Serine/threonine-protein kinase Aurora-A Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Tozasertib	IC50	20.0 [1]
	Tozasertib	Ki	0.6 [1]
	Staurosporine	IC50	3.67 [1]
	Alisertib	IC50	1.0 [1]
	4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid	IC50	4.0 [1]
	N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide	IC50	110.0 [1]
	2-(1,3-Dimethyl-1H-pyrazole-4-yl)-6-chloro-7-[4-(phenylcarbamoyl)phenoxy]-3H-imidazo[4,5-b]pyridine	IC50	65.0 [1]
	MK-5108	IC50	0.06 [1]
	2-({2-[(4-Carboxyphenyl)amino]pyrimidin-4-yl}amino)benzoic acid	IC50	6.1 [1]
	4-[[6-Chloro-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-cyclobutylbenzamide	IC50	42.0 [1]
	(E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine	IC50	14.0 [1]
	2,4-Bisanilinopyrimidine, 10	IC50	3.4 [1], 390.0 [2], 2000.0 [3], 2500.0 [4]
	N~4~-(2-Chlorophenyl)-N~2~-[4-(1h-Tetrazol-5-Yl)phenyl]pyrimidine-2,4-Diamine	IC50	3.1 [1], 10000.0 [2]
	Sorafenib	IC50	3800.0 [1]
	Danusertib	IC50	13.0 [1]
	Danusertib	Ki	2.5 [1], 13.0 [2]
	N-(2,6-Diethylphenyl)-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide	IC50	27.0 [1]
	4-[[2-[4-[2-(4-Acetylpiperazin-1-yl)-2-oxoethyl]anilino]-5-fluoropyrimidin-4-yl]amino]-N-(2-chlorophenyl)benzamide	IC50	4.3 [1], 1600.0 [2], 2500.0 [3], 2800.0 [4]
	6-[[4-[(Z)-[2-(4-Ethylphenyl)imino-3-methyl-4-oxo-1,3-thiazolidin-5-ylidene]methyl]pyridin-2-yl]amino]pyridine-3-carboxylic acid	IC50	1.7 [1], 2.0 [2], 760.0 [3], 1400.0 [4]
	5-[[4-(2-Chloroanilino)-5-fluoropyrimidin-2-yl]amino]-2-(2H-tetrazol-5-yl)phenol	IC50	17.3 [1], 10000.0 [2]
	4-{[4-(Phenylamino)pyrimidin-2-Yl]amino}benzoic Acid	IC50	8.9 [1], 10.0 [2]
	4-({4-[(2-Chlorophenyl)amino]pyrimidin-2-Yl}amino)benzoic Acid	IC50	0.74 [1], 2.5 [2]
	4-({4-[(2-Chlorophenyl)amino]-5-Fluoropyrimidin-2-Yl}amino)benzoic Acid	IC50	0.2 [1], 0.8 [2]
	4-[[4-(2-Chloroanilino)pyrimidin-2-yl]amino]benzamide	IC50	1.0 [1], 30.2 [2], 1000.0 [3]
	4-[[4-(2-Chloroanilino)pyrimidin-2-yl]amino]-N-(2-morpholin-4-ylethyl)benzamide	IC50	28.1 [1], 216.0 [2], 1000.0 [3], 5500.0 [4]
	4-[[4-(2-Chloroanilino)pyrimidin-2-yl]amino]-N-[2-(dimethylamino)ethyl]benzamide	IC50	28.1 [1], 216.0 [2], 1000.0 [3], 5500.0 [4]
	4-[[4-(2-Chloroanilino)pyrimidin-2-yl]amino]-N-(2-methoxyethyl)benzamide	IC50	18.0 [1], 1000.0 [2], 5500.0 [3]
	4-N-(2-Chlorophenyl)-2-N-(4-methylsulfonylphenyl)pyrimidine-2,4-diamine	IC50	44.9 [1], 1000.0 [2], 10000.0 [3]
	5-[[4-(2-Chloroanilino)pyrimidin-2-yl]amino]-1,3-dihydrobenzimidazol-2-one	IC50	316.0 [1], 3000.0 [2], 5500.0 [3]
	4-[[4-(2-Chloroanilino)pyrimidin-2-yl]amino]-2-methoxybenzoic acid	IC50	116.5 [1], 3000.0 [2], 10000.0 [3]
	4-N-(2-Chlorophenyl)-2-N-(4-morpholin-4-ylphenyl)pyrimidine-2,4-diamine	IC50	1.0 [1], 27.0 [2], 1000.0 [3]
	4-[[4-(2-Chloroanilino)pyrimidin-2-yl]amino]benzenesulfonamide	IC50	1.0 [1], 253.0 [2], 1000.0 [3]
	4-N-(2-Chlorophenyl)-5-fluoro-2-N-(4-morpholin-4-ylphenyl)pyrimidine-2,4-diamine	IC50	1.0 [1], 21.4 [2], 1000.0 [3]
	4-N-(2-Chlorophenyl)-5-fluoro-2-N-[4-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine	IC50	1.0 [1], 23.2 [2], 1000.0 [3]
	4-[[4-(2-Chloroanilino)pyrimidin-2-yl]amino]-N-(2-hydroxyethyl)benzamide	IC50	1.0 [1], 12.3 [2], 1000.0 [3]
	4-[[4-(2-Chloroanilino)-5-fluoropyrimidin-2-yl]amino]benzamide	IC50	1.0 [1], 14.4 [2], 300.0 [3]
	4-[[4-(2-Chloroanilino)-5-fluoropyrimidin-2-yl]amino]benzenesulfonamide	IC50	21.2 [1], 1000.0 [2], 10000.0 [3]
	4-N-(2-Chlorophenyl)-5-fluoro-2-N-[4-(2H-tetrazol-5-yl)phenyl]pyrimidine-2,4-diamine	IC50	2.9 [1], 3000.0 [2], 10000.0 [3]
	5-Chloro-4-N-(2-chlorophenyl)-2-N-[4-(2H-tetrazol-5-yl)phenyl]pyrimidine-2,4-diamine	IC50	3.0 [1], 3000.0 [2], 10000.0 [3]
	Linifanib	IC50	760.0 [1]
	3-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylurea	IC50	1259.0 [1]
	3-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylurea	Ki	490.0 [1], 492.0 [2]
	Cct-129202	IC50	42.0 [1]
	N-(5-Methyl-1H-pyrazol-3-yl)-2-phenylquinazolin-4-amine	IC50	28.0 [1]
	N-(5-Methyl-1H-pyrazol-3-yl)-2-phenylquinazolin-4-amine	Ki	58.0 [1]
	Aurora Kinase Inhibitor III	IC50	42.0 [1]
	Aurora Kinase Inhibitor II	IC50	310.0 [1], 393.0 [2]
	CID 9916282	IC50	1.0 [1]
	8-Anilino-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	50.0 [1]
	8-Anilino-N,1-dimethyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	312.0 [1]
	4-(4-Methylpiperazin-1-yl)-N-[5-(2-phenylacetyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]benzamide	IC50	130.0 [1], 140.0 [2]
	8-Anilino-1-methyl-N-phenyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	10000.0 [1]
	N-[5-[[6-Methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino]pyrimidin-2-yl]benzamide	IC50	3.0 [1]
	1-{5-[2-(Thieno[3,2-D]pyrimidin-4-Ylamino)ethyl]-1,3-Thiazol-2-Yl}-3-[3-(Trifluoromethyl)phenyl]urea	IC50	22.0 [1]
	1-Phenyl-3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1,3-thiazol-2-yl]urea	IC50	52.0 [1]
	4-(6-Chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N,N-dimethyl-aniline	IC50	570.0 [1], 4970.0 [2]
	6-Chloro-7-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridine	IC50	30.0 [1], 38.0 [2]
	4-(6,7-Dimethoxy-9H-pyrimido[4,5-b]indol-4-yl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]piperazine-1-carbothioamide	IC50	94.0 [1], 900.0 [2]
	Unii-LM7NL857V1	IC50	4.0 [1], 80.0 [2], 160.0 [3]
	N-(2-Chlorophenyl)-4-[[5-fluoro-2-(4-hydroxyanilino)pyrimidin-4-yl]amino]benzamide	IC50	10.0 [1], 1600.0 [2], 5000.0 [3]
	4-({4-[(2-Fluorophenyl)amino]pyrimidin-2-Yl}amino)benzoic Acid	IC50	3.7 [1]
	4-{[4-(Biphenyl-2-Ylamino)pyrimidin-2-Yl]amino}benzoic Acid	IC50	149.0 [1]
	4-[(4-{[2-(Trifluoromethyl)phenyl]amino}pyrimidin-2-Yl)amino]benzoic Acid	IC50	35.0 [1], 35.1 [2]
	4-({4-[(2-Bromophenyl)amino]pyrimidin-2-Yl}amino)benzoic Acid	IC50	2.1 [1]
	4-({4-[(2-Cyanophenyl)amino]pyrimidin-2-Yl}amino)benzoic Acid	IC50	43.0 [1]
	(3S,6S,9R,14R,17S,20S,23S,26S)-9-Amino-N-(2-amino-2-oxoethyl)-3-[3-(diaminomethylideneamino)propyl]-6-[(1R)-1-hydroxyethyl]-20,23-bis(1H-indol-3-ylmethyl)-17-(2-methylpropyl)-2,5,8,16,19,22,25-heptaoxo-11,12-dithia-1,4,7,15,18,21,24-heptazabicyclo[24.3.0]nonacosane-14-carboxamide	IC50	7000.0 [1]
	(3S,6S,9R,14R,17S,20S,23S,26S)-9-Amino-N-(2-amino-2-oxoethyl)-3-[3-(diaminomethylideneamino)propyl]-6-[(1R)-1-hydroxyethyl]-20,23-bis(1H-indol-3-ylmethyl)-17-(2-methylpropyl)-2,5,8,16,19,22,25-heptaoxo-11,12-dithia-1,4,7,15,18,21,24-heptazabicyclo[24.3.0]nonacosane-14-carboxamide	Ki	27200.0 [1], 31500.0 [2]
	2-[[2-(4-Carboxyanilino)-5-methylpyrimidin-4-yl]amino]benzoic acid	IC50	145.0 [1], 281.0 [2]
	Barasertib	IC50	1400.0 [1]
	Barasertib	Ki	1368.0 [1]
	Quizartinib	IC50	10000.0 [1]
	Entrectinib	IC50	215.0 [1], 338.0 [2]
	1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea	IC50	3.0 [1], 3.3 [2]
	Azd-1152hqpa	IC50	1400.0 [1]
	Azd-1152hqpa	Ki	1400.0 [1]
	1-(3-Chlorophenyl)-3-{5-[2-(Thieno[3,2-D]pyrimidin-4-Ylamino)ethyl]-1,3-Thiazol-2-Yl}urea	IC50	9.0 [1]
	4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine	IC50	44.0 [1]
	4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine	Ki	8.0 [1]
	2-N,4-N-Diphenylpyrimidine-2,4-diamine	IC50	423.0 [1]
	CID 44556162	IC50	10000.0 [1], 30000.0 [2]
	Ilorasertib	IC50	12.0 [1], 4743.1 [2]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	5400.0 [1], 9900.0 [2]
	PF-03814735	IC50	0.8 [1], 20.0 [2]
	2-[4-(Dimethylamino)phenyl]-1H-imidazo[4,5-b]pyridine	IC50	4300.0 [1]
	Chembl272125	IC50	560.0 [1], 15100.0 [2]
	2-[(5,6-Diphenylfuro[2,3-D]pyrimidin-4-YL)amino]ethanol	IC50	273.0 [1], 309.0 [2]
	2-(4-Methoxyphenyl)-1H-imidazo[4,5-b]pyridine	IC50	6600.0 [1]
	N-[5-[(2S)-2-Methoxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide	IC50	354.0 [1]
	2-(1H-Pyrazol-3-yl)-1H-benzimidazole	IC50	910.0 [1]
	N-[4-[4-(4-Methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamide	IC50	1.6 [1]
	N-[4-[4-(4-Methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamide	Ki	1.6 [1]
	2-(2-Methoxyphenyl)-1H-imidazo[4,5-b]pyridine	IC50	29000.0 [1]
	3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide	IC50	8090.0 [1]
	(7S)-2-(2-Aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one	IC50	4000.0 [1]
	2-{[5-Fluoro-2-(phenylamino)pyrimidin-4-yl]amino}benzoic acid	IC50	11.3 [1]
	2-[[4-(3,4-Dimethoxyanilino)-6-(quinolin-6-ylamino)-1,3,5-triazin-2-yl]amino]-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanamide	IC50	0.27 [1], 270.0 [2]
	CID 56673651	IC50	340.0 [1]
	N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-morpholinopyrimidin-2-ylthio)phenyl)propionamide	IC50	1.7 [1]
	N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-morpholinopyrimidin-2-ylthio)phenyl)propionamide	Ki	1.7 [1]
	4-Tert-butyl-N-[5-(2-phenylacetyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]benzamide	IC50	130.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase Aurora-A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-aurora-a-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 21). Quest Database™ Serine/threonine-protein kinase Aurora-A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-aurora-a-inhibitors-ic50-ki.
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