Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide	Ki	31.0 [1], 230.0 [2]
	2-[2-[2-(2-Chlorophenyl)propan-2-yl]-1-[4-(3-methylsulfonylphenyl)phenyl]imidazol-4-yl]propan-2-ol	Ki	68.0 [1]
	2-[2-[2-(2,6-Dichlorophenyl)propan-2-yl]-1-[2-fluoro-4-[3-fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol	Ki	19.0 [1]
	1-(2-Chlorophenyl)-5-[5-(3-methylsulfonylphenyl)thiophen-2-yl]-3-(trifluoromethyl)pyrazole	Ki	68.0 [1]
	1-[(2,4-Difluorophenyl)methyl]-2-oxo-6-(4-phenoxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile	Ki	26.0 [1]
	Tert-butyl 6-[[4-[acetyl(methyl)amino]phenoxy]methyl]-2-hydroxy-3-(trifluoromethyl)benzoate	Ki	270.0 [1]
	2-[2-[2-(2,6-Dichlorophenyl)propan-2-yl]-1-[4-(3-methylsulfonylphenyl)phenyl]imidazol-4-yl]propan-2-ol	Ki	16.0 [1]
	6-[4-[[2-[(2-Methylpropan-2-yl)oxycarbonyl]-4-(trifluoromethyl)phenyl]methoxy]phenyl]hexanoic acid	Ki	8600.0 [1]
	4-[N-Methyl-4-[[2-[(2-methylpropan-2-yl)oxycarbonyl]-4-(trifluoromethyl)phenyl]methoxy]anilino]-4-oxobutanoic acid	Ki	4000.0 [1]
	3-[4-[[2-[(2-Methylpropan-2-yl)oxycarbonyl]-4-(trifluoromethyl)phenyl]methoxy]phenyl]benzoic acid	Ki	6300.0 [1]
	4-[4-[[2-[(2-Methylpropan-2-yl)oxycarbonyl]-4-(trifluoromethyl)phenyl]methoxy]phenyl]benzoic acid	Ki	10000.0 [1]
	2-[2-[2-(2-Chlorophenyl)propan-2-yl]-1-[4-[4-(hydroxymethyl)-3-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol	Ki	74.0 [1]
	2-[2-[2-(2-Chlorophenyl)propan-2-yl]-1-[4-[3-fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol	Ki	53.0 [1]
	2-[2-[2-(2-Chlorophenyl)propan-2-yl]-1-[4-[4-(1-hydroxyethyl)-3-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol	Ki	180.0 [1]
	2-[1-[4-[3-Fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]-2-[2-(2-fluorophenyl)propan-2-yl]imidazol-4-yl]propan-2-ol	Ki	81.0 [1]
	2-[1-[2-Chloro-4-[3-fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]-2-[2-(2,6-dichlorophenyl)propan-2-yl]imidazol-4-yl]propan-2-ol	Ki	50.0 [1]
	2-[2-[1-(2,6-Dichlorophenyl)ethyl]-1-[2-fluoro-4-[3-fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol	Ki	17.0 [1]
	2-[2-[(2,6-Dichlorophenyl)methyl]-1-[4-[3-fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol	Ki	75.0 [1]
	2-[2-[2-(2-Chlorophenyl)propan-2-yl]-1-[2-fluoro-4-[3-fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol	Ki	9.0 [1]
	2-[2-[2-(2,6-Dichlorophenyl)propan-2-yl]-1-[4-[3-fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol	Ki	38.0 [1]
	2-[2-[2-(2-Chloro-3-fluorophenyl)propan-2-yl]-1-[4-[3-fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol	Ki	53.0 [1]
	2-[2-[2-(2-Chloro-6-fluorophenyl)propan-2-yl]-1-[2-fluoro-4-[3-fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol	Ki	70.0 [1]
	3-[3-[[2-Chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]benzoic acid	Ki	210.0 [1]
	2-(2-Chlorophenyl)-1-[4-(3-methylsulfonylphenyl)phenyl]-4-(trifluoromethyl)imidazole	Ki	61.0 [1]
	2-[2-(2,6-Dichloro-phenyl)-1-(3'-methanesulfonyl-biphenyl-4-yl)-1H-imidazol-4-yl]-propan-2-ol	Ki	2500.0 [1]
	2-[1-[4-(3-Methylsulfonylphenyl)phenyl]-2-[[2-(trifluoromethyl)phenyl]methyl]imidazol-4-yl]propan-2-ol	Ki	66.0 [1]
	2-[2-[(2-Chlorophenyl)methyl]-1-[4-(3-methylsulfonylphenyl)phenyl]imidazol-4-yl]propan-2-ol	Ki	25.0 [1]
	2-[2-[(2-Chlorophenyl)methyl]-1-[4-[4-(hydroxymethyl)-3-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol	Ki	31.0 [1]
	2-[2-(2-Chlorophenyl)-1-[4-(3-methylsulfonylphenyl)phenyl]imidazol-4-yl]propan-2-ol	Ki	1600.0 [1]
	2-[1-(2-Chlorophenyl)-5-[5-(3-methylsulfonylphenyl)thiophen-2-yl]pyrazol-3-yl]propan-2-ol	Ki	1500.0 [1]
	Methyl 1-(2-chlorophenyl)-5-[5-(3-methylsulfonylphenyl)thiophen-2-yl]pyrazole-3-carboxylate	Ki	150.0 [1]
	1-(2-Chlorophenyl)-5-[4-(3-methylsulfonylphenyl)phenyl]-3-(trifluoromethyl)pyrazole	Ki	180.0 [1]
	5-[5-(3-Methylsulfonylphenyl)thiophen-2-yl]-3-(trifluoromethyl)-1-[2-(trifluoromethyl)phenyl]pyrazole	Ki	240.0 [1]
	1-(2-Chlorophenyl)-5-[3-(3-methylsulfonylphenyl)phenyl]-3-(trifluoromethyl)pyrazole	Ki	300.0 [1]
	1-[(2,4-Difluorophenyl)methyl]-6-[5-(3-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile	Ki	11.0 [1]
	2-[4-[5-[5-Cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-3-methylphenyl]acetic acid	Ki	36.0 [1]
	2-[4-[4-[[2-[(2-Methylpropan-2-yl)oxycarbonyl]-4-(trifluoromethyl)phenyl]methoxy]phenyl]phenyl]acetic acid	Ki	1000.0 [1]
	(4'-{[2-(Tert-Butoxycarbonyl)-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-3-yl)acetic acid	Ki	5100.0 [1]
	1-[(2,4-Difluorophenyl)methyl]-5-[5-(3-methylsulfonylphenyl)thiophen-2-yl]-3-(trifluoromethyl)pyrazole	Ki	20.0 [1]
	Tert-Butyl 2-[[4-[ethanoyl(Methyl)amino]phenoxy]methyl]-5-(Trifluoromethyl)benzoate	Ki	870.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 40 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/retinoic-acid-receptor-rxr-alpha-oxysterols-receptor-lxr-alpha-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/retinoic-acid-receptor-rxr-alpha-oxysterols-receptor-lxr-alpha-inhibitors-ic50-ki.
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