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Serine/threonine-protein kinase PIM Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(3R,5S)-3,5-Diamino-1-[3-[[2-(3-fluoropyridin-2-yl)imidazo[1,5-b]pyridazin-7-yl]amino]pyridin-4-yl]piperidin-4-olIC50115.0 [1]
(3S,5R)-3,5-Diamino-1-[3-[[2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl]amino]pyridin-4-yl]piperidin-4-olIC5031.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2-chlorophenyl)imidazo[1,5-b]pyridazin-7-amineIC502668.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2,4-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC501761.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2-fluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC501536.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(1,3-thiazol-2-yl)imidazo[1,5-b]pyridazin-7-amineIC50602.0 [1]
N-[4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC5028.0 [1]
N-[4-[(3S,4S)-3-Amino-4-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC502982.0 [1]
N-[4-[(3S,4R)-3-Amino-4-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC50212.0 [1]
N-[4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(3-fluoropyridin-2-yl)imidazo[1,5-b]pyridazin-7-amineIC5045.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC50403.0 [1]
(3S)-1-[3-[[2-(2,6-Difluorophenyl)imidazo[1,5-b]pyridazin-7-yl]amino]pyridin-4-yl]piperidin-3-olIC504807.0 [1]
N-[4-[(3S,5R)-3-Amino-5-fluoropiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC50983.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(3-chloropyridin-2-yl)imidazo[1,5-b]pyridazin-7-amineIC50620.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(3-fluoropyridin-2-yl)imidazo[1,5-b]pyridazin-7-amineIC50286.0 [1]
N-[4-[(1R,3S)-3-Aminocyclohexyl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC505120.0 [1]
N-[4-[(2S,3S)-3-Amino-2-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC502530.0 [1]
N-[4-[(2R,3S)-3-Amino-2-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC50221.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2,4-dichlorophenyl)imidazo[1,5-b]pyridazin-7-amineIC505007.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-pyridin-2-ylimidazo[1,5-b]pyridazin-7-amineIC501760.0 [1]
N-[4-[(3S,5S)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC50522.0 [1]
N-[2-[(3S)-3-Aminopiperidin-1-yl]phenyl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC503440.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2-fluoropyridin-3-yl)imidazo[1,5-b]pyridazin-7-amineIC506599.0 [1]
N-[4-[(3S)-3-Aminopiperidin-1-yl]pyrimidin-5-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC5015800.0 [1]
N-[4-[(3R,4R)-3-Amino-4-fluoropiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC506100.0 [1]
N-[4-[(2R,5S)-5-Amino-2-methylpiperidin-1-yl]pyridin-3-yl]-2-(3-fluoropyridin-2-yl)imidazo[1,5-b]pyridazin-7-amineIC50258.0 [1]
2-(3-Anilino-2-methylquinoxalin-5-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-oneIC50184.0 [1]
Macrocyclic Quinoxaline-PyrrolodihydropiperidinoneIC5025.0 [1]
(9S,13S)-13,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,15(23),16,18,20-heptaen-6-oneIC5040.0 [1]
(9S,11Z)-12,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-oneIC5014.0 [1]
(9S,11E)-12,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-oneIC5016.0 [1]
(9R)-16-Methyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,15(23),16,18,20-heptaen-6-oneIC50100.0 [1]
(9S,11E)-16-Methyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-oneIC50106.0 [1]
(9S,11E,13S)-13,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-oneIC5026.0 [1]
(9S)-16-Methyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,15(23),16,18,20-heptaen-6-oneIC5020.0 [1]
(9S,11E,13R)-13,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-oneIC5020.0 [1]
(9R,11E)-16-Methyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-oneIC50880.0 [1]
(9R,11Z)-16-Methyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-oneIC50370.0 [1]
(9S,11Z)-16-Methyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-oneIC5021.0 [1]
(9S,13R)-13,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,15(23),16,18,20-heptaen-6-oneIC5037.0 [1]
(9S,12R)-12,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,15(23),16,18,20-heptaen-6-oneIC5025.0 [1]
(9S,12S)-12,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,15(23),16,18,20-heptaen-6-oneIC5037.0 [1]
N-[4-[(2R,5S)-5-Amino-2-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC5049.0 [1]
N-[4-[(2S,5S)-5-Amino-2-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amineIC50142.0 [1]
Items per page: 1 - 10 of 44
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase PIM Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pim-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Serine/threonine-protein kinase PIM Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pim-inhibitors-ic50-ki.
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