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Ribosomal protein S6 kinase alpha 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanoneIC5015.0 [1]
[(2S,3S,4S,5R,6S)-4-Acetyloxy-6-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]oxy-5-hydroxy-2-methyloxan-3-yl] acetateIC5089.0 [1], 370.0 [2], 583.0 [3], 990.0 [4]
N-(1-Methylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC509.0 [1], 200.0 [2]
N-(3-Methyl-1,2-oxazol-5-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5019.0 [1], 200.0 [2]
N-(1-Methylpyrazol-4-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5011.0 [1], 790.0 [2]
2,6-Difluoro-4-[4-(4-morpholin-4-ylphenyl)pyridin-3-yl]phenolIC504.0 [1], 210.0 [2]
4,4'-(1h-Pyrazole-3,4-Diyl)diphenolIC5020.0 [1], 24.0 [2], 2800.0 [3]
2,6-Difluoro-4-{4-[4-(4-Methylpiperazin-1-Yl)phenyl]pyridin-3-Yl}phenolIC505.0 [1], 340.0 [2]
3-(4-Amino-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propan-1-olIC50430000.0 [1], 1200000.0 [2], 30000000.0 [3]
CID 53246941IC501.0 [1], 20.0 [2]
1-Oxo-N-pyridin-3-yl-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carboxamideIC50730.0 [1], 10000.0 [2]
1-Oxo-N-pyridin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC50240.0 [1], 1940.0 [2]
4-Methyl-1-oxo-N-pyridin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC501200.0 [1], 4890.0 [2]
3-(2-Furylmethylene)-1,3-dihydro-2H-indol-2-oneIC503470.0 [1], 7760.0 [2]
4-Methyl-1-oxo-N-pyridin-3-yl-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carboxamideIC50170.0 [1], 1630.0 [2]
4-[4-(4-Methylpiperazin-1-yl)phenyl]-5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridineIC50240.0 [1], 2400.0 [2]
2,6-Difluoro-4-[4-(4-morpholin-4-ylphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenolIC502.0 [1], 50.0 [2]
5-(3,5-Difluoro-4-methoxyphenyl)-4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridineIC50500.0 [1], 20000.0 [2]
5-[4-(Difluoromethyl)phenyl]-4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridineIC50800.0 [1], 18100.0 [2]
2,6-Difluoro-4-[4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]phenolIC500.3 [1], 54.0 [2]
2,6-Difluoro-4-[4-(4-methylphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenolIC502.0 [1], 232.0 [2]
5-(3,5-Difluorophenyl)-4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridineIC5038.0 [1], 6000.0 [2]
5-[4-[4-(4-Methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridin-2-amineIC50810.0 [1], 7200.0 [2]
5-(2-Fluoropyridin-4-yl)-4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridineIC501100.0 [1], 20000.0 [2]
5-(4-Fluorophenyl)-4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridineIC501900.0 [1], 20000.0 [2]
4,4-Dimethyl-1-oxo-N-pyridin-3-yl-2,3-dihydropyrazino[1,2-a]indole-7-carboxamideIC50210.0 [1], 1550.0 [2]
N-(1-Ethylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC501.0 [1], 40.0 [2]
N-(6-Chloro-1-ethylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5012.0 [1], 90.0 [2]
1-Oxo-N-[1-(pyridin-4-ylmethyl)pyrazol-4-yl]-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC502.0 [1], 90.0 [2]
(5S)-N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-5-methyl-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5014.0 [1], 100.0 [2]
N-(1H-Benzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC504.0 [1], 10000.0 [2]
(3Z)-3-[[5-(2-Nitrophenyl)-1H-pyrazol-4-yl]methylidene]-1H-indol-2-oneIC501.6 [1], 500.0 [2]
(3S,4R)-3,4-Dimethyl-1-oxo-N-pyridin-3-yl-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carboxamideIC5045.0 [1], 840.0 [2]
1-Oxo-N-(1-propan-2-ylpyrazolo[3,4-b]pyridin-5-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5053.0 [1], 840.0 [2]
1-Oxo-N-(3-phenyl-1,2-oxazol-5-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5086.0 [1], 360.0 [2]
1-Oxo-N-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC50290.0 [1], 1930.0 [2]
N-(2-Carbamoylphenyl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5021.0 [1], 560.0 [2]
1-Oxo-N-quinolin-2-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5068.0 [1], 1130.0 [2]
N-[6-Chloro-1-[3-(dimethylamino)propyl]benzimidazol-2-yl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5020.0 [1], 160.0 [2]
N-(1H-Imidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5026.0 [1], 290.0 [2]
N-(1,3-Benzoxazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC50367.0 [1], 10000.0 [2]
N-(5-Chloro-1-ethylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC506.0 [1], 130.0 [2]
N-[1-(Cyclohexylmethyl)pyrazol-4-yl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC507.0 [1], 120.0 [2]
1-Oxo-N-pyridin-4-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5034.0 [1], 620.0 [2]
1-Oxo-N-(1H-pyrazol-4-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5043.0 [1], 10000.0 [2]
1-Oxo-N-quinolin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5034.0 [1], 340.0 [2]
1-Oxo-N-[1-(pyridin-2-ylmethyl)pyrazol-4-yl]-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5010.0 [1], 460.0 [2]
N-(3-Cyclopropyl-1,2-oxazol-5-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5018.0 [1], 250.0 [2]
N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-4,4-dimethyl-1-oxo-3,5-dihydro-2H-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5027.0 [1], 290.0 [2]
1-Oxo-N-(1-propan-2-ylbenzimidazol-2-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5020.0 [1], 180.0 [2]
1-Oxo-N-(1-phenylbenzimidazol-2-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5061.0 [1], 1000.0 [2]
N-(3-Ethylimidazo[4,5-b]pyridin-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC504.0 [1], 80.0 [2]
1-Oxo-N-(3-propan-2-yl-1,2-oxazol-5-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5026.0 [1], 460.0 [2]
N-(3-Benzyl-1,2-oxazol-5-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5013.0 [1], 130.0 [2]
5-Methyl-1-oxo-N-pyridin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5041.0 [1], 890.0 [2]
1-Oxo-N-pyridin-2-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC50220.0 [1], 2630.0 [2]
1-Oxo-N-(pyridin-3-ylmethyl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5010000.0 [1]
N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC5021.0 [1], 200.0 [2]
2-[(Z)-[2-Bromo-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidineIC50607.1 [1], 1230.0 [2]
StaurosporineIC500.5 [1]
SunitinibIC50183.9 [1]
DasatinibIC5020000.0 [1]
TofacitinibIC5010000.0 [1]
Bisindolylmaleimide IXIC5010.0 [1]
(5Z)-5-(Quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-oneKi2000.0 [1]
1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)ureaIC501.0 [1]
A-674563Ki580.0 [1]
JNK Inhibitor VIC5010000.0 [1]
JNK Inhibitor VIIIKi7400.0 [1]
CID 59604787IC5010000.0 [1]
(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamideIC5013.0 [1]
2-[Ethyl-[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]amino]-2-methylpropan-1-olIC50180.0 [1]
2-Amino[1,3]thiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dioneIC509990.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi7400.0 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideKi7400.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi7368.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
Khk-IN-1IC5040000.0 [1]
1-Oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC509100.0 [1]
Tert-butyl N-[3-[3-[4-(2-methoxyphenyl)-2,5-dioxopyrrol-3-yl]pyrrolo[2,3-b]pyridin-1-yl]propyl]carbamateIC50640.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi7400.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi7400.0 [1]
2-(4-Aminophenyl)-4-methyl-1H-benzo[d]imidazol-5-amineIC50320.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi3300.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi7400.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC5083.0 [1]
(E)-Methyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)acrylateIC50250.0 [1]
3-Methyl-N-[6-methylsulfanyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amineIC501306.0 [1]
N-[6-Methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(piperidin-1-ylmethyl)-1,2-thiazol-5-amineIC50360.0 [1]
2-((4-Morpholinophenylamino)methyl)isoindoline-1,3-dioneIC50950.0 [1]
3-Methyl-1-oxo-N-pyridin-3-yl-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carboxamideIC50350.0 [1]
1-Oxo-N-(1,3-thiazol-2-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC502200.0 [1]
4-(Aminomethyl)-1-oxo-N-pyridin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamideIC501800.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amineIC504000.0 [1]
3-[(1R)-1-[(2S,6R)-2,6-Dimethylmorpholin-4-yl]ethyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amineIC50330.0 [1]
Tert-butyl (E)-3-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyanoprop-2-enoateIC507.0 [1]
(E)-3-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-propan-2-ylprop-2-enamideIC505.0 [1]
(E)-3-(4-Amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)acrylonitrileIC50750.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Ribosomal protein S6 kinase alpha 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-alpha-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Ribosomal protein S6 kinase alpha 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-alpha-3-inhibitors-ic50-ki.
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