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Proto-oncogene tyrosine-protein kinase ROS Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
CrizotinibIC507.1 [1]
CrizotinibKi0.6 [1], 5.8 [2], 330.0 [3]
CeritinibIC502.0 [1], 141.8 [2], 2000.0 [3]
CeritinibKi0.4 [1], 0.7 [2], 230.0 [3]
StaurosporineIC500.07 [1], 0.2 [2], 1.0 [3]
ForetinibIC5010.0 [1]
ForetinibKi8.2 [1], 16.0 [2], 20.0 [3]
LorlatinibKi0.02 [1], 0.03 [2], 0.1 [3], 12.0 [4]
AlectinibKi2000.0 [1], 2400.0 [2], 3000.0 [3]
EntrectinibIC505.0 [1], 7.0 [2]
2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-[[(2S)-2-hydroxypropyl]amino]-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrileIC501.7 [1], 199.0 [2], 775.0 [3]
2-[4-[6-(3-Hydroxypropylamino)-2-pyridin-3-ylpyrimidin-4-yl]-3-(3-methoxy-5-methylphenyl)pyrazol-1-yl]acetonitrileIC50119.0 [1], 50900.0 [2]
2-[4-[6-(4-Hydroxybutylamino)-2-pyridin-3-ylpyrimidin-4-yl]-3-(3-methoxy-5-methylphenyl)pyrazol-1-yl]acetonitrileIC5056.0 [1], 33900.0 [2]
2-[3-(3-Methoxy-5-methylphenyl)-4-[6-(2-morpholin-4-ylethylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrileIC50148.0 [1], 57600.0 [2]
2-[3-(3-Methoxy-5-methylphenyl)-4-[6-(3-morpholin-4-ylpropylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrileIC5088.0 [1], 28400.0 [2]
2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-(3-hydroxypropylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrileIC50108.0 [1], 73400.0 [2]
2-[4-[6-(4-Hydroxybutylamino)-2-pyridin-3-ylpyrimidin-4-yl]-3-(3-hydroxy-5-methylphenyl)pyrazol-1-yl]acetonitrileIC5024.0 [1], 13600.0 [2]
2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-(2-morpholin-4-ylethylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrileIC50478.0 [1], 90900.0 [2]
2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-(3-morpholin-4-ylpropylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrileIC50183.0 [1], 55500.0 [2]
6-Ethyl-5-[(4-hydroxy-4-methylcyclohexyl)amino]-3-[3-methyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]pyrazine-2-carboxamideIC500.78 [1], 0.86 [2]
MitoxantroneIC502998.7 [1]
Staurosporine HClIC500.25 [1]
DoramapimodIC5030000.0 [1]
Nvp-tae 684IC502.0 [1]
BrigatinibIC501.9 [1]
Alk-IN-1IC501.9 [1]
GilteritinibIC501.9 [1]
Nms-P937 (nms1286937)IC5010000.0 [1]
CID 59604787IC5010000.0 [1]
Unii-76pnd635L1Ki0.02 [1]
6,6-Dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrileIC501000.0 [1]
5-Chloro-2-N-[2-methoxy-4-[4-[(4-methylpiperazin-1-yl)methyl]triazol-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamineIC501.1 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
N-[5-Amino-1-[(4-methoxyphenyl)methyl]pyrazol-4-yl]-5-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-2-methylbenzamideIC501.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
3-Methyl-5-[1-methyl-4-(6-morpholin-4-yl-2-pyridin-3-ylpyrimidin-4-yl)pyrazol-3-yl]phenolIC5013.6 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-olIC5010000.0 [1]
4-[6-[3-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]morpholineIC5059.1 [1]
1-[6-[3-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]azetidin-3-olIC50108.0 [1]
4-[[6-[3-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]amino]butan-1-olIC5063.8 [1]
(2S)-1-[[6-[3-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]amino]propan-2-olIC50241.0 [1]
4-[6-[5-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]morpholineIC50104.0 [1]
1-[6-[5-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]azetidin-3-olIC5074.2 [1]
4-[[6-[5-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]amino]butan-1-olIC50138.0 [1]
(2S)-1-[[6-[5-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]amino]propan-2-olIC50283.0 [1]
1-[6-[3-(3-Hydroxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]azetidin-3-olIC5086.5 [1]
3-[4-[6-(4-Hydroxybutylamino)-2-pyridin-3-ylpyrimidin-4-yl]-1-methylpyrazol-3-yl]-5-methylphenolIC50133.0 [1]
3-[4-[6-[[(2S)-2-Hydroxypropyl]amino]-2-pyridin-3-ylpyrimidin-4-yl]-1-methylpyrazol-3-yl]-5-methylphenolIC50105.0 [1]
3-Methyl-5-[2-methyl-4-(6-morpholin-4-yl-2-pyridin-3-ylpyrimidin-4-yl)pyrazol-3-yl]phenolIC5091.5 [1]
1-[6-[5-(3-Hydroxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]azetidin-3-olIC5056.6 [1]
3-[4-[6-(4-Hydroxybutylamino)-2-pyridin-3-ylpyrimidin-4-yl]-2-methylpyrazol-3-yl]-5-methylphenolIC5025.4 [1]
3-[4-[6-[[(2S)-2-Hydroxypropyl]amino]-2-pyridin-3-ylpyrimidin-4-yl]-2-methylpyrazol-3-yl]-5-methylphenolIC50139.0 [1]
2-[3-(3-Methoxy-5-methylphenyl)-4-[6-(2-methylpropylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrileIC50920.0 [1]
2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-(2-methylpropylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrileIC50780.0 [1]
6-[4-(2-Chloro-4-fluorophenyl)-2-methylpyrimidin-5-yl]-N-(3-methoxypropyl)-2-pyridin-3-ylpyrimidin-4-amineIC501330.0 [1]
6-[4-(2,4-Dichlorophenyl)-2-methylpyrimidin-5-yl]-N-(3-methoxypropyl)-2-pyridin-3-ylpyrimidin-4-amineIC50357.0 [1]
4-(2-Chloro-4-fluorophenyl)-2-methyl-5-(2-pyridin-3-ylpyridin-4-yl)pyrimidineIC50570.0 [1]
4-(2,4-Dichlorophenyl)-2-methyl-5-(2-pyridin-3-ylpyridin-4-yl)pyrimidineIC50330.0 [1]
4-[5-(3-Methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(4-methoxyphenyl)pyridineIC501250.0 [1]
N-[4-[4-[1-(Cyanomethyl)-5-(3-methoxy-5-methylphenyl)pyrazol-4-yl]pyridin-2-yl]phenyl]acetamideIC506250.0 [1]
4-[6-(Benzylamino)imidazo[1,2-B]pyridazin-3-Yl]benzonitrileIC50300.0 [1]
6-[(2r)-2-(3-Fluorophenyl)pyrrolidin-1-Yl]-3-(Pyridin-2-Yl)imidazo[1,2-B]pyridazineIC50600.0 [1]
2-[4-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acidIC5060.0 [1]
1-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-olIC50210.0 [1]
5-Chloro-2-N-[(E)-(3-methoxyphenyl)methylideneamino]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamineIC505.8 [1]
5-Chloro-2-N-[(E)-(4-methoxyphenyl)methylideneamino]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamineIC502.3 [1]
5-Chloro-4-N-(2-propan-2-ylsulfonylphenyl)-2-N-[(E)-[4-(trifluoromethyl)phenyl]methylideneamino]pyrimidine-2,4-diamineIC503.4 [1]
5-Chloro-4-N-(2-propan-2-ylsulfonylphenyl)-2-N-[(E)-[3-(trifluoromethyl)phenyl]methylideneamino]pyrimidine-2,4-diamineIC505.0 [1]
5-Chloro-2-N-[(E)-1-(4-fluorophenyl)ethylideneamino]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamineIC502.7 [1]
5-Chloro-2-N-[(E)-(4-fluorophenyl)methylideneamino]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamineIC501.8 [1]
5-Chloro-4-N-(2-propan-2-ylsulfonylphenyl)-2-N-[(E)-[4-(trifluoromethoxy)phenyl]methylideneamino]pyrimidine-2,4-diamineIC505.5 [1]
5-Chloro-2-N-[(E)-1-(4-methoxyphenyl)ethylideneamino]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamineIC504.7 [1]
4-Chloro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-isoquinolin-6-ylpyridin-2-yl]phenolIC50168.5 [1]
4-Fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenolIC501000.0 [1]
5-Fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenolIC501000.0 [1]
4-Chloro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenolIC50272.9 [1]
N-[2-[[5-Chloro-2-[[2-methoxy-6-(4-methylpiperazin-1-yl)pyridin-3-yl]amino]pyrimidin-4-yl]amino]phenyl]methanesulfonamideIC502300.0 [1]
N-[(3,5-Difluorophenyl)methyl]-3-[1-[2-[(1-methylpyrazol-4-yl)amino]pyridin-4-yl]oxyethyl]benzamideIC502400.0 [1]
N-[(4-Methylphenyl)methyl]-3-[1-[2-[(4-methylpiperazin-1-yl)amino]pyridin-4-yl]oxyethyl]benzamideIC5010000.0 [1]
N-[[4-Chloro-3-(trifluoromethyl)phenyl]methyl]-3-[1-[2-[(4-methylpiperazin-1-yl)amino]pyridin-4-yl]oxyethyl]benzamideIC509100.0 [1]
3-[1-[2-[(1,3-Dimethylpyrazol-4-yl)amino]pyridin-4-yl]oxyethyl]-N-[(4-methylphenyl)methyl]benzamideIC501400.0 [1]
N-[(4-Methylphenyl)methyl]-3-[1-[2-(pyrimidin-2-ylamino)pyridin-3-yl]oxyethyl]benzamideIC506200.0 [1]
N-[[4-Chloro-3-(trifluoromethyl)phenyl]methyl]-3-[1-[2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyridin-4-yl]oxyethyl]benzamideIC502300.0 [1]
N-[(4-Cyanophenyl)methyl]-3-[1-[2-[(1-methylpyrazol-4-yl)amino]pyridin-4-yl]oxyethyl]benzamideIC501500.0 [1]
3-[1-[2-[[1-(Cyanomethyl)pyrazol-4-yl]amino]pyridin-3-yl]oxyethyl]-N-[(4-methylphenyl)methyl]benzamideIC508700.0 [1]
N-[(4-Methylphenyl)methyl]-3-[1-[2-[(5-methyl-1,3-thiazol-2-yl)amino]pyridin-3-yl]oxyethyl]benzamideIC509400.0 [1]
N-[(3,4-Dimethoxyphenyl)methyl]-3-[1-[2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyridin-4-yl]oxyethyl]benzamideIC50570.0 [1]
N-[(4-Methylphenyl)methyl]-3-[1-[2-[(1-methylpyrazol-4-yl)amino]pyridin-4-yl]oxyethyl]benzamideIC501800.0 [1]
3-[1-[2-[[1-(2-Hydroxy-2-methylpropyl)pyrazol-4-yl]amino]pyridin-4-yl]oxyethyl]-N-[(4-methylphenyl)methyl]benzamideIC502400.0 [1]
N-[(3,4-Dimethoxyphenyl)methyl]-3-[1-[2-[(1-piperidin-4-ylpyrazol-4-yl)amino]pyridin-4-yl]oxyethyl]benzamideIC50370.0 [1]
N-[[4-Chloro-3-(trifluoromethyl)phenyl]methyl]-3-[1-[2-[[1-(2-hydroxy-2-methylpropyl)pyrazol-4-yl]amino]pyridin-4-yl]oxyethyl]benzamideIC508400.0 [1]
N-[(4-Methylphenyl)methyl]-3-[1-[2-(1,2,4-triazol-4-ylamino)pyridin-3-yl]oxyethyl]benzamideIC5010000.0 [1]
N-[(4-Methylphenyl)methyl]-3-[1-[2-(1,3,4-thiadiazol-2-ylamino)pyridin-3-yl]oxyethyl]benzamideIC5010000.0 [1]
3-[1-[2-(1H-Benzimidazol-2-ylamino)pyridin-4-yl]oxyethyl]-N-[(4-methylphenyl)methyl]benzamideIC5010000.0 [1]
N-[(4-Methylphenyl)methyl]-3-[1-[2-(3,4,5-trimethoxyanilino)pyridin-4-yl]oxyethyl]benzamideIC502400.0 [1]
N-[(4-Methylphenyl)methyl]-3-[1-[2-(1,3-thiazol-2-ylamino)pyridin-3-yl]oxyethyl]benzamideIC5010000.0 [1]
3-[1-[2-[[1-(2-Hydroxy-2-methylpropyl)pyrazol-4-yl]amino]pyridin-3-yl]oxyethyl]-N-[(4-methylphenyl)methyl]benzamideIC509400.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Proto-oncogene tyrosine-protein kinase ROS Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/proto-oncogene-tyrosine-protein-kinase-ros-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Proto-oncogene tyrosine-protein kinase ROS Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/proto-oncogene-tyrosine-protein-kinase-ros-inhibitors-ic50-ki.
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