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Pyruvate dehydrogenase kinase isoform 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
Dichloroacetic acidIC50504000.0 [1], 9000000.0 [2]
2-[(2,4-Dihydroxyphenyl)sulfonyl]-2,3-Dihydro-1h-Isoindole-4,6-DiolIC50456.0 [1], 800.0 [2]
(3S)-3-Amino-4-[4-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-4-oxobutanamideIC5058.0 [1], 81.0 [2]
Dimorpholinethiuram disulfideKi176.0 [1]
CID 86280454IC5084.0 [1]
4-[(5-Amino-1,3-dihydroisoindol-2-yl)sulfonyl]benzene-1,3-diolIC501177.0 [1]
4-[[5-[(1-Benzylpiperidin-4-yl)amino]-1,3-dihydroisoindol-2-yl]sulfonyl]benzene-1,3-diolIC50416.0 [1]
4-[[5-[[1-(2,3-Dihydroxypropyl)piperidin-4-yl]amino]-1,3-dihydroisoindol-2-yl]sulfonyl]benzene-1,3-diolIC50154.0 [1]
[4-[[2-(2,4-Dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-[(3R,5R)-3,4,5-trihydroxycyclohexyl]methanoneIC50432.0 [1]
4-({5-[(Piperidin-4-Yl)amino]-1,3-Dihydro-2h-Isoindol-2-Yl}sulfonyl)benzene-1,3-DiolIC50195.0 [1]
4-[[5-(Cyclohexylamino)-1,3-dihydroisoindol-2-yl]sulfonyl]benzene-1,3-diolIC501196.0 [1]
N-[2-(Ethylamino)-2-oxoethyl]-2,4-dihydroxy-N-(4-methoxyphenyl)benzamideKi2170.0 [1]
(2S)-2,6-Diamino-1-[4-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]hexan-1-oneIC50580.0 [1]
(4S)-4-Amino-5-[4-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-5-oxopentanamideIC5072.0 [1]
(3S)-3-Amino-4-[4-[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]-1,4-diazepan-1-yl]-4-oxobutanamideIC501514.0 [1]
(3S)-3-Amino-4-[(3S)-3-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]pyrrolidin-1-yl]-4-oxobutanamideIC50156.0 [1]
(2S)-2-Amino-N-[2-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]ethyl]butanediamideIC50357.0 [1]
(2S)-2-Amino-N-[3-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]propyl]butanediamideIC5067.0 [1]
(3S)-3-Amino-4-[(3R)-3-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]pyrrolidin-1-yl]-4-oxobutanamideIC50221.0 [1]
(3S)-3-Amino-4-[3-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]azetidin-1-yl]-4-oxobutanamideIC5065.0 [1]
(3S)-3-Amino-4-[4-[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]piperazin-1-yl]-4-oxobutanamideIC50767.0 [1]
(E)-3-[5-(5-Chloro-2,4-dihydroxyphenyl)-4-(4-hydroxyphenyl)-1,2-oxazol-3-yl]-1-[4-(2-methoxyphenyl)piperazin-1-yl]prop-2-en-1-oneIC501126.0 [1]
3-[4-[[2-(2,4-Dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-3-oxopropanoic acidIC501657.0 [1]
9-[4-[[2-(2,4-Dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-9-oxononanoic acidIC50629.0 [1]
6-[4-[[2-(2,4-Dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-6-oxohexanoic acidIC501610.0 [1]
N-[4-(Dimethylcarbamoyl)phenyl]-2,4-dihydroxy-N-methylbenzamideKi150.0 [1]
4-[(5-Piperazin-1-yl-1,3-dihydroisoindol-2-yl)sulfonyl]benzene-1,3-diolIC501346.0 [1]
(2S,3S)-2-Amino-1-[4-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-3-hydroxybutan-1-oneIC5091.0 [1]
[(3R)-3-(Methoxymethyl)morpholine-4-carbothioyl]sulfanyl (3R)-3-(methoxymethyl)morpholine-4-carbodithioateKi702.0 [1]
N-[2-(Diethylamino)ethyl]-2,4-dihydroxy-N-(4-methoxyphenyl)benzamideKi1330.0 [1]
2-[4-[[2-(2,4-Dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidine-1-carbonyl]benzoic acidIC50565.0 [1]
(2S)-2-Amino-1-[4-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-3-hydroxypropan-1-oneIC5068.0 [1]
1,4-Oxazepane-4-carbothioylsulfanyl 1,4-oxazepane-4-carbodithioateKi1278.0 [1]
4-[(5-Piperidin-1-yl-1,3-dihydroisoindol-2-yl)sulfonyl]benzene-1,3-diolIC504371.0 [1]
3-(4-Bromophenyl)-7-(2-(4-(2-hydroxyethyl)piperazin-1-yl)ethoxy)-4H-chromen-4-oneIC5010900.0 [1]
3-(3,4-Dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-oneIC505200.0 [1]
2,4-Dihydroxy-N-(4-methoxyphenyl)-N-methylbenzamideKi1070.0 [1]
4-[(5-Hydroxy-1,3-Dihydro-2h-Isoindol-2-Yl)sulfonyl]benzene-1,3-DiolIC50570.0 [1]
2-[4-[(9R)-9-Hydroxy-2-[2-(3-hydroxy-1-adamantyl)ethoxy]-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]acetamideIC505.1 [1]
(9R)-2-(2-Hydroxy-2-methylpropoxy)-4-(1-methylpyrazol-4-yl)-9-(trifluoromethyl)fluoren-9-olIC507.4 [1]
(9R)-4-[1-(2-Hydroxyethyl)pyrazol-4-yl]-2-(2-hydroxy-2-methylpropoxy)-9-(trifluoromethyl)fluoren-9-olIC506.7 [1]
4-[9-Hydroxy-4-(1-methylpyrazol-4-yl)-9-(trifluoromethyl)fluoren-2-yl]oxybutanoic acidIC5019.0 [1]
2-[4-[9-Hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]-2-methylpropane-1,3-diolIC5030.0 [1]
2-(Hydroxymethyl)-2-[4-[9-hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]propane-1,3-diolIC5031.0 [1]
2-Fluoro-4-[1-(2-hydroxyethyl)pyrazol-4-yl]-9-(trifluoromethyl)fluoren-9-olIC5020.0 [1]
(+)-3-[4-(9-Hydroxy-2-methyl-9-trifluoromethyl-9H-fluoren-4-yl)-pyrazol-1-yl]-propionic acidIC5026.0 [1]
4-[1-(2-Hydroxyethyl)pyrazol-4-yl]-2-methyl-9-(trifluoromethyl)fluoren-9-olIC5017.0 [1]
(+)-4-[4-(9-Hydroxy-2-methyl-9-trifluoromethyl-9H-fluoren-4-yl)-pyrazol-1-yl]-butyric acidIC5027.0 [1]
(+)-2-[4-(2-Fluoro-9-hydroxy-9-trifluoromethyl-9H-fluoren-4-yl)-pyrazol-1-yl]-propane-1,3-diolIC5022.0 [1]
2-(Hydroxymethyl)-2-[4-[9-hydroxy-2-methyl-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]propane-1,3-diolIC5019.0 [1]
2-[9-Hydroxy-4-(1-methylpyrazol-4-yl)-9-(trifluoromethyl)fluoren-2-yl]oxyacetamideIC5018.0 [1]
4-[9-Hydroxy-4-pyrimidin-5-yl-9-(trifluoromethyl)fluoren-2-yl]oxybutanoic acidIC5035.0 [1]
2-[4-[2-Fluoro-9-hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]-2-(hydroxymethyl)propane-1,3-diolIC5020.0 [1]
2-[4-[9-Hydroxy-2-methyl-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]propane-1,3-diolIC5019.0 [1]
2-[4-[2-Fluoro-9-hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]-2-methylpropane-1,3-diolIC5022.0 [1]
(-)-2-(1-Ethyl-1H-pyrazol-4-yl)-9-hydroxy-9-trifluoromethyl-9H-fluorene-4-carboxamideIC5020.0 [1]
[9-Hydroxy-4-[1-(2-hydroxyethyl)pyrazol-4-yl]-9-(trifluoromethyl)fluoren-2-yl]-pyrrolidin-1-ylmethanoneIC5020.0 [1]
2-[1-(2,2-Dimethylpropyl)pyrazol-4-yl]-4-(hydroxymethyl)-9-(trifluoromethyl)fluoren-9-olIC5017.0 [1]
2-[4-[2-(3,3-Dimethylbutyl)-9-hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]propane-1,3-diolIC5017.0 [1]
4-(Hydroxymethyl)-2-[1-(2-methylpropyl)pyrazol-4-yl]-9-(trifluoromethyl)fluoren-9-olIC5037.0 [1]
2-(5-Hydroxypentoxy)-4-(1-methylpyrazol-4-yl)-9-(trifluoromethyl)fluoren-9-olIC5031.0 [1]
1-[4-[4-Chloro-9-hydroxy-9-(trifluoromethyl)fluoren-2-yl]piperazin-1-yl]-2,2-dimethylpropan-1-oneIC5056.0 [1]
2-(5-Hydroxypentoxy)-4-pyrimidin-5-yl-9-(trifluoromethyl)fluoren-9-olIC5025.0 [1]
4-(Aminomethyl)-9-(trifluoromethyl)fluoren-9-olIC5010000.0 [1]
2-[4-[9-Hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]acetamideIC5039.0 [1]
[3-(2-Hydroxyethoxy)azetidin-1-yl]-[9-hydroxy-4-(1-methylpyrazol-4-yl)-9-(trifluoromethyl)fluoren-2-yl]methanoneIC5050.0 [1]
Tert-butyl N-[2-[9-hydroxy-9-(trifluoromethyl)fluoren-2-yl]oxyethyl]-N-methylcarbamateIC50203.0 [1]
1-(Azetidin-1-yl)-2-[9-hydroxy-4-[1-(2-hydroxyethyl)pyrazol-4-yl]-9-(trifluoromethyl)fluoren-2-yl]oxyethanoneIC5023.0 [1]
3-[2-[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]oxyethyl]-1,3-oxazinan-2-oneIC50168.0 [1]
3-[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]oxypropanoic acidIC505826.0 [1]
1-[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]-N-methylpiperidine-4-carboxamideIC503607.0 [1]
2-[1-(Cyclohexylmethyl)pyrazol-4-yl]-9-hydroxy-9-(trifluoromethyl)fluorene-4-carboxamideIC5015.0 [1]
4-(Methylamino)-9-(trifluoromethyl)fluoren-9-olIC5023099.0 [1]
4-(1-Hydroxyethyl)-2-[1-(2-hydroxyethyl)pyrazol-4-yl]-9-(trifluoromethyl)fluoren-9-olIC50513.0 [1]
4-[1-(2-Hydroxyethyl)pyrazol-4-yl]-2-methoxy-9-(trifluoromethyl)fluoren-9-olIC5039.0 [1]
9-Hydroxy-N-(4-hydroxybutyl)-4-pyrimidin-5-yl-9-(trifluoromethyl)fluorene-2-carboxamideIC50617.0 [1]
3-Methoxy-9-(trifluoromethyl)fluoren-9-olIC504909.0 [1]
N-[2-[4-[9-Hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]ethyl]-N-methylacetamideIC50197.0 [1]
4-Fluoro-9-(trifluoromethyl)fluoren-9-olIC506792.0 [1]
2-[5-[2-Fluoro-9-hydroxy-9-(trifluoromethyl)fluoren-4-yl]-1,3-oxazol-2-yl]propane-1,3-diolIC5079.0 [1]
Methyl 7-fluoro-9-hydroxy-9-(trifluoromethyl)fluorene-4-carboxylateIC5010000.0 [1]
1-[(2S)-2-(Hydroxymethyl)pyrrolidin-1-yl]-2-[9-hydroxy-9-(trifluoromethyl)fluoren-2-yl]oxyethanoneIC501225.0 [1]
2-[9-Hydroxy-4-[1-(2-hydroxyethyl)pyrazol-4-yl]-9-(trifluoromethyl)fluoren-2-yl]oxyacetamideIC5018.0 [1]
4-(1-Methyltetrazol-5-yl)-9-(trifluoromethyl)fluoren-9-olIC5010000.0 [1]
4-[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]benzamideIC50182.0 [1]
2-Ethyl-9-hydroxy-9-(trifluoromethyl)fluorene-4-carboxamideIC50560.0 [1]
Methyl 9-hydroxy-9-(trifluoromethyl)fluorene-2-carboxylateIC50571.0 [1]
Ethyl 5-[9-hydroxy-9-(trifluoromethyl)fluoren-2-yl]oxypentanoateIC50571.0 [1]
[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]-[3-(methylamino)pyrrolidin-1-yl]methanoneIC502192.0 [1]
N-[2-[9-Hydroxy-4-pyrimidin-5-yl-9-(trifluoromethyl)fluoren-2-yl]oxyethyl]-N-methylacetamideIC5023.0 [1]
4-[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]-N,N-dimethylbenzamideIC50182.0 [1]
Azetidin-1-yl-[5-hydroxy-2-methoxy-5-(trifluoromethyl)indeno[1,2-b]pyridin-3-yl]methanoneIC50803.0 [1]
2-Morpholin-4-yl-9-(trifluoromethyl)fluoren-9-olIC502113.0 [1]
1-[9-Hydroxy-9-(trifluoromethyl)fluorene-2-carbonyl]pyrrolidine-2-carboxylic acidIC5010000.0 [1]
[9-Hydroxy-4-(1-methylpyrazol-4-yl)-9-(trifluoromethyl)fluoren-2-yl]-[3-(hydroxymethyl)pyrrolidin-1-yl]methanoneIC5058.0 [1]
2-(4-Chlorophenyl)-9-(trifluoromethyl)fluoren-9-olIC501340.0 [1]
1-(2-Hydroxyethyl)-5-[[9-hydroxy-9-(trifluoromethyl)fluoren-2-yl]oxymethyl]pyrrolidin-2-oneIC50247.0 [1]
2-(Methylamino)-9-(trifluoromethyl)fluoren-9-olIC507831.0 [1]
Methyl 9-hydroxy-4-pyrimidin-5-yl-9-(trifluoromethyl)fluorene-2-carboxylateIC50178.0 [1]
4-[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]-N-methylbenzamideIC50216.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Pyruvate dehydrogenase kinase isoform 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/pyruvate-dehydrogenase-kinase-isoform-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Pyruvate dehydrogenase kinase isoform 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pyruvate-dehydrogenase-kinase-isoform-2-inhibitors-ic50-ki.
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