RAS guanyl releasing protein 3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	CID 25053598	Ki	0.18 [1], 0.33 [2], 0.84 [3]
	[(4E)-2-(Hydroxymethyl)-4-[(4-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	3.8 [1]
	[(4E)-4-[[4-(Dimethylamino)phenyl]methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	4.68 [1], 26.8 [2]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-methoxybenzoate	Ki	3.3 [1], 26.5 [2]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	3.7 [1], 18.2 [2]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	23.8 [1], 271.0 [2]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoate	Ki	35.8 [1], 89.7 [2]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-methyl-2-(2-methylpropyl)pentanoate	Ki	0.7 [1], 5.07 [2]
	(4-(4-Nitrobenzylidene)-2-(hydroxymethyl)-5-oxo-tetrahydrofuran-2-yl)methyl 4-methoxybenzoate	Ki	6.7 [1]
	[(4E)-4-[[4-(Dimethylamino)phenyl]methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-methoxybenzoate	Ki	7.48 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(4-methoxyphenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	7.0 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(4-methoxyphenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-methoxybenzoate	Ki	4.17 [1]
	[(2Z,4E)-6-[(3S,4R,5S,6R,7Z,10S)-4,10-Dihydroxy-6-(3-hydroxypropyl)-10-methyl-7-(1-oxopropan-2-ylidene)spiro[4.5]decan-3-yl]-2-(4-methylpent-3-enyl)hepta-2,4,6-trienyl] acetate	Ki	41.7 [1]
	Chembl4169454	Ki	1.75 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl (E)-3-pyridin-2-ylprop-2-enoate	Ki	149.0 [1]
	[(4E)-4-[(4-Chlorophenyl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-chlorobenzoate	Ki	2.69 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(4-methoxyphenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-chlorobenzoate	Ki	1.54 [1]
	[(4E)-4-(1-Benzothiophen-3-ylmethylidene)-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	1.67 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(5-methoxy-1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	4.76 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	192.0 [1]
	[(4E)-4-[(4-Chlorophenyl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	2.73 [1]
	[(4Z)-4-(1-Benzothiophen-3-ylmethylidene)-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	4.26 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-chlorobenzoate	Ki	11.2 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl heptanoate	Ki	5.3 [1]
	[(4E)-4-[[4-(Dimethylamino)phenyl]methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-chlorobenzoate	Ki	1.81 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methyl-5-nitroindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	3490.0 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl (E)-3-(1-methylindol-3-yl)prop-2-enoate	Ki	15.7 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindazol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	7.22 [1]
	[(4E)-2-(Hydroxymethyl)-4-[[1-(2-methylpropyl)indol-3-yl]methylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	3.03 [1]
	[(4E)-4-[(1-Butylindol-3-yl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	1.87 [1]
	[(4Z)-4-(1-Benzofuran-3-ylmethylidene)-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	11.67 [1]
	[(4E)-4-[[4-(Dimethylamino)phenyl]methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	1.07 [1]
	[(4E)-4-[(5-Chloro-1-methylindol-3-yl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	1.01 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl (E)-3-phenylprop-2-enoate	Ki	25.0 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl cyclohexanecarboxylate	Ki	2.86 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(4-methoxyphenyl)methylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	1.09 [1]
	[(4Z)-4-[(5-Chloro-1-methylindol-3-yl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	4.32 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-tert-butylcyclohexane-1-carboxylate	Ki	2.15 [1]
	[(4Z)-2-(Hydroxymethyl)-4-[(1-methyl-5-nitroindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	1390.0 [1]
	[(4E)-4-(1-Benzofuran-3-ylmethylidene)-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	2.8 [1]
	[(4E)-4-[(4-Chlorophenyl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-methoxybenzoate	Ki	2.25 [1]
	[(4E)-4-[[1-(Cyclopropylmethyl)indol-3-yl]methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	3.58 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 4-chlorobenzoate	Ki	29.0 [1]
	[(4E)-4-[(4-Chlorophenyl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoate	Ki	0.53 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(4-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 3-(dimethylamino)benzoate	Ki	2.3 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(3-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	8.0 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(3-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 3-(dimethylamino)benzoate	Ki	5.3 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(2-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	14.4 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(2-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 3-(dimethylamino)benzoate	Ki	16.4 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoate	Ki	0.72 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoate	Ki	83.0 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoate	Ki	1.6 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoate	Ki	670.0 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-4-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoate	Ki	13.8 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoate	Ki	1.7 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoate	Ki	4.6 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoate	Ki	32.2 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(4-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-nitrobenzoate	Ki	2.22 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	59.0 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-4-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	54.0 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-4-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	2360.0 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	2040.0 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	137.0 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoate	Ki	2470.0 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoate	Ki	81.0 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoate	Ki	5500.0 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-4-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoate	Ki	54.2 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoate	Ki	1390.0 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoate	Ki	17.4 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoate	Ki	907.0 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	1970.0 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	1410.0 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-4-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoate	Ki	3660.0 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(4-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 2-(dimethylamino)benzoate	Ki	1.8 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(3-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 2-(dimethylamino)benzoate	Ki	3.9 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoate	Ki	11.0 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoate	Ki	8.2 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoate	Ki	0.52 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(2-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 2-(dimethylamino)benzoate	Ki	9.4 [1]
	[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-4-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoate	Ki	44.0 [1]
	(2Z)-2-[(2R,3S,4S)-4-Hydroxy-3-(hydroxymethyl)-2-(3-hydroxypropyl)-4-methyl-3-[(3Z,5E)-4-methyl-6-[(1R,5S)-2,5,6,6-tetramethylcyclohex-2-en-1-yl]hexa-3,5-dienyl]cyclohexylidene]propanal	Ki	15.5 [1]
	[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 4-methyl-2-(2-methylpropyl)pentanoate	Ki	0.2 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-6-yl)methylidene]-5-oxooxolan-2-yl]methyl 2-propylpentanoate	Ki	1.22 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-4-yl)methylidene]-5-oxooxolan-2-yl]methyl 2-propylpentanoate	Ki	1.63 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-5-yl)methylidene]-5-oxooxolan-2-yl]methyl 2-propylpentanoate	Ki	0.34 [1]
	[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-7-yl)methylidene]-5-oxooxolan-2-yl]methyl 2-propylpentanoate	Ki	1.12 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 86 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ RAS guanyl releasing protein 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/ras-guanyl-releasing-protein-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ RAS guanyl releasing protein 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ras-guanyl-releasing-protein-3-inhibitors-ic50-ki.
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