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Serine/threonine-protein kinase Chk1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
StaurosporineIC501.2 [1]
IsogranulatimideIC50100.0 [1]
DebromohymenialdisineIC50330.0 [1], 725.0 [2], 3000.0 [3]
GranulatimideIC5080.0 [1], 81.0 [2], 250.0 [3]
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamideIC505.0 [1], 6.0 [2], 7.89 [3]
4-[4-(6,7-Dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenyl]phenolIC501.6 [1], 2.0 [2]
4-[4-(6,7-Dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenyl]phenolKi1.58 [1]
2-(Carbamoylamino)-5-Phenyl-N-[(3s)-Piperidin-3-Yl]thiophene-3-CarboxamideIC507.0 [1]
4-(6-{[(4-Methylcyclohexyl)amino]methyl}-1,4-Dihydroindeno[1,2-C]pyrazol-3-Yl)benzoic AcidIC5020.0 [1], 22.0 [2]
4-(6-{[(4-Methylcyclohexyl)amino]methyl}-1,4-Dihydroindeno[1,2-C]pyrazol-3-Yl)benzoic AcidKi19.95 [1]
9-Hydroxy-4-phenyl-6H-pyrrolo[3,4-C]carbazole-1,3-dioneIC5047.0 [1]
(R)-5-(8-Chloroisoquinolin-3-Ylamino)-3-(1-(Dimethylamino)propan-2-Yloxy)pyrazine-2-CarbonitrileIC506.1 [1], 13.0 [2], 55.0 [3]
Hymenialdisine Analogue 1IC50234.0 [1], 237.0 [2], 470.0 [3]
CID 54758482IC506.0 [1], 7.7 [2], 29.0 [3]
Bis-imide AIC5020.0 [1]
(3Z)-6-(4-Hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-oneIC507.0 [1]
(3Z)-6-(4-Hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-oneKi31.62 [1]
7-Chloro-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileIC507.0 [1], 11.0 [2]
3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-CarboxamideIC506.2 [1]
3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-CarboxamideKi6.31 [1]
7-Chloro-3-oxo-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5(10),6,8,17(21),18-hexaene-18-carbonitrileIC506.0 [1]
9-(3-Methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-oneIC5010.0 [1]
9-(3-Methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-oneKi10.0 [1]
Methyl 6-((5-cyanopyrazin-2-yl)amino)-4-((piperidin-4-ylmethyl)amino)nicotinateIC5021.0 [1], 36.0 [2], 825.0 [3]
3-[4-(4-Methylpiperazin-1-Yl)phenyl]-9h-Pyrrolo[2,3-B:5,4-C']dipyridine-6-CarbonitrileIC501.3 [1], 98.0 [2]
3-[(2R)-1-(Dimethylamino)propan-2-yl]oxy-5-[[4-(methylamino)-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]pyrazine-2-carbonitrileIC503.1 [1], 8.0 [2], 27.0 [3]
(2S,3R,4R,6R,18S)-18-Hydroxy-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-oneIC505.6 [1], 10.0 [2]
HymenialdisineIC501900.0 [1], 1950.0 [2]
Wee1 InhibitorIC50440.0 [1]
(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amineIC504200.0 [1]
(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amineKi5011.87 [1]
4-(2,6-Dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC501200.0 [1]
2-[(5,6-Diphenylfuro[2,3-D]pyrimidin-4-YL)amino]ethanolIC5020900.0 [1]
2-[(5,6-Diphenylfuro[2,3-D]pyrimidin-4-YL)amino]ethanolKi13700.0 [1]
4-(2-Chlorophenyl)-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50220.0 [1]
Wee1 Inhibitor IIIC5035000.0 [1]
9-Hydroxy-6-methyl-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC5056.0 [1]
1-(5-Chloro-2,4-Dimethoxyphenyl)-3-(5-Cyanopyrazin-2-Yl)ureaIC507.0 [1]
1-(5-Chloro-2,4-Dimethoxyphenyl)-3-(5-Cyanopyrazin-2-Yl)ureaKi10.0 [1]
4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50170.0 [1]
(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamineIC5016000.0 [1]
9-(4-Hydroxy-3-methoxyphenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-oneIC5082.0 [1]
9-(4-Hydroxy-3-methoxyphenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-oneKi79.43 [1]
4-(6-(Morpholinomethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acidIC507.9 [1]
4-(6-(Morpholinomethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acidKi7.94 [1]
3-[5-Chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopyrazin-2-yl)ureaIC503.0 [1]
3-[5-Chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopyrazin-2-yl)ureaKi3.16 [1]
7-Chloro-3-oxo-8-(pyridin-4-ylmethylamino)-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileIC5013.0 [1]
7-Chloro-3-oxo-8-(pyridin-4-ylmethylamino)-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi12.59 [1]
18-Chloro-11,12,13,14-Tetrahydro-1h,10h-8,4-(Azeno)-9,15,1,3,6-Benzodioxatriazacycloheptadecin-2-OneIC5010.0 [1]
18-Chloro-11,12,13,14-Tetrahydro-1h,10h-8,4-(Azeno)-9,15,1,3,6-Benzodioxatriazacycloheptadecin-2-OneKi7.94 [1]
(S)-2-Phenyl-4-(piperidin-3-ylamino)thieno[3,2-c]pyridine-7-carboxamideIC504.0 [1], 7.0 [2]
4,9,19-Triazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13,15,17-hexaene-3,5,10-trioneIC5050.0 [1], 51.0 [2]
3-(4'-Hydroxybiphenyl-4-Yl)-2,4-Dihydroindeno[1,2-C]pyrazol-6-OlIC504.4 [1]
3-(4'-Hydroxybiphenyl-4-Yl)-2,4-Dihydroindeno[1,2-C]pyrazol-6-OlKi6.31 [1]
4-[4-[6-(Hydroxymethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]phenyl]phenolIC507.7 [1]
4-[4-[6-(Hydroxymethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]phenyl]phenolKi7.94 [1]
3-[5-(Morpholin-4-ylmethyl)-1h-indol-2-yl]-1h-indazole-6-carbonitrileIC5030.0 [1]
8-Hydroxy-6,9,19-triazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(19),2,4,7,11,13,15,17-octaen-10-oneIC5024.0 [1]
4'-[7-(Hydroxymethyl)-2,4-Dihydroindeno[1,2-C]pyrazol-3-Yl]biphenyl-4-OlIC504.4 [1]
4'-[7-(Hydroxymethyl)-2,4-Dihydroindeno[1,2-C]pyrazol-3-Yl]biphenyl-4-OlKi3.98 [1]
4-(6-(((1r,4r)-4-Methylcyclohexylamino)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenolIC50124.0 [1]
4-(6-(((1r,4r)-4-Methylcyclohexylamino)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenolKi125.89 [1]
4-[4-[5-(Hydroxymethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]phenyl]phenolIC507.8 [1]
4-[4-[5-(Hydroxymethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]phenyl]phenolKi7.94 [1]
4-(5-(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)pyridin-2-yl)phenolIC500.5 [1]
4-(5-(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)pyridin-2-yl)phenolKi0.25 [1]
2-[[3-[4-(4-Hydroxyphenyl)phenyl]-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl]oxy]propane-1,3-diolIC500.1 [1]
2-[[3-[4-(4-Hydroxyphenyl)phenyl]-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl]oxy]propane-1,3-diolKi0.1 [1]
N-(4-Morpholin-4-ylpyridin-2-yl)-5-(5-pyrimidin-5-ylpyridin-3-yl)-1,3-thiazol-2-amineIC5037.0 [1]
N-(4-Piperazin-1-ylpyridin-2-yl)-5-[5-(1H-pyrazol-4-yl)pyridin-3-yl]-1,3-thiazol-2-amineIC508.0 [1]
5-[2-[[4-(4-Acetylpiperazin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]-N-(2-aminoethyl)pyridine-3-carboxamideIC500.03 [1]
N-(2-Aminoethyl)-5-[2-[[4-(4-methylsulfonylpiperazin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]pyridine-3-carboxamideIC500.03 [1]
N-(2-Aminoethyl)-5-[2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl]pyridine-3-carboxamideIC500.05 [1]
3-Methyl-N-[3-(1-methylpyrazol-4-yl)-5-piperidin-3-ylpyrazolo[1,5-a]pyrimidin-7-yl]-1,2-thiazol-5-amineIC509.0 [1]
5-(6-Methylpyridin-3-yl)-N-(4-piperazin-1-ylpyridin-2-yl)-1,3-thiazol-2-amineIC5037.0 [1]
7-Chloro-3-oxo-11,18-dioxa-2,4,21,23-tetrazatricyclo[17.3.1.05,10]tricosa-1(22),5(10),6,8,19(23),20-hexaene-20-carbonitrileIC5028.0 [1]
4,14-Diazapentacyclo[11.7.0.02,6.07,12.015,20]icosa-1,6,9,12,15,17,19-heptaene-3,5,8,11-tetroneIC50269.0 [1]
8,11-Dihydroxy-4,14-diazapentacyclo[11.7.0.02,6.07,12.015,20]icosa-1(13),2(6),7,9,11,15,17,19-octaene-3,5-dioneIC50311.0 [1]
1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureaIC505.0 [1]
1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureaKi3.98 [1]
2-(2,3-Dihydro-1-Benzofuran-5-Yl)-N-[2-(Piperazin-1-Yl)phenyl]-1,3-Thiazole-4-CarboxamideIC5075.0 [1]
8-Chloro-5,10-Dihydro-11h-Dibenzo[b,E][1,4]diazepin-11-OneIC5017000.0 [1]
8-Chloro-5,10-Dihydro-11h-Dibenzo[b,E][1,4]diazepin-11-OneKi15848.93 [1]
Ethyl 4-[2-(aminomethyl)morpholin-4-yl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylateIC501000.0 [1], 1200.0 [2]
5-(6,7-Dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)pyridine-2-carbonitrileIC500.8 [1], 0.81 [2]
6,7-Dimethoxy-3-[4-(1h-Tetrazol-5-Yl)phenyl]-1,4-Dihydroindeno[1,2-C]pyrazoleIC5011.0 [1]
6,7-Dimethoxy-3-[4-(1h-Tetrazol-5-Yl)phenyl]-1,4-Dihydroindeno[1,2-C]pyrazoleKi12.59 [1]
4-[(6,7-Dimethoxy-2,4-Dihydroindeno[1,2-C]pyrazol-3-Yl)ethynyl]-2-MethoxyphenolIC505.0 [1]
4-[(6,7-Dimethoxy-2,4-Dihydroindeno[1,2-C]pyrazol-3-Yl)ethynyl]-2-MethoxyphenolKi5.01 [1]
(13Z)-8-Amino-7-chloro-3-oxo-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5(10),6,8,13,17(21),18-heptaene-18-carbonitrileIC500.3 [1]
(13Z)-8-Amino-7-chloro-3-oxo-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5(10),6,8,13,17(21),18-heptaene-18-carbonitrileKi0.32 [1]
5-Methyl-8-(1h-Pyrrol-2-Yl)[1,2,4]triazolo[4,3-A]quinolin-1(2h)-OneIC500.1 [1]
8-[4-(Hydroxymethyl)phenyl]-5-methyl-2H-[1,2,4]triazolo[4,3-a]quinolin-1-oneIC5010.0 [1]
5-Methyl-8-(thiophen-2-yl)-[1,2,4]triazolo[4,3-a]quinolin-1(2H)-oneIC5020.0 [1]
3-(1-Methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amineIC5060.0 [1]
3-Bromo-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amineIC501080.0 [1]
1-Morpholin-4-yl-2-[4-[2-[(5-pyridin-3-yl-1,3-thiazol-2-yl)amino]pyridin-4-yl]piperazin-1-yl]ethanoneIC5047.0 [1]
N-(4-Morpholin-4-ylpyridin-2-yl)-5-(5-pyridin-3-ylpyridin-3-yl)-1,3-thiazol-2-amineIC5019.0 [1]
5-Methyl[1,2,4]triazolo[4,3-a]quinolin-1(2h)-oneIC50800.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase Chk1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-chk1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Serine/threonine-protein kinase Chk1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-chk1-inhibitors-ic50-ki.
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