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Serine/threonine-protein kinase Nek1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(3E,5E)-3,5-Bis[(2-fluorophenyl)methylidene]piperidin-4-oneIC5077000.0 [1]
9-[4-[(2R)-1-(Dimethylamino)propan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5032.0 [1]
9-[4-[(2R)-1-(Dimethylamino)propan-2-yl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC502.5 [1]
3,5-Bis(2-pyridylmethylene)piperidine-4-oneIC50500.0 [1]
(R)-9-(4-(1-Aminopropan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-oneIC5016.0 [1]
(3Z,5Z)-3,5-Bis(pyridin-2-ylmethylidene)thian-4-oneIC5014000.0 [1]
(3E,5E)-1-Methyl-3,5-bis(pyridin-2-ylmethylidene)piperidin-4-oneIC503500.0 [1]
CID 49837564IC50170.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC50630.0 [1]
TilfrinibIC5010000.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
(3S,8S,9S,10R,13S,14S,17S)-17-Isoquinolin-7-yl-N,N,10,13-tetramethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-amineIC5010000.0 [1]
(2E)-2-[(3,4-Dihydroxyphenyl)methylidene]-1-benzofuran-3-oneIC5011500.0 [1]
1-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]piperidine-4-Carboxylic AcidIC502600.0 [1]
1-[3-Amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl]piperidine-4-carboxylic acidIC5022500.0 [1]
N-[5-[6-(Methylamino)pyrazin-2-yl]-2-oxo-1H-pyridin-3-yl]-4-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]benzamideKi1000.0 [1]
2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideIC501000.0 [1]
(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-oneIC5083000.0 [1]
(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-oneIC5083000.0 [1]
(3S,4S)-3-Methoxy-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-oneIC50150.4 [1]
8-Hydroxy-9-(1H-indazol-6-yl)thieno[2,3-c]quinolin-4(5H)-oneIC503.5 [1]
9-[4-(Aminomethyl)phenyl]-8-hydroxythieno[2,3-c]quinolin-4(5H)-oneIC500.38 [1]
8-[(3S)-3-Aminopyrrolidin-1-yl]-2-(4-hydroxyphenyl)-5H-thieno[2,3-c]quinolin-4-oneIC5078.0 [1]
4-(8-Hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)benzenesulfonamideIC501.8 [1]
N-[4-(8-Hydroxy-4-oxo-5H-thieno[2,3-c]quinolin-9-yl)phenyl]methanesulfonamideIC502.6 [1]
2-[4-(8-Hydroxy-4-oxo-5H-thieno[2,3-c]quinolin-9-yl)phenyl]acetonitrileIC5012.0 [1]
8-Hydroxy-9-(1,2,3,6-tetrahydropyridin-4-yl)thieno[2,3-c]quinolin-4(5H)-oneIC500.78 [1]
9-{4-[2-(Dimethylamino)ethyl]phenyl}-8-hydroxythieno[2,3-c]quinolin-4(5H)-oneIC505.4 [1]
9-[4-(Aminomethyl)phenyl]-8-hydroxy-2-methylthieno[2,3-c]quinolin-4(5H)-oneIC504.4 [1]
9-[4-(1-Amino-2-methylpropan-2-yl)phenyl]-6-bromo-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5072.0 [1]
9-[4-(1-Aminoethyl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5012.0 [1]
9-[4-(2-Aminoethyl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5019.0 [1]
(R)-9-(4-(1-(Dimethylamino)propan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-oneIC503.3 [1]
9-[4-(2-Aminopropan-2-yl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5010.0 [1]
9-[4-(Aminomethyl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5016.0 [1]
9-[4-(1-Aminoethyl)phenyl]-8-hydroxythieno[2,3-c]quinolin-4(5H)-oneIC500.73 [1]
9-[4-(2-Aminoethyl)phenyl]-8-hydroxythieno[2,3-c]quinolin-4(5H)-oneIC501.1 [1]
(E)-9-[3-(4-Aminopiperidin-1-yl)prop-1-enyl]-8-methoxythieno[2,3-c]quinolin-4(5H)-oneIC5031.0 [1]
9-[4-(1-Aminobutan-2-yl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5015.0 [1]
9-(4-Amino-3-hydroxyphenyl)-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC502.3 [1]
9-[4-(2-Aminopropyl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5041.0 [1]
9-[4-[1-(Aminomethyl)cyclobutyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC501.7 [1]
9-[4-(1-Aminoethyl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5012.0 [1]
9-[4-(2-Aminoethyl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5020.0 [1]
9-[4-[(2R)-1-Aminopropan-2-yl]phenyl]-6-chloro-8-methoxy-5H-thieno[2,3-c]quinolin-4-oneIC5020.0 [1]
9-[4-(1-Aminopropyl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5016.0 [1]
8-Methoxy-9-{4-[(methylamino)methyl]phenyl}thieno[2,3-c]quinolin-4(5H)-oneIC507.8 [1]
9-[4-(2-Aminoethyl)phenyl]-8-methoxythieno[2,3-c]quinolin-4(5H)-oneIC5022.0 [1]
9-[4-[1-(Diethylamino)ethyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC504.5 [1]
9-[4-(Aminomethyl)phenyl]-6-fluoro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC502.5 [1]
9-[4-[(Dimethylamino)methyl]phenyl]-8-methoxy-5H-thieno[2,3-c]quinolin-4-oneIC5011.0 [1]
8-Hydroxy-9-[4-[(propan-2-ylamino)methyl]phenyl]-5H-thieno[2,3-c]quinolin-4-oneIC504.2 [1]
9-[4-[1-(Dimethylamino)propyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC501.9 [1]
8-Hydroxy-9-[4-(1-pyrrolidin-1-ylethyl)phenyl]-5H-thieno[2,3-c]quinolin-4-oneIC502.8 [1]
9-[4-(Aminomethyl)phenyl]-6-bromo-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5031.0 [1]
9-[4-[3-[2-(Diethylamino)ethylamino]propoxy]phenyl]-8-methoxy-5H-thieno[2,3-c]quinolin-4-oneIC5047.0 [1]
9-[4-(1-Aminoethyl)phenyl]-6-bromo-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5047.0 [1]
9-[4-(2-Aminoethyl)phenyl]-6-bromo-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5045.0 [1]
N-(1-Bromopropan-2-yl)-4-(8-hydroxy-4-oxo-5H-thieno[2,3-c]quinolin-9-yl)benzenesulfonamideIC5031.0 [1]
9-[4-(Aminomethyl)phenyl]-6-fluoro-8-methoxy-5H-thieno[2,3-c]quinolin-4-oneIC5026.0 [1]
9-[4-(1-Aminopropan-2-yl)-3-chlorophenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5010.0 [1]
9-(4-Acetylphenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-oneIC5023.0 [1]
9-[4-(1-Amino-3-methylbutan-2-yl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5018.0 [1]
9-[4-[1-(Diethylamino)ethyl]-3-fluorophenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC503.6 [1]
9-[4-[(2S)-1-Aminopropan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5016.0 [1]
9-[4-[1-(Aminomethyl)cyclopropyl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC509.6 [1]
9-[4-(2-Aminopropyl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5037.0 [1]
9-[4-[(2S)-1-(Dimethylamino)propan-2-yl]-3-fluorophenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5058.0 [1]
9-[4-[1-(Dimethylamino)propan-2-yl]-3-fluorophenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5046.0 [1]
9-[4-(1-Amino-2-methylpropan-2-yl)-3-fluorophenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC501.0 [1]
9-[4-(1-Amino-2-methylpropan-2-yl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5039.0 [1]
N-(2-Bromoethyl)-2-fluoro-4-(8-hydroxy-4-oxo-5H-thieno[2,3-c]quinolin-9-yl)benzenesulfonamideIC5013.0 [1]
9-[4-(1-Aminopropyl)phenyl]-8-methoxy-5H-thieno[2,3-c]quinolin-4-oneIC505.2 [1]
8-Hydroxy-9-{4-[(methylamino)methyl]phenyl}thieno[2,3-c]quinolin-4(5H)-oneIC500.9 [1]
9-(4-(1-Aminopropan-2-yl)phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-oneIC503.2 [1]
9-[5-(Aminomethyl)thiophen-2-yl]-8-hydroxythieno[2,3-c]quinolin-4(5H)-oneIC500.78 [1]
9-[4-(1-Aminopropyl)phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC500.82 [1]
9-[4-(3-Aminopropyl)phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC500.74 [1]
9-[4-(1-Aminopropan-2-yl)phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC501.3 [1]
9-[4-[(2R)-1-Aminopropan-2-yl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC501.3 [1]
9-[4-[1-(Aminomethyl)cyclopropyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC501.9 [1]
9-[4-(2-Aminopropyl)phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC501.3 [1]
9-[4-(2-Aminopropan-2-yl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC508.3 [1]
9-[4-(1-Aminobutan-2-yl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5019.0 [1]
9-[4-[1-(Ethylamino)ethyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC503.9 [1]
8-Hydroxy-9-[4-[(2S)-1-(methylamino)propan-2-yl]phenyl]-5H-thieno[2,3-c]quinolin-4-oneIC502.8 [1]
9-[4-[2-(Dimethylamino)ethyl]-3-fluorophenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC501.9 [1]
9-[4-(2-Aminoethyl)-3-fluorophenyl]-8-methoxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5057.0 [1]
3-[4-(8-Hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenyl]propanenitrileIC503.2 [1]
6-Chloro-9-[4-[(2R)-1-(dimethylamino)propan-2-yl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC5043.0 [1]
9-[4-[(2R)-1-[Ethyl(methyl)amino]propan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5076.0 [1]
9-[4-(Aminomethyl)phenyl]-4-oxo-5H-thieno[2,3-c]quinoline-8-carbonitrileIC5013.0 [1]
(R)-9-(4-(1-Aminopropan-2-yl)phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-oneIC502.0 [1]
9-[4-(2-Amino-1-cyclopentylethyl)phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC504.6 [1]
9-[4-[1-(Dimethylamino)ethyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC501.9 [1]
9-[3-Fluoro-4-[3-methyl-1-(methylamino)butan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5017.0 [1]
9-[4-(1-Amino-3-methylbutan-2-yl)phenyl]-8-methoxy-5H-thieno[2,3-c]quinolin-4-oneIC504.1 [1]
9-[4-[(Dimethylamino)methyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC506.9 [1]
9-[4-(1-Amino-3-methylbutan-2-yl)phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-oneIC501.4 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase Nek1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-nek1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Serine/threonine-protein kinase Nek1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-nek1-inhibitors-ic50-ki.
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