Retinoic acid receptor alpha Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Tretinoin	IC50	0.78 [1], 0.89 [2], 15.0 [3], 9000.0 [4]
	Tretinoin	Ki	0.1 [1], 3.3 [2], 16.0 [3], 187.0 [4]
	Bexarotene	Ki	180.0 [1], 1000.0 [2], 5453.0 [3]
	Alitretinoin	IC50	7.0 [1]
	Alitretinoin	Ki	22.3 [1]
	Adapalene	Ki	1100.0 [1]
	Tamibarotene	IC50	78.0 [1]
	Tamibarotene	Ki	6.5 [1]
	Ttnpb	IC50	36.0 [1]
	Ttnpb	Ki	21.0 [1]
	6-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)nicotinic acid	Ki	1550.0 [1], 2745.0 [2]
	(2E,4E,6Z)-7-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-3-methylocta-2,4,6-trienoic acid	Ki	54.0 [1], 1000.0 [2]
	6-(1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acid	Ki	580.0 [1]
	6-(3-Tert-butyl-4-hydroxyphenyl)-2-naphthoic acid	Ki	3000.0 [1], 10000.0 [2]
	(E)-3-[4-(5,5,8,8-Tetramethyl-3-propoxy-6,7-dihydronaphthalen-2-yl)-4,5,6,7-tetrahydro-1-benzofuran-2-yl]prop-2-enoic acid	IC50	1000.0 [1]
	(E)-3-[4-(5,5,8,8-Tetramethyl-3-propoxy-6,7-dihydronaphthalen-2-yl)-4,5,6,7-tetrahydro-1-benzofuran-2-yl]prop-2-enoic acid	Ki	1000.0 [1]
	6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic Acid	Ki	6500.0 [1]
	4-{[(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid	IC50	41.0 [1]
	4-[2-[5,5-Dimethyl-8-(4-methylphenyl)-6H-naphthalen-2-yl]ethynyl]benzoic acid	IC50	31.0 [1]
	4-(2,18,18,21,21-Pentamethyl-2,14-diazapentacyclo[13.8.0.03,12.04,9.017,22]tricosa-1(15),3(12),4,6,8,10,13,16,22-nonaen-13-yl)benzoic acid	Ki	1300.0 [1]
	4-(5,7,7,10,10-Pentamethyl-8,9-dihydronaphtho[2,3-b][1,4]benzodiazepin-13-yl)benzoic acid	Ki	1400.0 [1]
	(2E,4E,6Z)-3-Methyl-7-(5,5,8,8-tetramethyl-3-propoxy-6,7-dihydronaphthalen-2-yl)octa-2,4,6-trienoic acid	Ki	1791.0 [1]
	4-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid	Ki	5.3 [1]
	4-{(E)-2-[5,5-Dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl]ethenyl}benzoic acid	IC50	114.0 [1]
	4-(7,7,10,10-Tetramethyl-8,9-dihydronaphtho[2,3-b][1,5]benzothiazepin-12-yl)benzoic acid	Ki	900.0 [1]
	6-(4-Methoxy-3-(1-methylcyclohexyl)phenyl)-2-naphthalenecarboxylic acid	Ki	1120.0 [1]
	7-(3,5-Ditert-butylphenyl)-3-methylocta-2,4,6-trienoic acid	Ki	1.1 [1]
	Benzoic acid, 4-(4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-2-thiazolyl)-	IC50	83.0 [1]
	6-[[3-[(2S)-1-Methoxypropan-2-yl]oxy-5-[(2S)-1-phenylpropan-2-yl]oxybenzoyl]amino]pyridine-3-carboxylic acid	IC50	470.0 [1]
	4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzoic acid	Ki	10000.0 [1]
	4-[5-(4-Phenyl-8-propan-2-ylquinolin-2-yl)-1H-pyrrol-2-yl]benzoic acid	IC50	31.2 [1]
	4-(2-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propenyl) benzoic acid	IC50	638.0 [1]
	3-[(2S)-1-Methoxypropan-2-yl]oxy-5-(4-methylsulfonylphenoxy)-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzamide	IC50	30000.0 [1]
	4-{3-[3-Adamantan-1-yl-4-(2-methoxy-ethoxymethoxy)-phenyl]-3-oxo-propenyl}-benzoic acid	IC50	4474.0 [1]
	(2E,4E,6E,8E)-3,7-Dimethyl-9-[2,6,6-trimethyl-3-(1,2,4-triazol-1-yl)cyclohexen-1-yl]nona-2,4,6,8-tetraenoic acid	IC50	1000000.0 [1]
	Benzoic acid, 4-(5-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1H-pyrrol-2-yl)-	IC50	2.2 [1]
	4-((+/-)-(1H-Imidazol-1-yl)-(E)-retinoic acid	IC50	20000.0 [1]
	(2E,4E,6E,8E)-3,7-Dimethyl-9-[2,6,6-trimethyl-3-(1,2,4-triazol-4-yl)cyclohexen-1-yl]nona-2,4,6,8-tetraenoic acid	IC50	410000.0 [1]
	4-[(5,5,8,8-Tetramethyl-6,7-dihydroquinoxaline-2-carbonyl)amino]benzoic acid	IC50	40.0 [1]
	4-[(E)-2-(3-Tert-Butyl-4-methoxy-phenyl)-propenyl]-benzoic acid	Ki	130.0 [1]
	(S)-6-(3-(3,5-Difluorophenoxy)-5-(1-methoxypropan-2-yloxy)benzamido)nicotinic acid	IC50	1.0 [1]
	(2E,4E,6E)-7-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acid	Ki	8300.0 [1]
	4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid	Ki	944.0 [1]
	(2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(2-fluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid	Ki	6756.0 [1]
	4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid	IC50	100.0 [1]
	6-(3-Isobutoxy-5-isopropoxy-benzoylamino)-nicotinic acid	IC50	10.0 [1]
	(E)-3-[4-[3,5-Ditert-butyl-2-(3-fluoropropoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid	Ki	7280.0 [1]
	4-(7,7,10,10-Tetramethyl-8,9-dihydronaphtho[2,3-b][1,5]benzoxazepin-12-yl)benzoic acid	Ki	980.0 [1]
	4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-anthracen-2-yl)-benzoic acid	IC50	20.0 [1]
	(E)-3-[4-(3,5,5,8,8-Pentamethyl-6,7-dihydronaphthalen-2-yl)-4,5,6,7-tetrahydro-1-benzofuran-2-yl]prop-2-enoic acid	Ki	1000.0 [1]
	(E)-3-[4-(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]prop-2-enoic acid	Ki	1000.0 [1]
	(E)-3-[4-(3,5-Diisopropyl-2-propoxy-phenyl)-benzo[b]thiophen-2-yl]-but-2-enoic acid	Ki	6910.0 [1]
	(E)-3-[4-(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)-4,5,6,7-tetrahydro-1,3-benzoxazol-2-yl]prop-2-enoic acid	Ki	1000.0 [1]
	4-[5,5-Dimethyl-8-(5-methyl-2-thienyl)-5,6-dihydroanthracene-2-yl]benzoic acid	IC50	20.0 [1]
	(E)-3-[7-(3,5-Diisopropyl-2-propoxy-phenyl)-benzofuran-2-yl]-but-2-enoic acid	Ki	8500.0 [1]
	6-[3-Adamantan-1-yl-4-(1,2-dihydroxy-ethyl)-phenyl]-naphthalene-2-carboxylic acid	Ki	10000.0 [1]
	(Z)-3-[7-[2-(2,2-Difluoroethoxy)-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]-2-fluorobut-2-enoic acid	Ki	10000.0 [1]
	(E)-3-[4-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid	Ki	8360.0 [1]
	(E)-3-[4-[3,5-Ditert-butyl-2-(3,3-difluoropropoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid	Ki	10000.0 [1]
	(E)-3-[4-[3,5-Ditert-butyl-2-(2,2,2-trifluoroethoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid	Ki	10000.0 [1]
	(E)-3-{7-[2-(3-Fluoro-propoxy)-3,5-diisopropyl-phenyl]-benzofuran-2-yl}-but-2-enoic acid	Ki	10000.0 [1]
	6-[3-Adamantan-1-yl-4-(2,3-dihydroxy-propoxy)-phenyl]-naphthalene-2-carboxylic acid	Ki	5000.0 [1]
	4-{(E)-4-[2-(4-Tert-Butyl-phenyl)-6,6-dimethyl-cyclohex-1-enyl]-but-3-en-1-ynyl}-benzoic acid	IC50	875.0 [1]
	(E)-3-[4-(3-Methoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-4,5,6,7-tetrahydro-1-benzofuran-2-yl]prop-2-enoic acid	Ki	1000.0 [1]
	(E)-3-[7-(2-Ethoxy-3,5-diisopropyl-phenyl)-benzo[b]thiophen-2-yl]-but-2-enoic acid	Ki	6024.0 [1]
	(E)-3-[4-(2-Ethoxy-3,5-diisopropyl-phenyl)-benzo[b]thiophen-2-yl]-but-2-enoic acid	Ki	10000.0 [1]
	(E)-3-[7-(2-Ethoxy-3,5-diisopropyl-phenyl)-benzofuran-2-yl]-but-2-enoic acid	Ki	10000.0 [1]
	(E)-3-[7-[2-(2,2-Difluoroethoxy)-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]but-2-enoic acid	Ki	10000.0 [1]
	4-(8,8,11,11-Tetramethyl-10,13-dihydro-9H-naphtho[2,3-c][1]benzazepin-6-yl)benzoic acid	Ki	1600.0 [1]
	4-[(E)-2-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid	IC50	1000.0 [1]
	4-[(E)-4-(3,3-Dimethyl-6-p-tolyl-cyclohexa-1,5-dienyl)-but-3-en-1-ynyl]-benzoic acid	IC50	225.0 [1]
	4-[(E)-2-(3-Adamantan-1-yl-4-hydroxy-phenyl)-propenyl]-benzoic acid	Ki	1144.0 [1]
	6-[3-(1-Adamantyl)-4-(2,3-dihydroxypropyl)phenyl]-2-naphthoic acid	Ki	10000.0 [1]
	4-(2,2-Dimethyl-4-p-tolyl-2H-1-thia-anthracen-6-yl)-benzoic acid	IC50	1.5 [1]
	4-[(E)-2-(3-Tert-butyl-4-hydroxyphenyl)propenyl]benzoic acid	Ki	834.0 [1]
	4-[(E)-2-[3-(1-Adamantyl)-4-hydroxyphenyl]ethenyl]benzoic acid	Ki	610.0 [1]
	4-[5-(5,5,8,8-Tetramethyl-6,7-dihydroquinoxalin-2-yl)thiophen-3-yl]benzoic acid	IC50	2.4 [1]
	4-(8,8,11,11,13-Pentamethyl-10,13-dihydro-9H-naphtho[2,3-c][1]benzazepin-6-yl)benzoic acid	Ki	2000.0 [1]
	4-[5-(5,5,8,8-Tetramethyl-6,7-dihydroquinoxalin-2-yl)furan-3-yl]benzoic acid	IC50	19.0 [1]
	4-[5-(5,5,8,8-Tetramethyl-6,7-dihydroquinoxalin-2-yl)thiophen-2-yl]benzoic acid	IC50	130.0 [1]
	4-[5-(5,5,8,8-Tetramethyl-6,7-dihydroquinoxalin-2-yl)furan-2-yl]benzoic acid	IC50	32.0 [1]
	(2E,4E,6Z)-7-(3-Ethoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-3-methylocta-2,4,6-trienoic acid	Ki	2582.0 [1]
	4-{(E)-2-[4-Hydroxy-3-(1-methyl-cyclohexyl)-phenyl]-propenyl}-benzoic acid	Ki	1056.0 [1]
	4-[(E)-2-(3-(1-Methylcyclohexyl)-4-methoxyphenyl)propenyl]benzoic acid	Ki	420.0 [1]
	6-[4-Hydroxy-3-(1-methyl-cyclohexyl)-phenyl]-naphthalene-2-carboxylic acid	Ki	10000.0 [1]
	4-[(E)-2-(3-Adamantan-1-yl-4-methoxy-phenyl)-propenyl]-benzoic acid	Ki	460.0 [1]
	6-(3-Adamantan-1-yl-4-carboxy-phenyl)-naphthalene-2-carboxylic acid	Ki	10000.0 [1]
	6-[3-(1-Adamantyl)-4-(3-hydroxypropyl)phenyl]-2-naphthoic acid	Ki	695.0 [1]
	(E)-3-[5-(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)furan-2-yl]prop-2-enoic acid	Ki	93.0 [1]
	3-[4-(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]propanoic acid	Ki	1000.0 [1]
	(2E,4E,6E,8E)-3,7-Dimethyl-1-(1,2,4-triazol-1-yl)-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-one	IC50	20000.0 [1]
	(2Z,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethylcyclohexen-1-yl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid	IC50	100000.0 [1]
	(E)-3-[6-Methyl-4-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-5,7-dihydro-4H-furo[2,3-c]pyridin-2-yl]prop-2-enoic acid	Ki	1000.0 [1]
	(2E,4E,6E,8E)-1-Imidazol-1-yl-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-one	IC50	1000000.0 [1]
	(E)-3-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-furan-2-yl]-acrylic acid	Ki	1000.0 [1]
	(E)-3-[5-Methyl-4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)methyl]furan-2-yl]prop-2-enoic acid	Ki	1000.0 [1]
	(E)-3-[4-(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)-4,5,6,7-tetrahydro-1-benzofuran-2-yl]but-2-enoic acid	Ki	1000.0 [1]
	(2E,4E,6Z)-7-(3-Methoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-3-methylocta-2,4,6-trienoic acid	Ki	306.0 [1]
	6-(3-Adamantan-1-yl-4-hexyloxy-phenyl)-naphthalene-2-carboxylic acid	Ki	10000.0 [1]
	4-[2-[5-(1-Adamantyl)-4-hydroxy-2-methylphenyl]-1,3-thiazol-5-yl]benzoic acid	IC50	1277.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Retinoic acid receptor alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/retinoic-acid-receptor-alpha-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Retinoic acid receptor alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/retinoic-acid-receptor-alpha-inhibitors-ic50-ki.
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