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Receptor-interacting serine/threonine-protein kinase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CID 77108121IC501.0 [1]
CID 77108121Ki0.98 [1]
5-Benzyl-N-[(3S)-4-oxo-3,5-dihydro-2H-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamideIC5016.0 [1], 200.0 [2]
5-Benzyl-N-[(3s)-5-Methyl-4-Oxo-2,3,4,5-Tetrahydro-1,5-Benzoxazepin-3-Yl]-1,2-Oxazole-3-CarboxamideIC501.6 [1], 2.8 [2], 10.0 [3]
5-Benzyl-N-[(3s)-5-Methyl-4-Oxo-2,3,4,5-Tetrahydro-1,5-Benzoxazepin-3-Yl]-1,2-Oxazole-3-CarboxamideKi0.8 [1]
1-[4-(1-Aminoisoquinolin-5-Yl)phenyl]-3-(5-Tert-Butyl-1,2-Oxazol-3-Yl)ureaIC5010.0 [1], 16.0 [2], 25.0 [3], 500.0 [4], 630.0 [5]
3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ureaIC5013.0 [1], 63.0 [2], 250.0 [3]
3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ureaKi2.04 [1]
5-Benzyl-N-[(3R)-4-oxo-3,5-dihydro-2H-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamideIC5010000.0 [1]
CID 76332060IC501.3 [1], 16.0 [2], 32.0 [3]
(5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-DioneIC50200.0 [1], 320.0 [2], 630.0 [3]
3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[3,5-bis(trifluoromethyl)phenyl]ureaIC5032.0 [1], 320.0 [2], 7900.0 [3]
3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[3-(trifluoromethyl)phenyl]ureaIC5010.0 [1], 20.0 [2], 1000.0 [3]
5-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1H-1,5-benzodiazepin-3-yl]-1,2-oxazole-3-carboxamideIC500.79 [1], 40.0 [2]
5-Benzyl-N-[(3S)-1-methyl-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-1,2-oxazole-3-carboxamideIC500.2 [1], 6.3 [2]
3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-chloro-5-(trifluoromethyl)phenyl]ureaIC502500.0 [1], 10000.0 [2]
1-Phenyl-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]ureaIC50400.0 [1], 600.0 [2], 1300.0 [3]
5-Benzyl-N-[(3R)-5-methyl-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl]-1,2-oxazole-3-carboxamideIC500.06 [1], 0.94 [2], 2.0 [3]
1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-chlorophenyl)ureaIC50160.0 [1], 200.0 [2], 7900.0 [3]
N-[(3S)-4-Oxo-3,5-dihydro-2H-1,5-benzoxazepin-3-yl]-3-phenoxybenzamideIC507.9 [1], 40.0 [2], 400.0 [3]
1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]ureaIC5013.0 [1], 130.0 [2], 630.0 [3]
1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]ureaIC5020.0 [1], 25.0 [2], 630.0 [3]
1-(3-Nitrophenyl)-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]ureaIC5016.0 [1], 320.0 [2]
1-[3-(5-Phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]ureaIC5032.0 [1], 79.0 [2]
1-[3-[5-(4-Ethylsulfonylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]ureaIC503.2 [1], 10.0 [2], 25.0 [3]
1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-[3-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]ureaIC504.0 [1], 6.3 [2], 7.9 [3]
1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]ureaIC50160.0 [1], 500.0 [2], 1300.0 [3]
3-[3-[3-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]benzamideIC5010.0 [1], 16.0 [2], 63.0 [3]
1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-3-(trifluoromethyl)phenyl]ureaIC50200.0 [1], 250.0 [2], 10000.0 [3]
1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]ureaIC5040.0 [1], 160.0 [2], 2000.0 [3]
1-(3-Acetylphenyl)-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]ureaIC5010.0 [1], 13.0 [2], 320.0 [3]
1-[3-[5-(4-Aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]ureaIC5016.0 [1], 32.0 [2], 50.0 [3]
1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[2-fluoro-3-(trifluoromethyl)phenyl]ureaIC504000.0 [1], 10000.0 [2]
1-Cyclopentyl-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]ureaIC50500.0 [1], 2000.0 [2], 7900.0 [3]
1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[3-fluoro-5-(trifluoromethyl)phenyl]ureaIC5063.0 [1], 130.0 [2], 5000.0 [3]
1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]ureaIC5032.0 [1], 160.0 [2], 1300.0 [3]
1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-ethylphenyl)ureaIC5010.0 [1], 25.0 [2], 250.0 [3]
1-(3-Methylphenyl)-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]ureaIC5013.0 [1], 20.0 [2], 160.0 [3]
1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]ureaIC5010.0 [1], 320.0 [2], 2500.0 [3]
1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-[3-[5-(3-methylsulfonylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]ureaIC5010.0 [1], 50.0 [2], 63.0 [3]
1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-[3-[5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]ureaIC506.0 [1], 16.0 [2], 63.0 [3]
1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[3-fluoro-5-(trifluoromethyl)phenyl]ureaIC5025.0 [1], 160.0 [2], 2500.0 [3]
1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[2-chloro-5-(trifluoromethyl)phenyl]ureaIC50630.0 [1], 3200.0 [2], 10000.0 [3]
1-(3-Methoxyphenyl)-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]ureaIC506.3 [1], 32.0 [2], 400.0 [3]
1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)ureaIC5016.0 [1], 32.0 [2], 200.0 [3]
1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]ureaIC5080.0 [1], 160.0 [2], 200.0 [3]
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-ImidazolidinoneIC50182.0 [1], 760.0 [2]
3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-naphthalen-2-ylureaIC50100.0 [1], 790.0 [2]
5-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,3,4-oxadiazole-2-carboxamideIC500.79 [1], 7.9 [2]
N-[(3S)-5-Methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(2-methylpropyl)-1,2-oxazole-3-carboxamideIC501600.0 [1], 6310.0 [2]
1-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]imidazole-4-carboxamideIC500.4 [1], 6.3 [2]
N-[(3S)-4-Oxo-3,5-dihydro-2H-1,5-benzoxazepin-3-yl]-5-pentyl-1H-pyrazole-3-carboxamideIC50320.0 [1], 1600.0 [2]
1-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2,4-triazole-3-carboxamideIC500.63 [1], 1.6 [2]
2-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]tetrazole-5-carboxamideIC500.08 [1], 2.5 [2]
1-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]pyrazole-4-carboxamideIC5063.0 [1], 631.0 [2]
1-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]triazole-4-carboxamideIC501.0 [1], 25.0 [2]
5-Benzyl-N-[(3S)-5-methyl-4-oxo-7-(1H-pyrazol-5-yl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamideIC501.0 [1], 6.3 [2]
5-Benzyl-N-[(3S)-5-methyl-4-oxo-7-(2-oxo-3H-1,3,4-oxadiazol-5-yl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamideIC500.5 [1], 3.2 [2]
2-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,3-oxazole-4-carboxamideIC50794.0 [1], 2512.0 [2]
5-Benzyl-N-[(4S)-5-oxo-2,3,4,6-tetrahydro-1,6-benzoxazocin-4-yl]-1,2-oxazole-3-carboxamideIC50200.0 [1], 631.0 [2]
5-Benzyl-N-[(3S)-1,5-dimethyl-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-1,2-oxazole-3-carboxamideIC505.0 [1], 20.0 [2]
Methyl N-[(3S)-3-[(5-benzyl-1,2-oxazole-3-carbonyl)amino]-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-7-yl]carbamateIC500.32 [1], 10.0 [2]
5-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,3-thiazole-2-carboxamideIC50631.0 [1], 794.0 [2]
5-Benzyl-N-[(3S)-5-ethyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamideIC503162.0 [1], 7943.0 [2]
RIP1 kinase inhibitor 1IC501.3 [1]
RIP1 kinase inhibitor 1Ki0.91 [1]
5-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,3-oxazole-2-carboxamideIC500.05 [1], 1.0 [2]
5-Benzyl-N-[(3R)-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamideIC5010000.0 [1]
5-Benzyl-N-[(6S)-5-oxo-1,4-oxazepan-6-yl]-1,2-oxazole-3-carboxamideIC5010000.0 [1]
N-[(3S)-5-Methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-pentyl-1,2-oxazole-3-carboxamideIC50100.0 [1], 126.0 [2]
5-Benzyl-1-methyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]pyrazole-3-carboxamideIC500.4 [1], 10.0 [2]
4-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]pyridine-2-carboxamideIC502.0 [1], 40.0 [2]
5-(Cyclohexylmethyl)-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamideIC50251.0 [1], 501.0 [2]
5-Benzyl-N-[(3S)-5-cyclopropyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamideIC5010000.0 [1]
5-Benzyl-N-[(3S)-7-(methanesulfonamido)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamideIC500.63 [1], 13.0 [2]
5-Benzyl-N-(2-oxo-3,4-dihydro-1H-quinolin-3-yl)-1,2-oxazole-3-carboxamideIC5010000.0 [1]
5-Benzyl-N-[(3S)-3-methyl-4-oxo-2,5-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamideIC5010000.0 [1]
N-[(3S)-5-Methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(piperidin-1-ylmethyl)-1,2-oxazole-3-carboxamideIC5010000.0 [1]
5-Benzyl-N-methyl-N-[(3S)-4-oxo-3,5-dihydro-2H-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamideIC5010000.0 [1]
2-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-imidazole-5-carboxamideIC501259.0 [1], 1995.0 [2]
3-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]benzamideIC50251.0 [1], 398.0 [2]
N-[(3S)-7-Acetamido-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-benzyl-1,2-oxazole-3-carboxamideIC500.32 [1], 7.9 [2]
5-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2,4-oxadiazole-3-carboxamideIC500.5 [1], 5.0 [2]
TozasertibIC50208.0 [1]
Necrostatin 2 racemateIC50754.0 [1]
CID 121439991IC5013.0 [1]
Ripk1-IN-7IC5011.0 [1]
5-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-pyrazole-3-carboxamideIC500.4 [1]
5-Benzyl-N-[(3R)-1,1,4-trioxo-3,5-dihydro-2H-1lambda6,5-benzothiazepin-3-yl]-1,2-oxazole-3-carboxamideIC5079.0 [1]
5-Benzyl-N-[(3S)-4-oxo-1,2,3,5-tetrahydro-1,5-benzodiazepin-3-yl]-1,2-oxazole-3-carboxamideIC503.2 [1]
N-[(3S)-5-Methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-[[3-[3-(trifluoromethyl)diazirin-3-yl]phenyl]methyl]-1H-pyrazole-3-carboxamideIC5035.0 [1]
5-Benzyl-N-[(3S)-1-methyl-2-oxo-7-[3-(trifluoromethyl)diazirin-3-yl]-4,5-dihydro-3H-1-benzazepin-3-yl]-1,2-oxazole-3-carboxamideIC50210.0 [1]
(3S)-3-(2-Benzyl-3-chloro-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl)-N,5-dimethyl-4-oxo-2,3-dihydro-1,5-benzoxazepine-8-carboxamideKi0.91 [1]
(3S)-3-[2-[(2-Fluorophenyl)methyl]-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl]-5-methyl-2,3-dihydro-1,5-benzoxazepin-4-oneKi1.74 [1]
(3S)-3-[2-(Cyclobutylmethyl)-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl]-5-methyl-2,3-dihydro-1,5-benzoxazepin-4-oneKi13.8 [1]
(3S)-3-(2-Benzyl-4-oxo-6,7-dihydropyrazolo[4,3-c]pyridin-5-yl)-5-methyl-2,3-dihydro-1,5-benzoxazepin-4-oneKi251.19 [1]
(3S)-3-[2-[(2,6-Difluorophenyl)methyl]-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl]-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepine-8-carbonitrileKi1.78 [1]
(3S)-3-(2-Benzyl-3-methyl-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl)-5-methyl-2,3-dihydro-1,5-benzoxazepin-4-oneKi2.57 [1]
(3S)-3-[2-[(1,1-Dioxothian-4-yl)methyl]-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl]-5-methyl-2,3-dihydro-1,5-benzoxazepin-4-oneKi6918.31 [1]
2-Benzyl-6-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamideKi2.51 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Receptor-interacting serine/threonine-protein kinase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/receptor-interacting-serine-threonine-protein-kinase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Receptor-interacting serine/threonine-protein kinase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/receptor-interacting-serine-threonine-protein-kinase-1-inhibitors-ic50-ki.
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