Serine/threonine-protein kinase Chk2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	27.0 [1]
	2-[4-[(4-Hydroxyphenyl)thio]phenyl]-1H-benzoimidazole-5-carboxamide	IC50	2.3 [1]
	Chk2 Inhibitor II	IC50	15.0 [1], 16.0 [2]
	Chk2 Inhibitor II	Ki	37.0 [1]
	Debromohymenialdisine	IC50	183.0 [1], 3500.0 [2]
	Hymenialdisine Analogue 1	IC50	8.0 [1]
	2-(4-Phenoxyphenyl)-3H-benzimidazole-5-carboxylic acid	IC50	640.0 [1], 844.0 [2]
	Hymenialdisine	IC50	42.0 [1]
	2-(4-Phenoxyphenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	55.0 [1]
	3-Hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenylamino-phenylamino)-isothiazole-4-carboxamidine	IC50	13.0 [1], 460.0 [2]
	Methyl 6-((5-cyanopyrazin-2-yl)amino)-4-((piperidin-4-ylmethyl)amino)nicotinate	IC50	9600.0 [1], 12000.0 [2]
	Ethyl 4-[2-(aminomethyl)morpholin-4-yl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylate	IC50	50000.0 [1], 74000.0 [2]
	2-[4-(3,4-Dimethyl-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	12.0 [1]
	2-[4-(3,4-Dichloro-phenylsulfamoyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	3.0 [1], 3.4 [2]
	2-(4-Phenylcarbamoyl-phenyl)-1H-benzoimidazole-5-carboxylic acid amide	IC50	410.0 [1]
	3-[4-(5-Carbamoyl-1H-benzoimidazol-2-yl)-phenoxy]-benzoic acid	IC50	715.0 [1]
	2-[4-(4-Chloro-3-hydroxy-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	9.8 [1], 10.0 [2]
	2-[4-(4-Chloro-benzenesulfinyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	13.0 [1]
	2-[4-(2-Fluoro-5-trifluoromethyl-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	12.0 [1]
	2-(4-(4-Chlorophenoxy)phenyl)-1H-benzo[d]imidazole-5-carboxylic acid	IC50	133.0 [1]
	2-[4-(3-Chloro-4-methyl-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	4.0 [1], 4.4 [2]
	2-[4-(4-Chloro-phenylsulfanyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	7.0 [1], 8.2 [2]
	2-[4-(4-Chloro-benzenesulfonyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	6.6 [1], 7.0 [2]
	2-[4-(4-Chloro-phenylsulfamoyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	10.0 [1], 14.0 [2]
	2-[4-(4-Chloro-3-trifluoromethyl-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	3.0 [1], 4.5 [2]
	2-[4-(3,4-Dichloro-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	5.0 [1], 5.5 [2]
	2-[4-[4-(Methanesulfonamido)phenoxy]phenyl]-3H-benzimidazole-5-carboxamide	IC50	41.0 [1], 46.0 [2]
	2-[4-(4-Chlorophenyl)phenyl]-3H-benzimidazole-5-carboxamide	IC50	250.0 [1], 253.0 [2]
	2-[4-(3,4-Dimethoxy-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	31.0 [1]
	2-[4-(3-Diethylcarbamoyl-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	820.0 [1]
	2-[4-(3-Chloro-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	17.0 [1]
	2-(4-(4-Chlorophenoxy)phenyl)-1H-imidazo[4,5-b]pyridine-5-carboxamide	IC50	77.0 [1]
	2-[4-(Naphthalen-2-yloxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	12.0 [1]
	2-[4-(4-Chloro-phenylcarbamoyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	679.0 [1], 680.0 [2]
	2-(4-(2-(1-Acetylpiperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	292.0 [1]
	2-(4-((1-Benzoylpiperidin-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	39.0 [1], 52.0 [2]
	2-(4-(Piperidin-4-ylmethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	231.0 [1]
	2-(4-(2-(1-Benzoylpiperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	52.0 [1]
	2-(4-(Piperidin-3-ylmethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	158.0 [1]
	2-(4-(2-(1-(4-Chlorobenzyl)piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	82.0 [1]
	2-(4-{[1-(4-Chlorobenzyl)piperidin-4-Yl]methoxy}phenyl)-1h-Benzimidazole-5-Carboxamide	IC50	60.0 [1]
	2-(4-((1-Acetylpiperidin-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	78.0 [1]
	2-{4-[(1-Benzylpiperidin-4-YL)methoxy]phenyl}-1H-benzimidazole-6-carboxamide	IC50	70.0 [1]
	2-(4-(2-(1-Benzylpiperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	45.0 [1]
	2-(4-((1-(4-Methoxybenzyl)piperidin-3-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	55.0 [1]
	2-(4-(3-(Piperidin-1-yl)propoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	110.0 [1]
	2-(4-((1-(3,4-Dichlorobenzyl)piperidin-3-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	75.0 [1], 180.0 [2]
	2-(4-(4-Hydroxycyclohexyloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	80.0 [1]
	2-(4-(Piperidin-4-yloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	710.0 [1]
	2-(4-(3-Hydroxycyclopentyloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	72.0 [1]
	2-(4-((1-Benzylpiperidin-3-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	37.0 [1]
	2-[4-[2-[1-[(4-Methylphenyl)methyl]piperidin-2-yl]ethoxy]phenyl]-3H-benzimidazole-5-carboxamide	IC50	61.0 [1]
	2-(4-((1-(4-Methoxybenzyl)piperidin-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	67.0 [1]
	2-(4-(2-(1-(4-Methoxybenzyl)piperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	74.0 [1]
	2-(4-(2-(1-(4-Methoxybenzyl)piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	95.0 [1]
	2-(4-(3-(Dimethylamino)propoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	122.0 [1], 176.0 [2]
	2-{4-[1-(4-Methyl-benzyl)-piperidin-4-ylmethoxy]-phenyl}-1H-benzoimidazole-5-carboxylic acid amide	IC50	70.0 [1], 76.0 [2]
	2-(4-(2-Hydroxyethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	52.0 [1]
	2-(4-(1-Methylpyrrolidin-3-yloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	659.0 [1], 710.0 [2]
	2-(4-(1-Methylpiperidin-4-yloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	233.0 [1]
	2-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	174.0 [1]
	2-(4-(Piperidin-3-yloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	180.0 [1]
	2-(4-((1-(3,4-Dichlorobenzyl)piperidin-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	110.0 [1], 176.0 [2]
	2-(4-(3-Hydroxypropoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	73.0 [1]
	2-(4-(2-(1-(3,4-Dichlorobenzyl)piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	157.0 [1]
	2-(4-(2-(1-(3,4-Dichlorobenzyl)piperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	30.0 [1], 114.0 [2]
	2-(4-(2-(1-Acetylpiperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	86.0 [1]
	2-{4-[1-(4-Methyl-benzyl)-piperidin-3-ylmethoxy]-phenyl}-1H-benzoimidazole-5-carboxylic acid amide	IC50	57.0 [1]
	2-(4-((1-Acetylpiperidin-3-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	140.0 [1]
	2-(4-(2-(1-Benzoylpiperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	23.0 [1]
	2-[4-[2-[1-[(4-Methylphenyl)methyl]piperidin-4-yl]ethoxy]phenyl]-3H-benzimidazole-5-carboxamide	IC50	90.0 [1]
	2-(4-((1-(4-Chlorobenzyl)piperidin-3-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	14.0 [1], 35.0 [2]
	2-(4-(1-Acetylpiperidin-3-yloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	100.0 [1]
	2-(4-(1-Benzylpyrrolidin-3-yloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	84.0 [1], 109.0 [2]
	2-(4-(2-(1-(4-Chlorobenzyl)piperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	53.0 [1]
	2-(4-(2-(1-Benzylpiperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide	IC50	90.0 [1]
	2-[4-[4-(Hydroxymethyl)cyclohexyl]oxyphenyl]-3H-benzimidazole-5-carboxamide	IC50	35.0 [1], 400.0 [2]
	N~7~-(4-Ethoxyphenyl)-6-Methyl-N~5~-[(3s)-Piperidin-3-Yl]pyrazolo[1,5-A]pyrimidine-5,7-Diamine	IC50	1700.0 [1], 30000.0 [2]
	2-(4-p-Tolyloxy-phenyl)-1H-benzoimidazole-5-carboxylic acid amide	IC50	24.0 [1]
	2-[4-(4-Methoxy-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	23.0 [1]
	2-(4-Phenoxy-phenyl)-1H-benzoimidazole-5-sulfonic acid amide	IC50	289.0 [1], 290.0 [2]
	2-[4-(4-Carbamoyl-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	47.0 [1]
	2-Biphenyl-4-yl-1H-benzoimidazole-5-carboxylic acid amide	IC50	100.0 [1], 103.0 [2]
	2-[4-(4-Nitro-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide	IC50	81.0 [1], 82.0 [2]
	2-[4-[(4-Hydroxycyclohexyl)methoxy]phenyl]-3H-benzimidazole-5-carboxamide	IC50	54.0 [1], 400.0 [2]
	2-[(Z)-[2-Bromo-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine	IC50	1960.0 [1], 88500.0 [2]
	Sunitinib	IC50	16.84 [1]
	(2S,3R,4R,6R,18S)-18-Hydroxy-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one	IC50	10.0 [1]
	Doramapimod	IC50	19000.0 [1]
	(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide	IC50	10.0 [1]
	4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid	IC50	28000.0 [1]
	2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one	IC50	1100.0 [1]
	Isogranulatimide	IC50	3000.0 [1]
	JNK Inhibitor VIII	Ki	9500.0 [1]
	5-(2-Chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methylpyrazolo(3,4-b)(1,4)benzodiazepine	IC50	24.0 [1]
	Cct-241533	IC50	3.0 [1]
	(R)-5-(8-Chloroisoquinolin-3-Ylamino)-3-(1-(Dimethylamino)propan-2-Yloxy)pyrazine-2-Carbonitrile	IC50	100000.0 [1]
	CID 59604787	IC50	10000.0 [1]
	3-(3-Hydroxypropyl)-7-(propan-2-yloxymethyl)-3,13-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-14-one	IC50	3000.0 [1]
	CID 54758482	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase Chk2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-chk2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Serine/threonine-protein kinase Chk2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-chk2-inhibitors-ic50-ki.
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