![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_b0f6535d633b24658defe8380c006aae.svg) | Vemurafenib | IC50 | 2.1 [1], 950.0 [2] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_c8494007663098abb5d227cb27cc738b.svg) | Sorafenib | IC50 | 7.1 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_55635e1e49159e77f5424d0e58fcfe56.svg) | Dabrafenib | IC50 | 26.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_777898ba417f4e875e6f3109cad807ee.svg) | LY-3009120 | IC50 | 44.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_a7ee75d4a7ce2e8d7ffa73cb444c324f.svg) | 5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_51153882d3ab9f3566d96aeaf5c3eeab.svg) | 6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_7e48d32e7daeb2ee4f7db01fb4366f20.svg) | N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[2-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide | IC50 | 194.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_4d63f8cb4fff33707884fdd365d6419c.svg) | 4-Methyl-3-[[1-[6-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]-N-[4-(1-methylpiperidin-4-yl)oxy-3-(trifluoromethyl)phenyl]benzamide | IC50 | 43.4 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_c1203c5df94cfcef79ac4bcd67b8cc54.svg) | N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide | IC50 | 17.8 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_c8c1d9eb0cda8b2b6de23288da086da8.svg) | N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-(2-piperidin-1-ylethylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide | IC50 | 57.4 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_9dbf35a2e8379eb7227adf6e7532ce57.svg) | N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[[1-[6-[3-(dimethylamino)propylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]-4-methylbenzamide | IC50 | 34.1 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_f6227dc90d8ce22201cca63cdeae1e66.svg) | N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-[(1-methylpiperidin-4-yl)methylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide | IC50 | 42.2 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_a0e6a236f86fded142a2d2125612a4a1.svg) | 4-Methyl-3-[[1-[6-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]-N-[4-[(1-methylpiperidin-4-yl)methoxy]-3-(trifluoromethyl)phenyl]benzamide | IC50 | 37.6 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_6c3435a0e71a6769dfce98fe5040dfdc.svg) | N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-(2-pyrrolidin-1-ylethylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide | IC50 | 46.9 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_1de3ed2284ef29c137427e50619d929a.svg) | N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide | IC50 | 25.3 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_981b6420f0a1ea1caa7bab15e8fe7cb3.svg) | 4-Methyl-3-[[1-[6-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]-N-[4-(3-morpholin-4-ylpropoxy)-3-(trifluoromethyl)phenyl]benzamide | IC50 | 40.7 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_653d3d18f59984f6639af52c1eacc87b.svg) | N-[3-Chloro-4-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide | IC50 | 25.3 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_25e7679448f05d91483f45af979eb968.svg) | N-[3-Chloro-4-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[2-[2-(4-methylpiperazin-1-yl)ethylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide | IC50 | 30.1 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_e16fdbc96157d13baa93f28fa89046ad.svg) | 5-[[(1S,1Ar,6bS)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one | IC50 | 5.6 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_65d383cdc92e9966fa0a473d378597a4.svg) | N-[2,4-Difluoro-3-(5-methoxy-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2,5-difluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_3f9a34e00498e6a1760cdbebdc396888.svg) | N-[3-(5-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2-fluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_fe3a473314b73fcbeab6b387169788ab.svg) | N-[2,4-Difluoro-3-(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2-fluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_82b032bee94aed6c545f37ebfc628998.svg) | N-[2,4-Difluoro-3-(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2,5-difluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_bfa7e7d73da8a100bfa58dee2ee2cf57.svg) | N-[2,4-Difluoro-3-(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-3-fluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_b8da5e217d0a0fb586584de88ac55426.svg) | N-[3-(4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2-fluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_fab01bdf7b21351c8d79713ad5514bb5.svg) | N-[3-(4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2,5-difluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_544478d00ea30a8193628cd96ff0cd16.svg) | N-[3-(4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-3-fluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_9ae898bfbc38ce6506564441ad0ce8f8.svg) | N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2-fluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_23fd85c7fed767a3fec8c662ecc0f46a.svg) | N-[2,4-Difluoro-3-(4-methoxy-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2,5-difluorobenzenesulfonamide | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_8233652f156cc003e2e7d60b9ba55602.svg) | N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2,5-difluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_35bc6432aca2432f34abbe1e16c9e285.svg) | N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2,6-difluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_19b37372bc4e0f5387e11ce885ff17b9.svg) | N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-3-fluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_e2c791978ca96ee79fa48185329472d9.svg) | N-[3-(5-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]benzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_ff8c01383e77b047b7ca41e3abdbb22d.svg) | N-[3-(5-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluorophenyl]benzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_63e93b92e8c452d17cb00cd10bd4252d.svg) | N-[2,4-Difluoro-3-(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]pyridine-3-sulfonamide | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_639ef8e9b2d322a0ef8451820da0e1b5.svg) | N-[3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]pyridine-3-sulfonamide | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_1dda000fee4a3b47928ae0ed319c75db.svg) | N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]pyridine-3-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_5c2f54d1a22b07390fc07014da38eabd.svg) | N-[2,4-Difluoro-3-[5-[4-(methanesulfonamido)phenyl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_479daff64584d4aff39aa1725a89ed19.svg) | N-[3-[5-[2-(Dimethylamino)pyrimidin-5-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_d2cc9a38e4f5dbab38a847199687bd1f.svg) | 5-[3-[2,6-Difluoro-3-(propylsulfonylamino)benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_a234f44d84a03b0a38027b8d1e9c8a59.svg) | N-[2,4-Difluoro-3-[5-(6-propylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_248eeea725a1f6aedf3a747b227e63d0.svg) | N-[2,4-Difluoro-3-[5-(6-pyrrolidin-1-ylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_157b840291fc3dd8694a650b78bdd392.svg) | N-[2,4-Difluoro-3-[5-[6-(2-morpholin-4-ylethoxy)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_762aa68fbda6d25109efe6a1af4d74f5.svg) | N-[2,4-Difluoro-3-[5-[6-(2-pyrrolidin-1-ylethoxy)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_819526d7a957b629127979b3500ec919.svg) | N-[2,4-Difluoro-3-[5-(6-oxo-1H-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_767faa2b4a1d51722324e8d5f3fbb177.svg) | N-[2,4-Difluoro-3-[5-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_3698ee4b9d70f74d2970f67911a3ed7b.svg) | N-[2,4-Difluoro-3-[5-[6-(3-morpholin-4-ylpropoxy)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_5e610cf1da5ea987f7fbd8bad3f2625f.svg) | N-[2,4-Difluoro-3-(5-methoxy-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2-fluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_79e8b1ab0a9b46bce7914f51edbed41a.svg) | N-[2,4-Difluoro-3-[5-(3-methoxyprop-1-ynyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_acb74ae5252ec079d9d02a146a867988.svg) | N-[3-(5-Ethynyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_026852d4b888f23dce3cdb1041b01a47.svg) | N-[2-Fluoro-3-[5-(2-methoxypyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_b4fde61f7bed1728945ef16a8317b6c9.svg) | N-[3-[5-[2-(Dimethylamino)pyrimidin-5-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2-fluorophenyl]propane-1-sulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_d9ae33216c9492d9b5ed9acdb99ce810.svg) | N-[3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2,5-difluorobenzenesulfonamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_9a67dafbc26491875ea56a64ad5824db.svg) | 1-(3,3-Dimethylbutyl)-3-[4-fluoro-3-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]urea | IC50 | 31.0 [1] |
![](https://images.aatbio.com/dataset/ic50/serine-threonine-protein-kinase-a-raf_85e9f67c035fb0e6cbd0c0135c33ddf9.svg) | 1-(3-Fluoro-3-methylbutyl)-3-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]urea | IC50 | 120.0 [1] |