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Serine/threonine-protein kinase mTOR Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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DactolisibIC5020.74 [1]
PI-103IC5019.0 [1]
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneIC503018.0 [1]
PictilisibIC50410.0 [1]
PictilisibKi570.0 [1], 580.0 [2]
SirolimusIC503.47 [1]
4-[5-(4-Hydroxyphenyl)-2-oxo-1H-imidazo[4,5-b]pyrazin-3-yl]cyclohexane-1-carboxamideIC505000.0 [1]
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanolIC500.13 [1], 0.8 [2], 4.0 [3], 8.0 [4], 13.0 [5]
PF-04691502IC507.9 [1]
PF-04691502Ki16.0 [1]
CID 46244454IC5038.0 [1], 720.0 [2], 2400.0 [3]
BuparlisibIC5094.0 [1], 1981.0 [2], 4600.0 [3]
BuparlisibKi199.0 [1]
Ku-0063794IC502.5 [1], 3.0 [2], 100.0 [3], 150.0 [4]
OmipalisibIC500.18 [1], 0.3 [2], 0.31 [3], 0.68 [4]
(3-(9-(1-Benzylpiperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenyl)methanolIC50634.0 [1], 691.0 [2], 1000.0 [3]
1-(4-Amino-6-Methyl-1,3,5-Triazin-2-Yl)-N-(1h-Pyrazol-3-Yl)-1h-Benzimidazol-2-AmineIC5023.0 [1], 27.0 [2], 55.0 [3], 390.0 [4]
2-[[4-[2-(3-Hydroxyanilino)benzimidazol-1-yl]-6-methyl-1,3,5-triazin-2-yl]amino]acetonitrileIC508.0 [1], 17.0 [2], 380.0 [3]
[(4-{2-[(3-Hydroxyphenyl)amino]-1h-Benzimidazol-1-Yl}-1,3,5-Triazin-2-Yl)amino]acetonitrileIC5093.0 [1], 97.0 [2], 700.0 [3], 1700.0 [4]
2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-olIC508.0 [1]
2-(Morpholin-4-yl)-benzo[h]chromen-4-oneIC506400.0 [1]
4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholineIC50350.0 [1], 370.0 [2]
VistusertibIC502.8 [1], 20.0 [2]
ApitolisibKi17.0 [1]
GedatolisibIC500.4 [1], 1.6 [2]
Imino-methyl-[1-[6-[(3R)-3-methylmorpholin-4-yl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]cyclopropyl]-oxo-lambda6-sulfaneIC50370.0 [1], 5700.0 [2], 23000.0 [3]
1-[4-(3-Ethyl-7-morpholin-4-yltriazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]ureaIC501.7 [1], 2.0 [2], 3.0 [3]
1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5010.0 [1]
4-[2-[(6-Methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC504763.0 [1], 4800.0 [2], 10000.0 [3]
CID 118502708IC50200.0 [1], 610.0 [2]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1], 14800.0 [2]
4-Hydroxy-3,5-dimethoxybenzaldehyde [4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazoneIC50270.0 [1], 1370.0 [2]
BimiralisibIC5089.0 [1], 205.0 [2]
BimiralisibKi62.0 [1]
1-Methyl-3-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]ureaIC500.38 [1], 0.4 [2]
Methyl 4-[6-[4-(methylcarbamoylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylateIC500.46 [1], 0.5 [2]
5-[6-[(4-Methylsulfonylpiperazin-1-yl)methyl]-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]pyrimidin-2-amineIC5029.0 [1]
5-[6-[(4-Methylsulfonylpiperazin-1-yl)methyl]-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]pyrimidin-2-amineKi29.0 [1]
1-Ethyl-3-[4-[6-(2-hydroxypropan-2-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]phenyl]ureaKi3.0 [1]
4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]-1H-indoleIC50330.0 [1], 1460.0 [2], 5900.0 [3]
2-Amino-8-cyclopentyl-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-oneIC5030.09 [1]
2-Amino-8-cyclopentyl-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-oneKi142.0 [1], 200.0 [2]
1-Ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-6,6-dioxo-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl]phenyl]ureaIC506.0 [1], 48.0 [2]
1-Ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-6,6-dioxo-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl]phenyl]ureaKi8.0 [1]
(3R)-3-Methyl-4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]morpholineIC5034.0 [1], 270.0 [2], 1400.0 [3]
N-Methyl-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amineIC5052.0 [1], 1500.0 [2], 4000.0 [3]
3-(Oxan-4-ylmethyl)-5-[4-(1H-1,2,4-triazol-5-yl)phenyl]-1H-imidazo[4,5-b]pyrazin-2-oneIC502.0 [1], 150.0 [2], 273.0 [3]
5-(1H-Indol-5-yl)-3-(oxan-4-ylmethyl)-1H-imidazo[4,5-b]pyrazin-2-oneIC5021.0 [1], 50.0 [2], 231.0 [3]
5-(3H-Benzimidazol-5-yl)-3-(cyclohexylmethyl)-1H-imidazo[4,5-b]pyrazin-2-oneIC5021.0 [1], 137.0 [2], 427.0 [3]
5-[4-(1H-Imidazol-2-yl)phenyl]-3-(oxan-4-ylmethyl)-1H-imidazo[4,5-b]pyrazin-2-oneIC505.0 [1], 55.0 [2], 273.0 [3]
5-[[1-(4-Amino-6-methyl-1,3,5-triazin-2-yl)benzimidazol-2-yl]amino]benzene-1,3-diolIC500.2 [1], 5.0 [2], 97.0 [3]
3-[[4-Methyl-6-[2-(1H-pyrazol-5-ylamino)benzimidazol-1-yl]-1,3,5-triazin-2-yl]amino]propanenitrileIC5060.0 [1], 82.0 [2], 1300.0 [3]
N-[3-[[1-(4-Amino-6-methyl-1,3,5-triazin-2-yl)benzimidazol-2-yl]amino]phenyl]acetamideIC50120.0 [1], 290.0 [2], 1500.0 [3]
3-(1-(4-Amino-6-methyl-1,3,5-triazin-2-yl)-1H-benzo[d]imidazol-2-ylamino)phenolIC507.0 [1], 9.0 [2], 150.0 [3]
1-(4-Amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-indazol-6-yl)benzimidazol-2-amineIC5027.0 [1], 120.0 [2], 1500.0 [3]
3-(1-(2-Methylpyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)phenolIC50370.0 [1], 600.0 [2], 8900.0 [3]
3-(1-(6-Amino-2-methylpyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)phenolIC5043.0 [1], 87.0 [2], 1200.0 [3]
2-[[4-Methyl-6-[2-(1H-pyrazol-5-ylamino)benzimidazol-1-yl]-1,3,5-triazin-2-yl]amino]acetonitrileIC5031.0 [1], 73.0 [2], 600.0 [3]
1-(2-Cyanoethyl)-3-[4-[7,7-dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]ureaIC5026.0 [1], 30.0 [2]
1-(2-Cyanoethyl)-3-[4-[7,7-dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]ureaKi3.2 [1]
1-[(2R)-2,3-Dihydroxypropyl]-3-[4-[7,7-dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]ureaIC5037.0 [1], 47.0 [2]
1-[(2R)-2,3-Dihydroxypropyl]-3-[4-[7,7-dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]ureaKi3.6 [1]
1-Ethyl-3-[4-[(7S)-7-(2-methoxyethyl)-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]ureaIC5012.0 [1], 15.0 [2]
1-Ethyl-3-[4-[(7S)-7-(2-methoxyethyl)-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]ureaKi1.7 [1]
1-[4-[(7S)-7-(2-Cyanoethyl)-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylureaIC5011.0 [1], 15.0 [2]
1-[4-[(7S)-7-(2-Cyanoethyl)-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylureaKi1.3 [1]
1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylureaIC504.6 [1], 13.0 [2]
1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylureaKi1.4 [1]
1-Ethyl-3-[4-[(7R)-7-(hydroxymethyl)-7-methyl-4-morpholin-4-yl-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]ureaIC5030.0 [1], 32.0 [2]
1-Ethyl-3-[4-[(7R)-7-(hydroxymethyl)-7-methyl-4-morpholin-4-yl-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]ureaKi4.4 [1]
1-Ethyl-3-[4-[(7S)-7-(2-hydroxyethyl)-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]ureaIC501.6 [1], 1.7 [2]
1-Ethyl-3-[4-[(7S)-7-(2-hydroxyethyl)-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]ureaKi0.7 [1]
1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-(oxetan-3-yl)ureaIC5030.0 [1], 37.0 [2]
1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-(oxetan-3-yl)ureaKi3.0 [1]
1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-(2-hydroxyethyl)ureaIC504.0 [1], 4.8 [2]
1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-(2-hydroxyethyl)ureaKi1.6 [1]
1-Ethyl-3-[4-[1-methyl-7-[(3S)-3-methylmorpholin-4-yl]pyrazolo[4,3-d]pyrimidin-5-yl]phenyl]ureaIC508.0 [1], 47.0 [2]
1-Ethyl-3-[4-[1-methyl-7-[(3S)-3-methylmorpholin-4-yl]pyrazolo[4,3-d]pyrimidin-5-yl]phenyl]ureaKi8.0 [1]
1-Ethyl-3-[4-[7-methyl-6-[(3S)-3-methylmorpholin-4-yl]purin-2-yl]phenyl]ureaIC50630.0 [1], 2200.0 [2]
1-Ethyl-3-[4-[7-methyl-6-[(3S)-3-methylmorpholin-4-yl]purin-2-yl]phenyl]ureaKi30.0 [1]
1-Ethyl-3-[4-[7-methyl-6-[(3R)-3-methylmorpholin-4-yl]purin-2-yl]phenyl]ureaIC50650.0 [1], 730.0 [2]
1-Ethyl-3-[4-[7-methyl-6-[(3R)-3-methylmorpholin-4-yl]purin-2-yl]phenyl]ureaKi69.0 [1]
(S)-1-Ethyl-3-(4-(6-(3-ethylmorpholino)-7-methyl-7H-purin-2-yl)phenyl)ureaIC5069.0 [1], 153.0 [2]
(S)-1-Ethyl-3-(4-(6-(3-ethylmorpholino)-7-methyl-7H-purin-2-yl)phenyl)ureaKi4.0 [1]
1-Ethyl-3-[4-[7-methyl-6-(1,4-oxazepan-4-yl)purin-2-yl]phenyl]ureaIC507200.0 [1], 8900.0 [2]
1-Ethyl-3-[4-[7-methyl-6-(1,4-oxazepan-4-yl)purin-2-yl]phenyl]ureaKi120.0 [1]
1-Ethyl-3-[4-[7-[(3S)-3-ethylmorpholin-4-yl]-1,3-dimethylpyrazolo[4,3-d]pyrimidin-5-yl]phenyl]ureaIC504.0 [1], 8.0 [2]
1-Ethyl-3-[4-[7-[(3S)-3-ethylmorpholin-4-yl]-1,3-dimethylpyrazolo[4,3-d]pyrimidin-5-yl]phenyl]ureaKi2.0 [1]
1-Ethyl-3-[4-[7-[(3S)-3-ethylmorpholin-4-yl]-1-methylpyrazolo[4,3-d]pyrimidin-5-yl]phenyl]ureaIC508.0 [1], 15.0 [2]
1-Ethyl-3-[4-[7-[(3S)-3-ethylmorpholin-4-yl]-1-methylpyrazolo[4,3-d]pyrimidin-5-yl]phenyl]ureaKi1.0 [1]
1-Ethyl-3-[4-[1-methyl-7-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[4,3-d]pyrimidin-5-yl]phenyl]ureaIC50270.0 [1], 340.0 [2]
1-Ethyl-3-[4-[1-methyl-7-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[4,3-d]pyrimidin-5-yl]phenyl]ureaKi28.0 [1]
1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5-oxofuro[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylureaIC507.6 [1], 13.0 [2]
1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5-oxofuro[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylureaKi1.2 [1]
1-[4-(7,7-Dimethyl-4-morpholin-4-yl-5-oxofuro[3,4-d]pyrimidin-2-yl)phenyl]-3-ethylureaIC5016.0 [1], 20.0 [2]
1-[4-(7,7-Dimethyl-4-morpholin-4-yl-5-oxofuro[3,4-d]pyrimidin-2-yl)phenyl]-3-ethylureaKi2.6 [1]
1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-(1-methylpyrazol-4-yl)ureaIC504.3 [1], 6.0 [2]
1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-(1-methylpyrazol-4-yl)ureaKi0.8 [1]
6-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]anilino]-1H-pyridin-2-oneIC509.3 [1], 15.0 [2]
6-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]anilino]-1H-pyridin-2-oneKi1.2 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase mTOR Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-mtor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Serine/threonine-protein kinase mTOR Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-mtor-inhibitors-ic50-ki.
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