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Pyruvate dehydrogenase kinase isoform 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CID 86280454IC5010.0 [1], 35.0 [2], 573.0 [3]
CID 86280454Ki28.0 [1]
N-Benzyl-2,4-dihydroxy-N-[4-[methyl(quinoxalin-6-ylmethyl)carbamoyl]phenyl]benzamideIC5010.0 [1], 62.7 [2], 5650.0 [3]
N-Benzyl-2,4-dihydroxy-N-[4-[methyl(quinoxalin-6-ylmethyl)carbamoyl]phenyl]benzamideKi26.0 [1]
N-Benzyl-N-[4-(2-chloro-5-methylpyrimidin-4-yl)phenyl]-2,4-dihydroxybenzamideIC5010.0 [1], 72.0 [2], 1720.0 [3]
N-Benzyl-N-[4-(2-chloro-5-methylpyrimidin-4-yl)phenyl]-2,4-dihydroxybenzamideKi67.0 [1]
N-[4-(2-Chloro-5-methylpyrimidin-4-yl)phenyl]-2,4-dihydroxy-N-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]benzamideIC5010.0 [1], 101.0 [2], 2150.0 [3]
N-[4-(2-Chloro-5-methylpyrimidin-4-yl)phenyl]-2,4-dihydroxy-N-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]benzamideKi37.0 [1]
N-Benzyl-2,4-dihydroxy-N-[4-[(4-methoxyphenyl)methyl-methylcarbamoyl]phenyl]benzamideIC50100.0 [1], 201.0 [2], 10600.0 [3]
N-Benzyl-2,4-dihydroxy-N-[4-[(4-methoxyphenyl)methyl-methylcarbamoyl]phenyl]benzamideKi241.0 [1]
[(2S)-6-(2-Chloro-5-methylpyrimidin-4-yl)-2-methyl-3,4-dihydro-2H-quinolin-1-yl]-(2,4-dihydroxyphenyl)methanoneIC5063.0 [1], 2740.0 [2]
[(2S)-6-(2-Chloro-5-methylpyrimidin-4-yl)-2-methyl-3,4-dihydro-2H-quinolin-1-yl]-(2,4-dihydroxyphenyl)methanoneKi37.0 [1]
(2,4-Dihydroxyphenyl)-[(2S)-2-methyl-6-(3-methylquinolin-2-yl)-3,4-dihydro-2H-quinolin-1-yl]methanoneIC50139.0 [1], 2680.0 [2]
(2,4-Dihydroxyphenyl)-[(2S)-2-methyl-6-(3-methylquinolin-2-yl)-3,4-dihydro-2H-quinolin-1-yl]methanoneKi124.0 [1]
[(2S)-6-(2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2-methyl-3,4-dihydro-2H-quinolin-1-yl]-(2,4-dihydroxyphenyl)methanoneIC50135.0 [1], 1820.0 [2]
[(2S)-6-(2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2-methyl-3,4-dihydro-2H-quinolin-1-yl]-(2,4-dihydroxyphenyl)methanoneKi640.0 [1]
(2S)-1-(2,4-Dihydroxybenzoyl)-N,2-dimethyl-N-(quinoxalin-6-ylmethyl)-3,4-dihydro-2H-quinoline-6-carboxamideIC5036.0 [1], 3010.0 [2]
(2S)-1-(2,4-Dihydroxybenzoyl)-N,2-dimethyl-N-(quinoxalin-6-ylmethyl)-3,4-dihydro-2H-quinoline-6-carboxamideKi16.0 [1]
[(2S)-6-(2-Chlorothieno[3,2-d]pyrimidin-4-yl)-2-methyl-3,4-dihydro-2H-quinolin-1-yl]-(2,4-dihydroxyphenyl)methanoneIC50198.0 [1], 2780.0 [2]
[(2S)-6-(2-Chlorothieno[3,2-d]pyrimidin-4-yl)-2-methyl-3,4-dihydro-2H-quinolin-1-yl]-(2,4-dihydroxyphenyl)methanoneKi467.0 [1]
Dichloroacetic acidIC501025000.0 [1], 5100000.0 [2]
RadicicolIC50230000.0 [1], 400000.0 [2]
6-[2-[(E)-2-[4-(Morpholin-4-ylmethyl)phenyl]ethenyl]pyridin-4-yl]-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-oneIC502000.0 [1], 2200.0 [2]
N-Benzyl-2,4-dihydroxy-N-phenylbenzamideIC501000.0 [1]
N-Benzyl-2,4-dihydroxy-N-phenylbenzamideKi980.0 [1]
[(2R)-6-(2-Chloro-5-methylpyrimidin-4-yl)-2-pyridin-3-yl-3,4-dihydro-2H-quinolin-1-yl]-(2,4-dihydroxyphenyl)methanoneIC5015.0 [1], 5770.0 [2]
(3S)-3-Amino-4-[4-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-4-oxobutanamideIC502060.0 [1], 2540.0 [2]
6-[2-[(E)-2-[4-[2-(Dimethylamino)ethoxy]phenyl]ethenyl]pyridin-4-yl]-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-oneIC503300.0 [1], 3400.0 [2]
2,4-Dihydroxy-N-[4-(3-methylquinolin-2-yl)phenyl]-N-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]benzamideIC50100.0 [1]
TofacitinibIC5010000.0 [1]
Hexyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylateIC50300.0 [1]
DoramapimodIC5030000.0 [1]
SotrastaurinIC506700.0 [1]
2,2'-DithiobisbenzothiazoleIC50379.0 [1]
1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)ureaIC5010.0 [1]
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamideIC5010000.0 [1]
CID 10077147IC5065.0 [1]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC5010000.0 [1]
O6-Cyclohexylmethoxy-2-(4'-sulphamoylanilino) purineIC50800.0 [1]
LY-2090314IC506200.0 [1]
CID 16741245IC5041.0 [1]
Pha-793887IC5010000.0 [1]
4-[4-(4-Methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diolIC50648000.0 [1]
CID 44464263IC50421.0 [1]
(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dioneIC5010000.0 [1]
JNK Inhibitor VIIIKi3800.0 [1]
Dimorpholinethiuram disulfideKi462.0 [1]
Nms-P937 (nms1286937)IC5010000.0 [1]
3-Imidazo[1,2-a]pyridin-3-yl-4-[10-(morpholine-4-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]pyrrole-2,5-dioneIC5020000.0 [1]
CID 11634725Ki10000.0 [1]
CID 59604787IC503500.0 [1]
5-[2,4-Dihydroxy-6-(4-Nitrophenoxy)phenyl]-N-(1-Methylpiperidin-4-Yl)-1,2-Oxazole-3-CarboxamideIC5010.0 [1]
8-[2-Methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5010000.0 [1]
5-(2-Aminopyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamideIC5010000.0 [1]
B-Raf IN 1IC502000.0 [1]
3-(4-Imidazo[1,2-a]pyridin-3-yl-2,5-dioxopyrrol-3-yl)-N,N-dimethyl-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-10-carboxamideIC5020000.0 [1]
4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[4-(4-methylpiperazin-1-yl)but-1-ynyl]quinoline-3-carbonitrileIC505000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi3800.0 [1]
5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(piperidin-1-ylmethyl)phenyl]-1,2-oxazole-3-carboxamideIC5011900.0 [1]
(7S)-2-(2-Aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-oneIC504000.0 [1]
5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrileIC5010000.0 [1]
4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[2-(dimethylamino)ethyl]benzamideIC50100000.0 [1]
Pyrazolo[1,5-a]pyrimidine-3-carboxylateIC5010000.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi3482.0 [1]
(2s)-1-{[6-Furan-3-Yl-5-(3-Methyl-2h-Indazol-5-Yl)pyridin-3-Yl]oxy}-3-(1h-Indol-3-Yl)propan-2-AmineIC5050.0 [1]
4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamideIC50100000.0 [1]
4-[(2R,5S)-2,5-Dimethyl-4-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]piperazine-1-carbonyl]benzonitrileIC5066.0 [1]
3-Imidazo[1,2-a]pyridin-3-yl-4-[10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]pyrrole-2,5-dioneIC504300.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi3800.0 [1]
cis-3-(3-Azetidin-1-ylmethylcyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-ylamineIC5030000.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi3800.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi3800.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi3800.0 [1]
3-[(4-Morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[3,2-c]pyrazole-5-carboxamideIC50762.0 [1]
4-Chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diolIC5020000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
9-Cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamineIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC50136.0 [1]
4-(Cyclopentylamino)-2-[(2-methoxyphenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC5030000.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC5030000.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamideIC5030000.0 [1]
2-[(2,4-Dihydroxyphenyl)sulfonyl]-2,3-Dihydro-1h-Isoindole-4,6-DiolIC502100.0 [1]
N~2~-(1h-Benzimidazol-6-Yl)-N~4~-(5-Cyclobutyl-1h-Pyrazol-3-Yl)quinazoline-2,4-DiamineIC50420.0 [1]
N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3,5-difluorobenzamideIC5010000.0 [1]
Propan-2-yl 3-(4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxopyrrol-3-yl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-10-carboxylateIC506500.0 [1]
(2S)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-3-hydroxypropanamideIC5010000.0 [1]
(S)-1-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamideIC5010000.0 [1]
(R)-1-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamideIC5010000.0 [1]
(R)-2-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methylamino)propanamideIC5010000.0 [1]
3-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-(2-methoxyethyl)azetidine-3-carboxamideIC5010000.0 [1]
[(1S,3Ar,6E,9S,9aR,10R,11aS)-6-[[3-(dimethylamino)propyl-methylamino]methylidene]-1,5-dihydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4,7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-h]isochromen-10-yl] acetateIC50200000.0 [1]
(R)-2-(((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)(methyl)amino)propanamideIC5010000.0 [1]
(R)-1-((4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamideIC5010000.0 [1]
3-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-methylazetidine-3-carboxamideIC5010000.0 [1]
(S)-1-((4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamideIC5010000.0 [1]
3-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-propan-2-ylazetidine-3-carboxamideIC5010000.0 [1]
(S)-2-(((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)(methyl)amino)propanamideIC5010000.0 [1]
4-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-methylpiperidine-4-carboxamideIC5010000.0 [1]
(2R)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-N-methylpropanamideIC5010000.0 [1]
2-(((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)(methyl)amino)acetamideIC5010000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Pyruvate dehydrogenase kinase isoform 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/pyruvate-dehydrogenase-kinase-isoform-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Pyruvate dehydrogenase kinase isoform 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pyruvate-dehydrogenase-kinase-isoform-1-inhibitors-ic50-ki.
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