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Ribosomal protein S6 kinase alpha 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
StaurosporineIC500.09 [1], 0.1 [2], 0.5 [3], 1.2 [4]
4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC503100.0 [1]
SunitinibIC50131.3 [1]
DasatinibIC5020000.0 [1]
DorsomorphinIC50210.0 [1]
DoramapimodIC5030000.0 [1]
4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amineIC5010280.0 [1]
Gsk-690693IC501260.0 [1]
Aminofurazanyl-azabenzimidazole 6nIC50132.0 [1]
CID 44219749IC5050000.0 [1]
CID 11373846IC50780.0 [1]
CID 59604787IC5010000.0 [1]
1-(4-Methoxyphenyl)-3-[(2-oxo-3-indolyl)amino]thioureaIC5034900.0 [1]
CID 11548023IC50398.0 [1]
(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamideIC5061.0 [1]
4-(3,4-Dichlorophenyl)-N-1H-indazol-5-yl-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxamideIC50620.0 [1]
N-(1H-Indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxamideIC501100.0 [1]
N-(7-Chloro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamideIC5090.0 [1]
6-Methyl-N-(3-methyl-2H-indazol-5-yl)-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamideIC501950.0 [1]
[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]-[(3S)-3-aminopyrrolidin-1-yl]methanoneIC5035.0 [1]
AKT Kinase InhibitorIC501.0 [1]
4-[2-[4-(3-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholineIC502100.0 [1]
3-{[(1R)-1-Phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dioneIC50810.0 [1]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3R)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC501580.0 [1]
CID 25207521IC50290.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
3-[7-[4-[(1S,4S)-5-Methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]phenyl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenolIC509710.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC505000.0 [1]
5-(3-Tert-butyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4-difluorophenyl)-1,3-oxazoleIC5010000.0 [1]
5-(3-Propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazoleIC5010000.0 [1]
N-(1H-Indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamideIC50740.0 [1]
4-[7-(3-Aminopropoxy)-1-ethyl-4-phenyl-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amineIC5044.0 [1]
4-(4-Fluorophenyl)-N-1H-indazol-5-yl-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamideIC501410.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
CID 11641672IC50510.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-phenyl-1,4-dihydropyrimidine-5-carboxamideIC505300.0 [1]
6-[4-[(5-Tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-N-[3-(dimethylamino)propyl]imidazo[2,1-b][1,3]thiazole-3-carboxamideIC5010000.0 [1]
3-(5-Cyclopropyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amineIC50311.0 [1]
(5R)-4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-(2-pyrrolidin-1-ylethyl)imidazol-2-yl]piperidin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-oneIC5020.0 [1]
4-[7-[1-[2-(Dimethylamino)ethyl]pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-[(3-fluorophenyl)methoxy]benzamideIC505.4 [1]
5-(1,3-Benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5010000.0 [1]
N-(4-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamideIC5010000.0 [1]
4-(2-Chloro-4-fluorophenyl)-5-(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-oxazoleIC5010000.0 [1]
N-Ethyl-6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-[1,2,4]triazolo[4,3-a]pyridin-3-amineIC5010000.0 [1]
6-[5-(2,5-Difluorophenyl)-1H-pyrazol-4-yl]-3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridineIC5010000.0 [1]
4-[(4-Methyl-1H-indol-5-yl)amino]-2-[(E)-3-oxo-3-pyrrolidin-1-ylprop-1-enyl]thieno[2,3-b]pyridine-5-carbonitrileIC5050000.0 [1]
4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-iumIC5010000.0 [1]
4-[7-(3-Aminopropoxy)-1-ethyl-4-(1H-pyrrol-2-yl)imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amineIC5013.0 [1]
4-[7-(3-Aminopropoxy)-1-ethyl-4-(furan-3-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amineIC5071.0 [1]
4-[7-(3-Aminopropoxy)-4-(2-cyclopropylethynyl)-1-ethylimidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amineIC50251.0 [1]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC501259.0 [1]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethylimidazo[4,5-c]pyridin-4-yl]but-3-yn-1-olIC506.0 [1]
4-[7-(4-Aminobutoxy)-2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC50790.0 [1]
4-[7-(2-Aminoethoxy)-2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC50500.0 [1]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-[(3S)-3-amino-4-phenylbutoxy]-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC501560.0 [1]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(pyrrolidin-3-ylmethoxy)imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC501990.0 [1]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[3-[2-(4-methoxyphenyl)ethylamino]propoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC502510.0 [1]
(2S)-3-[3-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-ynyl)imidazo[4,5-c]pyridin-7-yl]oxypropylamino]propane-1,2-diolIC50500.0 [1]
2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl]amino}-2-phenylacetamideIC50780.0 [1]
5-[(E)-4-[(3R)-3-Aminopiperidin-1-yl]but-1-enyl]-4-[(4-methyl-1H-indol-5-yl)amino]pyridine-3-carbonitrileIC5011000.0 [1]
2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamideIC5010000.0 [1]
N-(2-Hydroxyethyl)-4-[3-[(Z)-(4-hydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-1-methylpyrrolo[2,3-b]pyridin-4-yl]benzamideIC5045.9 [1]
3-[[2-(2-Fluorophenyl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dioneIC5050000.0 [1]
3-[[2-(Furan-2-yl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dioneIC5050000.0 [1]
3-[[(1R)-1-Phenylethyl]amino]-4-[(2-thiophen-3-ylpyridin-4-yl)amino]cyclobut-3-ene-1,2-dioneIC5050000.0 [1]
Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylateIC5050000.0 [1]
Tert-butyl 4-[6-(4-aminophenyl)-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylateIC5050000.0 [1]
4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrileIC5050000.0 [1]
6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrileIC5050000.0 [1]
CID 46179972IC5050000.0 [1]
1-[4-[4-(3-Oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(oxan-4-yl)-1,3,5-triazin-2-yl]phenyl]-3-[4-(4-propan-2-ylpiperazine-1-carbonyl)phenyl]ureaIC5050000.0 [1]
29-(Dimethylamino)-4,14,24,30-tetrazaheptacyclo[26.2.2.14,11.117,24.05,10.012,16.018,23]tetratriaconta-1(30),5,7,9,11(34),12(16),17(33),18,20,22,28,31-dodecaene-13,15-dioneIC501900.0 [1]
5-[6-[4-(2-Morpholin-4-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-1H-pyridin-2-oneIC502100.0 [1]
Akt-IN-2IC50568.0 [1]
N-[5-[6-(Methylamino)pyrazin-2-yl]-2-oxo-1H-pyridin-3-yl]-4-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]benzamideKi1000.0 [1]
4-(5-(3,4-Dihydroxyphenyl)oxazol-2-ylamino)benzenesulfonamideIC503400.0 [1]
4-[6-[4-(2-Morpholin-4-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]benzene-1,2-diolIC50560.0 [1]
4-[2-[4-[3-(1H-Pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl]phenoxy]ethyl]morpholineIC50220.0 [1]
4-[6-[4-(2-Morpholin-4-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]pyridin-2-amineIC501100.0 [1]
4-(5-(6-Oxo-1,6-dihydropyridin-3-yl)oxazol-2-ylamino)benzenesulfonamideIC5010000.0 [1]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-4-ylmethoxy)imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol;2,2,2-trifluoroacetic acidIC502510.0 [1]
4-[7-(3-Aminopropoxy)-4-(3-aminoprop-1-ynyl)-1-ethylimidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine;2,2,2-trifluoroacetic acidIC50251.0 [1]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-piperidin-4-yloxyimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol;2,2,2-trifluoroacetic acidIC503980.0 [1]
2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideIC501000.0 [1]
Chembl4126067IC50699.0 [1]
Chembl4129817IC50272.0 [1]
6-(1,9-Diazaspiro[5.5]undecan-9-Yl)-9h-PurineIC5063000.0 [1]
6-(2,9-Diazaspiro[5.5]undecan-9-Yl)-9h-PurineIC5013000.0 [1]
1-[(3-Hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea;methanesulfonic acidIC501.0 [1]
3-Isopropyl-6-(4-phenyl-oxazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridineIC5010000.0 [1]
5-(3-Tert-butyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazoleIC5010000.0 [1]
N-[2-(4-Chloro-3-fluorophenyl)ethyl]-7-(oxan-4-ylamino)-1,6-naphthyridine-2-carboxamideIC50476.0 [1]
(3S,4S)-3-Methoxy-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-oneIC500.19 [1]
2-[(Z)-[2-Bromo-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidineIC501181.0 [1]
6-(4-Fluorophenyl)sulfanyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC504253.0 [1]
N-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-7-[(2-methylpyrazol-3-yl)amino]-1,6-naphthyridine-2-carboxamideIC509.84 [1]
N-[(S)-(3-Fluoro-4-methoxyphenyl)-(1-methylpyrazol-4-yl)methyl]-7-[[(2S)-1-hydroxypropan-2-yl]amino]-1,6-naphthyridine-2-carboxamideIC5037.8 [1]
N-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-3-(oxan-4-ylamino)isoquinoline-6-carboxamideIC5014.8 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Ribosomal protein S6 kinase alpha 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-alpha-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Ribosomal protein S6 kinase alpha 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-alpha-1-inhibitors-ic50-ki.
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