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Serine/threonine-protein kinase PAK 4 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
PF-03758309IC5018.7 [1]
PF-03758309Ki15.0 [1], 36.0 [2]
1-({1-(2-Aminopyrimidin-4-Yl)-2-[(2-Methoxyethyl)amino]-1h-Benzimidazol-6-Yl}ethynyl)cyclohexanolIC504.77 [1], 7.5 [2]
1-({1-(2-Aminopyrimidin-4-Yl)-2-[(2-Methoxyethyl)amino]-1h-Benzimidazol-6-Yl}ethynyl)cyclohexanolKi3.3 [1]
2-N-(3-Methoxyphenyl)-4-N-(oxolan-2-ylmethyl)quinazoline-2,4-diamineIC5014500.0 [1], 14900.0 [2]
N-(1H-Indazol-5-yl)-N'-[2-(1H-indol-3-yl)ethyl]-6-methoxy-1,3,5-triazine-2,4-diamineIC50790.0 [1]
(3Z)-N-[(1S)-2-Hydroxy-1-phenylethyl]-3-(1H-imidazol-5-ylmethylidene)-2-oxo-1H-indole-5-carboxamideIC5016.0 [1], 16.22 [2]
2-N-[(4-Chloro-1H-benzimidazol-5-yl)methyl]-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-methylpyrimidine-2,4-diamineKi272.0 [1]
4-[1-(4-Amino-1,3,5-Triazin-2-Yl)-2-(Ethylamino)-1h-Benzimidazol-6-Yl]-2-Methylbut-3-Yn-2-OlIC5065.5 [1]
4-[1-(4-Amino-1,3,5-Triazin-2-Yl)-2-(Ethylamino)-1h-Benzimidazol-6-Yl]-2-Methylbut-3-Yn-2-OlKi60.0 [1]
[6-Chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]-[(3R)-3-methylpiperazin-1-yl]methanoneIC5011.1 [1]
[6-Chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]-[(3R)-3-methylpiperazin-1-yl]methanoneKi9.0 [1]
N~2~-[(trans-4-Aminocyclohexyl)methyl]-N~4~-(3-Cyclopropyl-1h-Pyrazol-5-Yl)pyrimidine-2,4-DiamineKi4.0 [1], 38.0 [2]
StaurosporineIC501.9 [1]
SunitinibKi500.0 [1]
SeliciclibIC506900.0 [1]
DoramapimodIC5030000.0 [1]
Purvalanol AIC50130.0 [1]
DanusertibIC5010000.0 [1]
EntrectinibIC5010000.0 [1]
Gsk-690693IC5010.0 [1]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC5010000.0 [1]
MilciclibIC5010000.0 [1]
Pha-793887IC5010000.0 [1]
Bis(2-hydroxy-1-naphthyl) disulfideIC5010000.0 [1]
CID 70934541IC5010000.0 [1]
CID 68060125IC50779.0 [1]
JNK Inhibitor VIIIKi5500.0 [1]
Nms-P937 (nms1286937)IC5010000.0 [1]
MivavotinibIC5076.0 [1]
5-[2,4-Dihydroxy-6-(4-Nitrophenoxy)phenyl]-N-(1-Methylpiperidin-4-Yl)-1,2-Oxazole-3-CarboxamideIC5010.0 [1]
2-({2-[(3-Hydroxyphenyl)amino]pyrimidin-4-YL}amino)benzamideIC505500.0 [1]
8-[2-Methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5010000.0 [1]
N-(3-Cyclopropyl-1H-pyrazol-5-YL)-2-(2-naphthyl)acetamideIC5010000.0 [1]
5-(2-Aminopyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamideIC5010000.0 [1]
2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamideIC5010000.0 [1]
CID 68181876Ki2900.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi5500.0 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideKi5400.0 [1]
(7S)-2-(2-Aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-oneIC504000.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi5454.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
6-Phenyl-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-4-amineIC50100000.0 [1]
7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamideKi10000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi5500.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi5500.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi5500.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi5500.0 [1]
3-[(4-Morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[3,2-c]pyrazole-5-carboxamideIC50455.0 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC5046.0 [1]
5-(1-Benzyl-1h-1,2,3-triazol-4-yl)-1h-indazol-3-amineKi3750.0 [1]
3-Benzyl-5-(1H-indazol-5-yl)isoxazoleKi3750.0 [1]
5-(1H-Indazol-5-yl)-3-propylisoxazoleKi3750.0 [1]
5-(1H-Indazol-5-yl)-3-(piperidin-1-ylmethyl)isoxazoleKi3750.0 [1]
5-(4-Benzyl-1H-1,2,3-triazol-1-yl)-1H-indazoleKi3750.0 [1]
5-(3-Benzylisoxazol-5-yl)-1h-indazol-3-amineKi3588.0 [1]
4-(2-(4-(4-Fluorophenyl)-5-(1H-indazol-5-yl)-1H-imidazol-1-yl)ethyl)morpholineKi3750.0 [1]
5-(1-Benzyl-1h-1,2,3-triazol-4-yl)-1h-indazoleKi5450.0 [1]
2-(1H-Indazol-5-yl)-N-propan-2-ylimidazo[1,2-a]pyrimidin-3-amineKi3750.0 [1]
4-(1H-Indazol-5-yl)-N-phenyl-1,3-thiazol-2-amineKi3750.0 [1]
N-Benzyl-4-(1H-indazol-5-yl)-1,3-thiazol-2-amineKi3750.0 [1]
n-Butyl-2-(1h-indazol-5-yl)imidazo[1,2-a]pyrimidin-3-amineKi3750.0 [1]
2-(1h-Indazol-5-yl)imidazo[1,2-a]pyrimidineKi3750.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC509332.54 [1]
5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amineIC502300.0 [1]
N-[3-[5-[2-(3-Morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamideIC501000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
4-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-N-(1H-indol-5-ylmethyl)pyrimidine-2,4-diamineKi144.0 [1]
4-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-N-[(1S)-1-(1H-indol-5-yl)ethyl]pyrimidine-2,4-diamineKi42.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC5030000.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamideIC5030000.0 [1]
CID 71553154IC505720.0 [1]
N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3,5-difluorobenzamideIC5010000.0 [1]
6-Phenyl-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-2,4-diamineIC50100000.0 [1]
6-(4-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amineIC50100000.0 [1]
CID 10732141IC50100000.0 [1]
N-Benzyl-3-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamideIC5020000.0 [1]
N-Butyl-N-methyl-3-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamideIC5020000.0 [1]
3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-olIC5010000.0 [1]
(2R)-4-[3-(4-Amino-1,3,5-triazin-2-yl)-2-(methylamino)benzimidazol-5-yl]-2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-olIC5035.5 [1]
2-(4-Aminopiperidin-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)furo[3,2-d]pyrimidin-4-amineKi45.0 [1]
2-(4-Aminopiperidin-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amineKi283.0 [1]
6-(4-Aminopiperidin-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyridin-2-amineKi612.0 [1]
2-(4-Aminopiperidin-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyridin-4-amineKi1820.0 [1]
4-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-N-(piperidin-4-ylmethyl)pyrimidine-2,4-diamineKi80.0 [1]
2-N-(4-Aminocyclohexyl)-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamineKi100.0 [1]
2-N-[(6-Aminopyridin-3-yl)methyl]-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamineKi563.0 [1]
4-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-N-[[6-(methylamino)pyridin-3-yl]methyl]pyrimidine-2,4-diamineKi610.0 [1]
4-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-N-[[6-(dimethylamino)pyridin-3-yl]methyl]pyrimidine-2,4-diamineKi907.0 [1]
4-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-N-[(1-methylbenzimidazol-5-yl)methyl]pyrimidine-2,4-diamineKi1660.0 [1]
4-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-N-[(3-methylbenzimidazol-5-yl)methyl]pyrimidine-2,4-diamineKi1900.0 [1]
2-N-[(4-Chloro-1H-benzimidazol-5-yl)methyl]-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-ethylpyrimidine-2,4-diamineKi547.0 [1]
3-[3-[[2-[(4-Chloro-1H-benzimidazol-5-yl)methyl-methylamino]pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]cyclopentan-1-oneKi629.0 [1]
2-N-[(4-Chloro-1H-benzimidazol-5-yl)methyl]-4-N-[5-(1-methoxypropan-2-yl)-1H-pyrazol-3-yl]-2-N-methylpyrimidine-2,4-diamineKi617.0 [1]
N-[[3-[[2-[(4-Chloro-1H-benzimidazol-5-yl)methyl-methylamino]pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]methyl]-N-methylacetamideKi2900.0 [1]
(3S)-3-[3-[[2-[(4-Chloro-1H-benzimidazol-5-yl)methyl-methylamino]pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]-1-methylpyrrolidin-2-oneKi2900.0 [1]
(3R)-3-[3-[[2-[(4-Chloro-1H-benzimidazol-5-yl)methyl-methylamino]pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]-1-methylpyrrolidin-2-oneKi950.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase PAK 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pak-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Serine/threonine-protein kinase PAK 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pak-4-inhibitors-ic50-ki.
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