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Serine/threonine-protein kinase c-TAK1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
7-[(1S)-1-(4-Fluorophenyl)ethyl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-oneIC5061.0 [1], 62.0 [2]
7-[(2S)-Butan-2-yl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-oneIC5082.0 [1], 117.0 [2]
7-[(2R)-Butan-2-yl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-oneIC50738.0 [1]
7-(1-Acetylpiperidin-4-yl)-2-anilino-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC501300.0 [1], 1302.0 [2]
7-Cyclohexyl-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-oneIC50346.0 [1]
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-IC5010000.0 [1]
JNK Inhibitor VIIIKi6700.0 [1]
N-[3-[[5-Cyclopropyl-2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC5012.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi6700.0 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideKi6700.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi6667.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi6700.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi6700.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi6700.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi6700.0 [1]
7-Chloro-9-ethyl-6-hydroxy-1H,3H,4H,9H-quinolino[2,3-c][1,2]oxazole-3,4-dioneKi6670.0 [1]
5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amineIC50210.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC501.2 [1]
TilfrinibIC5010000.0 [1]
3-{5-Chloro-2-[(3-methyloxetan-3-yl)methoxy]phenyl}-1-(5-cyanopyrazin-2-yl)ureaIC5010000.0 [1]
3-(5-Chloro-2-{[1-(dimethylamino)propan-2-yl]oxy}phenyl)-1-(5-cyanopyrazin-2-yl)ureaIC501508.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi5000.0 [1]
7-(1-Acetylpiperidin-4-yl)-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-oneIC502100.0 [1]
5,5,7-Trimethyl-2-(3-piperazin-1-ylanilino)pyrrolo[2,3-d]pyrimidin-6-oneIC50850.0 [1]
2-Anilino-7-[(1R)-2,2-difluoro-1-phenylethyl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC502564.0 [1]
2-Anilino-5,5-dimethyl-7-phenylpyrrolo[2,3-d]pyrimidin-6-oneIC502800.0 [1]
2-Anilino-7-cyclopentyl-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC50226.0 [1]
2-Anilino-7-cyclohexyl-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC50304.0 [1]
7'-[(2S)-Butan-2-yl]-2'-(pyridin-3-ylamino)spiro[cyclopropane-1,5'-pyrrolo[2,3-d]pyrimidine]-6'-oneIC5060.0 [1]
7-Cyclohexyl-5,5-dimethyl-N-phenyl-6H-pyrrolo[2,3-d]pyrimidin-2-amineIC5030000.0 [1]
7-[(1S)-1-(3-Hydroxyphenyl)ethyl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-oneIC5010.0 [1]
7-[(1R)-1-(4-Fluorophenyl)ethyl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-oneIC501524.0 [1]
7-[(1S)-4-Amino-2,3-dihydro-1H-inden-1-yl]-2-anilino-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010.0 [1]
2-Anilino-5,5-dimethyl-7-[(2S)-3-methylbutan-2-yl]pyrrolo[2,3-d]pyrimidin-6-oneIC5080.0 [1]
7-(1-Acetylpiperidin-4-yl)-2-(4-fluoroanilino)-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC502800.0 [1]
2-Anilino-5,5-dimethyl-7-propan-2-ylpyrrolo[2,3-d]pyrimidin-6-oneIC50627.0 [1]
2-Anilino-7-ethyl-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC503000.0 [1]
2-Anilino-5,5-dimethyl-6-(1-methylpyrazol-4-yl)pyrrolo[3,4-d]pyrimidin-7-oneIC5030000.0 [1]
7-Cyclohexyl-5,5-dimethyl-2-(3-piperazin-1-ylanilino)pyrrolo[2,3-d]pyrimidin-6-oneIC5014.0 [1]
7-[(2S)-Butan-2-yl]-5,5-dimethyl-2-[4-(5-methyl-1H-1,2,4-triazol-3-yl)anilino]pyrrolo[2,3-d]pyrimidin-6-oneIC5080.0 [1]
5,5-Dimethyl-7-(2-phenylpropan-2-yl)-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-oneIC501644.0 [1]
7-[(2S)-Butan-2-yl]-5,5-dimethyl-2-(4-methylsulfonylanilino)pyrrolo[2,3-d]pyrimidin-6-oneIC50120.0 [1]
2-Anilino-5,5-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-6-oneIC5012770.0 [1]
2-Anilino-5,5-dimethyl-7-(1-methylpyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-6-oneIC504300.0 [1]
7-[(1S)-2,3-Dihydro-1H-inden-1-yl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-oneIC5027.0 [1]
7-[(1R)-1-(3-Hydroxyphenyl)ethyl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-oneIC501800.0 [1]
N-[(1S)-1-(2-Anilino-5,5-dimethyl-6-oxopyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydro-1H-inden-4-yl]methanesulfonamideIC5019.0 [1]
2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)acetamideIC503650.0 [1]
2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamideIC5010000.0 [1]
N-[3-[[5-Cyclopropyl-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC5020.0 [1]
5,5-Dimethyl-7-[(1S)-1-phenylethyl]-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-oneIC5037.0 [1]
3-(Tert-butylamino)-4-[[2-(4-pyridin-4-ylanilino)pyrimidin-4-yl]amino]cyclobut-3-ene-1,2-dioneKi4830.0 [1]
N-[(6S)-6-Amino-2,2-difluorocyclohexyl]-5-chloro-4-imidazo[1,2-a]pyridin-3-yl-1,3-thiazole-2-carboxamideIC50720.0 [1]
N-[(6R)-6-Amino-2,2-difluorocyclohexyl]-4-imidazo[1,2-b]pyridazin-3-yl-5-methylthiophene-2-carboxamideIC5020.0 [1]
N-[(6S)-6-Amino-2,2-difluorocyclohexyl]-4-imidazo[1,2-b]pyridazin-3-ylthiophene-2-carboxamideIC5015.0 [1]
N-[(6R)-6-Amino-2,2-difluorocyclohexyl]-5-ethyl-4-(7-methylimidazo[1,2-b]pyridazin-3-yl)thiophene-2-carboxamideIC50140.0 [1]
N-[(6R)-6-Amino-2,2-difluorocyclohexyl]-4-[7-(4-fluorophenyl)imidazo[1,2-b]pyridazin-3-yl]thiophene-2-carboxamideIC500.5 [1]
Items per page: 1 - 10 of 60
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase c-TAK1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-c-tak1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Serine/threonine-protein kinase c-TAK1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-c-tak1-inhibitors-ic50-ki.
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