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Rho-associated protein kinase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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FasudilIC50400.0 [1]
Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-IC5089.0 [1]
Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-Ki300.0 [1]
[3-[[4-(Aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC5010.0 [1], 32.0 [2], 340.0 [3]
N-(4-(1H-Pyrazol-4-yl)phenyl)-3,4-dihydro-2H-chromene-3-carboxamideIC502.0 [1], 25.0 [2]
(S)-2-Methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazineIC505.0 [1], 12.0 [2]
RipasudilIC503.8 [1], 19.0 [2], 197.0 [3]
Oxolan-2-ylmethyl 3-[2-(aminomethyl)-5-[(3-fluoropyridin-4-yl)carbamoyl]phenyl]benzoateIC502.5 [1], 49.0 [2]
StaurosporineIC507.8 [1], 9.0 [2]
N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideIC50270.0 [1], 3630.78 [2]
TofacitinibIC503400.0 [1]
5-AminoindazoleIC50119700.0 [1]
1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)ureaIC506.0 [1]
1-[(1S)-2-Hydroxy-1-phenylethyl]-3-(4-pyridin-4-ylphenyl)ureaIC50100.0 [1]
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-YL)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamideIC503.0 [1], 3.2 [2]
N-[4-(Pyridin-4-yl)-1,3-thiazol-2-yl]-2,3-dihydro-1,4-benzodioxine-2-carboxamideIC500.56 [1], 7.2 [2]
CID 71283262IC501.0 [1], 4.1 [2]
5-Bromo-N-(pyridin-4-yl)pyridine-3-carboxamideIC50357200.0 [1]
[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]-[(3S)-3-aminopyrrolidin-1-yl]methanoneIC506.0 [1], 7.0 [2]
1-Benzyl-3-(1H-indazol-5-yl)ureaIC505500.0 [1]
(2S,3S,4R,5R)-N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamideIC50162.18 [1], 977.24 [2]
Nicotinamide, N-(4-pyridyl)-IC5055900.0 [1]
1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)ureaIC5011.0 [1], 14.0 [2]
4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamideIC5066.0 [1], 143.0 [2]
N-(7-Chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(dimethylamino)-2-phenylacetamideIC5019.0 [1], 26.0 [2]
N-(7-Chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(methylamino)-2-phenylacetamideIC5012.0 [1]
2-Amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)acetamideIC50120.0 [1]
N-(7-Chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)piperidine-4-carboxamideIC5028.0 [1]
2-(Chroman-3-yl)-6-(pyridin-4-yl)-1H-benzo[d]imidazoleIC502.0 [1], 6.0 [2]
4-(2-(Chroman-3-yl)-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amineIC508.0 [1], 66.0 [2]
4-(2-(6-Methoxychroman-3-yl)-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amineIC502.0 [1], 99.0 [2]
3-[6-(2-Aminopyrimidin-4-yl)-1H-benzimidazol-2-yl]-N-benzyl-3,4-dihydro-2H-chromene-6-carboxamideIC501.0 [1], 23.0 [2]
3-Amino-N-isoquinolin-6-yl-2-phenylpropanamideIC501.1 [1]
3-Amino-N-isoquinolin-6-yl-2-phenylpropanamideKi0.8 [1]
2-(4-(6-(Pyridin-4-yl)-3-(pyrrolidin-1-yl)pyrazin-2-yl)piperazin-1-yl)ethanolIC5039.0 [1], 78.0 [2]
CID 46864283IC501.0 [1], 51.0 [2]
2-Amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-phenylacetamideIC5026.0 [1], 57.0 [2]
N-(7-Chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-1-methylpiperidine-4-carboxamideIC5031.0 [1]
(R)-N-(7-Chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)pyrrolidine-3-carboxamideIC5067.0 [1]
N-[(3-Methoxyphenyl)methyl]-6-(1H-pyrazol-4-yl)-1H-indole-2-carboxamideIC502.0 [1]
N-[(3-Methoxyphenyl)methyl]-6-(1H-pyrazol-4-yl)-1H-indole-3-carboxamideIC501.0 [1]
N-[(3-Methoxyphenyl)methyl]-6-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamideIC502.0 [1]
N-[(3-Methoxyphenyl)methyl]-6-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamideIC502.0 [1]
2-Amino-N-isoquinolin-6-yl-2-phenylacetamideIC501.5 [1]
2-Amino-N-isoquinolin-6-yl-2-phenylacetamideKi1.5 [1]
1-Ethyl-1-[(3-methoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC501.0 [1]
1-(2-Methoxyethyl)-1-[(3-methoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC5016.98 [1], 17.0 [2]
1-(2-Hydroxyethyl)-1-[(3-methoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC501.0 [1]
1-[(3-Methoxyphenyl)methyl]-1-(2-morpholin-4-ylethyl)-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC5013.0 [1]
1-[3-(Dimethylamino)-1-phenylpropyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC502.0 [1]
1-Benzyl-3-[2-fluoro-4-(1H-pyrazol-4-yl)phenyl]-1-(2-hydroxyethyl)ureaIC5014.0 [1]
1-(3-Hydroxy-1-phenylpropyl)-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC501.0 [1]
1-[2-(Dimethylamino)ethyl]-1-[(3-methoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC501.0 [1]
1-(2-Hydroxy-1-phenylethyl)-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC502.0 [1]
1-(Cyclohexylmethyl)-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC50751.0 [1], 751.62 [2]
1-[(3-Methoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]-1-(3-pyrrolidin-1-ylpropyl)ureaIC505.0 [1]
1-[(3-Methoxyphenyl)methyl]-1-propan-2-yl-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC503.0 [1]
1-(2-Aminoethyl)-1-[(3-methoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC501.0 [1]
1-Benzyl-1-(2-hydroxyethyl)-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC5011.99 [1], 12.0 [2]
1-[(3-Methoxyphenyl)methyl]-1-(2-piperidin-1-ylethyl)-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC505.0 [1]
1-[1-(3-Fluorophenyl)-3-hydroxypropyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC502.0 [1]
1-Cyclopropyl-1-[(3-methoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC501.0 [1]
1-[3-Hydroxy-1-(3-methoxyphenyl)propyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC502.0 [1]
1-[(3-Methoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]-1-(2-pyrrolidin-1-ylethyl)ureaIC503.0 [1]
1-[(3-Methoxyphenyl)methyl]-1-(3-morpholin-4-ylpropyl)-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC504.0 [1]
1-[(3-Methoxyphenyl)methyl]-1-methyl-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC501.0 [1]
1-[(3-Methoxyphenyl)methyl]-1-(3-piperidin-1-ylpropyl)-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC504.0 [1]
1-(2-Phenylethyl)-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC5088.0 [1]
1-(3-Phenylpropyl)-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC501017.0 [1]
N-[4-(1H-Pyrazol-4-yl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamideIC50279.9 [1], 280.0 [2]
1-[(2,3-Dimethoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC50253.0 [1]
1-[(2,4-Dimethoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC50331.0 [1], 331.13 [2]
1-[(2,5-Dimethoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC50570.0 [1]
1-[(2,6-Dimethoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC50924.0 [1]
1-[(3,4-Dimethoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC50424.62 [1], 425.0 [2]
1-[(3,5-Dimethoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC50281.0 [1]
1-[(3-Fluoro-4-methoxyphenyl)methyl]-3-[4-(1H-pyrazol-4-yl)phenyl]ureaIC50357.0 [1]
1-Ethyl-1-[(3-methoxyphenyl)methyl]-3-[2-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(1H-pyrazol-4-yl)phenyl]ureaIC501.0 [1]
4-(Aminomethyl)-N-(3-fluoropyridin-4-yl)-3-[3-(phenylcarbamoyl)phenyl]benzamideIC501.0 [1], 31.0 [2]
[(2S)-Butan-2-yl] 3-[[3-[2-(aminomethyl)-5-[(3-fluoropyridin-4-yl)carbamoyl]phenyl]benzoyl]amino]-4-fluorobenzoateIC505.5 [1], 72.0 [2]
2-Methoxyethyl 3-[[3-[2-(aminomethyl)-5-[(3-fluoropyridin-4-yl)carbamoyl]phenyl]phenyl]carbamoyl]-4-fluorobenzoateIC501.0 [1], 2.2 [2]
Methyl 3-[[3-[2-(aminomethyl)-5-[(3-fluoropyridin-4-yl)carbamoyl]phenyl]benzoyl]amino]-2-fluorobenzoateIC501.2 [1], 8.8 [2]
Cyclopentyl 3-[[3-[2-(aminomethyl)-5-[(3-fluoropyridin-4-yl)carbamoyl]phenyl]benzoyl]amino]-2-fluorobenzoateIC501.4 [1], 41.0 [2]
N-[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-6-[2-(isoquinolin-5-ylsulfonylamino)ethylamino]hexanamideIC502.46 [1]
N-[3-(4-Dimethylaminomethyl-phenylcarbamoyl)-benzyl]-3,4-dimethoxy-benzamideIC5069.0 [1], 230.0 [2]
3-Chloro-N-[3-(4-dimethylaminomethyl-phenylcarbamoyl)-benzyl]-4-methoxy-benzamideIC5092.0 [1], 230.0 [2]
N-[3-(4-Dimethylaminomethyl-phenylcarbamoyl)-benzyl]-4-methoxy-3-trifluoromethyl-benzamideIC50350.0 [1], 160000.0 [2]
N-[3-(4-Dimethylaminomethyl-phenylcarbamoyl)-benzyl]-4-methoxy-3-methyl-benzamideIC50660.0 [1], 266000.0 [2]
N-[3-(4-Dimethylaminomethyl-phenylcarbamoyl)-benzyl]-4-methoxy-benzamideIC506500.0 [1], 1300000.0 [2]
4-Cyano-N-[3-(4-dimethylaminomethyl-phenylcarbamoyl)-benzyl]-benzamideIC506500.0 [1], 1700000.0 [2]
N-[3-(4-Dimethylaminomethyl-phenylcarbamoyl)-benzyl]-3-methoxy-benzamideIC507000.0 [1], 7000000.0 [2]
3-Chloro-N-[3-(4-dimethylaminomethyl-phenylcarbamoyl)-benzyl]-4-trifluoromethoxy-benzamideIC501300.0 [1], 670000.0 [2]
3-[3-(4-Cyano-phenyl)-ureidomethyl]-N-(1,2,3,4-tetrahydro-isoquinolin-7-yl)-benzamideIC5014.0 [1], 48.0 [2]
N-(4-Aminomethyl-phenyl)-3-[3-(4-cyano-phenyl)-ureidomethyl]-benzamideIC50210.0 [1], 70000.0 [2]
3-[3-(4-Cyano-phenyl)-ureidomethyl]-N-(4-dimethylaminomethylphenyl)-benzamideIC5065.0 [1], 160.0 [2]
3,4-Dimethoxy-N-[3-(2-piperidin-3-yl-ethylcarbamoyl)-benzyl]-benzamideIC5053.0 [1], 140.0 [2]
3,4-Dimethoxy-N-[3-(1,2,3,4-tetrahydro-isoquinolin-6-ylcarbamoyl)-benzyl]-benzamideIC50320.0 [1], 100000.0 [2]
N-[4-(1H-Pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamideIC502.0 [1], 72.0 [2]
N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)chroman-3-carboxamideIC503.0 [1], 6.0 [2]
4-(2-(6-Methoxy-3,4-dihydro-2H-chromen-3-yl)benzo[d]oxazol-6-yl)pyrimidin-2-amineIC502.0 [1], 46.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Rho-associated protein kinase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/rho-associated-protein-kinase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Rho-associated protein kinase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/rho-associated-protein-kinase-2-inhibitors-ic50-ki.
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