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Ribonucleoside-diphosphate reductase RR1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-LeuIC5025000.0 [1], 36000.0 [2], 42000.0 [3]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(3-phenylpropanoylamino)butanoyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC5024.0 [1], 588.0 [2]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-2-(2-ethylbutanoylamino)-3-methylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC50860.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3,3-dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC503.0 [1], 925.0 [2]
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(3-phenylpropanoylamino)butanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC504000.0 [1], 15000.0 [2]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-Benzyl-3-phenylpropanoyl)amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC500.7 [1], 22.0 [2]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-[methyl(3-phenylpropanoyl)amino]butanoyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC507.5 [1], 210.0 [2]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(3-phenylpropanoylamino)butanoyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC504.0 [1], 123.0 [2]
1-[(1S)-2-[[(1S)-1-Carboxy-3-methylbutyl]amino]-1-[[(2S)-2-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(3-phenylpropanoylamino)butanoyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-2-oxoethyl]cyclopentane-1-carboxylic acidIC501.0 [1], 37.0 [2]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(3-phenylpropanoylamino)butanoyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4,4-dimethylpentanoic acidIC505.0 [1], 9800.0 [2]
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[2-benzyl-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC50450.0 [1], 600000.0 [2]
Val-Val-Asn-Asp-LeuIC50760000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC5013300.0 [1]
1-[(E)-(4-Hydroxyphenyl)methylideneamino]-3-(2-methoxyphenyl)thioureaIC5041591.06 [1]
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC5058000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC50880.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3-methyl-2-(propan-2-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC50440.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3-methyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC5015.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-2-(heptan-4-ylcarbamoylamino)-3-methylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC507.0 [1]
(3S)-4-[[(1S)-1-Carboxy-3-methylbutyl]amino]-3-[[(2S)-2-[[(2S)-2-(2-ethylbutanoylamino)-3,3-dimethylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-2,2-dimethyl-4-oxobutanoic acidIC5043.0 [1]
4-Hydroxybenzaldehyde N-phenylthiosemicarbazoneIC50242102.9 [1]
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[(2-benzyl-3-phenylpropanoyl)amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC50180.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-[[(2R)-2-methyl-3-phenylpropanoyl]amino]butanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC50860.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-[[(2S)-2-methyl-3-phenylpropanoyl]amino]butanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC5011000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[(2-benzyl-3-phenylpropanoyl)-methylamino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC5022.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3-methyl-2-[[(2S)-2-(3-phenylpropanoylamino)butanoyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC50340.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3-methyl-2-[[2-(3-phenylpropanoylamino)acetyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC50115000.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-2-[[(2S)-3,3-dimethyl-2-(3-phenylpropanoylamino)butanoyl]amino]-3-methylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC5036.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-cyclohexyl-2-(3-phenylpropanoylamino)acetyl]amino]-3-methylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC5022.0 [1]
(3S)-4-[[(2S)-1-Hydroxy-4,4-dimethylpentan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(3-phenylpropanoylamino)butanoyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-4-oxobutanoic acidIC5034.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-2-(3-ethylpentanoylamino)-3,3-dimethylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC502200.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3,3-dimethyl-2-(pentan-3-yloxycarbonylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC507000.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3,3-dimethyl-2-[2-oxo-2-(pentan-3-ylamino)ethyl]butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC503500.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3-methyl-2-[[(2S)-2-(3-phenylpropanoylamino)propanoyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC508800.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC50400000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC50400000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acidIC50500000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC50400000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-2-phenylacetyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-cyclohexylpropanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC501900.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)propanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoic acidIC5020000.0 [1]
(3S)-3-[[2-[(3S,3Ar,5S,7S,7aS)-7-[3-(9H-fluoren-9-yl)propanoyloxymethyl]-3-hydroxy-5-(2-methylpropoxy)-3,3a,4,5,7,7a-hexahydro-2H-pyrano[3,4-b]pyrrol-1-yl]acetyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC5040000.0 [1]
1-[(E)-(4-Hydroxyphenyl)methylideneamino]-3-(4-methylphenyl)thioureaIC5014190.58 [1]
1-[(E)-(4-Hydroxyphenyl)methylideneamino]-3-(2-nitrophenyl)thioureaIC5039264.49 [1]
1-(4-Chlorophenyl)-3-[(E)-(4-hydroxyphenyl)methylideneamino]thioureaIC50287078.06 [1]
1-[(E)-(4-Hydroxyphenyl)methylideneamino]-3-(2-methylphenyl)thioureaIC5036475.39 [1]
1-(2-Chlorophenyl)-3-[(E)-(4-hydroxyphenyl)methylideneamino]thioureaIC5046773.51 [1]
1-(3-Chlorophenyl)-3-[(E)-(4-hydroxyphenyl)methylideneamino]thioureaIC5029308.93 [1]
1-[(E)-(4-Hydroxyphenyl)methylideneamino]-3-(3-methylphenyl)thioureaIC5030408.85 [1]
1-[(E)-(4-Hydroxyphenyl)methylideneamino]-3-(4-nitrophenyl)thioureaIC5045081.67 [1]
1-(2-Hydroxyphenyl)-3-[(E)-(4-hydroxyphenyl)methylideneamino]thioureaIC5029308.93 [1]
1-(3-Hydroxyphenyl)-3-[(E)-(4-hydroxyphenyl)methylideneamino]thioureaIC5028575.91 [1]
1-(4-Hydroxyphenyl)-3-[(E)-(4-hydroxyphenyl)methylideneamino]thioureaIC5043251.38 [1]
[(2R,3S,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3-hydroxy-4-methylideneoxolan-2-yl]methyl phosphono hydrogen phosphateKi830000.0 [1]
1-[(1S)-2-[[(1S)-1-Carboxy-3-methylbutyl]amino]-1-[[(2S)-2-[[(2S)-2-(2-ethylbutanoylamino)-3,3-dimethylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-2-oxoethyl]cyclopent-3-ene-1-carboxylic acidIC506.4 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC50412000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC50400000.0 [1]
(4S)-5-[[(2S)-1-[[(2S)-3-Carboxy-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[3-(9H-fluoren-9-ylmethoxy)-3-oxo-2-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoic acidIC502400.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[3-(9H-fluoren-9-ylmethoxy)-3-oxo-2-phenylpropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-cyclohexylpropanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC502400.0 [1]
(3S)-4-[[(1S)-1-Carboxy-2-phenylethyl]amino]-3-[[(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoic acidIC5022000.0 [1]
(2R)-2-[[(2R)-3-Carboxy-2-[[(2S)-2-[[(2R)-2-[[(2S,6R)-2,6-dimethylcyclohexyl]carbamoylamino]-3-methylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC5055.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-2-(cyclohexylcarbamoylamino)-3-methylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC50500.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3,3-dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4,4-dimethylpentanoic acidIC500.6 [1]
(3S)-3-[[(2S)-2-[[(2S)-3,3-Dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-4-[[(2S)-1-hydroxy-4,4-dimethylpentan-2-yl]amino]-4-oxobutanoic acidIC506.0 [1]
(3S)-4-(3,3-Dimethylbutylamino)-3-[[(2S)-2-[[(2S)-3,3-dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-4-oxobutanoic acidIC50100.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-3,3-Dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-4-(3-methylbutylamino)-4-oxobutanoic acidIC50350.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-3,3-Dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-4-(2,2-dimethylpropylamino)-4-oxobutanoic acidIC5040.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-3,3-Dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-4-(2-methylpropylamino)-4-oxobutanoic acidIC501900.0 [1]
(3S)-4-[[(2R)-3,3-Dimethylbutan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3,3-dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-4-oxobutanoic acidIC5027.0 [1]
(3S)-4-[[(3R)-2,2-Dimethylpentan-3-yl]amino]-3-[[(2S)-2-[[(2S)-3,3-dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-4-oxobutanoic acidIC5018.0 [1]
(3S)-4-[[(2S)-3,3-Dimethylbutan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3,3-dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-4-oxobutanoic acidIC502700.0 [1]
(3S)-4-[[(3S)-2,2-Dimethylpentan-3-yl]amino]-3-[[(2S)-2-[[(2S)-3,3-dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-4-oxobutanoic acidIC502000.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S,5S)-6,6-dimethyl-4-oxo-2-(2-oxo-2-pyrrolidin-1-ylethyl)-5-(pentan-3-ylcarbamoylamino)heptanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC507.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3,3-dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-5,5-dimethyl-4-oxohexanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC503.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2R,5S)-2-(3,3-dimethyl-2-oxobutyl)-6,6-dimethyl-4-oxo-5-(pentan-3-ylcarbamoylamino)heptanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC505.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-3-methyl-2-[[(2S,3S)-3-methyl-2-(3-phenylpropanoylamino)pentanoyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC5061.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-Acetamido-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC50400000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-Acetamido-3-(4-azidophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC50100000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-Acetamido-3-(4-aminophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC50100000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC5030000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC5028000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3S)-2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC5011000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acidIC5080000.0 [1]
(3S)-3-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-4-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acidIC50322000.0 [1]
(3S)-3-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-4-[[(2S)-1-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acidIC50207000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-[(2-naphthalen-2-ylacetyl)amino]butanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC505000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC5012000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-(benzylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC506000.0 [1]
(2R)-2-[[(2R)-3-Carboxy-2-[[(2S)-2-[[(2R)-2-[[(2S,6S)-2,6-dimethylcyclohexyl]carbamoylamino]-3-methylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]propanoyl]amino]-4-methylpentanoic acidIC5020.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoic acidIC5015000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Ribonucleoside-diphosphate reductase RR1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/ribonucleoside-diphosphate-reductase-rr1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Ribonucleoside-diphosphate reductase RR1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ribonucleoside-diphosphate-reductase-rr1-inhibitors-ic50-ki.
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