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Serine/threonine-protein kinase A-Raf Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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VemurafenibIC502.1 [1], 950.0 [2]
SorafenibIC507.1 [1]
DabrafenibIC5026.0 [1]
LY-3009120IC5044.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[2-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamideIC50194.0 [1]
4-Methyl-3-[[1-[6-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]-N-[4-(1-methylpiperidin-4-yl)oxy-3-(trifluoromethyl)phenyl]benzamideIC5043.4 [1]
N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamideIC5017.8 [1]
N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-(2-piperidin-1-ylethylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamideIC5057.4 [1]
N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[[1-[6-[3-(dimethylamino)propylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]-4-methylbenzamideIC5034.1 [1]
N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-[(1-methylpiperidin-4-yl)methylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamideIC5042.2 [1]
4-Methyl-3-[[1-[6-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]-N-[4-[(1-methylpiperidin-4-yl)methoxy]-3-(trifluoromethyl)phenyl]benzamideIC5037.6 [1]
N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-(2-pyrrolidin-1-ylethylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamideIC5046.9 [1]
N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamideIC5025.3 [1]
4-Methyl-3-[[1-[6-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]-N-[4-(3-morpholin-4-ylpropoxy)-3-(trifluoromethyl)phenyl]benzamideIC5040.7 [1]
N-[3-Chloro-4-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamideIC5025.3 [1]
N-[3-Chloro-4-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[2-[2-(4-methylpiperazin-1-yl)ethylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamideIC5030.1 [1]
5-[[(1S,1Ar,6bS)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-oneIC505.6 [1]
N-[2,4-Difluoro-3-(5-methoxy-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2,5-difluorobenzenesulfonamideIC5010.0 [1]
N-[3-(5-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2-fluorobenzenesulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2-fluorobenzenesulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2,5-difluorobenzenesulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-3-fluorobenzenesulfonamideIC5010.0 [1]
N-[3-(4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2-fluorobenzenesulfonamideIC5010.0 [1]
N-[3-(4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2,5-difluorobenzenesulfonamideIC5010.0 [1]
N-[3-(4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-3-fluorobenzenesulfonamideIC5010.0 [1]
N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2-fluorobenzenesulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-(4-methoxy-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2,5-difluorobenzenesulfonamideIC50100.0 [1]
N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2,5-difluorobenzenesulfonamideIC5010.0 [1]
N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2,6-difluorobenzenesulfonamideIC5010.0 [1]
N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-3-fluorobenzenesulfonamideIC5010.0 [1]
N-[3-(5-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]benzenesulfonamideIC5010.0 [1]
N-[3-(5-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluorophenyl]benzenesulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]pyridine-3-sulfonamideIC50100.0 [1]
N-[3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]pyridine-3-sulfonamideIC50100.0 [1]
N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]pyridine-3-sulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-[5-[4-(methanesulfonamido)phenyl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamideIC5010.0 [1]
N-[3-[5-[2-(Dimethylamino)pyrimidin-5-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamideIC5010.0 [1]
5-[3-[2,6-Difluoro-3-(propylsulfonylamino)benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamideIC5010.0 [1]
N-[2,4-Difluoro-3-[5-(6-propylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-[5-(6-pyrrolidin-1-ylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-[5-[6-(2-morpholin-4-ylethoxy)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-[5-[6-(2-pyrrolidin-1-ylethoxy)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-[5-(6-oxo-1H-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-[5-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-[5-[6-(3-morpholin-4-ylpropoxy)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-(5-methoxy-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2-fluorobenzenesulfonamideIC5010.0 [1]
N-[2,4-Difluoro-3-[5-(3-methoxyprop-1-ynyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamideIC5010.0 [1]
N-[3-(5-Ethynyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamideIC5010.0 [1]
N-[2-Fluoro-3-[5-(2-methoxypyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamideIC5010.0 [1]
N-[3-[5-[2-(Dimethylamino)pyrimidin-5-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2-fluorophenyl]propane-1-sulfonamideIC5010.0 [1]
N-[3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2,5-difluorobenzenesulfonamideIC5010.0 [1]
1-(3,3-Dimethylbutyl)-3-[4-fluoro-3-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]ureaIC5031.0 [1]
1-(3-Fluoro-3-methylbutyl)-3-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]ureaIC50120.0 [1]
Items per page: 1 - 10 of 55
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase A-Raf Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-a-raf-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Serine/threonine-protein kinase A-Raf Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-a-raf-inhibitors-ic50-ki.
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