Receptor protein-tyrosine kinase erbB-2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Erlotinib	IC50	300.0 [1]
	Lapatinib	IC50	10.2 [1]
	Gefitinib	IC50	343.0 [1]
	Canertinib	IC50	30.0 [1]
	Tykerb	IC50	9.0 [1]
	Cudc-101	IC50	15.7 [1], 16.4 [2], 100.0 [3], 188.0 [4]
	Ibrutinib	IC50	1.5 [1], 9.4 [2]
	Neratinib	IC50	1.0 [1], 59.0 [2]
	4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline	IC50	5.7 [1], 24.0 [2], 114.0 [3]
	Sapitinib	IC50	3.0 [1], 14.0 [2], 60.0 [3]
	[(3R,5S)-5-[2-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]thieno[3,2-d]pyrimidin-6-yl]ethynyl]pyrrolidin-3-yl] morpholine-4-carboxylate	IC50	50.0 [1], 80.0 [2], 84.0 [3]
	Staurosporine	IC50	34.0 [1], 60.8 [2], 115.0 [3]
	Tyrphostin B42	IC50	13489.63 [1], 13500.0 [2]
	Afatinib	IC50	2.0 [1], 14.0 [2], 17.3 [3]
	Dacomitinib	IC50	16.7 [1], 45.7 [2], 46.0 [3]
	Pelitinib	IC50	1229.0 [1], 1230.0 [2]
	Tyrphostin AG 555	IC50	34673.69 [1], 35000.0 [2]
	Tyrphostin B56	IC50	500000.0 [1], 501187.23 [2]
	N6,N6-Dimethyl-N4-[1-(phenylmethyl)-5-indazolyl]pyrido[3,4-d]pyrimidine-4,6-diamine	IC50	16.0 [1], 70.0 [2], 97.0 [3]
	Tak-285	IC50	3.0 [1], 17.0 [2]
	Tyrphostin B48	IC50	41686.94 [1], 42000.0 [2]
	Tyrphostin AG 698	IC50	22908.68 [1], 23000.0 [2]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	13100.0 [1], 26000.0 [2], 50000.0 [3]
	N-[1-[(3-Fluorophenyl)methyl]indazol-5-yl]-5-[[(2S)-morpholin-2-yl]methoxymethyl]pyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	55.0 [1]
	Tyrphostin deriv. 36	IC50	34673.69 [1], 35000.0 [2]
	[(3R,5S)-5-[2-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]thieno[3,2-d]pyrimidin-6-yl]ethynyl]pyrrolidin-3-yl] N,N-dimethylcarbamate	IC50	10.0 [1], 68.0 [2]
	[(3R,5S)-5-[2-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]thieno[3,2-d]pyrimidin-6-yl]ethynyl]pyrrolidin-3-yl] N-ethylcarbamate	IC50	10.0 [1], 43.0 [2]
	(2R)-N,N-Dimethyl-2-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-5-yl]oxypropanamide	IC50	1.0 [1], 23.0 [2]
	4-(1-(3-Fluorobenzyl)-1H-indazol-5-ylamino)-6-aminopyrimidine-5-carbaldehyde O-methyl oxime	IC50	12.0 [1], 301.0 [2]
	N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-5-(4-methylpiperazin-1-yl)pent-2-ynamide	IC50	0.7 [1], 0.8 [2], 1.0 [3]
	N-[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-7-chloro-1,3-benzoxazol-2-amine	IC50	7.5 [1], 200.0 [2], 340.0 [3]
	4-[(1-Benzylindazol-5-yl)amino]-5-ethyl-N-(3-imidazol-1-ylpropyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide	IC50	30.0 [1], 5800.0 [2], 7000.0 [3]
	3-Imidazol-1-ylpropyl 4-[(1-benzylindazol-5-yl)amino]-5-ethylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate	IC50	240.0 [1], 1600.0 [2], 3100.0 [3]
	4-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]-N-(2-methylsulfonylethyl)-1,3-thiazol-2-amine	IC50	14.0 [1], 110.0 [2], 130.0 [3]
	4-[4-[(1-Benzylindazol-5-yl)amino]quinazolin-6-yl]-N-(2-methylsulfonylethyl)-1,3-thiazol-2-amine	IC50	28.0 [1], 60.0 [2], 90.0 [3]
	4-[4-(3-Chloro-4-phenylmethoxyanilino)quinazolin-6-yl]-N-(2-methylsulfonylethyl)-1,3-thiazol-2-amine	IC50	14.0 [1], 280.0 [2], 360.0 [3]
	4-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-N-(2-methylsulfonylethyl)-1,3-thiazol-2-amine	IC50	200.0 [1], 2400.0 [2], 4400.0 [3]
	N-(2-Methylsulfonylethyl)-4-[4-(4-phenylmethoxyanilino)quinazolin-6-yl]-1,3-thiazol-2-amine	IC50	48.0 [1], 860.0 [2], 1500.0 [3]
	N-(2-Methylsulfonylethyl)-4-[4-[4-[[3-(trifluoromethyl)phenyl]methoxy]anilino]quinazolin-6-yl]-1,3-thiazol-2-amine	IC50	550.0 [1], 7400.0 [2], 15000.0 [3]
	N-[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-fluorophenyl]-7-chloro-1,3-benzoxazol-2-amine	IC50	16.0 [1], 362.0 [2], 1350.0 [3]
	2-Imidazol-1-ylethyl N-[4-[(1-benzylindazol-5-yl)amino]-5-ethylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate	IC50	40.0 [1], 460.0 [2], 860.0 [3]
	Erlotinib hydrochloride	IC50	1520.0 [1], 1890.0 [2]
	Dasatinib	IC50	710.0 [1]
	Nintedanib	IC50	10000.0 [1], 50000.0 [2]
	N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)but-2-ynamide	IC50	17.0 [1], 378.0 [2]
	Tyrphostin A46	IC50	6400.0 [1], 6456.54 [2]
	Tyrphostin AG 538	IC50	16982.44 [1], 18000.0 [2]
	Falnidamol	IC50	3.0 [1], 3400.0 [2]
	PDGF Receptor Tyrosine Kinase Inhibitor IV	IC50	10000.0 [1]
	CID 9874913	IC50	10.0 [1], 12.0 [2]
	Bms-599626	IC50	22.0 [1], 23.0 [2]
	N-(2,6-Difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamide	IC50	1000.0 [1], 10000.0 [2]
	Tyrphostin AG 528	IC50	4897.79 [1], 4900.0 [2]
	EGFR/ErbB-2/ErbB-4 Inhibitor	IC50	1.1 [1], 24.0 [2]
	N-(2-Chloro-6-methylphenyl)-2-[(2,6-dimethylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide	IC50	500.0 [1], 5200.0 [2]
	6-Alkoxy-4-anilinoquinazoline 8b	IC50	234.0 [1], 1680.0 [2]
	(E)-N-[4-(3-Bromoanilino)-3-cyano-8-methoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide	IC50	9300.0 [1], 9350.0 [2]
	N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-(1H-pyrrol-2-yl)thieno[3,2-d]pyrimidin-4-amine	IC50	121.0 [1], 826.0 [2]
	Unii-W39547M0FP	IC50	8.0 [1], 11.0 [2]
	4-(3-Chloro-4-(2-pyridylmethoxy)anilino)-5-(1-methylpiperidin-4-yloxy)quinazoline	IC50	2.0 [1], 61.0 [2]
	(6S,7S)-N-Hydroxy-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide	IC50	18.0 [1]
	(6S,7S)-N-Hydroxy-6-[(4-phenylpiperazin-1-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxamide	IC50	52.0 [1]
	CID 44446843	IC50	358.0 [1], 359.0 [2]
	Tyrphostin deriv. 25	IC50	12882.5 [1], 13600.0 [2]
	Tyrphostin deriv. 28	IC50	10000.0 [1]
	Tyrphostin deriv. 29	IC50	18000.0 [1], 18197.01 [2]
	Tyrphostin deriv. 30	IC50	12000.0 [1], 12022.64 [2]
	Tyrphostin deriv. 33	IC50	3000.0 [1], 3019.95 [2]
	N-[4-(3-Chloro-4-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide	IC50	4.3 [1]
	N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide	IC50	2.2 [1], 22.0 [2]
	5-[(4-Aminopiperidin-1-yl)methyl]-N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	22.0 [1], 23.0 [2]
	2-(4-(4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)acetamide	IC50	46.0 [1], 107.0 [2]
	N-[4-(3-Bromo-4-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide	IC50	7.3 [1]
	N-[4-(3-Chloro-4-fluoro-phenylamino)-pyrido[3,2-d]pyrimidin-6-yl]-acrylamide	IC50	12.0 [1]
	(E)-N-[4-[3-Chloro-4-[(3-chlorophenyl)methoxy]anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide	IC50	8.0 [1]
	(E)-N-[4-[3-Chloro-4-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide	IC50	13.0 [1]
	(E)-N-[4-[3-Chloro-4-[(5-phenyl-1,3-thiazol-2-yl)sulfanyl]anilino]-3-cyano-7-methoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide	IC50	1000.0 [1], 1007.0 [2]
	[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]urea	IC50	26.8 [1], 287.0 [2]
	(6S,7S)-N-Hydroxy-6-{[(3R)-3-phenylpyrrolidin-1-yl]carbonyl}-5-azaspiro[2.5]octane-7-carboxamide	IC50	92.0 [1]
	(6S,7S)-N-Hydroxy-5-methyl-6-[(4-phenylpiperazin-1-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxamide	IC50	230.0 [1]
	(E)-2-Cyano-N-cyclohexyl-3-(3,4-dihydroxyphenyl)prop-2-enamide	IC50	16982.44 [1], 17000.0 [2]
	[(3R,5S)-5-[2-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]thieno[3,2-d]pyrimidin-6-yl]ethynyl]pyrrolidin-3-yl] N-methylcarbamate	IC50	20.0 [1]
	N-(4-(3-Fluorobenzyloxy)-3-chlorophenyl)pyrimidin-4-amine	IC50	21000.0 [1], 25000.0 [2]
	N-[1-[(3-Fluorophenyl)methyl]indazol-5-yl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	88.0 [1]
	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-5-[[(2S)-morpholin-2-yl]methoxymethyl]pyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	560.0 [1]
	N-[1-[(3-Fluorophenyl)methyl]indazol-5-yl]-6-methoxy-5-[[(2S)-morpholin-2-yl]methoxymethyl]pyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	250.0 [1]
	N-[3-[5-[2-(3-Morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide	IC50	73.0 [1], 680.0 [2]
	2-(2-Methyl-5-nitroimidazol-1-yl)ethyl (E)-3-(4-phenylphenyl)prop-2-enoate	IC50	2150.0 [1]
	Tyrphostin deriv. 39	IC50	50000.0 [1], 50118.72 [2]
	Tyrphostin deriv. 54	IC50	57000.0 [1], 57543.99 [2]
	Tyrphostin deriv. 58	IC50	331131.12 [1], 333000.0 [2]
	Tyrphostin deriv. 64	IC50	165958.69 [1], 166000.0 [2]
	Tyrphostin deriv. 70	IC50	33884.42 [1], 34000.0 [2]
	4-Anilinoquinazoline deriv. 10n	IC50	9.0 [1], 122.0 [2]
	6-Alkoxy-4-anilinoquinazoline 8c	IC50	210.0 [1], 1380.0 [2]
	6-Alkoxy-4-anilinoquinazoline 8f	IC50	19.0 [1], 390.0 [2]
	6,6-Dimethyl-8-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	50000.0 [1]
	(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)prop-2-enamide	IC50	37000.0 [1], 37153.52 [2]
	7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrile	IC50	10000.0 [1]
	2-[4-[3-Chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethanol	IC50	12.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Receptor protein-tyrosine kinase erbB-2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/receptor-protein-tyrosine-kinase-erbb-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Receptor protein-tyrosine kinase erbB-2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/receptor-protein-tyrosine-kinase-erbb-2-inhibitors-ic50-ki.
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