Serine/threonine-protein kinase Aurora-C Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Tozasertib	IC50	4.6 [1], 70.0 [2]
	Tozasertib	Ki	4.6 [1]
	Danusertib	IC50	61.0 [1]
	Danusertib	Ki	61.0 [1]
	3-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylurea	IC50	6.5 [1]
	3-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylurea	Ki	1.5 [1]
	N-(2,6-Diethylphenyl)-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide	IC50	120.0 [1]
	Ethyl (9S)-9-[3-(1H-benzimidazol-2-yloxy)phenyl]-8-oxo-2,4,5,6,7,9-hexahydropyrrolo[3,4-b]quinoline-3-carboxylate	IC50	3.0 [1], 91.0 [2]
	6-Bromoindirubin-3'-oxime	IC50	200.0 [1]
	Su6656	IC50	17.0 [1]
	Indirubin-3'-monoxime	IC50	300.0 [1]
	Barasertib	IC50	17.0 [1]
	Orantinib	IC50	210.0 [1]
	Azd-1152hqpa	Ki	17.0 [1]
	N-(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine	IC50	1.0 [1]
	MK-5108	IC50	12.0 [1]
	4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine	IC50	65.0 [1]
	3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine	IC50	290.0 [1]
	7-Bromo-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one	IC50	700.0 [1]
	Cct-129202	IC50	227.0 [1]
	7-Bromoindirubin	IC50	100000.0 [1]
	7-Fluoro-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one	IC50	1000.0 [1]
	7-Chloro-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one	IC50	900.0 [1]
	7-Chloroindirubin	IC50	100000.0 [1]
	7-Fluoroindirubin	IC50	100000.0 [1]
	2-(2-Hydroxy-7-iodo-1H-indol-3-yl)indol-3-one	IC50	100000.0 [1]
	7-Iodo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol	IC50	600.0 [1]
	N-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)quinazolin-2-ylthio)phenyl)acetamide	Ki	11.0 [1]
	3-[(4-Morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[3,2-c]pyrazole-5-carboxamide	IC50	62.0 [1]
	4-(Prop-2-enoylamino)-N-[4-[(5,8,11-trimethyl-6-oxopyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]benzamide	IC50	63.0 [1]
	Indirubin-3-methoxime	IC50	400.0 [1]
	Indirubin-3-acetoxime	IC50	700.0 [1]
	3-Chloro-N-(4-morpholin-4-ylphenyl)-6-pyridin-3-ylimidazo[1,2-a]pyrazin-8-amine	IC50	1950.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	Tilfrinib	IC50	259.0 [1]
	2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	1000.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	10000.0 [1]
	2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	1000.0 [1]
	5-[(Z)-[6-[[3-(4-Methoxyanilino)-3-oxopropanoyl]amino]-2-oxo-1H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid	IC50	153.5 [1]
	4-(Propanoylamino)-N-[4-[(5,8,11-trimethyl-6-oxopyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]benzamide	IC50	53.0 [1]
	[(Z)-[2-(7-Chloro-2-hydroxy-1H-indol-3-yl)indol-3-ylidene]amino] acetate	IC50	100000.0 [1]
	7-Chloro-3-[(3Z)-3-methoxyiminoindol-2-yl]-1H-indol-2-ol	IC50	100000.0 [1]
	[(Z)-[2-(2-Hydroxy-7-iodo-1H-indol-3-yl)indol-3-ylidene]amino] acetate	IC50	28000.0 [1]
	[(Z)-[2-(7-Bromo-2-hydroxy-1H-indol-3-yl)indol-3-ylidene]amino] acetate	IC50	4500.0 [1]
	[(Z)-[2-(7-Fluoro-2-hydroxy-1H-indol-3-yl)indol-3-ylidene]amino] acetate	IC50	1000.0 [1]
	7-Fluoro-3-[(3Z)-3-methoxyiminoindol-2-yl]-1H-indol-2-ol	IC50	100000.0 [1]
	7-Bromo-3-[(3Z)-3-methoxyiminoindol-2-yl]-1H-indol-2-ol	IC50	100000.0 [1]
	7-Iodo-3-[(3Z)-3-methoxyiminoindol-2-yl]-1H-indol-2-ol	IC50	100000.0 [1]
	3-[(3S)-3-Aminopyrrolidine-1-carbonyl]-5,10-dihydroxy-2-methylnaphtho[2,3-f][1]benzofuran-4,11-dione;methanesulfonic acid	IC50	5000.0 [1]
	1-(3-Chlorophenyl)-3-[5-[2-(thieno[2,3-d]pyrimidin-4-ylamino)ethyl]-2,3-dihydro-1,3-thiazol-2-yl]urea	IC50	3.0 [1]
	(2E)-2-[(3,4-Dihydroxyphenyl)methylidene]-1-benzofuran-3-one	IC50	4750.0 [1]
	3-[[4-[6-Bromo-2-(4-methylpiperazin-1-yl)-1H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]methyl]-5-methyl-1,2-oxazole	IC50	19.0 [1]
	N-[(4-Methoxyphenyl)methyl]-[1]benzofuro[2,3-b]pyridin-4-amine	Ki	1000000.0 [1]
	4-[[(3S,4R)-1-(5-Cyanopyridin-2-yl)-3-fluoropiperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide	IC50	1000.0 [1]
	2-{3-[3-(Piperidin-4-Yl)propoxy]phenyl}-N-[4-(Pyridin-4-Yl)-1,3-Thiazol-2-Yl]acetamide	IC50	5000.0 [1]
	2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	IC50	2000.0 [1]
	N-(4-Fluorophenyl)-N'-[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]propanediamide	IC50	67.2 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 57 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase Aurora-C Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-aurora-c-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 20). Quest Database™ Serine/threonine-protein kinase Aurora-C Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-aurora-c-inhibitors-ic50-ki.
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