Serine/threonine-protein kinase AKT2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Akt inhibitor VIII	IC50	210.0 [1]
	Staurosporine	IC50	6.5 [1], 9.0 [2], 16.0 [3]
	N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	IC50	300.0 [1], 590.0 [2]
	2-[4-(3-Phenylquinoxalin-2-yl)phenyl]propan-2-amine	IC50	23000.0 [1], 250000.0 [2]
	Merck-22-6	IC50	212.0 [1], 276.0 [2], 730.0 [3]
	7-[4-[[4-(4-Aminopyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]methyl]phenyl]-6-phenylpyrido[2,3-d]pyrimidin-4-amine	IC50	99.0 [1], 468.0 [2]
	N,N-Dimethyl-2-[4-[6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]piperazin-1-yl]ethanamine	IC50	4.0 [1], 39.0 [2]
	N-Methyl-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-amine	IC50	94.0 [1], 94.4 [2], 899.0 [3]
	7-[4-[[4-(6-Fluoro-1H-benzimidazol-2-yl)piperidin-1-yl]methyl]phenyl]-6-phenylpyrido[2,3-d]pyrimidin-4-amine	IC50	239.0 [1], 1811.0 [2]
	Gsk-690693	IC50	13.0 [1]
	Gsk-690693	Ki	4.0 [1]
	1-(1-{[4-(3-Phenylquinoxalin-2-yl)phenyl]methyl}piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one	IC50	2057.0 [1], 2090.0 [2], 50000.0 [3]
	1-(2-Aminophenyl)-3-[[4-(2-methylsulfanyl-6-phenylpyrido[2,3-d]pyrimidin-7-yl)phenyl]methylamino]propan-1-one	IC50	90.0 [1], 388.0 [2]
	9-Phenyl-8-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-[1,2,4]triazolo[3,4-f][1,6]naphthyridine	IC50	10.0 [1], 41.0 [2]
	7-Azaindole	IC50	100000.0 [1]
	4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine	IC50	6.0 [1]
	(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine	IC50	6.8 [1]
	3-[1-[[4-(5-Methyl-6-oxo-2-phenyl-1H-pyrazin-3-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	20000.0 [1], 24000.0 [2]
	3-[4-[[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-2-phenylquinoxaline-6-carboxylic acid	IC50	388.0 [1]
	2-[4-[[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-3-phenylquinoxaline-6-carboxylic acid	IC50	281.0 [1]
	(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamine	IC50	257.0 [1]
	3-[1-[[4-[5-(2-Methylpropyl)-6-oxo-3-phenyl-1H-pyrazin-2-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	325.0 [1], 20000.0 [2]
	3-[1-[[4-[5-(2-Methylpropyl)-6-oxo-2-phenyl-1H-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	18000.0 [1]
	3-[1-[[4-[5-(2-Methylpropyl)-6-oxo-2-phenyl-1H-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	Ki	325.0 [1]
	3-[1-[[4-[3-Phenyl-7-(2H-tetrazol-5-yl)quinoxalin-2-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	144.0 [1]
	3-[1-[[4-[3-Phenyl-6-(2H-tetrazol-5-yl)quinoxalin-2-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	65.0 [1]
	N-Methyl-1-[4-(9h-Purin-6-Yl)phenyl]methanamine	IC50	6900.0 [1]
	4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	IC50	2.2 [1], 66.0 [2]
	6-{4-[4-(4-Chlorophenyl)piperidin-4-Yl]phenyl}-9h-Purine	IC50	20.0 [1]
	4-[1-Ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine	IC50	1000.0 [1]
	N-[2-(Diethylamino)ethyl]-2-[4-[[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-3-phenylquinoxaline-6-carboxamide	IC50	359.0 [1], 617.0 [2]
	3-[1-[[4-(4-Amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	259.0 [1], 5084.0 [2]
	6-Phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine-2-carbonitrile	IC50	59.0 [1], 586.0 [2]
	2-(4-Methylpiperazin-1-yl)-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	27.0 [1], 52.0 [2]
	N,N-Dimethyl-4-[6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]piperazine-1-carboxamide	IC50	40.0 [1], 177.0 [2]
	1-Ethyl-3-[1-[[4-(2-methylsulfanyl-6-phenylpyrido[2,3-d]pyrimidin-7-yl)phenyl]methyl]piperidin-4-yl]urea	IC50	1909.0 [1], 5296.0 [2]
	6-Phenyl-7-[4-[[4-(3-pyridin-4-yl-1H-pyrazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-4-amine	IC50	85.0 [1], 1198.0 [2]
	3-Phenyl-2-[4-[[4-(3-pyrimidin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-6H-1,6-naphthyridin-5-one	IC50	44.0 [1], 69.0 [2]
	5-[1-[[4-(2-Methylsulfanyl-6-phenylpyrido[2,3-d]pyrimidin-7-yl)phenyl]methyl]piperidin-4-yl]-1,3,4-thiadiazol-2-amine	IC50	267.0 [1], 1572.0 [2]
	1-[1-[[4-(2-Methylsulfanyl-6-phenylpyrido[2,3-d]pyrimidin-7-yl)phenyl]methyl]piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-amine	IC50	44.0 [1], 828.0 [2]
	3-Phenyl-2-[4-[[4-(3-pyrazin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-6H-1,6-naphthyridin-5-one	IC50	21.0 [1], 405.0 [2]
	6-Phenyl-2-piperidin-1-yl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	93.0 [1], 229.0 [2]
	1-({4-[2-(Methylsulfanyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]phenyl}methyl)piperidine-4-carboxamide	IC50	928.0 [1], 9259.0 [2]
	N,N-Dimethyl-1-[6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]piperidin-4-amine	IC50	22.0 [1], 70.0 [2]
	2-[4-[6-Phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]piperazin-1-yl]ethanol	IC50	31.0 [1], 41.0 [2]
	2-Methoxy-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	107.2 [1], 2295.0 [2]
	1-[[4-(2-Methylsulfanyl-6-phenylpyrido[2,3-d]pyrimidin-7-yl)phenyl]methyl]-N-pyridin-4-ylpiperidine-4-carboxamide	IC50	301.0 [1], 1131.0 [2]
	6-Phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine-2-carboxamide	IC50	35.0 [1], 3706.0 [2]
	2-[4-(1-Methylazetidin-3-yl)piperazin-1-yl]-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	9.0 [1], 27.0 [2]
	2-Methylsulfanyl-6-phenyl-7-[4-[[4-(3-pyridin-4-yl-1H-pyrazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	57.0 [1], 635.0 [2]
	1-[6-Phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]piperidin-4-ol	IC50	45.0 [1], 168.0 [2]
	2-(Dimethylamino)-1-[4-[6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]piperazin-1-yl]ethanone	IC50	6.0 [1], 19.0 [2]
	4-[6-Phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]morpholine	IC50	43.0 [1], 243.0 [2]
	2-(3,3-Difluoropyrrolidin-1-yl)-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	252.0 [1], 462.0 [2]
	2-[(3R,5S)-3,5-Dimethylpiperazin-1-yl]-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	77.0 [1], 101.0 [2]
	2-[(3R)-3-Methylpiperazin-1-yl]-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	25.0 [1], 44.0 [2]
	(2R,6S)-2,6-Dimethyl-4-[6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]morpholine	IC50	102.0 [1], 184.0 [2]
	1-[4-[6-Phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]piperazin-1-yl]ethanone	IC50	16.0 [1], 145.0 [2]
	7-[4-[[4-(2-Methylbenzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-6-phenylpyrido[2,3-d]pyrimidin-4-amine	IC50	281.0 [1], 344.0 [2]
	2-Imidazol-1-yl-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	73.0 [1], 684.0 [2]
	2-[(3S)-3-Methylpiperazin-1-yl]-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	47.0 [1], 125.0 [2]
	2-[4-[[4-[3-(6-Methoxypyridin-3-yl)-1H-1,2,4-triazol-5-yl]piperidin-1-yl]methyl]phenyl]-3-phenyl-6H-1,6-naphthyridin-5-one	IC50	16.0 [1], 159.0 [2]
	2-(6,8-Dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	138.0 [1], 735.0 [2]
	2-[4-[[4-[3-(6-Oxo-1H-pyridin-3-yl)-1H-1,2,4-triazol-5-yl]piperidin-1-yl]methyl]phenyl]-3-phenyl-6H-1,6-naphthyridin-5-one	IC50	8.0 [1], 284.0 [2]
	5-[5-[1-[[4-(3-Phenyl-1,8-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]-1H-pyrazol-3-yl]-1H-pyridin-2-one	IC50	83.0 [1], 613.0 [2]
	3-Methyl-9-phenyl-8-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-[1,2,4]triazolo[3,4-f][1,6]naphthyridine	IC50	14.6 [1], 176.5 [2]
	9-Phenyl-8-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one	IC50	6.7 [1], 167.7 [2]
	9-Phenyl-8-[4-[[4-(4-pyridin-2-ylimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-amine	IC50	2.8 [1], 74.8 [2]
	9-Phenyl-8-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridine-3-thione	IC50	10.4 [1], 107.6 [2]
	9-Phenyl-8-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-amine	IC50	9.4 [1], 47.7 [2]
	3-Phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-4aH-1,6-naphthyridin-5-one	IC50	42.0 [1], 266.0 [2]
	3-Phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-1,5-naphthyridine	IC50	70.0 [1], 1476.0 [2]
	3-Phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-1,6-naphthyridine	IC50	210.0 [1], 2679.0 [2]
	3-Phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-1,7-naphthyridine	IC50	160.0 [1], 981.0 [2]
	3-Phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-pyrazol-5-yl)piperidin-1-yl]methyl]phenyl]-1,8-naphthyridine	IC50	280.0 [1], 995.0 [2]
	3-Phenyl-2-[4-[[4-(3-pyridin-4-yl-1H-pyrazol-5-yl)piperidin-1-yl]methyl]phenyl]-1,8-naphthyridine	IC50	260.0 [1], 1454.0 [2]
	3-Phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-7,8-dihydro-6H-1,6-naphthyridin-5-one	IC50	26.0 [1], 224.0 [2]
	2-[4-[[4-[3-(6-Aminopyridin-3-yl)-1H-1,2,4-triazol-5-yl]piperidin-1-yl]methyl]phenyl]-3-phenyl-6H-1,6-naphthyridin-5-one	IC50	33.0 [1], 165.0 [2]
	2-[(2R,5S)-2,5-Dimethylpiperazin-1-yl]-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	29.0 [1], 199.0 [2]
	N',N'-Dimethyl-N-[6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]ethane-1,2-diamine	IC50	154.0 [1], 223.0 [2]
	(2R)-4-[6-Phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]piperazin-2-ol	IC50	67.0 [1], 421.0 [2]
	2-(4-Methylsulfonylpiperazin-1-yl)-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	23.0 [1], 196.0 [2]
	6-(4-Methylpiperazin-1-yl)-3-phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-1,7-naphthyridine	IC50	59.0 [1], 133.0 [2]
	[9-Phenyl-8-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-yl]urea	IC50	24.1 [1], 1213.0 [2]
	3-(Chloromethyl)-9-phenyl-8-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-[1,2,4]triazolo[3,4-f][1,6]naphthyridine	IC50	10.5 [1], 483.3 [2]
	3-[(4-Methylpiperazin-1-yl)methyl]-9-phenyl-8-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-[1,2,4]triazolo[3,4-f][1,6]naphthyridine	IC50	55.1 [1], 376.1 [2]
	2-[[9-Phenyl-8-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-yl]methylamino]ethanol	IC50	77.9 [1], 251.4 [2]
	3-Phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-1,8-naphthyridine	IC50	220.0 [1], 1077.0 [2]
	2-Methylsulfanyl-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidine	IC50	26.0 [1], 589.0 [2]
	Crizotinib	IC50	10000.0 [1]
	MK-2206	IC50	12.0 [1]
	Doramapimod	IC50	30000.0 [1]
	Nvp-tae 684	Ki	10000.0 [1]
	Capivasertib	IC50	8.0 [1]
	4-Amino-N-[1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	IC50	22.0 [1]
	(2s)-1-(1h-Indol-3-Yl)-3-{[5-(3-Methyl-1h-Indazol-5-Yl)pyridin-3-Yl]oxy}propan-2-Amine	IC50	30.0 [1]
	Ipatasertib	IC50	18.0 [1]
	Afuresertib	IC50	10.0 [1]
	Amg-458	IC50	25000.0 [1]
	Aminofurazanyl-azabenzimidazole 6n	IC50	1350.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase AKT2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-akt2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Serine/threonine-protein kinase AKT2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-akt2-inhibitors-ic50-ki.
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