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Serine/threonine-protein kinase B-raf Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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SorafenibIC5038.0 [1]
SorafenibKi22.0 [1], 38.0 [2]
VemurafenibIC5031.0 [1]
DabrafenibIC501.0 [1]
CID 46209401IC508.3 [1]
2,6-Difluoro-N-(3-Methoxy-2h-Pyrazolo[3,4-B]pyridin-5-Yl)-3-[(Propylsulfonyl)amino]benzamideIC505.01 [1]
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamideIC5044.0 [1]
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamideKi2.6 [1], 4.0 [2]
(E)-5-(1-(2-Hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oximeIC500.13 [1], 0.17 [2], 1000.0 [3]
(E)-5-(1-(2-Hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oximeKi0.13 [1], 0.17 [2], 0.19 [3]
(NE)-N-[5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC500.16 [1], 290.0 [2]
(NE)-N-[5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineKi0.16 [1], 0.3 [2]
2,6-Difluoro-3-(propylsulfonylamino)-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamideIC5042.0 [1]
Raf265(chir-265)IC5040.0 [1]
AZ-628IC5027.0 [1]
B-Raf inhibitor 1IC502.0 [1]
B-Raf inhibitor 1Ki1.0 [1]
2,6-Difluoro-3-(propylsulfonylamino)-N-(1H-pyrazolo[3,4-b]pyridin-5-yl)benzamideIC5018.0 [1]
6-Chloro-2-fluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamideIC501.7 [1]
N-(6-Aminopyridin-3-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamideIC50920.0 [1]
StaurosporineIC504.5 [1], 5.0 [2], 5.03 [3], 8.7 [4], 14.0 [5]
LY-3009120IC505.8 [1], 15.0 [2], 31.0 [3], 37.0 [4], 5800.0 [5]
2,6-Difluoro-N-(1h-Imidazo[4,5-B]pyridin-6-Yl)-3-[(Propylsulfonyl)amino]benzamideIC5061.0 [1], 2386.0 [2], 2400.0 [3], 3000.0 [4]
N-(3-Bromo-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamideIC503.4 [1], 3.98 [2], 39.0 [3], 190.0 [4]
2,6-Difluoro-3-(propylsulfonylamino)-N-pyridin-3-ylbenzamideIC503000.0 [1], 3880.0 [2], 3900.0 [3], 6700.0 [4], 6730.0 [5]
N-(2-Methoxyethyl)-4-[(6-Pyridin-4-Ylquinazolin-2-Yl)amino]benzamideIC5077.0 [1], 77.62 [2], 190.0 [3], 890.0 [4], 30000.0 [5]
4-Amino-N-[6-chloro-2-fluoro-3-(3-fluoropropylsulfonylamino)phenyl]thieno[3,2-d]pyrimidine-7-carboxamideIC500.18 [1], 2.0 [2], 4.6 [3], 22.0 [4]
EncorafenibIC500.3 [1], 2.0 [2]
4-(4-Fluorophenyl)-5-pyridin-4-yl-2-(2,4,6-trichlorophenyl)pyrazol-3-amineIC50270.0 [1], 592.0 [2], 990.0 [3]
Furan-2-yl(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanoneIC50200.0 [1], 1800.0 [2]
N-(3-Bromo-2H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamideIC504.0 [1], 44.0 [2], 260.0 [3]
2,6-Difluoro-N-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamideIC5012.0 [1], 86.0 [2], 830.0 [3]
1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[2-fluoro-4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]ureaIC5040.0 [1], 110.0 [2]
1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[2-methylsulfanyl-4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]ureaIC5056.0 [1], 76.0 [2]
2,6-Difluoro-3-(propylsulfonylamino)-N-pyrazolo[1,5-a]pyrimidin-6-ylbenzamideIC50247.0 [1], 488.0 [2]
2,6-Difluoro-N-(2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamideIC504.6 [1], 7.0 [2], 12.0 [3], 17.0 [4]
2,6-Difluoro-N-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamideIC5011.0 [1], 54.0 [2]
2-[3-Pyridin-3-yl-1-[(5-pyridin-2-yl-2-thienyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-yl]phenolIC5017.0 [1], 23.0 [2], 180.0 [3]
4-[4-(1,4-Dihydroindeno[1,2-c]pyrazol-6-yl)-3-pyridin-4-ylpyrazol-1-yl]cyclohexan-1-amineIC500.66 [1], 22.9 [2], 396.0 [3], 1516.0 [4]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]benzenesulfonamideIC507.0 [1], 17.0 [2], 20.0 [3], 28.0 [4]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1-methylpyrazole-4-sulfonamideIC508.0 [1], 19.0 [2], 120.0 [3], 710.0 [4]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]propane-2-sulfonamideIC5014.0 [1], 17.0 [2], 45.0 [3], 66.0 [4]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]thiophene-2-sulfonamideIC500.5 [1], 1.0 [2], 7.0 [3], 12.0 [4]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]propane-1-sulfonamideIC509.0 [1], 12.0 [2], 23.0 [3], 24.0 [4]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclohexanesulfonamideIC5018.0 [1], 40.0 [2], 51.0 [3], 206.0 [4]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclopropanesulfonamideIC5041.0 [1], 50.0 [2], 132.0 [3], 173.0 [4]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]morpholine-4-sulfonamideIC5062.0 [1], 102.0 [2], 293.0 [3], 1300.0 [4]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pyridine-3-sulfonamideIC501.0 [1], 4.0 [2], 10.0 [3]
1-(3-Chloro-4-fluorophenyl)-3-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]phenyl]ureaIC5013.0 [1], 22.0 [2]
5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinoneIC501.5 [1], 5.4 [2], 10.71 [3]
Acetamide, N-[3-[6-[(3,4,5-trimethoxyphenyl)amino]pyrazinyl]phenyl]-IC503500.0 [1], 3600.0 [2]
4-[2-(3-Tert-butylanilino)-1-methylbenzimidazol-5-yl]oxy-N-methylpyridine-2-carboxamideIC5045.0 [1], 280.0 [2]
Pyrazolo[1,5-a]pyrimidine-3-carboxylateIC501500.0 [1], 1540.0 [2]
(1E)-5-(1-Piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oximeIC500.03 [1], 9.0 [2]
N-[3-[2-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]phenyl]-3-(trifluoromethyl)benzamideIC502.0 [1], 4.0 [2], 97.0 [3]
1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]ureaIC5023.0 [1], 2390.0 [2]
3-(2-Aminopropan-2-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamideIC502.1 [1], 4.2 [2]
(E)-Ethyl 3-(1-(hydroxyimino)-2,3-dihydro-1H-inden-5-ylamino)furo[2,3-c]pyridine-2-carboxylateIC502.0 [1], 30.0 [2]
2,6-Difluoro-N-[2-fluoro-3-[5-[2-[(6-morpholin-4-ylpyridin-3-yl)amino]pyrimidin-4-yl]-2-propan-2-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamideIC500.5 [1], 3.8 [2], 23.0 [3]
N-[4-[2-(3-Tert-butylanilino)-1-methylbenzimidazol-5-yl]oxypyridin-2-yl]acetamideIC503.0 [1], 44.0 [2]
4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]cyclohexyl]oxy-N-methylpyridine-2-carboxamideIC50330.0 [1], 570.0 [2], 5000.0 [3]
N-[3-(3-Aminoisoquinolin-7-yl)-2,4-difluorophenyl]propane-1-sulfonamideIC508.7 [1], 549.0 [2], 549.54 [3]
N-[4-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-3,5-difluorophenyl]propane-1-sulfonamideIC5013.0 [1], 160.0 [2], 800.0 [3]
6-[2-[[3-(Dimethylsulfamoylamino)-2,6-Bis(Fluoranyl)phenyl]amino]pyridin-3-Yl]-7~{h}-PurineIC508.0 [1], 54.0 [2], 90.0 [3]
1-(3-Tert-butyl-1,2-oxazol-5-yl)-3-[2-fluoro-5-[7-(methylamino)-2-oxo-1-[(3S)-oxolan-3-yl]-1,6-naphthyridin-3-yl]phenyl]ureaIC501.0 [1], 6.8 [2], 18.0 [3]
1-(3,3-Dimethylbutyl)-3-[5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluoro-4-methylphenyl]ureaIC504.2 [1], 11.0 [2], 40.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1,3-thiazole-2-sulfonamideIC501.0 [1], 2.0 [2], 31.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1H-pyrazole-4-sulfonamideIC500.2 [1], 1.0 [2], 6.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pyridine-2-sulfonamideIC5021.0 [1], 41.0 [2], 177.0 [3]
6-[2-[3-(Diethylsulfamoylamino)-2,6-difluoroanilino]pyridin-3-yl]-7H-purineIC5057.0 [1], 165.0 [2], 603.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pyrrolidine-1-sulfonamideIC502.0 [1], 31.0 [2], 44.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]piperidine-1-sulfonamideIC5015.0 [1], 38.0 [2], 65.0 [3]
(3S)-N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3-hydroxypyrrolidine-1-sulfonamideIC509.0 [1], 122.0 [2], 201.0 [3]
(3R)-N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3-hydroxypyrrolidine-1-sulfonamideIC5016.0 [1], 68.0 [2], 233.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2-methylpropane-1-sulfonamideIC506.0 [1], 16.0 [2], 17.0 [3]
1-Cyclopropyl-N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]methanesulfonamideIC508.0 [1], 26.0 [2], 33.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2,2-dimethylpropane-1-sulfonamideIC505.0 [1], 6.0 [2], 63.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2-fluorobenzenesulfonamideIC503.0 [1], 10.0 [2], 12.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3-fluorobenzenesulfonamideIC503.0 [1], 4.0 [2], 15.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclopentanesulfonamideIC502.0 [1], 11.0 [2], 21.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]oxolane-3-sulfonamideIC505.0 [1], 26.0 [2], 31.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]oxane-4-sulfonamideIC5031.0 [1], 179.0 [2], 356.0 [3]
6-[2-[3-[[Ethyl(methyl)sulfamoyl]amino]-2,6-difluoroanilino]pyridin-3-yl]-7H-purineIC5022.0 [1], 87.0 [2], 157.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]piperazine-1-sulfonamideIC501000.0 [1]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1-phenylmethanesulfonamideIC50111.0 [1], 186.0 [2], 1000.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]butane-2-sulfonamideIC507.0 [1], 27.0 [2], 38.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pentane-2-sulfonamideIC5018.0 [1], 112.0 [2], 130.0 [3]
N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclobutanesulfonamideIC504.0 [1], 41.0 [2], 46.0 [3]
1-Propan-2-yl-3-[2-[3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl]ethynyl]pyrazolo[3,4-d]pyrimidin-4-amineIC5014.0 [1], 65.0 [2], 10000.0 [3]
N-[3-Chloro-4-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[2-[2-(4-methylpiperazin-1-yl)ethylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamideIC5012.6 [1], 19.7 [2]
N-[(1R)-1-[4-[(6-Pyridin-4-ylquinazolin-2-yl)amino]phenyl]ethyl]acetamideIC5019.0 [1], 34.0 [2], 57.54 [3]
N-Methyl-N-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]acetamideIC5057.0 [1], 57.54 [2], 63.0 [3]
3-Methoxy-N-[(1R)-1-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]ethyl]propanamideIC5026.92 [1], 27.0 [2], 60.0 [3]
3-Methoxy-N-methyl-N-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]propanamideIC5032.0 [1], 32.36 [2], 45.0 [3]
3-Methoxy-N-[(1S)-1-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]ethyl]propanamideIC5051.0 [1], 51.29 [2], 160.0 [3]
2-Chloro-3-(2-cyanopropan-2-yloxy)-N-[5-[[2-(cyclopropanecarbonylamino)-[1,3]thiazolo[5,4-b]pyridin-5-yl]-methylamino]-2-fluorophenyl]benzamideIC5038.0 [1], 47.0 [2], 69.0 [3]
(5-(2-Hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(thiophen-2-yl)methanoneIC5017.0 [1], 24.2 [2], 1500.0 [3]
N-(6-Amino-5-Bromopyridin-3-Yl)-2,6-Difluoro-3-[(Propylsulfonyl)amino]benzamideIC50110.0 [1], 310.0 [2], 1200.0 [3]
N-[3-(Dimethylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamideIC508.2 [1], 40.0 [2], 650.0 [3]
1-(5-Tert-butyl-2-phenylpyrazol-3-yl)-3-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]ureaIC5089.0 [1], 1330.0 [2], 3140.0 [3]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase B-raf Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-b-raf-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Serine/threonine-protein kinase B-raf Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-b-raf-inhibitors-ic50-ki.
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