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Serine/threonine-protein kinase PAK 1/PAK 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-[2-(1-methylpiperidin-4-yl)ethylamino]pyrido[2,3-d]pyrimidin-7-oneIC50220.0 [1]
8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-oneIC5071.0 [1]
6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-(2-methoxyethyl)-2-(oxetan-3-ylamino)pyrido[2,3-d]pyrimidin-7-oneIC50290.0 [1]
8-(3-Amino-2,2-difluoropropyl)-6-[2-chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-oneIC50460.0 [1]
6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-[(3,3-difluoropiperidin-4-yl)methyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-oneIC5078.0 [1]
6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)-8-[2-(1-methylazetidin-3-yl)oxyethyl]pyrido[2,3-d]pyrimidin-7-oneIC5088.0 [1]
6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-[2-(3-fluoro-1-methylazetidin-3-yl)ethyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-oneIC5033.0 [1]
8-(3-Aminopropyl)-6-[2-chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-oneIC50602.0 [1]
6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-ethyl-2-(methylamino)pyrido[2,3-d]pyrimidin-7-oneIC50340.0 [1]
6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-ethyl-2-(oxetan-3-ylamino)pyrido[2,3-d]pyrimidin-7-oneIC50150.0 [1]
6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-(2-hydroxyethyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-oneIC50930.0 [1]
6-[2-Cyclopropyl-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)-8-[[(2S)-morpholin-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-oneIC5015000.0 [1]
6-[2-Chloro-4-(4-methyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)-8-[[(2R)-morpholin-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-oneIC5030000.0 [1]
6-[2-Chloro-4-(3-ethyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)-8-[[(2R)-morpholin-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-oneIC50240.0 [1]
6-[2-Chloro-4-(3-methyl-2-oxopyrazin-1-yl)phenyl]-8-[(3,3-difluoropiperidin-4-yl)methyl]-2-(oxetan-3-ylamino)pyrido[2,3-d]pyrimidin-7-oneIC50280.0 [1]
6-[2-Chloro-4-(5-methyl-6-oxopyrimidin-1-yl)phenyl]-8-(2-methoxyethyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-oneIC50800.0 [1]
8-[(4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]pyrido[2,3-d]pyrimidin-7-oneIC506000.0 [1]
6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-(2-methoxyethyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-oneIC50450.0 [1]
Items per page: 1 - 10 of 18
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase PAK 1/PAK 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pak-1-pak-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Serine/threonine-protein kinase PAK 1/PAK 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pak-1-pak-2-inhibitors-ic50-ki.
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