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Proto-oncogene tyrosine-protein kinase MER Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1-[(trans-4-Aminocyclohexyl)methyl]-N-Butyl-3-(4-Fluorophenyl)-1h-Pyrazolo[3,4-D]pyrimidin-6-AmineIC502.9 [1], 141.0 [2]
1-[(trans-4-Aminocyclohexyl)methyl]-N-Butyl-3-(4-Fluorophenyl)-1h-Pyrazolo[3,4-D]pyrimidin-6-AmineKi4.3 [1]
2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineIC5011000.0 [1], 11300.0 [2]
4-[2-(Butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC500.46 [1], 0.74 [2], 2.7 [3]
4-[5-[4-[(4-Methyl-1,4-diazepan-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC500.6 [1], 2.4 [2], 13.8 [3]
Bms-777607IC5014.0 [1]
BemcentinibIC5015.0 [1], 700.0 [2]
Unii-T7755XP5Y6IC501.1 [1]
4-[[2-(Butylamino)-5-[5-(morpholin-4-ylmethyl)pyridin-2-yl]pyrimidin-4-yl]amino]cyclohexan-1-olIC501.7 [1], 9.8 [2]
2-(Butylamino)-4-[(4-hydroxycyclohexyl)amino]-N-[(4-imidazol-1-ylphenyl)methyl]pyrimidine-5-carboxamideIC504.3 [1], 22.0 [2]
1-[(4-Aminocyclohexyl)methyl]-N-methyl-3-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amineIC5018.0 [1]
1-[(4-Aminocyclohexyl)methyl]-N-methyl-3-phenylpyrazolo[3,4-d]pyrimidin-6-amineIC5056.0 [1], 180.0 [2]
1-[(4-Aminocyclohexyl)methyl]-N-butyl-3-(6-piperazin-1-ylpyridin-3-yl)pyrazolo[3,4-d]pyrimidin-6-amineIC501.8 [1]
1-[(4-Aminocyclohexyl)methyl]-N-butyl-3-(6-piperazin-1-ylpyridin-3-yl)pyrazolo[3,4-d]pyrimidin-6-amineKi2.7 [1]
1-[(4-Aminocyclohexyl)methyl]-N-butyl-3-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amineIC500.25 [1]
1-[(4-Aminocyclohexyl)methyl]-N-butyl-3-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amineKi0.73 [1]
1-[(4-Aminocyclohexyl)methyl]-N-(3-phenylpropyl)-3-(6-piperazin-1-ylpyridin-3-yl)pyrazolo[3,4-d]pyrimidin-6-amineIC500.76 [1]
1-[(4-Aminocyclohexyl)methyl]-N-(3-phenylpropyl)-3-(6-piperazin-1-ylpyridin-3-yl)pyrazolo[3,4-d]pyrimidin-6-amineKi1.4 [1]
1-[(4-Aminocyclohexyl)methyl]-N-(3-phenylpropyl)-3-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amineIC500.15 [1]
1-[(4-Aminocyclohexyl)methyl]-N-(3-phenylpropyl)-3-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amineKi0.56 [1]
4-[[6-(Methylamino)-3-phenylpyrazolo[3,4-d]pyrimidin-1-yl]methyl]cyclohexan-1-olIC50200.0 [1], 210.0 [2]
1-[(4-Aminocyclohexyl)methyl]-3-(4-fluorophenyl)-N-(3-phenylpropyl)pyrazolo[3,4-d]pyrimidin-6-amineIC503.0 [1]
1-[(4-Aminocyclohexyl)methyl]-3-(4-fluorophenyl)-N-(3-phenylpropyl)pyrazolo[3,4-d]pyrimidin-6-amineKi2.0 [1]
PaclitaxelIC504900.0 [1]
StaurosporineIC5083.0 [1]
CrizotinibIC50100.0 [1]
CID 53469448IC50474.0 [1]
1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)ureaIC501.0 [1]
MK-2461IC5024.0 [1]
CID 59604787IC5010000.0 [1]
4-Tert-Butyl-N-[6-(1h-Imidazol-1-Yl)imidazo[1,2-A]pyridin-2-Yl]benzamideIC506456.54 [1]
2-Amino-N-[3-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]phenyl]acetamideIC501000.0 [1]
Ripk1-IN-7IC5029.0 [1]
N-[2-(4-Methoxyanilino)-4-quinazolinyl]-N-methylamineIC502250.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
N-(4-Methoxyphenyl)-4-(morpholin-4-yl)quinazolin-2-amineIC502060.0 [1]
4-(Cyclopentylamino)-2-[(2-methoxyphenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC504680.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC501920.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamideIC50775.0 [1]
(7S)-7-Amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamideIC504.4 [1]
N-(4-Fluorophenyl)-4-(morpholin-4-yl)quinazolin-2-amineIC5030000.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
4-[5-[4-(Morpholin-4-ylmethyl)phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC503.2 [1]
4-[5-[3-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC504.9 [1]
4-[2-(Butylamino)-5-[4-(piperidin-4-ylamino)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC505.2 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2R)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5022.0 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-(pentan-2-ylamino)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC503.5 [1]
4-[2-[[(2S)-Heptan-2-yl]amino]-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC503.6 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC504.3 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2S)-1,1,1-trifluoropentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC501068.0 [1]
4-[2-(2-Methylbutylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC505.2 [1]
4-[2-(2-Ethylbutylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5019.0 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2R)-1,1,1-trifluoropentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5020.0 [1]
4-[2-[[(2S)-Hexan-2-yl]amino]-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC502.6 [1]
4-[5-[4-[[2-(Diethylamino)ethylamino]methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC502.5 [1]
4-[2-[[(2S)-Pentan-2-yl]amino]-5-[4-(piperidin-4-ylamino)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC504.9 [1]
4-[5-[4-(Cyclohexylamino)phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5072.0 [1]
4-[5-[4-(7-Azabicyclo[2.2.1]heptan-7-ylmethyl)phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC502.0 [1]
4-[5-[2-Fluoro-4-(4-methylpiperazin-1-yl)sulfonylphenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC503.5 [1]
4-[2-(Butylamino)-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5078.0 [1]
4-[2-(Butylamino)-5-[4-(4-methylpiperazin-1-yl)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC503.5 [1]
2-Fluoro-4-[8-fluoro-3-(quinolin-6-ylmethyl)imidazo[1,2-a]pyridin-6-yl]-N-methylbenzamideIC5010000.0 [1]
4-[6-(Benzylamino)imidazo[1,2-B]pyridazin-3-Yl]benzonitrileIC505400.0 [1]
2-[4-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acidIC504700.0 [1]
1-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-olIC505100.0 [1]
6-(1-Methylpyrazol-4-yl)-2-[[3-[[5-(1-methylpyrazol-4-yl)pyrimidin-2-yl]amino]phenyl]methyl]pyridazin-3-oneIC501000.0 [1]
2-N-(4-Methoxyphenyl)-2-N,4-N-dimethylquinazoline-2,4-diamineIC5010200.0 [1]
3-[[2-(4-Aminoanilino)quinazolin-4-yl]amino]propan-1-olIC5030000.0 [1]
2-N-(4-Methoxyphenyl)-2-N-methyl-4-N-propylquinazoline-2,4-diamineIC501840.0 [1]
4-[[4-(Cyclopentylamino)quinazolin-2-yl]amino]benzonitrileIC5030000.0 [1]
2-N-(4-Aminophenyl)-4-N-cyclopentylquinazoline-2,4-diamineIC507270.0 [1]
4-[[4-(3-Hydroxypropylamino)quinazolin-2-yl]amino]benzonitrileIC501720.0 [1]
4-N-(4-Morpholin-4-ylquinazolin-2-yl)benzene-1,4-diamineIC5030000.0 [1]
2-N-(4-Methoxyphenyl)-2-N-methyl-4-N-(oxan-4-ylmethyl)quinazoline-2,4-diamineIC5030000.0 [1]
4-N-Cyclopentyl-2-N-(4-methoxyphenyl)-2-N-methylquinazoline-2,4-diamineIC501140.0 [1]
3-[[2-(4-Methoxy-N-methylanilino)quinazolin-4-yl]amino]propan-1-olIC502010.0 [1]
N-(4-Methoxyphenyl)-N-methyl-4-morpholin-4-ylquinazolin-2-amineIC5030000.0 [1]
6-[Difluoro-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinolineIC501000.0 [1]
18-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,13,15,21-tetrazatricyclo[12.5.2.017,20]henicosa-14,16,18,20-tetraen-5-olIC501.8 [1]
19-Pyridin-2-yl-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC5054.0 [1]
19-(4-Fluorophenyl)-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC50150.0 [1]
(6S)-6-Amino-20-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1,8,15,17,23-pentazatricyclo[14.5.2.019,22]tricosa-16,18,20,22-tetraen-7-oneIC502.2 [1]
19-(4-Methoxyphenyl)-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC5086.0 [1]
19-Pyridin-3-yl-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC5013.0 [1]
19-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC503.0 [1]
17-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,12,14,20-tetrazatricyclo[11.5.2.016,19]icosa-13,15,17,19-tetraen-6-olIC508.0 [1]
19-(Oxan-4-yl)-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC5094.0 [1]
N-[4-(6-Hydroxy-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-19-yl)phenyl]morpholine-4-carboxamideIC5030.0 [1]
19-(3-Methoxyphenyl)-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC50160.0 [1]
[4-(6-Hydroxy-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-19-yl)phenyl]-morpholin-4-ylmethanoneIC508.1 [1]
19-Phenyl-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC50140.0 [1]
18-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,13,15,21-tetrazatricyclo[12.5.2.017,20]henicosa-14,16,18,20-tetraen-6-olIC504.0 [1]
19-(2-Methoxyphenyl)-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC50170.0 [1]
19-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-5-olIC509.6 [1]
16-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,11,13,19-tetrazatricyclo[10.5.2.015,18]nonadeca-12,14,16,18-tetraen-5-olIC504.1 [1]
20-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,15,17,23-tetrazatricyclo[14.5.2.019,22]tricosa-16,18,20,22-tetraen-7-olIC503.1 [1]
16-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,6,11,13,19-pentazatricyclo[10.5.2.015,18]nonadeca-12,14,16,18-tetraen-5-oneIC5065.0 [1]
18-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,13,15,21-tetrazatricyclo[12.5.2.017,20]henicosa-14,16,18,20-tetraen-7-olIC504.1 [1]
(5S)-5-Amino-19-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1,7,14,16,22-pentazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-oneIC5017.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Proto-oncogene tyrosine-protein kinase MER Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/proto-oncogene-tyrosine-protein-kinase-mer-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Proto-oncogene tyrosine-protein kinase MER Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/proto-oncogene-tyrosine-protein-kinase-mer-inhibitors-ic50-ki.
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