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Serine/threonine-protein kinase AKT3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
StaurosporineIC500.64 [1], 5.0 [2], 10.0 [3]
Akt inhibitor VIIIIC502119.0 [1], 2200.0 [2], 10000.0 [3]
Gsk-690693IC509.0 [1]
Gsk-690693Ki13.0 [1]
2-[4-(3-Phenylquinoxalin-2-yl)phenyl]propan-2-amineIC5050000.0 [1], 250000.0 [2]
Merck-22-6IC507200.0 [1], 10000.0 [2]
(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amineIC5035.0 [1]
1-(1-{[4-(3-Phenylquinoxalin-2-yl)phenyl]methyl}piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-oneIC5027000.0 [1], 50000.0 [2]
3-[4-[[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-2-phenylquinoxaline-6-carboxylic acidIC503200.0 [1]
2-[4-[[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-3-phenylquinoxaline-6-carboxylic acidIC5050000.0 [1]
(2S,3S,4R,5R)-N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamideIC50774.0 [1]
(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamineIC50354.0 [1]
3-[1-[[4-[3-Phenyl-7-(2H-tetrazol-5-yl)quinoxalin-2-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC501613.0 [1]
3-[1-[[4-[3-Phenyl-6-(2H-tetrazol-5-yl)quinoxalin-2-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC501228.0 [1]
4-[1-Ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamineIC50398.0 [1]
N-[2-(Diethylamino)ethyl]-2-[4-[[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-3-phenylquinoxaline-6-carboxamideIC507400.0 [1], 8000.0 [2]
N-[(2S)-1-Amino-3-(2,4-dichlorophenyl)propan-2-yl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamideIC502.6 [1], 3.0 [2]
N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideIC50200.0 [1]
MK-2206IC5065.0 [1]
DoramapimodIC5030000.0 [1]
NeflamapimodIC505000.0 [1]
CapivasertibIC508.0 [1]
4-Amino-N-[1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamideIC5015.0 [1]
(2s)-1-(1h-Indol-3-Yl)-3-{[5-(3-Methyl-1h-Indazol-5-Yl)pyridin-3-Yl]oxy}propan-2-AmineIC5051.0 [1]
IpatasertibIC508.0 [1]
AfuresertibIC501.58 [1]
Aminofurazanyl-azabenzimidazole 6nIC501510.0 [1]
4-[1-Ethyl-7-[(piperidin-4-ylamino)methyl]imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amineIC50646.0 [1]
JNK Inhibitor VIIIKi9500.0 [1]
(S)-1-(4-(1H-Pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanolIC5050.0 [1]
CID 11634725Ki4000.0 [1]
H-89 DihydrochlorideIC50662.0 [1]
3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ureaIC5017378.01 [1]
CID 59604787IC5010000.0 [1]
2-(4-Fluorophenyl)-3-(4-pyridinyl)pyrazolo[1,5-a]pyridineIC5010000.0 [1]
3-[1-[[4-(5-Methyl-6-oxo-2-phenyl-1H-pyrazin-3-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC5050000.0 [1]
3-(4-Amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-7-yl)benzenesulfonamideIC5010000.0 [1]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-6-(pyrrolidin-1-ylmethyl)imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC5022.0 [1]
2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(methylamino)ethyl]imidazo[4,5-c]pyridine-7-carboxamideIC501410.0 [1]
4-[1-Ethyl-7-(piperazin-1-ylcarbonyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amineIC501549.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi9500.0 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideKi9500.0 [1]
[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]-[(3S)-3-aminopyrrolidin-1-yl]methanoneIC501290.0 [1]
Akt inhibitorIC5012.0 [1]
3-(3-Iodobenzyl)-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5010000.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi7157.0 [1]
(2s)-1-{[6-Furan-3-Yl-5-(3-Methyl-2h-Indazol-5-Yl)pyridin-3-Yl]oxy}-3-(1h-Indol-3-Yl)propan-2-AmineIC501.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
N-[(2S)-1-Amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamideIC507.6 [1]
3-[1-[[4-(6-Oxo-2-phenyl-1H-pyrazin-3-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC5050000.0 [1]
3-[1-[[4-[5-(2-Methylpropyl)-6-oxo-3-phenyl-1H-pyrazin-2-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC5021870.0 [1]
3-[1-[[4-(6-Oxo-3-phenyl-1H-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC5050000.0 [1]
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]-2-chloropyridin-3-yl}isoquinolineIC5073.0 [1]
3-[1-[[4-(5-Methyl-6-oxo-3-phenyl-1H-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC5033100.0 [1]
3-[1-[[4-[5-(2-Methylpropyl)-6-oxo-2-phenyl-1H-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC5050000.0 [1]
3-[1-[[4-(7-Phenyl-1H-pyrazolo[3,4-g]quinoxalin-6-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC502400.0 [1]
7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi4890.0 [1]
7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamideKi10000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi9500.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi9500.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi9500.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi9500.0 [1]
N-Methyl-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-amineIC502474.0 [1]
4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamideIC5057.0 [1]
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}isoquinolin-3-amineIC5076.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
3-[1-[[4-[5-[(4-Hydroxyphenyl)methyl]-6-oxo-2-phenyl-1H-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC5050000.0 [1]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3R)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC509.0 [1]
(2S,3S,4R,5R)-N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamideIC5014.6 [1]
(S)-1-(5-(3-Methyl-7-propyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-(1H-indol-3-yl)propan-2-amineIC5010000.0 [1]
(2S)-1-[6-(Furan-3-yl)-5-(3-methyl-2H-pyrazolo[3,4-b]pyrazin-5-yl)pyridin-3-yl]oxy-3-(1H-indol-3-yl)propan-2-amineIC5010.0 [1]
5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amineIC501100.0 [1]
N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamideIC5012.0 [1]
N-[3-[5-[2-(3-Morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamideIC501000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
TilfrinibIC5010000.0 [1]
3-[1-[[4-(5-Butan-2-yl-6-oxo-2-phenyl-1H-pyrazin-3-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC5050000.0 [1]
3-[1-[[4-(5-Butan-2-yl-6-oxo-3-phenyl-1H-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC5050000.0 [1]
(R)-2-Amino-3-(4-chlorophenyl)-1-(4-(quinazolin-4-yl)piperazin-1-yl)propan-1-oneIC50179.0 [1]
4-[1-Ethyl-7-(piperidin-4-ylmethoxy)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamineIC50380.0 [1]
N-(4-Fluorophenethyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamideIC503000.0 [1]
N-(2,4-Dichlorophenethyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamideIC50990.0 [1]
N-(2,4-Dichlorophenethyl)-5-(2-(ethylamino)pyrimidin-4-yl)thiophene-2-carboxamideIC501500.0 [1]
5-[2-(Methylamino)pyrimidin-4-yl]-N-[2-(4-sulfamoylphenyl)ethyl]thiophene-2-carboxamideIC5019000.0 [1]
N-(4-Fluorobenzyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamideIC504700.0 [1]
N-(3-Chlorophenethyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamideIC505400.0 [1]
5-(2-(Methylamino)pyrimidin-4-yl)-N-phenethylthiophene-2-carboxamideIC505000.0 [1]
N-(2-Chlorophenethyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamideIC502900.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
N-(2,4-Dichlorophenethyl)-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamideIC50610.0 [1]
N-[(2S)-1-(2,4-Dichlorophenyl)-3-hydroxypropan-2-yl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamideIC50280.0 [1]
N-(4-Chlorophenethyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamideIC501100.0 [1]
N-(3-(4-Fluorophenyl)propyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamideIC5018000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
N-(4-Bromophenethyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamideIC502600.0 [1]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-6-[(2R)-2-amino-3-phenylpropoxy]-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC503.0 [1]
4-[6-(Aminomethyl)-2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC5070.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase AKT3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-akt3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Serine/threonine-protein kinase AKT3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-akt3-inhibitors-ic50-ki.
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