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Serine/threonine-protein kinase Aurora-B Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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TozasertibIC5031.0 [1]
TozasertibKi18.0 [1]
StaurosporineIC501.8 [1]
AlisertibIC50396.0 [1]
N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamideIC50130.0 [1]
4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acidIC504000.0 [1]
DanusertibIC5079.0 [1]
DanusertibKi79.0 [1]
Azd-1152hqpaIC500.3 [1], 0.37 [2], 1.0 [3], 17.0 [4]
Azd-1152hqpaKi1.0 [1]
3-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylureaIC503.5 [1], 5.0 [2], 32.0 [3]
3-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylureaKi0.38 [1]
(E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amineIC50290.0 [1], 350.0 [2]
IlorasertibIC502.0 [1], 7.0 [2], 7.87 [3]
2,4-Bisanilinopyrimidine, 10IC5055.0 [1], 3400.0 [2], 27000.0 [3], 50000.0 [4]
4-[[2-[4-[2-(4-Acetylpiperazin-1-yl)-2-oxoethyl]anilino]-5-fluoropyrimidin-4-yl]amino]-N-(2-chlorophenyl)benzamideIC5057.0 [1], 3700.0 [2], 25000.0 [3], 27000.0 [4]
BarasertibIC500.37 [1], 1.0 [2]
BarasertibKi0.37 [1]
1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)ureaIC502.7 [1], 3.0 [2], 30.0 [3]
HesperadinIC503.0 [1], 250.0 [2]
N-(2,6-Diethylphenyl)-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamideIC50135.0 [1]
PF-03814735IC505.0 [1], 11.0 [2], 50.0 [3]
1-{5-[2-(Thieno[3,2-D]pyrimidin-4-Ylamino)ethyl]-1,3-Thiazol-2-Yl}-3-[3-(Trifluoromethyl)phenyl]ureaIC5014.0 [1]
1-Phenyl-3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1,3-thiazol-2-yl]ureaIC50120.0 [1]
N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(2-methylpropyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamideIC501.0 [1]
N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(2-methylpropyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamideKi1.0 [1]
2-[3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamideIC501.0 [1], 270.0 [2]
2-[3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamideKi1.0 [1]
N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamideIC501.0 [1], 45.0 [2]
N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamideKi1.0 [1]
N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(propyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamideIC501.0 [1], 18.0 [2]
N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(propyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamideKi1.0 [1]
N-(3-Fluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(propyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamideIC502.0 [1], 290.0 [2]
N-(3-Fluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(propyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamideKi2.0 [1]
N-[4-[4-(4-Tert-butylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamideIC5011.0 [1]
N-[4-[4-(4-Tert-butylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamideKi0.8 [1], 11.0 [2]
Unii-LM7NL857V1IC505.0 [1], 100.0 [2], 310.0 [3]
2-Chloro-N-[4-({5-Fluoro-2-[(4-Hydroxyphenyl)amino]pyrimidin-4-Yl}amino)phenyl]benzamideIC501400.0 [1], 12000.0 [2], 30000.0 [3]
N-(2-Chlorophenyl)-4-[[5-fluoro-2-(4-hydroxyanilino)pyrimidin-4-yl]amino]benzamideIC501900.0 [1], 25000.0 [2], 30000.0 [3]
N-Cyclopropyl-4-[[5-fluoro-2-(4-hydroxyanilino)pyrimidin-4-yl]amino]benzamideIC503800.0 [1], 25000.0 [2], 30000.0 [3]
4-[6-Amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl]-3,6-dihydro-2H-pyridine-1-carboxamideIC5011.0 [1], 1000.0 [2], 10000.0 [3]
2-(1,3-Dimethyl-1H-pyrazole-4-yl)-6-chloro-7-[4-(phenylcarbamoyl)phenoxy]-3H-imidazo[4,5-b]pyridineIC5012710.0 [1], 24650.0 [2], 76840.0 [3]
OrantinibIC5035.0 [1], 47.0 [2]
EntrectinibIC50338.0 [1], 1000.0 [2]
MK-5108IC5010.0 [1], 14.0 [2]
1-(3-Chlorophenyl)-3-{5-[2-(Thieno[3,2-D]pyrimidin-4-Ylamino)ethyl]-1,3-Thiazol-2-Yl}ureaIC5031.0 [1]
4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amineIC5019.0 [1]
4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amineKi9.2 [1]
3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dioneIC5017000.0 [1], 25000.0 [2]
N-(4-Chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamideIC5018.0 [1]
2-{[(3r,4r)-3-Aminotetrahydro-2h-Pyran-4-Yl]amino}-4-[(4-Methylphenyl)amino]pyrimidine-5-CarboxamideIC5015848.93 [1], 20000.0 [2]
4-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-phenylthieno[2,3-d]pyrimidineIC507.67 [1], 141.1 [2]
CID 9916282IC507.0 [1]
N-[5-[(2S)-2-Methoxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamideIC50630.0 [1]
N-[4-[4-(4-Methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamideIC5020.0 [1]
N-[4-[4-(4-Methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamideKi20.0 [1]
2-({2-[(4-Carboxyphenyl)amino]pyrimidin-4-yl}amino)benzoic acidIC5031.0 [1], 5400.0 [2]
N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-morpholinopyrimidin-2-ylthio)phenyl)propionamideIC5014.0 [1]
N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-morpholinopyrimidin-2-ylthio)phenyl)propionamideKi14.0 [1]
N-(3-Fluorophenyl)-2-[3-[[7-[3-[4-(hydroxymethyl)piperidin-1-yl]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamideIC502.0 [1], 680.0 [2]
Methyl 3-[[5-[4-(3,5-dimethoxyphenyl)triazol-1-yl]-2-hydroxybenzoyl]amino]benzoateIC503580.0 [1], 5940.0 [2]
N-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)quinazolin-2-ylthio)phenyl)acetamideKi27.0 [1]
N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-(piperidin-1-yl)pyrimidin-2-ylthio)phenyl)propionamideIC508.0 [1]
N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-(piperidin-1-yl)pyrimidin-2-ylthio)phenyl)propionamideKi8.0 [1]
N-[4-[4-(4-Ethylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamideIC5025.0 [1]
N-[4-[4-(4-Ethylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamideKi25.0 [1]
N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-(piperazin-1-yl)pyrimidin-2-ylthio)phenyl)propionamideIC5018.0 [1]
N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-(piperazin-1-yl)pyrimidin-2-ylthio)phenyl)propionamideKi18.0 [1]
N-[4-[4-(4-Cyclopropylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamideIC509.5 [1]
N-[4-[4-(4-Cyclopropylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamideKi9.5 [1]
N-[5-[(2R)-2-Hydroxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamideIC5048.0 [1]
4-(4-Methylpiperazin-1-yl)-N-[5-[(2R)-2-phenylpropanoyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]benzamideIC5099.0 [1]
N-[5-[(2R)-2-Fluoro-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamideIC50300.0 [1]
4-(4-Methylpiperazin-1-yl)-N-[5-[(2S)-2-phenylpropanoyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]benzamideIC501210.0 [1]
N-(4-(Benzo[d]thiazol-2-yl)phenyl)-6,7-dimethoxyquinazolin-4-amineIC50135.0 [1]
N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamideIC507.5 [1]
N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamideKi1.0 [1]
N-[3-Methyl-4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]-1H-benzimidazol-2-amineIC5077.0 [1], 80.0 [2]
1-[4-[4-Amino-7-(1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-methylphenyl)ureaIC508.0 [1], 8.44 [2]
N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amineIC509.0 [1], 10.0 [2]
3-Methyl-N-[6-methylsulfanyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amineIC5013.0 [1]
N-[6-Methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(piperidin-1-ylmethyl)-1,2-thiazol-5-amineIC5013.0 [1]
N-(4-(Benzo[d]thiazol-2-yl)-2-methylphenyl)-6,7-dimethoxyquinazolin-4-amineIC503700.0 [1]
4-Amino-N-[4-[(3-fluorophenyl)carbamoylamino]phenyl]pyrrolo[2,1-f][1,2,4]triazine-5-carboxamideIC503.0 [1], 9.0 [2]
6-(2-Aminopyrimidin-4-Yl)-1h-Indazol-3-AmineIC503162.28 [1], 3480.0 [2]
Ethyl (9S)-9-[3-(1H-benzimidazol-2-yloxy)phenyl]-8-oxo-2,4,5,6,7,9-hexahydropyrrolo[3,4-b]quinoline-3-carboxylateIC501.0 [1], 34.0 [2]
3-Methyl-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amineIC5013.0 [1]
2-[(3S,4S)-3-(4-Fluorophenoxy)-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamideIC5044.0 [1]
N~4~-(2-Chlorophenyl)-N~2~-[4-(1h-Tetrazol-5-Yl)phenyl]pyrimidine-2,4-DiamineIC50226.0 [1], 10000.0 [2]
N-[3-[[6-Bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclopentanecarboxamideIC5093.0 [1]
N-[3-[[6-Bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclobutanecarboxamideIC5038.0 [1]
4-[[4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]pyrimidin-2-yl]amino]cyclohexan-1-olIC50398.11 [1]
4-[[4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]pyrimidin-2-yl]amino]cyclohexan-1-olKi398.11 [1]
1-[4-[2-[(5-Chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[3-[[ethyl(methyl)amino]methyl]phenyl]ureaIC50140.4 [1], 10000.0 [2]
1-[4-[2-[(5-Chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[2-[(4-hydroxypiperidin-1-yl)methyl]phenyl]ureaIC5078.9 [1], 132.6 [2]
N-{4-[(6-Oxo-5,6-Dihydrobenzo[c][1,8]naphthyridin-1-Yl)amino]phenyl}benzamideIC501.0 [1], 208.0 [2]
1-[4-[2-[(5-Chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[2-[(dimethylamino)methyl]phenyl]ureaIC5023.7 [1], 45.0 [2]
1-[4-[2-[(5-Chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-phenylureaIC5066.3 [1], 191.2 [2]
3-[Dideuterio-(3,3-difluoropyrrolidin-1-yl)methyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;hydrochlorideIC5013.0 [1], 63.0 [2]
N-[6-Methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(piperidin-1-ylmethyl)-1,2-thiazol-5-amine;hydrochlorideIC5013.0 [1], 45.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase Aurora-B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-aurora-b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Serine/threonine-protein kinase Aurora-B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-aurora-b-inhibitors-ic50-ki.
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