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Rho-associated protein kinase 1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
FasudilIC50300.0 [1]
FasudilKi100.0 [1], 530.0 [2]
Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-IC5093.0 [1], 150.0 [2], 870.96 [3]
Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-Ki25.12 [1], 150.0 [2], 220.0 [3]
HydroxyfasudilIC50758.58 [1]
HydroxyfasudilKi31.62 [1], 150.0 [2]
StaurosporineIC500.64 [1], 0.68 [2], 1.1 [3], 19.0 [4]
(S)-6-(Piperidin-3-yloxy)-isoquinolin-1-ylamineIC502137.96 [1], 5011.87 [2]
(S)-6-(Piperidin-3-yloxy)-isoquinolin-1-ylamineKi37.15 [1]
(S)-6-(Piperidin-3-yloxy)-2H-isoquinolin-1-oneIC5061.66 [1], 251.19 [2], 660.69 [3]
(S)-6-(Piperidin-3-yloxy)-2H-isoquinolin-1-oneKi2.51 [1]
5-(1,4-Diazepan-1-ylsulfonyl)isoquinolin-1-amineIC50758.58 [1], 3162.28 [2], 6918.31 [3]
5-(1,4-Diazepan-1-ylsulfonyl)isoquinolin-1-amineKi34.67 [1]
(S)-2-Methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazineIC505.0 [1]
(S)-2-Methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazineKi6.0 [1]
4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamideIC5014.0 [1], 100.0 [2]
4-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amineIC5010.0 [1], 13.0 [2], 19.0 [3]
(S)-6-(1-Benzylpiperidine-3-yloxy)isoquinolin-1-yl amineIC50239.88 [1], 776.25 [2]
Y-27632 DihydrochlorideIC5046.0 [1]
Y-27632 DihydrochlorideKi140.0 [1]
Benzamide, 4-(1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, (R)-IC5030.0 [1], 120.0 [2]
Aminofurazanyl-azabenzimidazole 6nIC501.6 [1], 1.8 [2]
5-AminoindazoleIC50181300.0 [1]
1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)ureaIC508.0 [1], 9.0 [2]
1-[(1S)-2-Hydroxy-1-phenylethyl]-3-(4-pyridin-4-ylphenyl)ureaIC501690.0 [1]
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-YL)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamideIC5056.0 [1]
[3-[[4-(Aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC5069.0 [1], 2200.0 [2]
5-Bromo-N-(pyridin-4-yl)pyridine-3-carboxamideIC50270000.0 [1]
[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]-[(3S)-3-aminopyrrolidin-1-yl]methanoneIC505.6 [1], 14.0 [2]
1-Benzyl-3-(1H-indazol-5-yl)ureaIC5013900.0 [1]
Nicotinamide, N-(4-pyridyl)-IC5075500.0 [1]
(2s)-1-{[6-Furan-3-Yl-5-(3-Methyl-2h-Indazol-5-Yl)pyridin-3-Yl]oxy}-3-(1h-Indol-3-Yl)propan-2-AmineIC501580.0 [1]
1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)ureaIC5023.0 [1], 27.0 [2]
CID 24832012Ki165.0 [1], 170.0 [2]
4-[1-Ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamineIC508.0 [1]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3R)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC50890.0 [1], 1580.0 [2]
2-(4-(6-(Pyridin-4-yl)-3-(pyrrolidin-1-yl)pyrazin-2-yl)piperazin-1-yl)ethanolIC50300.0 [1], 570.0 [2]
2-(3-Methoxyphenyl)-N-[4-(Pyridin-4-Yl)-1,3-Thiazol-2-Yl]acetamideKi83.0 [1], 100.0 [2]
N-[(3-Methoxyphenyl)methyl]-6-(1H-pyrazol-4-yl)-1H-indole-2-carboxamideIC5019.0 [1]
N-[(3-Methoxyphenyl)methyl]-6-(1H-pyrazol-4-yl)-1H-indole-3-carboxamideIC501.0 [1]
N-[(3-Methoxyphenyl)methyl]-6-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamideIC5012.0 [1]
N-[(3-Methoxyphenyl)methyl]-6-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamideIC5011.0 [1]
1-(1H-Indazol-5-yl)-3-phenylureaIC50157100.0 [1]
4-N-(2,3-Dihydro-1H-inden-2-yl)-2-piperazin-1-yl-6-N-pyridin-4-ylpyrimidine-4,6-diamineIC502.0 [1], 12.0 [2]
4-N-(2,3-Dihydro-1H-inden-2-yl)-6-piperazin-1-yl-2-N-pyridin-4-ylpyrimidine-2,4-diamineIC5014.0 [1], 154.0 [2]
4-(2,3-Dihydro-1H-inden-2-yloxy)-6-piperazin-1-yl-N-pyridin-4-yl-1,3,5-triazin-2-amineIC508.0 [1], 57.0 [2]
6-(1,4-Diazepan-1-yl)-2-N-(2,3-dihydro-1H-inden-2-yl)-4-N-pyridin-4-yl-1,3,5-triazine-2,4-diamineIC5011.0 [1], 17.0 [2]
2-N-(2,3-Dihydro-1H-inden-2-yl)-6-piperazin-1-yl-4-N-pyridin-4-yl-1,3,5-triazine-2,4-diamineIC506.0 [1], 30.0 [2]
2-N-(2,3-Dihydro-1H-inden-2-yl)-6-[(3R)-3-methylpiperazin-1-yl]-4-N-pyridin-4-yl-1,3,5-triazine-2,4-diamineIC508.0 [1], 26.0 [2]
1-Phenethyl-3-[4-(4-pyridyl)thiazol-2-yl]ureaIC50480.0 [1]
6-[(3S)-1-Benzylpiperidin-3-yl]oxyisoquinolineIC50169.82 [1], 331.13 [2]
6-[(2-Phenylethylamino)methyl]isoquinolin-1-amineIC501288.25 [1]
6-[(2-Phenylethylamino)methyl]isoquinolin-1-amineKi63.1 [1]
1-Benzyl-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC50170.0 [1]
1-(1h-Indazol-5-Yl)-3-(2-Phenylethyl)ureaIC50650.0 [1]
1-[(1r)-1-(3-Methoxyphenyl)ethyl]-3-(4-Pyridin-4-Yl-1,3-Thiazol-2-Yl)ureaIC5030.0 [1]
1-[(1R)-2-Hydroxy-1-phenylethyl]-3-(4-pyridin-4-ylphenyl)ureaIC509070.0 [1]
1-[(2R)-1-Hydroxy-3-phenylpropan-2-yl]-3-(4-pyridin-4-ylphenyl)ureaIC501410.0 [1]
1-Benzyl-3-[4-(4-pyridinyl)phenyl]ureaIC501150.0 [1]
2-{3-[3-(Piperidin-4-Yl)propoxy]phenyl}-N-[4-(Pyridin-4-Yl)-1,3-Thiazol-2-Yl]acetamideIC507.0 [1]
2-{3-[3-(Piperidin-4-Yl)propoxy]phenyl}-N-[4-(Pyridin-4-Yl)-1,3-Thiazol-2-Yl]acetamideKi13.0 [1]
2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideIC508.0 [1]
2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideKi51.0 [1]
1'-(4-Fluorophenyl)-1'-hydroxy-6-(5-methyl-1H-pyrazol-4-yl)spiro[1,3-dihydrothieno[3,2-d]pyrimidine-2,4'-cyclohexane]-4-oneIC50130.0 [1], 820.0 [2]
1'-Cyclohexyl-1'-hydroxy-6-(5-methyl-1H-pyrazol-4-yl)spiro[1,3-dihydrothieno[3,2-d]pyrimidine-2,4'-cyclohexane]-4-oneIC50350.0 [1], 2900.0 [2]
3-[(3-Methoxyphenyl)methyl]-1-methyl-1-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC5030.0 [1], 60.0 [2]
1-[(2S)-1-Hydroxy-3-phenylpropan-2-yl]-3-(4-pyridin-4-ylphenyl)ureaIC5031010.0 [1]
3-(1H-Indazol-5-yl)-1,1-dimethylureaIC5059100.0 [1]
1-(2-Phenylethyl)-3-(4-pyridin-4-ylphenyl)ureaIC502610.0 [1]
5-(4-Fluorophenyl)-N-pyridin-4-ylpyridine-3-carboxamideIC50400000.0 [1], 4000000.0 [2]
1-(2-Hydroxy-2-phenylethyl)-3-(1H-indazol-5-yl)ureaIC502900.0 [1]
1-(1H-Indazol-5-yl)-3-(3-phenylpropyl)ureaIC502460.0 [1]
4-Chloro-N-pyridin-4-ylpyridine-3-carboxamideIC5072500.0 [1]
4-(4-Fluorophenyl)-N-pyridin-4-ylpyridine-3-carboxamideIC50400000.0 [1], 4000000.0 [2]
1-(1H-Indazol-5-yl)-3-[2-(4-methoxyphenyl)ethyl]ureaIC502600.0 [1]
1-[2-(4-Chlorophenyl)ethyl]-3-(1H-indazol-5-yl)ureaIC502200.0 [1]
3-(1H-Indazol-5-yl)-1-methyl-1-(2-phenylethyl)ureaIC5021500.0 [1]
1-[(4-Methylphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC505160.0 [1], 5200.0 [2]
1-[1-(3-Fluorophenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC50430.0 [1]
1-[(3-Chlorophenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC50140.0 [1]
1-[(3-Ethoxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC502100.0 [1], 2140.0 [2]
1-[(1R)-2-Hydroxy-1-phenylethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC505200.0 [1]
1-[(2-Fluorophenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC50400.0 [1]
1-[(3-Aminophenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC5050.0 [1]
1-[(2-Methylphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC50150.0 [1]
1-[(1S)-1-Phenylethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC502900.0 [1], 3290.0 [2]
1-(2-Hydroxy-1-phenylethyl)-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC5060.0 [1]
1-[(4-Chlorophenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC502390.0 [1], 2400.0 [2]
1-Benzyl-1-methyl-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC50110.0 [1]
1-[(4-Fluorophenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC50570.0 [1]
1-[(3-Propoxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC503360.0 [1]
1-[[3-(2-Methoxyethoxy)phenyl]methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC50500.0 [1]
1-[(1S)-1-Phenylpropyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC5052170.0 [1], 52200.0 [2]
1-[(2-Chlorophenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC50340.0 [1]
1-[(4-Hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC50380.0 [1]
1-[(3-Methoxyphenyl)methyl]-1-methyl-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC5040.0 [1]
1-[(2-Hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC50620.0 [1]
1-[(1R)-2-Methoxy-1-phenylethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC5029480.0 [1], 29500.0 [2]
1-[(3-Fluorophenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaIC50100.0 [1]
(2S)-2-Phenyl-2-[(4-pyridin-4-yl-1,3-thiazol-2-yl)carbamoylamino]acetamideIC5080.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Rho-associated protein kinase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 3 Jul. 2024, https://www.aatbio.com/data-sets/rho-associated-protein-kinase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, July 3). Quest Database™ Rho-associated protein kinase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/rho-associated-protein-kinase-1-inhibitors-ic50-ki.
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