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Rhodopsin kinase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
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▼
ParoxetineIC50100000.0 [1]
SangivamycinKi180.0 [1]
BalanolIC50340.0 [1]
4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
CID 11677079IC503100.0 [1]
N-(2,6-Difluorobenzyl)-3-({[4-Propyl-5-(Pyrimidin-4-Yl)-4h-1,2,4-Triazol-3-Yl]methyl}amino)benzamideIC509000.0 [1]
CID 118888941IC503900.0 [1]
4-[3-[(2,6-Dimethoxyphenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
N-Benzyl-3-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]benzamideIC5030000.0 [1]
N-Benzyl-3-[(4-methyl-3-pyridin-4-yl-1H-pyrazol-5-yl)methylamino]benzamideIC5030000.0 [1]
2-Fluoro-5-[5-(1H-indazol-5-ylcarbamoyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidin-4-yl]benzoic acidIC50100000.0 [1]
4-[4-Fluoro-3-(methylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[[3,5-Bis(trifluoromethyl)phenyl]methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-[2-(2-hydroxyethyl)morpholin-4-yl]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[(2,6-Dichlorophenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-(2,6-Dimethylphenyl)ethylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[(2-methoxyphenyl)methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5016000.0 [1]
4-[3-[2-[(2,6-Dimethylphenyl)methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[1-(2-methoxyphenyl)ethylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5016000.0 [1]
4-[3-[2-[[2,6-Bis(trifluoromethyl)phenyl]methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-[(2,6-Dimethoxyphenyl)methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-(Benzylcarbamoyl)-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5071000.0 [1]
4-[4-Fluoro-3-[(3-methylpyridin-2-yl)methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-[furan-2-ylmethyl(2-hydroxyethyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5026000.0 [1]
4-[4-Fluoro-3-(isoquinolin-1-ylmethylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100.0 [1]
4-[3-[2-[(1-Cyclopropylpiperidin-4-yl)methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-(2-pyridin-4-ylethylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-[2-methylpropyl(prop-2-ynyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-[methyl-[(5-methyl-1H-imidazol-2-yl)methyl]amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[3-[(5-methyl-1,3-oxazol-2-yl)methylamino]-3-oxopropyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-[furan-2-ylmethyl(prop-2-ynyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[(3-methoxyphenyl)methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[methyl(oxan-2-ylmethyl)carbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-(Azepan-1-yl)propylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
Methyl 1-[[2-fluoro-5-[5-(1H-indazol-5-ylcarbamoyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidin-4-yl]benzoyl]amino]cyclohexane-1-carboxylateIC5083000.0 [1]
4-[3-[[2,6-Bis(trifluoromethyl)phenyl]methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5030000.0 [1]
4-[4-Fluoro-3-[methyl-[(5-methyl-1H-pyrazol-3-yl)methyl]carbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[Butan-2-yl(methyl)carbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[(5-Ethyl-1,2,4-oxadiazol-3-yl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC503000.0 [1]
4-[4-Fluoro-3-[3-oxo-3-(2-phenylethylamino)propyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-(2-pyridin-2-ylethylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[(3-fluorophenyl)methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5011900.0 [1]
4-[3-[(2,6-Difluorophenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[(4-methoxyphenyl)methylcarbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[(2,6-Dimethylphenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-N,6-dimethyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
N-(1,3-Benzodioxol-5-yl)-4-[4-fluoro-3-(pyridin-2-ylmethylcarbamoyl)phenyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[(1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)carbamoyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
3-(9-Oxa-3,4,6,12-tetrazatricyclo[8.4.0.02,6]tetradeca-1(10),2,4,11,13-pentaen-5-ylmethylamino)-N-[[2-(trifluoromethyl)phenyl]methyl]benzamideIC50270.0 [1]
N-Benzyl-3-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)methylamino]benzamideIC5030000.0 [1]
N-Methyl-3-[(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)methylamino]benzamideIC5030000.0 [1]
4-[3-[2-[Butan-2-yl(hydroxymethyl)amino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-[(1-methyl-5-oxopyrrolidin-3-yl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-oxo-2-(3-propoxypyrrolidin-1-yl)ethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-(octan-2-ylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-[(6-Cyanopyridin-3-yl)methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[3-[[1-(hydroxymethyl)cyclopropyl]methylamino]-3-oxopropyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-(3,5-Dimethyl-1,2-oxazol-4-yl)ethylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[3-[2-methylpropyl(propan-2-yl)amino]-3-oxopropyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-[2-hydroxyethyl(3-methylbutyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-(imidazo[1,2-a]pyridin-2-ylmethylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5017000.0 [1]
4-[3-[2-[(2,5-Dimethylphenyl)methylamino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-(1-Azabicyclo[2.2.2]octan-3-ylcarbamoyl)-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-(3-methoxypropyl)piperidine-1-carbonyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[3-[(1-methylcyclohexyl)methylamino]-3-oxopropyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-[Bis(3-hydroxypropyl)amino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-(4-Tert-butylazepan-1-yl)-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[2-[Butyl(but-2-ynyl)amino]-2-oxoethyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-(5-methyl-1,3-dihydroisoindol-2-yl)-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-(6,7-Dihydro-5H-cyclopenta[b]pyridin-3-ylmethylcarbamoyl)-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-[2-hydroxyethyl(2-methylbutyl)amino]-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[3-(3-Ethyl-3-hydroxypiperidin-1-yl)-3-oxopropyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-[2-(9-methyl-3,9-diazabicyclo[4.2.1]nonan-3-yl)-2-oxoethyl]phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[4-Fluoro-3-(6-methylheptan-2-ylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
4-[3-[(2,6-Dimethylphenyl)methylcarbamoyl]-4-fluorophenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC50100000.0 [1]
Items per page: 1 - 10 of 76
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References

This online tool may be cited as follows

MLA

"Quest Database™ Rhodopsin kinase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/rhodopsin-kinase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Rhodopsin kinase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/rhodopsin-kinase-inhibitors-ic50-ki.
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