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Serine/threonine-protein kinase MRCK-A Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi9524.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi6630.0 [1]
7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileKi4440.0 [1]
N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamideKi10000.0 [1]
CID 46864283IC50669.0 [1]
N-[3-[5-[2-(3-Morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamideIC501000.0 [1]
Chroman 1IC50127.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
1-(2-Hydroxyethyl)-1-[(3-methoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC504306.0 [1]
1-[2-(Dimethylamino)ethyl]-1-[(3-methoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC508695.0 [1]
1-[1-(3-Fluorophenyl)-3-hydroxypropyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC506400.0 [1]
1-[(3-Methoxyphenyl)methyl]-1-methyl-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC501853.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
1-Ethyl-1-[(3-methoxyphenyl)methyl]-3-[2-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(1H-pyrazol-4-yl)phenyl]ureaIC501550.0 [1]
2-[(1S)-1-Amino-2-(4-fluorophenyl)ethyl]-6-(1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC501000.0 [1]
2-[Amino-(4-methoxyphenyl)methyl]-6-(1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC501000.0 [1]
2-[(1S)-1-Amino-2-(4-chlorophenyl)ethyl]-6-(1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC501000.0 [1]
2-[(3S,4R)-4-Phenylpyrrolidin-3-yl]-6-(1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC501000.0 [1]
2-[(3S,4R)-4-(4-Chlorophenyl)pyrrolidin-3-yl]-6-(1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC501000.0 [1]
N-[(4-Chlorophenyl)-[4-oxo-6-(1H-pyrazol-4-yl)-3H-quinazolin-2-yl]methyl]-2-(dimethylamino)acetamideIC501000.0 [1]
2-[(3S,4R)-4-(4-Methoxyphenyl)-1-methylpyrrolidin-3-yl]-6-(1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC501000.0 [1]
2-[(1R)-1-Amino-2-(3-fluorophenyl)ethyl]-8-methoxy-6-(1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC501000.0 [1]
2-[Amino-(3-chlorophenyl)methyl]-6-(1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC501000.0 [1]
2-[Amino-(3-chlorophenyl)methyl]-8-methoxy-6-(1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC501000.0 [1]
4-(Aminomethyl)-N-[(4-chlorophenyl)-[4-oxo-6-(1H-pyrazol-4-yl)-3H-quinazolin-2-yl]methyl]benzamideIC501000.0 [1]
2-[(1S)-1-Amino-2-(4-methoxyphenyl)ethyl]-6-(1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC501000.0 [1]
2-[(1R)-1-Amino-2-(4-fluorophenyl)ethyl]-6-(1H-pyrazol-4-yl)-3H-quinazolin-4-oneIC501000.0 [1]
N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)chroman-3-carboxamideIC50210.0 [1]
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamideIC50150.0 [1]
(3R)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamideIC505350.0 [1]
(3R)-N-[2-[2-(Dimethylamino)ethoxy]-5-fluoro-4-(1H-pyrazol-4-yl)phenyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamideIC50333.0 [1]
N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-6-fluorochroman-3-carboxamideIC5079.0 [1]
N-[2-(Dimethylamino)ethyl]-N-[(3-methoxyphenyl)methyl]-6-(1H-pyrazol-4-yl)-1,3-benzothiazole-2-carboxamideIC50247.0 [1]
N-[3-(Dimethylamino)propyl]-3-[6-(1H-pyrazol-4-yl)-1,3-benzothiazol-2-yl]-3,4-dihydro-2H-chromene-6-carboxamideIC509552.0 [1]
N-Ethyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)benzo[d]thiazole-2-carboxamideIC507861.0 [1]
(3R)-N-[2-[2-(Dimethylamino)ethoxy]-5-fluoro-4-(1H-pyrazol-4-yl)phenyl]-2-ethyl-3,4-dihydro-1H-isoquinoline-3-carboxamideIC50810.0 [1]
N,N-Dimethyl-2-[(3S,4R)-4-phenylpyrrolidin-3-yl]-6-(1H-pyrazol-4-yl)quinazolin-4-amineIC501000.0 [1]
1-[(3-Hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea;methanesulfonic acidIC502.87 [1]
(3R)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamideIC508640.0 [1]
(3S)-6-Methoxy-N-[4-(1H-pyrazol-4-yl)-2-(2-pyrrolidin-1-ylethoxy)phenyl]-3,4-dihydro-2H-chromene-3-carboxamideIC501275.0 [1]
(3R)-6-Methoxy-N-[4-(1H-pyrazol-4-yl)-2-(2-pyrrolidin-1-ylethoxy)phenyl]-3,4-dihydro-2H-chromene-3-carboxamideIC5020000.0 [1]
(3S)-6-Methoxy-N-[2-[(3R)-1-methylpyrrolidin-3-yl]oxy-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-2H-chromene-3-carboxamideIC50261.0 [1]
(3R)-6-Methoxy-N-[2-[(3R)-1-methylpyrrolidin-3-yl]oxy-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-2H-chromene-3-carboxamideIC5020000.0 [1]
(3S)-6-Methoxy-N-[2-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-2H-chromene-3-carboxamideIC50294.0 [1]
(3S)-N-[2-(3-Hydroxypropoxy)-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamideIC5074.0 [1]
Items per page: 1 - 10 of 46
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase MRCK-A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-mrck-a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Serine/threonine-protein kinase MRCK-A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-mrck-a-inhibitors-ic50-ki.
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