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Ribosomal protein S6 kinase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-[5-Chloro-3-[4-(3-ethyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-2-methylphenyl]-N',N'-dimethylethane-1,2-diamineIC502.0 [1], 45.0 [2], 211.0 [3]
N-[3-[4-(3-Bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-5-chloro-2-methylphenyl]-N',N'-dimethylethane-1,2-diamineIC502.0 [1], 43.0 [2], 141.0 [3]
5-Chloro-3-[4-(3-ethyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-2-methyl-N-(2-pyrrolidin-1-ylethyl)anilineIC503.0 [1], 80.0 [2], 832.0 [3]
Unii-olj18sri8AIC502.0 [1], 30.0 [2], 55.0 [3]
3-[4-(3-Bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-2-methyl-N-(2-pyrrolidin-1-ylethyl)-5-(2,2,2-trifluoroethoxymethyl)anilineIC502.0 [1], 17.0 [2], 66.0 [3]
1-[3-[4-(3-Bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-4-methyl-5-(2-pyrrolidin-1-ylethylamino)phenyl]propan-1-oneIC501.0 [1], 18.0 [2], 25.0 [3]
3-[4-(3-Bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-2-methyl-5-(2-methylpropoxy)-N-(2-pyrrolidin-1-ylethyl)anilineIC501.0 [1], 37.0 [2], 214.0 [3]
3-[4-(3-Bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-2-methyl-5-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(2-pyrrolidin-1-ylethyl)anilineIC501.0 [1], 13.0 [2], 47.0 [3]
Methyl 3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-4-methyl-5-(2-pyrrolidin-1-ylethylamino)benzoateIC502.0 [1], 44.0 [2], 52.0 [3]
3-[4-(3-Bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-5-(3,3-dimethylbutyl)-2-methyl-N-(2-pyrrolidin-1-ylethyl)anilineIC502.0 [1], 116.0 [2], 203.0 [3]
3-[4-(3-Bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-5-chloro-2-methyl-N-(2-pyrrolidin-1-ylethyl)anilineIC502.0 [1], 94.0 [2], 446.0 [3]
3-[4-(3-Bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-4-methyl-N-phenyl-5-(2-pyrrolidin-1-ylethylamino)benzamideIC501.0 [1], 14.0 [2], 190.0 [3]
4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC502850.0 [1]
5-Tert-butyl-N-[2-(dimethylamino)ethyl]-2-(1H-indazol-5-ylcarbamoylamino)thiophene-3-carboxamideIC50521.0 [1], 15000.0 [2]
5-Tert-butyl-N-cyclopropyl-2-(1H-indazol-5-ylcarbamoylamino)thiophene-3-carboxamideIC50685.0 [1], 10000.0 [2]
3-[4-(3-Bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-5-ethoxy-2-methyl-N-(2-pyrrolidin-1-ylethyl)anilineIC502.0 [1], 197.0 [2]
StaurosporineIC501.0 [1]
N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideIC5080.0 [1]
CrizotinibIC5010000.0 [1]
TofacitinibIC5010000.0 [1]
Bisindolylmaleimide IXIC5015.0 [1]
DoramapimodIC5030000.0 [1]
Amg-458IC5025000.0 [1]
4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amineKi540.0 [1]
4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amineIC50120.0 [1]
(3E,5E)-3,5-Bis[(2-fluorophenyl)methylidene]piperidin-4-oneIC5020000.0 [1]
LY-2584702IC504.0 [1]
4-[1-Ethyl-7-[(piperidin-4-ylamino)methyl]imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amineIC50270.0 [1]
1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanoneIC50950.0 [1]
CID 11373846IC501940.0 [1]
Pyrimidone, 22IC5010000.0 [1]
2-(4-Fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-oneIC505700.0 [1]
CID 59604787IC503500.0 [1]
4-(1-Ethyl-1H-benzimidazol-2-yl)-1,2,5-oxadiazol-3-amineKi50.0 [1]
3-Bromo-4-(4-(2-methoxyphenyl)piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidineIC509.1 [1]
2-(3-(1H-Indazol-5-yl)ureido)-5-(tert-butyl)thiophene-3-carboxylic acidIC5052000.0 [1]
N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamideIC501000.0 [1]
CID 11548023IC501000.0 [1]
4-(1-Methyl-1H-benzoimidazol-2-yl)-furazan-3-ylamineKi540.0 [1]
4-(3,4-Dichlorophenyl)-N-1H-indazol-5-yl-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxamideIC50560.0 [1]
N-(1H-Indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxamideIC501550.0 [1]
N-(7-Chloro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamideIC50590.0 [1]
3,5-Bis(2-pyridylmethylene)piperidine-4-oneIC501400.0 [1]
6-[4-(3-Chlorophenyl)piperazin-1-yl]-9H-purineIC50196.0 [1]
3-[1-(3-Aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)-1-methylpyrrole-2,5-dioneIC5025000.0 [1]
6-Methyl-N-(3-methyl-2H-indazol-5-yl)-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamideIC504790.0 [1]
7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC502710.0 [1]
10,11-Dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamineIC5010000.0 [1]
4-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amineIC5070.0 [1]
B-Raf IN 1IC502000.0 [1]
(3Z,5Z)-3,5-Bis(pyridin-2-ylmethylidene)thian-4-oneIC5012000.0 [1]
8-Bromo-4-(3-chloro-4-fluoroanilino)-6-[(1-methylimidazol-4-yl)methylamino]quinoline-3-carbonitrileIC5083100.0 [1]
(3E,5E)-1-Methyl-3,5-bis(pyridin-2-ylmethylidene)piperidin-4-oneIC506000.0 [1]
4-[4-(3-Chlorophenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidineIC50107.0 [1]
5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrileIC5010000.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi6668.0 [1]
(2s)-1-{[6-Furan-3-Yl-5-(3-Methyl-2h-Indazol-5-Yl)pyridin-3-Yl]oxy}-3-(1h-Indol-3-Yl)propan-2-AmineIC507.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
4-(1-Isopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi40.0 [1]
cis-3-(3-Azetidin-1-ylmethylcyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-ylamineIC5010000.0 [1]
6,9-Dichloro[1]benzothieno[3,2-d]pyrimidin-4(3H)-oneKi773.4 [1]
8-Bromo-4-(3-chloro-4-fluoroanilino)-6-(2H-triazol-4-ylmethylamino)quinoline-3-carbonitrileIC50100000.0 [1]
8-Chloro-4-(3-chloro-4-fluoroanilino)-6-(1H-imidazol-5-ylmethylamino)-3-quinolinecarbonitrileIC50100000.0 [1]
6-(2-Aminopyrimidin-4-Yl)-1h-Indazol-3-AmineIC506340.0 [1]
5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amineIC5010000.0 [1]
4-(4-Fluorophenyl)-N-[4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxyphenyl]phthalazin-1-amineIC5025000.0 [1]
N-[5-Amino-1-[(4-methoxyphenyl)methyl]pyrazol-4-yl]-5-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-2-methylbenzamideIC501.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5020000.0 [1]
4-[1-(Cyclopropylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amineKi12.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
4-(1-(Cyclobutylmethyl)-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi69.0 [1]
4-(1-Cyclopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi95.0 [1]
4-(1-Phenyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi110.0 [1]
2-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)benzonitrileKi26.0 [1]
4-(1-(3-Methoxyphenyl)-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi1900.0 [1]
4-(1-Cyclohexyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi12.0 [1]
4-(4-Fluorophenyl)-N-1H-indazol-5-yl-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamideIC501100.0 [1]
4-(1-Isobutyl-4-phenyl-1H-imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi89.0 [1]
4-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-3-methyl-2H-pyrazolo[3,4-d]pyrimidineIC509.0 [1]
[(1S,3Ar,6E,9S,9aR,10R,11aS)-6-[[3-(dimethylamino)propyl-methylamino]methylidene]-1,5-dihydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4,7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-h]isochromen-10-yl] acetateIC5030000.0 [1]
4-(1-Isobutyl-4-methyl-1H-imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi340.0 [1]
CID 11641672IC502100.0 [1]
1-[5-Tert-butyl-3-(1,1-dioxo-1,4-thiazinane-4-carbonyl)thiophen-2-yl]-3-(4-pyridin-4-yloxyphenyl)ureaIC5020000.0 [1]
2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-isobutyl-1H-imidazole-4-carbonitrileKi1600.0 [1]
4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-phenyl-1,4-dihydropyrimidine-5-carboxamideIC504500.0 [1]
1-[5-Tert-butyl-3-(1,1-dioxo-1,4-thiazinane-4-carbonyl)thiophen-2-yl]-3-(4-phenoxyphenyl)ureaIC5020000.0 [1]
3-(5-Cyclopropyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amineIC5023.0 [1]
(5R)-4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-(2-pyrrolidin-1-ylethyl)imidazol-2-yl]piperidin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-oneIC5035.0 [1]
4-[4-[3-[4-[(Propan-2-ylamino)methyl]anilino]-1H-pyrazol-5-yl]phenyl]benzene-1,3-diolIC5030000.0 [1]
8-(4-Hydroxyphenyl)-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-3H-[1]benzothiolo[3,2-d]pyrimidin-4-oneKi1000.0 [1]
4-[[4-(Trifluoromethyl)pyridin-2-yl]methylamino]-1,2,3-benzotriazine-8-carboxamideIC501000.0 [1]
2,6-Difluoro-4-[4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]phenolIC50120.0 [1]
N-(4-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamideIC5010000.0 [1]
2-Methyl-N-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamideIC50100000.0 [1]
N-[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-6-[2-(isoquinolin-5-ylsulfonylamino)ethylamino]hexanamideIC506.46 [1]
8-Bromo-4-(3-chloro-4-fluoroanilino)-6-[[1-[3-(dimethylamino)propyl]triazol-4-yl]methylamino]quinoline-3-carbonitrileIC5040000.0 [1]
8-Chloro-4-(3-chloro-4-fluoroanilino)-6-[(4-propyl-1H-imidazol-5-yl)methylamino]quinoline-3-carbonitrileIC5018800.0 [1]
4-(3-Chloro-4-fluoroanilino)-8-fluoro-6-(1H-imidazol-5-ylmethylamino)quinoline-3-carbonitrileIC5040000.0 [1]
8-Chloro-4-(3-chloro-4-fluoroanilino)-6-[(1-oxidopyridin-1-ium-2-yl)methylamino]quinoline-3-carbonitrileIC5040000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Ribosomal protein S6 kinase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Ribosomal protein S6 kinase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-1-inhibitors-ic50-ki.
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