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Receptor protein-tyrosine kinase erbB-4 Inhibitors (IC50, Ki)

Structure
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Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
CanertinibIC5010.0 [1], 14.0 [2], 27.0 [3], 31.0 [4]
IbrutinibIC500.1 [1], 1.8 [2]
StaurosporineIC5028.3 [1], 282.0 [2]
DacomitinibIC5074.0 [1], 83.67 [2]
2-PropenaMide, N-[cis-4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]cyclohexyl]-IC503.2 [1]
GefitinibIC50476.0 [1]
ErlotinibIC501130.0 [1]
LapatinibIC501000.0 [1]
DoramapimodIC5030000.0 [1]
Dacomitinib monohydrateIC5074.0 [1]
Nvp-aew541IC501700.0 [1]
4-[(3-Bromophenyl)amino]-6-acrylamidoquinazolineIC5012.0 [1]
Cfms Receptor Tyrosine Kinase InhibitorIC5024000.0 [1]
N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)but-2-ynamideIC5012.0 [1]
N6,N6-Dimethyl-N4-[1-(phenylmethyl)-5-indazolyl]pyrido[3,4-d]pyrimidine-4,6-diamineIC5020.0 [1]
Tak-285IC50260.0 [1]
Bms-599626IC50190.0 [1]
N-(2,6-Difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamideIC5025000.0 [1]
PD-153035 hydrochlorideIC5049.0 [1]
1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-oneIC5025200.0 [1]
EvobrutinibIC5037.9 [1]
EGFR InhibitorIC507640.0 [1]
EGFR/ErbB-2/ErbB-4 InhibitorIC500.5 [1]
4-Tert-Butyl-N-[6-(1h-Imidazol-1-Yl)imidazo[1,2-A]pyridin-2-Yl]benzamideIC5019952.62 [1]
N~3~-Cyclopropyl-N~4~'-(Cyclopropylmethyl)-6-Methylbiphenyl-3,4'-DicarboxamideIC5025000.0 [1]
CID 44814409IC5010000.0 [1]
2-(4-Fluorophenyl)-3-(4-pyridinyl)pyrazolo[1,5-a]pyridineIC5010000.0 [1]
2-Methyl-N-[2-[3-[[2-(prop-2-enoylamino)acetyl]amino]anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamideIC503.3 [1]
6,6-Dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrileIC50213.0 [1]
JAK3 covalent inhibitor-1IC5010000.0 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideKi3800.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi3750.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
2-Methyl-N-[2-[3-(prop-2-enoylamino)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamideIC505.5 [1]
7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamideKi10000.0 [1]
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC5050000.0 [1]
5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amineIC5010000.0 [1]
N-[3-[5-[2-(3-Morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamideIC5018.0 [1]
CID 46927672IC5010.0 [1]
N-[[2-[4-Amino-6-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]pyrimidin-5-yl]-1,3-oxazol-4-yl]methyl]prop-2-enamideIC504.0 [1]
1-(4-Fluorophenyl)-N-[3-fluoro-4-(5-phenylthieno[2,3-d]pyrimidin-4-yl)oxyphenyl]-2-oxopyridine-3-carboxamideIC5010000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
9-Cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamineIC5030.0 [1]
(E)-4-(Dimethylamino)-N-[7-fluoro-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamideIC5043.7 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
6-(6-Fluoroindol-1-yl)-2-[2-[7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyethyl]pyridazin-3-oneIC501000.0 [1]
N-Cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamideIC5025000.0 [1]
N-[4-Methyl-3-[2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]phenyl]-2-pyrrolidin-1-ylpyridine-4-carboxamideIC5025000.0 [1]
N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-[di(propan-2-yl)amino]but-2-ynamideIC50538.0 [1]
N-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-4-morpholin-4-ylbut-2-ynamideIC50229.0 [1]
N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-5-(4-methylpiperazin-1-yl)pent-2-ynamideIC501.2 [1]
N-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-4-(dibutylamino)but-2-ynamideIC50624.0 [1]
N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]hept-2-ynamideIC507.1 [1]
N-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-5-(diethylamino)pent-2-ynamideIC5016.0 [1]
N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-morpholin-4-ylbut-2-ynamideIC506.2 [1]
N-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-4-(diethylamino)but-2-ynamideIC50310.0 [1]
N-[4-[(3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-5-(4-morpholinyl)-2-pentynamideIC501.0 [1]
N-[4-[(3-Chloro-4-fluorophenyl)amino]-6-quinazolinyl]-5-(4-morpholinyl)-2-pentynamideIC504.3 [1]
N-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-4-hydroxybut-2-ynamideIC507.3 [1]
N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-5-piperidin-1-ylpent-2-ynamideIC501.8 [1]
N-[4-(3-Bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-5-(4-methylpiperazin-1-yl)pent-2-ynamideIC500.8 [1]
N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]hex-2-ynamideIC502.4 [1]
N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dibutylamino)but-2-ynamideIC5073.0 [1]
6,7-Diethoxy-N-(3-iodophenyl)quinazolin-4-amine;hydrochlorideIC5059.0 [1]
6,7-Diethoxy-N-[(4-fluorophenyl)methyl]quinazolin-4-amineIC50100.0 [1]
N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(diethylamino)but-2-ynamideIC50644.0 [1]
N-[4-(3-Bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-5-morpholin-4-ylpent-2-ynamideIC501.0 [1]
N-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-4-[di(propan-2-yl)amino]but-2-ynamideIC5011.0 [1]
2,3-Dimethyl-4-[2-methyl-3-(prop-2-enoylamino)phenyl]-1H-indole-7-carboxamideIC50240.0 [1]
4-[3-(Ethenylsulfonylamino)-2-methylphenyl]-2,3-dimethyl-1H-indole-7-carboxamideIC5010.0 [1]
6-[4-[(5-Tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-N-[3-(dimethylamino)propyl]imidazo[2,1-b][1,3]thiazole-3-carboxamideIC5010000.0 [1]
N-(3-Chloro-4-fluorophenyl)-6-(1-methylpyrazol-4-yl)quinazolin-4-amineIC50801.0 [1]
6-(1-Piperidin-4-ylpyrazol-4-yl)-N-quinolin-6-ylquinazolin-4-amineIC501100.0 [1]
6-(1-Methylpyrazol-4-yl)-N-quinolin-6-ylquinazolin-4-amineIC50930.0 [1]
N-(3-Ethynylphenyl)-6-(1-methylpyrazol-4-yl)quinazolin-4-amineIC50782.0 [1]
N-(3-Chloro-4-fluorophenyl)-6-(1-piperidin-4-ylpyrazol-4-yl)quinazolin-4-amineIC501603.0 [1]
Chmfl-egfr-202IC503.2 [1]
7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(prop-2-enoylamino)phenyl]-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamideIC50150.0 [1]
(E)-N-[4-[(1-Benzylindazol-5-yl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamideIC502.0 [1]
(E)-N-[4-[(1-Benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-morpholin-4-ylbut-2-enamideIC506.0 [1]
(E)-N-[4-(4-Phenoxyanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-pyrrolidin-1-ylbut-2-enamideIC502.0 [1]
(E)-N-[4-[[1-(Benzenesulfonyl)indol-5-yl]amino]-7-ethoxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamideIC5010.0 [1]
(E)-N-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]pyrido[3,4-d]pyrimidin-6-yl]-4-pyrrolidin-1-ylbut-2-enamideIC505.0 [1]
N-[4-[(1-Benzyl-2,3-dihydroindol-5-yl)amino]-7-methoxyquinazolin-6-yl]propanamideIC5082.0 [1]
(E)-N-[4-[[1-(Benzenesulfonyl)indol-5-yl]amino]-7-ethoxyquinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamideIC5011.0 [1]
(E)-N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-piperidin-1-ylbut-2-enamideIC507.0 [1]
N-[7-Methoxy-4-(4-phenylmethoxyanilino)quinazolin-6-yl]propanamideIC50460.0 [1]
(E)-N-[7-Methoxy-4-[4-(pyridin-2-ylmethyl)anilino]quinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamideIC5013.0 [1]
(E)-N-[4-[(1-Benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamideIC503.0 [1]
(E)-N-[4-[[1-(Benzenesulfonyl)indol-5-yl]amino]-7-ethoxyquinazolin-6-yl]-4-morpholin-4-ylbut-2-enamideIC5027.0 [1]
N-[4-(3-Chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]propanamideIC50376.0 [1]
N-[7-Methoxy-4-[[1-(pyridin-2-ylmethyl)indazol-5-yl]amino]quinazolin-6-yl]propanamideIC5015.0 [1]
(E)-4-(4-Methylpiperazin-1-yl)-N-[4-[4-(pyridin-2-ylmethyl)anilino]pyrido[3,4-d]pyrimidin-6-yl]but-2-enamideIC5094.0 [1]
(E)-N-[7-Ethoxy-4-[4-(pyridin-2-ylmethoxy)anilino]quinazolin-6-yl]-4-(4-methylpiperazin-1-yl)but-2-enamideIC5094.0 [1]
(E)-N-[4-[(1-Benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-(4-methylpiperazin-1-yl)but-2-enamideIC504.0 [1]
(E)-N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(4-methylpiperazin-1-yl)but-2-enamideIC50302.0 [1]
(E)-N-[4-[(1-Benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamideIC504.0 [1]
N-[7-Methoxy-4-[[1-(pyridin-4-ylmethyl)indol-5-yl]amino]quinazolin-6-yl]propanamideIC50213.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Receptor protein-tyrosine kinase erbB-4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/receptor-protein-tyrosine-kinase-erbb-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Receptor protein-tyrosine kinase erbB-4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/receptor-protein-tyrosine-kinase-erbb-4-inhibitors-ic50-ki.
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