Serine/threonine-protein kinase MST2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	0.41 [1], 4.72 [2]
	Su6656	IC50	110.0 [1]
	Doramapimod	IC50	30000.0 [1]
	JNK Inhibitor VIII	Ki	8800.0 [1]
	3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile	IC50	22.0 [1]
	Cep-11981	IC50	21.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	Ki	8800.0 [1]
	4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide	Ki	8800.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	5-(4-Chlorophenyl)-N-(4-piperazin-1-ylphenyl)furan-2-carboxamide	IC50	30000.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamide	Ki	8800.0 [1]
	N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide	Ki	8800.0 [1]
	N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide	Ki	8800.0 [1]
	N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamide	Ki	8800.0 [1]
	Ripk1-IN-7	IC50	50.0 [1]
	3-Methyl-N-[6-methylsulfanyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine	IC50	10000.0 [1]
	CID 27666048	IC50	100000.0 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine	IC50	570.0 [1]
	N-[3-[5-[2-(3-Morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide	IC50	650.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	CID 71553154	IC50	470.0 [1]
	3-[5-Chloro-4-[(2,4-difluorophenyl)methoxy]-6-oxopyrimidin-1-yl]-N-(2-hydroxyethyl)-4-methylbenzamide	IC50	10000.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	10000.0 [1]
	2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	10000.0 [1]
	3-[4-[(2S)-2-(5-Methyl-1,2,4-oxadiazol-3-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile	IC50	795.0 [1]
	3-[4-(2,3,3a,4,6,6a-Hexahydrofuro[2,3-c]pyrrol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile	IC50	626.0 [1]
	2-[Ethyl-[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]amino]ethanol	IC50	500.0 [1]
	2-(5-Methoxy-3-oxo-1H-isoindol-2-yl)-N-(4-piperazin-1-ylpyridin-3-yl)-1,3-thiazole-4-carboxamide	IC50	2100.0 [1]
	N-[6-Methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(pyridin-2-ylmethyl)-1,2-thiazol-5-amine	IC50	500.0 [1]
	3,4-Difluoro-2-(2-fluoro-4-iodoanilino)-5-[[(4-methylsulfonylphenyl)methylamino]methyl]benzoic acid	IC50	30000.0 [1]
	5-[[[(2S)-2,4-Diamino-4-oxobutanoyl]amino]methyl]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid	IC50	6000.0 [1]
	3,4-Difluoro-2-(2-fluoro-4-iodoanilino)-5-[(E)-[[5-(hydroxymethyl)furan-2-carbonyl]hydrazinylidene]methyl]benzoic acid	IC50	30000.0 [1]
	5-[(E)-[[2-(4-Chlorophenyl)sulfonylacetyl]hydrazinylidene]methyl]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid	IC50	30000.0 [1]
	Aurora inhibitor 1	IC50	1000.0 [1]
	3-[Dideuterio-(3,3-difluoropyrrolidin-1-yl)methyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;hydrochloride	IC50	100.0 [1]
	N-[5-[6-(Methylamino)pyrazin-2-yl]-2-oxo-1H-pyridin-3-yl]-4-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]benzamide	Ki	1000.0 [1]
	2-(4-Chlorophenyl)-8-piperazin-1-yl-5-[(2-pyridin-3-ylphenyl)methyl]-10H-furo[2,3-c][1]benzazepin-4-one	IC50	12000.0 [1]
	3-[(3,3-Difluoropyrrolidin-1-yl)methyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;hydrochloride	IC50	100.0 [1]
	SCH-1473759 (hydrochloride)	IC50	100.0 [1]
	(3R)-1-[2-[4-(4-Acetylphenyl)piperazin-1-yl]-2-oxoethyl]-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide	IC50	30000.0 [1]
	3-(Tert-butylamino)-4-[[2-(4-pyridin-4-ylanilino)pyrimidin-4-yl]amino]cyclobut-3-ene-1,2-dione	Ki	2900.0 [1]
	2-(3,5-Dichloroanilino)-4-[[4-(dimethylamino)cyclohexyl]amino]-N-(1-methylpiperidin-4-yl)pyrimidine-5-carboxamide	IC50	30000.0 [1]
	2-(3,5-Dichloroanilino)-4-[[(3R,4S)-4-hydroxyoxolan-3-yl]amino]-N-(1-methylpiperidin-4-yl)pyrimidine-5-carboxamide	IC50	30000.0 [1]
	3-{4-[(2S)-2-Methylmorpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}benzonitrile	IC50	179.0 [1]
	3-[4-[2-(3-Methyl-1,2,4-oxadiazol-5-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile	IC50	2388.0 [1]
	4-[5-(3-Cyanophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine-2-carbonitrile	IC50	288.0 [1]
	3-[4-[2-(1,2-Oxazol-5-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile	IC50	1333.0 [1]
	3-[4-[2-(Cyanomethyl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile	IC50	196.0 [1]
	3-[4-[(2R)-2-(5-Methyl-1,2,4-oxadiazol-3-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile	IC50	3239.0 [1]
	1-[4-[2-[5-(4-Chlorophenyl)furan-2-yl]imidazol-1-yl]phenyl]piperazine	IC50	30000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase MST2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-mst2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 21). Quest Database™ Serine/threonine-protein kinase MST2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-mst2-inhibitors-ic50-ki.
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