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Rho-associated protein kinase Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
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▼
Standard Values (in nM)
▲
▼
N1-Benzyl-N4-(1H-5-indazolyl)-1,4-cyclohexanediamineIC50320.0 [1], 520.0 [2]
N1-Phenylethyl-N4-(5-isoquinolyl)-1,4-cyclohexanediamineIC50440.0 [1], 580.0 [2]
N1-Cyclopropyl-N4-(5-isoquinolyl)-1,4-cyclohexanediamineIC5070.0 [1], 195.0 [2]
N1-Propyl-N4-(5-isoquinolyl)-1,4-cyclohexanediamineIC50180.0 [1]
FasudilIC50180.0 [1]
Fasudil hydrochlorideIC50180.0 [1]
1-Benzyl-3-(1H-indazol-5-yl)ureaIC50260.0 [1]
N-[1-(2-Chlorobenzyl)-3-piperidyl]-N-(5-isoquinolyl)amineIC50210.0 [1]
N-[1-(2-Aminobenzyl)-3-pyrrolidyl]-N-(5-isoquinolyl)amineIC50205.0 [1]
N-[1-(4-Aminobenzyl)-3-pyrrolidyl]-N-(5-isoquinolyl)amineIC50235.0 [1]
N-[1-(2,6-Difluorobenzyl)-3-pyrrolidyl]-N-(5-isoquinolyl)amineIC5075.0 [1]
N-[1-(2-Chlorobenzyl)-3-pyrrolidyl]-N-(5-isoquinolyl)amineIC50100.0 [1]
N-[1-(4-Chlorobenzyl)-3-piperidyl]-N-(5-isoquinolyl)amineIC50185.0 [1]
N-[1-(3-Chlorobenzyl)-3-pyrrolidyl]-N-(5-isoquinolyl)amineIC5065.0 [1]
N-[1-(3-Chlorobenzyl)-3-piperidyl]-N-(5-isoquinolyl)amineIC50265.0 [1]
N-[1-(4-Fluorobenzyl)-3-pyrrolidyl]-N-(5-isoquinolyl)amineIC5095.0 [1]
N-[1-(3-Aminobenzyl)-3-pyrrolidyl]-N-(5-isoquinolyl)amineIC50275.0 [1]
N-(1-Propyl-4-piperidyl)-N-(5-isoquinolyl)amineIC50345.0 [1]
N-(1-Isobutyl-4-piperidyl)-N-(5-isoquinolyl)amineIC50210.0 [1]
1-(2,4-Dichlorobenzyl)-3-(1H-indazol-5-yl)ureaIC50220.0 [1]
N-(1-Isopentyl-3-pyrrolidyl)-N-(5-isoquinolyl)amineIC50270.0 [1]
N-(1-Isopentyl-3-piperidyl)-N-(1H-5-indazolyl)-amineIC50340.0 [1]
1-(2,6-Dichlorobenzyl)-3-(1H-indazol-5-yl)ureaIC5020.0 [1]
N-[1-(2-Chlorobenzyl)-4-piperidyl]-N-(1H-5-indazolyl)amineIC50440.0 [1]
N-(1-Propyl-3-piperidyl)-N-(1H-5-indazolyl)amineIC50780.0 [1]
N-[1-(2-Chlorobenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5013.0 [1]
N-[1-(2-Chlorobenzyl)-3-pyrrolidyl]-N-(1H-5-indazolyl)amineIC5045.0 [1]
N-[1-(3,5-Dimethoxybenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5080.0 [1]
N-[1-(3-Chlorobenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5019.0 [1]
N-[1-(3-Chlorobenzyl)-4-piperidyl]-N-(1H-5-indazolyl)amineIC50290.0 [1]
N-[1-(3-Chlorobenzyl)-3-pyrrolidyl]-N-(1H-5-indazolyl)amineIC5020.0 [1]
N-[1-(4-Chlorobenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5011.0 [1]
N-[1-(4-Chlorobenzyl)-4-piperidyl]-N-(1H-5-indazolyl)amineIC50290.0 [1]
N-[1-(4-Chlorobenzyl)-3-pyrrolidyl]-N-(1H-5-indazolyl)amineIC5024.0 [1]
N-[1-(3-Nitrobenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC503.0 [1]
N-[1-(4-Methoxybenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5016.0 [1]
N-[1-(4-Methylbenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC509.0 [1]
N-[1-(4-Nitrobenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5087.0 [1]
1-Benzyl-N-(1H-5-indazolyl)piperidine-4-carboxamideIC50136.0 [1]
CID 22933917IC50540.0 [1]
N-[1-(2-Pyridylmethyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC50240.0 [1]
N-[1-(3-Pyridylmethyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5072.0 [1]
N-[1-(4-Pyridylmethyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC50190.0 [1]
N-[1-(1H-2-Pyrrolylmethyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5011.0 [1]
N-[1-(2-Thienylmethyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC505.0 [1]
N-[1-(3-Thienylmethyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC503.0 [1]
N-[1-(2-Furylmethyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5065.0 [1]
5-(1-Benzylpiperidin-4-yloxy)-1H-indazoleIC50100.0 [1]
5-(1-Benzylpiperidin-3-yloxy)-1H-indazoleIC5010.0 [1]
N-(1-Benzylpiperidin-3-yl)-3-methyl-2H-indazol-5-amineIC50150.0 [1]
N1-Benzyl-N1-methyl-N2-(1H-5-indazolyl)-1,2-ethanediamineIC507900.0 [1]
1-Benzyl-N-(1H-5-indazolyl)piperidine-3-carboxamideIC5018.0 [1]
N-[1-(2-Aminobenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5085.0 [1]
N-[1-(3-Aminobenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5035.0 [1]
N-[1-(4-Aminobenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5010.0 [1]
N-(1-Benzylpiperidin-4-yl)isoquinolin-5-amineIC50140.0 [1]
N-(1-Benzyl-4-piperidyl)-N-(1H-5-indazolyl)amineIC50240.0 [1]
N-(1-Benzylpiperidin-3-yl)-1H-indazol-5-amineIC5020.0 [1]
N-[1-(4-Fluorobenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5025.0 [1]
N-(1-Benzylpyrrolidin-3-yl)-1H-indazol-5-amineIC5032.0 [1]
1-(2,6-Difluorobenzyl)-3-(1H-indazol-5-yl)ureaIC5085.0 [1]
N-[1-(3,4-Difluorobenzyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC5010.0 [1]
N-[1-(4-Chlorobenzyl)-3-pyrrolidyl]-N-(5-isoquinolyl)amineIC5065.0 [1]
(3S)-N-[1-(3-Aminobenzyl)-3-pyrrolidyl]-N-(5-isoquinolyl)amineIC50310.0 [1]
5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[(2S,3S)-3-(2H-tetrazol-5-yl)-2-bicyclo[2.2.2]octanyl]pyrimidin-4-amineKi4000.0 [1]
[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]phosphonic acidKi4000.0 [1]
2-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]ethylphosphonic acidKi250.0 [1]
2-[[(2R,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]methyl]-1,2,4-oxadiazolidine-3,5-dioneKi4000.0 [1]
3-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]-2H-1,2-oxazol-5-oneKi4000.0 [1]
N-[[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]sulfonyl]acetamideKi4000.0 [1]
5-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]-1,2-oxazol-3-oneKi4000.0 [1]
(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-sulfonamideKi980.0 [1]
1-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]ethane-1,2-diolKi1500.0 [1]
5-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]-1,2-dihydropyrazol-3-oneKi4000.0 [1]
(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-N-methylbicyclo[2.2.2]octane-2-carboxamideKi4000.0 [1]
1-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]ethanolKi310.0 [1]
5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[(2S,3S)-3-(3-methyl-1,2,4-oxadiazol-5-yl)-2-bicyclo[2.2.2]octanyl]pyrimidin-4-amineKi4000.0 [1]
5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[(2S,3S)-3-(5-methyl-1,3,4-oxadiazol-2-yl)-2-bicyclo[2.2.2]octanyl]pyrimidin-4-amineKi4000.0 [1]
5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[(2S,3S)-3-methylsulfonyl-2-bicyclo[2.2.2]octanyl]pyrimidin-4-amineKi2700.0 [1]
3-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]-4H-1,2,4-oxadiazol-5-oneKi4000.0 [1]
N1-(1-Benzyl-4-piperidyl)-N1-(1H-5-indazolyl)acetamideIC5010000.0 [1]
N-[1-(1H-3-Pyrrolylmethyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC501000.0 [1]
N-[1-(3-Furylmethyl)-3-piperidyl]-N-(1H-5-indazolyl)amineIC50180.0 [1]
N-(1-Benzyl-3-piperidyl)-N-(1-methyl-5-indazolyl)amineIC5010000.0 [1]
N-[1-(4-Fluorobenzyl)-4-piperidyl]methyl-N-(1H-5-indazolyl)amineIC5010000.0 [1]
1-(1-Benzylpiperidin-4-yl)-3-(1H-indazol-5-yl)ureaIC5010000.0 [1]
(3R)-N-[1-(3-Aminobenzyl)-3-pyrrolidyl]-N-(5-isoquinolyl)amineIC5025.0 [1]
Items per page: 1 - 10 of 87
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References

This online tool may be cited as follows

MLA

"Quest Database™ Rho-associated protein kinase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/rho-associated-protein-kinase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Rho-associated protein kinase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/rho-associated-protein-kinase-inhibitors-ic50-ki.
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