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Serine/threonine-protein kinase Chk2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
StaurosporineIC5027.0 [1]
2-[4-[(4-Hydroxyphenyl)thio]phenyl]-1H-benzoimidazole-5-carboxamideIC502.3 [1]
Chk2 Inhibitor IIIC5015.0 [1], 16.0 [2]
Chk2 Inhibitor IIKi37.0 [1]
DebromohymenialdisineIC50183.0 [1], 3500.0 [2]
Hymenialdisine Analogue 1IC508.0 [1]
2-(4-Phenoxyphenyl)-3H-benzimidazole-5-carboxylic acidIC50640.0 [1], 844.0 [2]
HymenialdisineIC5042.0 [1]
2-(4-Phenoxyphenyl)-1H-benzo[d]imidazole-5-carboxamideIC5055.0 [1]
3-Hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenylamino-phenylamino)-isothiazole-4-carboxamidineIC5013.0 [1], 460.0 [2]
Methyl 6-((5-cyanopyrazin-2-yl)amino)-4-((piperidin-4-ylmethyl)amino)nicotinateIC509600.0 [1], 12000.0 [2]
Ethyl 4-[2-(aminomethyl)morpholin-4-yl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylateIC5050000.0 [1], 74000.0 [2]
2-[4-(3,4-Dimethyl-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC5012.0 [1]
2-[4-(3,4-Dichloro-phenylsulfamoyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC503.0 [1], 3.4 [2]
2-(4-Phenylcarbamoyl-phenyl)-1H-benzoimidazole-5-carboxylic acid amideIC50410.0 [1]
3-[4-(5-Carbamoyl-1H-benzoimidazol-2-yl)-phenoxy]-benzoic acidIC50715.0 [1]
2-[4-(4-Chloro-3-hydroxy-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC509.8 [1], 10.0 [2]
2-[4-(4-Chloro-benzenesulfinyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC5013.0 [1]
2-[4-(2-Fluoro-5-trifluoromethyl-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC5012.0 [1]
2-(4-(4-Chlorophenoxy)phenyl)-1H-benzo[d]imidazole-5-carboxylic acidIC50133.0 [1]
2-[4-(3-Chloro-4-methyl-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC504.0 [1], 4.4 [2]
2-[4-(4-Chloro-phenylsulfanyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC507.0 [1], 8.2 [2]
2-[4-(4-Chloro-benzenesulfonyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC506.6 [1], 7.0 [2]
2-[4-(4-Chloro-phenylsulfamoyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC5010.0 [1], 14.0 [2]
2-[4-(4-Chloro-3-trifluoromethyl-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC503.0 [1], 4.5 [2]
2-[4-(3,4-Dichloro-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC505.0 [1], 5.5 [2]
2-[4-[4-(Methanesulfonamido)phenoxy]phenyl]-3H-benzimidazole-5-carboxamideIC5041.0 [1], 46.0 [2]
2-[4-(4-Chlorophenyl)phenyl]-3H-benzimidazole-5-carboxamideIC50250.0 [1], 253.0 [2]
2-[4-(3,4-Dimethoxy-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC5031.0 [1]
2-[4-(3-Diethylcarbamoyl-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC50820.0 [1]
2-[4-(3-Chloro-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC5017.0 [1]
2-(4-(4-Chlorophenoxy)phenyl)-1H-imidazo[4,5-b]pyridine-5-carboxamideIC5077.0 [1]
2-[4-(Naphthalen-2-yloxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC5012.0 [1]
2-[4-(4-Chloro-phenylcarbamoyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC50679.0 [1], 680.0 [2]
2-(4-(2-(1-Acetylpiperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50292.0 [1]
2-(4-((1-Benzoylpiperidin-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5039.0 [1], 52.0 [2]
2-(4-(Piperidin-4-ylmethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50231.0 [1]
2-(4-(2-(1-Benzoylpiperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5052.0 [1]
2-(4-(Piperidin-3-ylmethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50158.0 [1]
2-(4-(2-(1-(4-Chlorobenzyl)piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5082.0 [1]
2-(4-{[1-(4-Chlorobenzyl)piperidin-4-Yl]methoxy}phenyl)-1h-Benzimidazole-5-CarboxamideIC5060.0 [1]
2-(4-((1-Acetylpiperidin-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5078.0 [1]
2-{4-[(1-Benzylpiperidin-4-YL)methoxy]phenyl}-1H-benzimidazole-6-carboxamideIC5070.0 [1]
2-(4-(2-(1-Benzylpiperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5045.0 [1]
2-(4-((1-(4-Methoxybenzyl)piperidin-3-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5055.0 [1]
2-(4-(3-(Piperidin-1-yl)propoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50110.0 [1]
2-(4-((1-(3,4-Dichlorobenzyl)piperidin-3-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5075.0 [1], 180.0 [2]
2-(4-(4-Hydroxycyclohexyloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5080.0 [1]
2-(4-(Piperidin-4-yloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50710.0 [1]
2-(4-(3-Hydroxycyclopentyloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5072.0 [1]
2-(4-((1-Benzylpiperidin-3-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5037.0 [1]
2-[4-[2-[1-[(4-Methylphenyl)methyl]piperidin-2-yl]ethoxy]phenyl]-3H-benzimidazole-5-carboxamideIC5061.0 [1]
2-(4-((1-(4-Methoxybenzyl)piperidin-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5067.0 [1]
2-(4-(2-(1-(4-Methoxybenzyl)piperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5074.0 [1]
2-(4-(2-(1-(4-Methoxybenzyl)piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5095.0 [1]
2-(4-(3-(Dimethylamino)propoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50122.0 [1], 176.0 [2]
2-{4-[1-(4-Methyl-benzyl)-piperidin-4-ylmethoxy]-phenyl}-1H-benzoimidazole-5-carboxylic acid amideIC5070.0 [1], 76.0 [2]
2-(4-(2-Hydroxyethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5052.0 [1]
2-(4-(1-Methylpyrrolidin-3-yloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50659.0 [1], 710.0 [2]
2-(4-(1-Methylpiperidin-4-yloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50233.0 [1]
2-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50174.0 [1]
2-(4-(Piperidin-3-yloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50180.0 [1]
2-(4-((1-(3,4-Dichlorobenzyl)piperidin-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50110.0 [1], 176.0 [2]
2-(4-(3-Hydroxypropoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5073.0 [1]
2-(4-(2-(1-(3,4-Dichlorobenzyl)piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50157.0 [1]
2-(4-(2-(1-(3,4-Dichlorobenzyl)piperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5030.0 [1], 114.0 [2]
2-(4-(2-(1-Acetylpiperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5086.0 [1]
2-{4-[1-(4-Methyl-benzyl)-piperidin-3-ylmethoxy]-phenyl}-1H-benzoimidazole-5-carboxylic acid amideIC5057.0 [1]
2-(4-((1-Acetylpiperidin-3-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50140.0 [1]
2-(4-(2-(1-Benzoylpiperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5023.0 [1]
2-[4-[2-[1-[(4-Methylphenyl)methyl]piperidin-4-yl]ethoxy]phenyl]-3H-benzimidazole-5-carboxamideIC5090.0 [1]
2-(4-((1-(4-Chlorobenzyl)piperidin-3-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5014.0 [1], 35.0 [2]
2-(4-(1-Acetylpiperidin-3-yloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC50100.0 [1]
2-(4-(1-Benzylpyrrolidin-3-yloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5084.0 [1], 109.0 [2]
2-(4-(2-(1-(4-Chlorobenzyl)piperidin-2-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5053.0 [1]
2-(4-(2-(1-Benzylpiperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamideIC5090.0 [1]
2-[4-[4-(Hydroxymethyl)cyclohexyl]oxyphenyl]-3H-benzimidazole-5-carboxamideIC5035.0 [1], 400.0 [2]
N~7~-(4-Ethoxyphenyl)-6-Methyl-N~5~-[(3s)-Piperidin-3-Yl]pyrazolo[1,5-A]pyrimidine-5,7-DiamineIC501700.0 [1], 30000.0 [2]
2-(4-p-Tolyloxy-phenyl)-1H-benzoimidazole-5-carboxylic acid amideIC5024.0 [1]
2-[4-(4-Methoxy-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC5023.0 [1]
2-(4-Phenoxy-phenyl)-1H-benzoimidazole-5-sulfonic acid amideIC50289.0 [1], 290.0 [2]
2-[4-(4-Carbamoyl-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC5047.0 [1]
2-Biphenyl-4-yl-1H-benzoimidazole-5-carboxylic acid amideIC50100.0 [1], 103.0 [2]
2-[4-(4-Nitro-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amideIC5081.0 [1], 82.0 [2]
2-[4-[(4-Hydroxycyclohexyl)methoxy]phenyl]-3H-benzimidazole-5-carboxamideIC5054.0 [1], 400.0 [2]
2-[(Z)-[2-Bromo-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidineIC501960.0 [1], 88500.0 [2]
SunitinibIC5016.84 [1]
(2S,3R,4R,6R,18S)-18-Hydroxy-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-oneIC5010.0 [1]
DoramapimodIC5019000.0 [1]
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamideIC5010.0 [1]
4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acidIC5028000.0 [1]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC501100.0 [1]
IsogranulatimideIC503000.0 [1]
JNK Inhibitor VIIIKi9500.0 [1]
5-(2-Chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methylpyrazolo(3,4-b)(1,4)benzodiazepineIC5024.0 [1]
Cct-241533IC503.0 [1]
(R)-5-(8-Chloroisoquinolin-3-Ylamino)-3-(1-(Dimethylamino)propan-2-Yloxy)pyrazine-2-CarbonitrileIC50100000.0 [1]
CID 59604787IC5010000.0 [1]
3-(3-Hydroxypropyl)-7-(propan-2-yloxymethyl)-3,13-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-14-oneIC503000.0 [1]
CID 54758482IC5010000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase Chk2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-chk2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Serine/threonine-protein kinase Chk2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-chk2-inhibitors-ic50-ki.
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