibitor 2IC5091.0 [1]
Pim-1 inhibitor 2Ki91.0 [1], 500.0 [2]
CID 44814409IC501.0 [1]
CID 44814409Ki0.01 [1], 1.0 [2]
CID 44222958IC501.0 [1], 5.0 [2]
7-[(cis-4-Aminocyclohexyl)amino]-5-Bromo-1-Benzofuran-2-Carboxylic AcidIC501.0 [1], 19.0 [2]
(3S)-1-[6-[5-(1-Methylpyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl]pyridin-2-yl]piperidin-3-amineKi0.06 [1]
5-[3-(6-Cyclopentyloxypyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5014.68 [1], 15.0 [2], 479.0 [3]
5-[3-(6-Cyclohexyloxypyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5040.55 [1], 41.0 [2], 1020.0 [3]
5-(3-(6-Ethoxypyrazin-2-yl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amineIC5019.73 [1], 21.0 [2], 200.0 [3]
5-(3-Quinolin-3-yl-1H-indol-5-yl)-1,3,4-thiadiazol-2-amineIC50163.0 [1], 177.54 [2], 2740.0 [3]
5-[3-(6-Ethoxypyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5014.71 [1], 17.0 [2], 141.0 [3]
5-[3-[6-(Cyclopentylamino)pyrazin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC501.0 [1], 1.5 [2], 57.0 [3]
5-(3-(6-Morpholinopyridin-2-yl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amineIC5016.0 [1], 94.92 [2], 152.0 [3]
5-(3-(6-(1-Pyrrolidinyl)-2-pyridinyl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amineIC5043.54 [1], 48.0 [2], 526.0 [3]
5-[3-(6-Cyclopentyloxypyrazin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5010.48 [1], 11.0 [2], 176.0 [3]
6-[5-(5-Amino-1,3,4-Thiadiazol-2-Yl)-1h-Indol-3-Yl]-N-Cyclopentylpyridin-2-AmineIC5012.0 [1], 12.43 [2], 111.0 [3]
5-[3-(6-Propan-2-yloxypyrazin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC508.0 [1], 92.0 [2], 297.23 [3]
5-[3-(6-Propan-2-yloxypyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC507.0 [1], 7.77 [2], 106.0 [3]
5-[3-[6-(Propan-2-ylamino)pyridin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC5020.9 [1], 24.0 [2], 384.0 [3]
5-[3-[6-(Cyclohexylamino)pyrazin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC503.15 [1], 4.0 [2], 56.0 [3]
5-[3-(6-Morpholin-4-ylpyrazin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC505.0 [1], 5.59 [2], 163.0 [3]
1-[6-(1,4-Diazepan-1-yl)pyridin-2-yl]-6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridineIC50574.0 [1]
1-[6-(1,4-Diazepan-1-yl)pyridin-2-yl]-6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridineKi0.02 [1]
(3S)-1-[3-Methoxy-6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]pyridin-2-yl]piperidin-3-amineIC50220.0 [1]
(3S)-1-[3-Methoxy-6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]pyridin-2-yl]piperidin-3-amineKi0.02 [1]
5-[3-[6-(Propan-2-ylamino)pyrazin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amineIC501.75 [1], 2.0 [2], 40.0 [3]
2-[3-[(3-Hydroxycyclobutyl)amino]-2-methylquinoxalin-5-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-oneIC502.5 [1], 3.1 [2], 3.4 [3]
Bisindolylmaleimide iIC5027.0 [1]
RuboxistaurinIC50200.0 [1]
SilmitasertibIC5046.0 [1], 48.0 [2]
Leucettine L41IC50880.0 [1], 4100.0 [2]
4-(5-Bromo-1H-indol-3-yl)pyrimidin-2-amineIC501000.0 [1], 1040.0 [2]
Leucettamine BIC5010000.0 [1]
CID 44545852IC505.0 [1]
CID 44545852Ki5.0 [1]
2,3-Diphenyl-1H-indole-7-carboxylic acidIC50550.0 [1]
2,3-Diphenyl-1H-indole-7-carboxylic acidKi550.0 [1]
Imidazopyridazin 1IC5061.0 [1]
5-Bromo-1-benzofuran-2-carboxylic acidIC508500.0 [1], 9000.0 [2]
8-Bromo[1]benzofuro[3,2-d]pyrimidin-4(3H)-oneIC50526.0 [1], 530.0 [2]
(2z)-2-(1h-Indazol-3-Ylmethylidene)-6-Methoxy-7-(Piperazin-1-Ylmethyl)-1-Benzofuran-3(2h)-OneIC503.0 [1], 6.0 [2]
7-Chloro-9-ethyl-6-fluoro-1H,9H-2-oxa-1,9-diaza-cyclopenta[b]naphthalene-3,4-dioneKi21.8 [1], 22.0 [2]
(2Z)-6-Methoxy-7-(piperazin-1-ylmethyl)-2-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylidene)-1-benzofuran-3-oneIC500.84 [1], 2.0 [2]
4-Chloro-1-methyl-2-[4-(4-methylpiperazin-1-yl)phenyl]pyrrolo[2,3-b]pyridine-6-carboxamideIC50200.0 [1], 250.0 [2]
8-Bromanyl-2-[[(3s)-3-Oxidanylpyrrolidin-1-Yl]methyl]-3h-[1]benzofuro[3,2-D]pyrimidin-4-OneIC5011.0 [1]
2-[[(3R)-3-Aminopyrrolidin-1-yl]methyl]-8-bromo-3H-[1]benzofuro[3,2-d]pyrimidin-4-oneIC506.0 [1]
2-[[(3S)-3-Aminopyrrolidin-1-yl]methyl]-8-bromo-3H-[1]benzofuro[3,2-d]pyrimidin-4-oneIC503.8 [1], 4.0 [2]
8-Bromo-2-(pyrrolidin-1-ylmethyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-oneIC5013.0 [1]
4-[6-[(4-Fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]phenolIC50130.0 [1]
N-[4-(8-Bromo-4-oxo-3H-[1]benzofuro[3,2-d]pyrimidin-2-yl)-3-chlorophenyl]-3-piperidin-1-ylpropanamideIC503.0 [1]
8-Bromo-2-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]-3H-[1]benzofuro[3,2-d]pyrimidin-4-oneIC505.0 [1], 13.0 [2]
2-(Azetidin-1-ylmethyl)-8-bromo[1]benzofuro[3,2-d]pyrimidin-4(3H)-oneIC509.0 [1]
8-Bromo-2-[2-chloro-4-[(piperidin-4-ylamino)methyl]phenyl]-3H-[1]benzofuro[3,2-d]pyrimidin-4-oneIC504.0 [1]
8-Bromo-2-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.2]octan-2-yl]methyl]-3H-[1]benzofuro[3,2-d]pyrimidin-4-oneIC503.0 [1]
N-Cyclohexyl-3-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-amineKi11.0 [1]
5-Bromo-7-methoxy-1-benzofuran-2-carboxylic acidIC505800.0 [1], 6000.0 [2]
2-(Acetylamino)-N-[2-(Piperidin-1-Yl)phenyl]-1,3-Thiazole-4-CarboxamideKi90.0 [1], 92.0 [2]
N-[2-Chloro-4-(4-methylpiperazin-1-yl)phenyl]-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC502.0 [1]
N-[4-[2-(Dimethylamino)ethoxy]-2-fluorophenyl]-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC507.0 [1]
4-[5-[(4-Fluorophenyl)methylamino]triazolo[4,5-b]pyridin-3-yl]phenolIC5069.0 [1]
N-[(1-Methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amineIC50155.0 [1]
6-Chloro-N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amineIC506.0 [1]
N-(7-Azaspiro[3.5]nonan-2-ylmethyl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amineIC504.0 [1]
7-Methoxy-N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amineIC501.0 [1]
N-(7-Azaspiro[3.5]nonan-2-ylmethyl)-3-[3-(trifluoromethyl)phenyl]triazolo[4,5-b]pyridin-5-amineIC509.0 [1]
N-(2-Methylphenyl)-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC507.0 [1]
N-(2-Chloro-3-methoxyphenyl)-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC508.0 [1]
N-(5-Fluoro-2-methylphenyl)-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC506.0 [1]
3-[3-(Dimethylamino)phenyl]-N-(piperidin-4-ylmethyl)triazolo[4,5-b]pyridin-5-amineIC505.0 [1]
3-Amino-N-[4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl]-6-(2-fluorophenyl)pyridine-2-carboxamideKi1.0 [1]
3-(6-(Piperazin-1-yl)pyridin-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridineKi0.04 [1]
(R)-1-(6-(5-(1-Methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)piperidin-3-amineKi0.04 [1], 0.14 [2]
N-[6-[3-(2-Aminopyrimidin-4-yl)-1H-indol-5-yl]pyrazin-2-yl]-N',N'-dimethylethane-1,2-diamineIC503.0 [1], 3.4 [2]
3,4-Dichloro-2-cyclopropyl-1-[(3S)-piperidin-3-yl]pyrrolo[2,3-b]pyridine-6-carboxamideIC501.0 [1], 43.0 [2]
3-Chloro-4-[[7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-yl]amino]phenolIC502.0 [1], 5.0 [2]
(2Z)-2-[(6-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methylidene]-6-methoxy-7-(piperazin-1-ylmethyl)-1-benzofuran-3-oneIC500.41 [1], 0.49 [2]
3,4-Dichloro-2-iodo-1-piperidin-3-ylpyrrolo[2,3-b]pyridine-6-carboxamideIC501.0 [1], 47.0 [2]
3,4-Dichloro-2-cyclopropyl-1-piperidin-3-ylpyrrolo[2,3-b]pyridine-6-carboxamideIC501.0 [1], 115.0 [2]
3,4-Dichloro-2-(2-cyclopropylethynyl)-1-piperidin-3-ylpyrrolo[2,3-b]pyridine-6-carboxamideIC500.7 [1], 75.0 [2]
3-Fluoro-4-[6-[6-(propan-2-ylamino)indazol-1-yl]pyrazin-2-yl]benzoic acidIC50200.0 [1], 5400.0 [2]
N'-[6-[6-(Propan-2-ylamino)indazol-1-yl]pyrazin-2-yl]propane-1,3-diamineIC5020.0 [1], 160.0 [2]
N-[2-Chloro-4-(2-morpholin-4-ylethoxy)phenyl]-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amineIC502.0 [1]
N-[4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamideIC501.0 [1]
N-[4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamideKi1.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase PIM1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pim1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Serine/threonine-protein kinase PIM1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pim1-inhibitors-ic50-ki.
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