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Serine-protein kinase ATM Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-oneIC5013.0 [1]
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-oneKi2.2 [1]
2-(Morpholin-4-yl)-benzo[h]chromen-4-oneIC50100000.0 [1]
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneIC5010000.0 [1], 100000.0 [2]
CID 118502708IC500.04 [1], 0.57 [2]
8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-oneIC5010000.0 [1], 100000.0 [2]
1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amineIC5020.0 [1], 400.0 [2]
CID 46244454IC5030000.0 [1]
8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-3-methyl-1-(oxetan-3-yl)imidazo[4,5-c]quinolin-2-oneIC501.46 [1], 1.5 [2]
8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-7-fluoro-3-methyl-1-(oxan-4-yl)imidazo[4,5-c]quinolin-2-oneIC500.78 [1]
1-(3-Methoxycyclobutyl)-3-methyl-8-[6-[3-(methylamino)propoxy]pyridin-3-yl]imidazo[4,5-c]quinolin-2-oneIC500.25 [1]
8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-3-methyl-1-[(3S)-oxan-3-yl]imidazo[4,5-c]quinolin-2-oneIC500.33 [1]
8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-oneIC500.25 [1]
8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-1-(3-hydroxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-oneIC500.24 [1]
1-(3-Methoxycyclobutyl)-3-methyl-8-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]imidazo[4,5-c]quinolin-2-oneIC500.17 [1], 0.18 [2]
8-[6-[3-(Dimethylamino)propoxy]-2-fluoropyridin-3-yl]-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-oneIC500.76 [1], 0.77 [2]
8-[6-[3-(Dimethylamino)propoxy]-2-fluoropyridin-3-yl]-7-fluoro-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-oneIC502.6 [1], 2.62 [2]
8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-7-fluoro-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-oneIC501.05 [1], 1.1 [2]
1-(3-Methoxycyclobutyl)-3-methyl-8-[6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]imidazo[4,5-c]quinolin-2-oneIC500.2 [1]
8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-3-methyl-1-[(3R)-oxan-3-yl]imidazo[4,5-c]quinolin-2-oneIC500.94 [1]
8-[6-[3-(Azetidin-1-yl)propoxy]pyridin-3-yl]-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-oneIC500.29 [1]
7-Fluoro-3-methyl-1-[(3S)-oxan-3-yl]-8-[6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]imidazo[4,5-c]quinolin-2-oneIC500.8 [1], 1.1 [2]
7-Fluoro-3-methyl-1-(oxan-4-yl)-8-[6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]imidazo[4,5-c]quinolin-2-oneIC501.1 [1], 1.2 [2]
ATM Inhibitor-1IC500.7 [1], 2.8 [2]
6-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamideIC500.29 [1], 1.9 [2]
7-Fluoro-1-(3-methoxycyclobutyl)-8-[6-(methoxymethyl)pyridin-3-yl]-3-methylimidazo[4,5-c]quinolin-2-oneIC50100.0 [1], 160.0 [2]
CaffeineIC50200000.0 [1]
ThioureaIC50200.0 [1]
DactolisibIC507.0 [1]
Schisandrin BIC501740000.0 [1]
PD173074IC5017600.0 [1]
AlpelisibIC5010000.0 [1]
3-Amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamideIC508000.0 [1]
KU-60019IC506.0 [1]
Imino-methyl-[1-[6-[(3R)-3-methylmorpholin-4-yl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]cyclopropyl]-oxo-lambda6-sulfaneIC5030000.0 [1]
CID 11964036IC5010000.0 [1]
Diphenyl acetamidotrichloroethyl fluoronitrophenyl thioureaIC50200.0 [1]
2-Methyl-2-[4-(2-oxo-9-quinolin-3-yl-4H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrileIC5036.0 [1]
2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-oneIC50100000.0 [1]
Cc-115IC5030000.0 [1]
2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-oneIC50100000.0 [1]
4-Hydroxy-3,5-dimethoxybenzaldehyde [4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazoneIC5010000.0 [1]
3-Amino-n,6-diphenylpyrazine-2-carboxamideIC508000.0 [1]
7-Fluoro-6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]quinoline-3-carboxamideIC5033.0 [1]
CID 134694318IC5046.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
3-Amino-6-[4-[1-(dimethylamino)propan-2-ylsulfonyl]phenyl]-N-phenylpyrazine-2-carboxamideIC508000.0 [1]
(3E)-3-(1H-Pyrrol-2-ylmethylidene)-1,3-dihydro-2H-indol-2-oneIC5012000.0 [1]
3-(4-Methylpiperazin-1-yl)-N-[6-(6-morpholin-4-yl-4-oxopyran-2-yl)thianthren-2-yl]propanamideIC503.0 [1]
(6R)-6-Methyl-3-(4-methylsulfonylphenyl)-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazineIC50130.0 [1]
(6R)-6-Methyl-3-(1-methylsulfonylpiperidin-4-yl)-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazineIC5014000.0 [1]
(6R)-5-(6-Chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-6-methyl-3-(1-methylsulfonylpiperidin-4-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazineIC504300.0 [1]
(3R)-3-Methyl-4-[1-methyl-6-(1H-pyrrolo[2,3-d]pyridazin-4-yl)imidazo[4,5-c]pyridin-4-yl]morpholineIC5015000.0 [1]
2-[4-[4-(5-Amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-6,7-dimethoxyquinazolin-2-yl]piperazin-1-yl]ethanolIC5040000.0 [1]
Ethyl 2-[[4-(5-amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-6,7-dimethoxyquinazolin-2-yl]amino]acetateIC5040000.0 [1]
2-[[4-(5-Amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-6,7-dimethoxyquinazolin-2-yl]amino]acetic acidIC5040000.0 [1]
4-(5-Amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-N,N-diethyl-6,7-dimethoxyquinazolin-2-amineIC5040000.0 [1]
2-(6,7-Dimethoxy-2-methylquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amineIC5010100.0 [1]
2-(6,7-Dimethoxy-2-phenylquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amineIC5040000.0 [1]
2-[7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]-5-pyridin-2-yl-1,2,4-triazol-3-amineIC502200.0 [1]
2-[6-Methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]-5-pyridin-2-yl-1,2,4-triazol-3-amineIC5040000.0 [1]
2-[6-[3-(Dimethylamino)propoxy]-7-methoxyquinazolin-4-yl]-5-pyridin-2-yl-1,2,4-triazol-3-amineIC506600.0 [1]
2-[6-[2-[Di(propan-2-yl)amino]ethoxy]-7-methoxyquinazolin-4-yl]-5-pyridin-2-yl-1,2,4-triazol-3-amineIC506100.0 [1]
2-[7-Methoxy-6-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]-5-pyridin-2-yl-1,2,4-triazol-3-amineIC502700.0 [1]
2-[7-Methoxy-6-[2-(4-methylpiperidin-1-yl)ethoxy]quinazolin-4-yl]-5-pyridin-2-yl-1,2,4-triazol-3-amineIC501700.0 [1]
2-[6-[3-(2,6-Dimethylmorpholin-4-yl)propoxy]-7-methoxyquinazolin-4-yl]-5-pyridin-2-yl-1,2,4-triazol-3-amineIC501600.0 [1]
2-[4-(5-Amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-yl]oxy-N,N-diethylacetamideIC505300.0 [1]
N-[3-[4-(5-Amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-yl]oxypropyl]-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]acetamideIC501700.0 [1]
Tert-butyl N-[3-[4-(5-amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-yl]oxypropyl]carbamateIC50900.0 [1]
4-(5-Amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-6,7-dimethoxyquinazolin-2-amineIC502100.0 [1]
6,7-Dimethoxy-4-(3-pyridin-2-yl-1,2,4-triazol-1-yl)quinazolineIC505300.0 [1]
6,7-Dimethoxy-4-(4-pyridin-2-yltriazol-2-yl)quinazolineIC5013300.0 [1]
2-(6,7-Dimethoxyquinazolin-4-yl)-5-pyridin-2-ylpyrazol-3-amineIC501600.0 [1]
2-[7-Methoxy-6-(2-piperidin-1-ylethoxy)quinazolin-4-yl]-5-pyridin-2-yl-1,2,4-triazol-3-amineIC505600.0 [1]
Tert-butyl N-[4-[4-(5-amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-yl]oxybutyl]carbamateIC50800.0 [1]
2,2,2-Trifluoroethyl N-[3-[4-(5-amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-yl]oxypropyl]carbamateIC501200.0 [1]
2-[(2R,6S)-2,6-Dimethylmorpholin-4-yl]-N-[6-(6-morpholin-4-yl-4-oxopyran-2-yl)thianthren-2-yl]acetamideIC506.3 [1]
Tert-butyl N-[2-[4-(5-amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-yl]oxyethyl]carbamateIC50800.0 [1]
Ethyl N-[3-[4-(5-amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-yl]oxypropyl]carbamateIC50800.0 [1]
Propan-2-yl N-[3-[4-(5-amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-yl]oxypropyl]carbamateIC501000.0 [1]
2-(6-Methoxy-7-phenylmethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amineIC5040000.0 [1]
Hexyl N-[3-[4-(5-amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-yl]oxypropyl]carbamateIC5028600.0 [1]
Phenyl N-[3-[4-(5-amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-yl]oxypropyl]carbamateIC5023500.0 [1]
2,2-Dimethylpropyl N-[3-[4-(5-amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-yl]oxypropyl]carbamateIC501900.0 [1]
N-[3-[4-(5-Amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-yl]oxypropyl]-2,2,2-trifluoroacetamideIC502900.0 [1]
2-[6,7-Bis(cyclopropylmethoxy)quinazolin-4-yl]-5-pyridin-2-yl-1,2,4-triazol-3-amineIC5040000.0 [1]
2-(6,7-Dimethoxy-2-morpholin-4-ylquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amineIC5040000.0 [1]
2-[6,7-Dimethoxy-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-5-pyridin-2-yl-1,2,4-triazol-3-amineIC5040000.0 [1]
2-(6,7-Dimethoxyquinazolin-4-yl)-5-(4-methylphenyl)pyrazol-3-amineIC5040000.0 [1]
5-(4-Chlorophenyl)-2-(6,7-dimethoxyquinazolin-4-yl)pyrazol-3-amineIC5040000.0 [1]
1-(6,7-Dimethoxyquinazolin-4-yl)-1,2,4-triazole-3,5-diamineIC5040000.0 [1]
2-(7-Methoxy-6-phenylmethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amineIC508600.0 [1]
2-(2-Chloro-6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amineIC5040000.0 [1]
6,7-Dimethoxy-N-(4-pyridin-2-ylphenyl)quinazolin-4-amineIC5012500.0 [1]
2-[6,7-Bis(2-methoxyethoxy)quinazolin-4-yl]-5-pyridin-2-yl-1,2,4-triazol-3-amineIC502300.0 [1]
5-Cyclohexyl-2-(6,7-dimethoxyquinazolin-4-yl)-1,2,4-triazol-3-amineIC5040000.0 [1]
6,7-Dimethoxy-N-pyridin-2-ylquinazolin-4-amineIC5040000.0 [1]
2-(6,7-Dimethoxyquinazolin-4-yl)-4-pyridin-2-ylpyrazol-3-amineIC502400.0 [1]
4-(5-Amino-3-pyridin-2-yl-1,2,4-triazol-1-yl)-7-methoxyquinazolin-6-olIC5012600.0 [1]
2-(6,7-Dimethoxyquinazolin-4-yl)-5-phenyl-1,2,4-triazol-3-amineIC502000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine-protein kinase ATM Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/serine-protein-kinase-atm-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Serine-protein kinase ATM Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-protein-kinase-atm-inhibitors-ic50-ki.
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