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Proteinase activated receptor 4 Inhibitors (IC50, Ki)

Structure
Compound Name
Standard Type
Standard Values (in nM)
2-Methoxy-6-[4-(trifluoromethyl)phenyl]imidazo[2,1-b][1,3,4]thiadiazoleIC5011.2 [1], 15.49 [2], 346.74 [3], 398.0 [4]
6-(4-Chlorophenyl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC5039.81 [1], 286.0 [2], 616.6 [3], 621.0 [4]
2-Methoxy-6-[4-(trifluoromethoxy)phenyl]imidazo[2,1-b][1,3,4]thiadiazoleIC5026.9 [1], 26.92 [2], 229.09 [3], 352.0 [4]
2-Methoxy-6-[1-methyl-5-(trifluoromethoxy)indol-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC5019.95 [1], 20.89 [2], 977.24 [3], 1000.0 [4]
2-Methoxy-6-[6-methoxy-4-[(2-phenyl-1,3-thiazol-4-yl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC500.0 [1], 0.02 [2], 4.7 [3], 5.0 [4]
2-Methoxy-6-[3-(trifluoromethyl)phenyl]imidazo[2,1-b][1,3,4]thiadiazoleIC5036.31 [1], 1318.26 [2]
6-(3,4-Dichlorophenyl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC5028.18 [1], 1445.44 [2]
6-[4-Fluoro-3-(trifluoromethyl)phenyl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC5069.18 [1], 1096.48 [2]
6-[4-(Difluoromethoxy)phenyl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC5083.18 [1], 2511.89 [2]
6-(3-Chlorophenyl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC5072.44 [1], 10000.0 [2]
6-[3,5-Bis(trifluoromethyl)phenyl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC5052.48 [1], 5623.41 [2]
2-Methoxy-6-[6-methoxy-4-[(3-phenylmethoxyphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC502.42 [1], 24.74 [2]
6-(1-Benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC501.69 [1], 58.8 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[(6-methylpyridin-2-yl)methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC509.23 [1], 101.0 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[(2,3,4-trifluorophenyl)methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC501.64 [1], 86.15 [2]
6-[4-[[3-[(4-Fluorophenyl)methoxy]phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC501.68 [1], 146.9 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[(2-methylphenyl)methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC502.42 [1], 38.32 [2]
6-[4-[(3-Fluoro-5-phenylmethoxyphenyl)methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC500.76 [1], 85.66 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[(3-methylphenyl)methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC501.77 [1], 54.98 [2]
6-[4-[[3-[(2,3-Dimethoxyphenyl)methoxy]phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC502.25 [1], 10.53 [2]
2-Methoxy-6-[6-methoxy-4-[[3-(pyridin-2-ylmethoxy)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC509.2 [1], 124.0 [2]
6-[4-[[3-[(2-Fluorophenyl)methoxy]phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC501.92 [1], 36.47 [2]
5-Tert-butyl-2-(2-ethylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1,3-benzoxazoleIC50574.9 [1], 30000.0 [2]
6-(4,6-Dimethoxy-3-methyl-1-benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC503.91 [1], 2326.0 [2]
6-(4,6-Dimethoxy-1-benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC500.99 [1], 200.0 [2]
2-(2-Methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-4-methyl-1,3-benzoxazoleIC5031.98 [1], 30000.0 [2]
5-Fluoro-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1,3-benzoxazoleIC5049.57 [1], 30000.0 [2]
5-(2-Methylbutan-2-yl)-2-(2-methylsulfanylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1,3-benzoxazoleIC50107.0 [1], 30000.0 [2]
2-(2-Methylsulfanylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-6-propan-2-yloxy-1,3-benzoxazoleIC5079.93 [1], 30000.0 [2]
2-(2-Methylsulfanylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-4-propan-2-yloxy-1,3-benzoxazoleIC5028.42 [1], 30000.0 [2]
6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1,3-benzoxazoleIC5015.37 [1], 9164.0 [2]
2-(2-Methylsulfanylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-4-[(3-phenylmethoxyphenyl)methoxy]-1,3-benzoxazoleIC5039.38 [1], 5275.0 [2]
2-Bromo-6-[4-(2-methoxyethoxy)-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC50120.8 [1], 30000.0 [2]
6-[4-[[3-[(2-Chloropyridin-4-yl)methoxy]phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC503.93 [1], 75.51 [2]
[3-[[6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]phenyl] benzoateIC501.65 [1], 33.33 [2]
2-(1,1-Difluoroethyl)-6-[6-methoxy-4-[(3-phenylmethoxyphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC502.74 [1], 579.3 [2]
6-[4-[[3-[[3-Fluoro-5-(trifluoromethyl)phenyl]methoxy]phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC501.66 [1], 108.8 [2]
2-Bromo-6-[4-[(4-fluorophenyl)methoxy]-6-methoxy-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC50195.4 [1], 30000.0 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[(3-phenoxyphenyl)methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC505.05 [1], 568.0 [2]
2-(1,1-Difluoroethyl)-6-[4-[(4-fluorophenyl)methoxy]-6-methoxy-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC5055.61 [1], 30000.0 [2]
6-[4-[[3-[[2-Fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC504.17 [1], 93.28 [2]
2-Ethoxy-6-[6-methoxy-4-[(3-phenylmethoxyphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC502.26 [1], 3083.0 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[(4-phenoxyphenyl)methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC502.27 [1], 3413.0 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC500.59 [1], 4.95 [2]
2-[(1S)-1-Fluoroethyl]-6-[6-methoxy-4-[(3-phenylmethoxyphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC501.12 [1], 462.5 [2]
6-[4-[[3-[(4-Tert-butylphenyl)methoxy]phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC5035.88 [1], 2502.0 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[[4-(trifluoromethoxy)phenyl]methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC503.68 [1], 615.9 [2]
6-[4-[[3-[(3,5-Dichlorophenyl)methoxy]phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC507.27 [1], 677.0 [2]
2-Methoxy-6-[6-methoxy-4-[[3-(pyridin-3-ylmethoxy)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC502.14 [1], 66.22 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[[2-(2-phenylethyl)phenyl]methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC5010.51 [1], 5818.0 [2]
6-[4-[[3-[[3,5-Di(propan-2-yloxy)phenyl]methoxy]phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC507.56 [1], 6910.0 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC502.54 [1], 95.63 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[(3-methoxy-5-phenylmethoxyphenyl)methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC507.63 [1], 2495.0 [2]
6-[4-[[3-[(2-Chloro-6-fluorophenyl)methoxy]phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC505.3 [1], 150.8 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[(3-phenylmethoxyphenyl)methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC508.68 [1], 594.2 [2]
6-[5-Benzyl-6-methoxy-4-[[3-[(3-methylphenyl)methoxy]phenyl]methoxy]-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC5041.47 [1], 2399.0 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[(4-methoxyphenyl)methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC501.44 [1], 105.3 [2]
6-[4-Fluoro-6-[(3-phenylmethoxyphenyl)methoxy]-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC504.81 [1], 73.23 [2]
6-[6-Ethoxy-4-[(3-phenylmethoxyphenyl)methoxy]-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC504.56 [1], 566.3 [2]
6-[4-[(4-Fluorophenyl)methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methylsulfanylimidazo[2,1-b][1,3,4]thiadiazoleIC5023.01 [1], 2955.0 [2]
6-[4,6-Bis(phenylmethoxy)-1-benzofuran-2-yl]-2-methylsulfanylimidazo[2,1-b][1,3,4]thiadiazoleIC50114.2 [1], 30000.0 [2]
6-[4-[(4-Fluorophenyl)methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC505.68 [1], 3189.0 [2]
2-(2-Ethoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1,3-benzothiazoleIC501777.0 [1], 30000.0 [2]
6-(4-Bromo-7-methoxy-1-benzofuran-2-yl)-2-methylsulfanylimidazo[2,1-b][1,3,4]thiadiazoleIC5049.58 [1], 5630.0 [2]
6-[4,6-Bis(phenylmethoxy)-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC50112.9 [1], 30000.0 [2]
6-(1-Benzofuran-2-yl)-2-bromoimidazo[2,1-b][1,3,4]thiadiazoleIC5055.28 [1], 16700.0 [2]
5-[3-[[6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]phenyl]pyridine-2-carbonitrileIC501.74 [1], 4.91 [2]
6-[4-[[3-(5-Fluoro-6-methylpyridin-2-yl)phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC500.57 [1], 2773.0 [2]
2-Methoxy-6-[6-methoxy-4-[[3-(5-methoxypyridin-2-yl)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC500.47 [1], 2.86 [2]
2-Methoxy-6-[6-methoxy-4-[[3-(1,2-thiazol-4-yl)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC501.03 [1], 65.88 [2]
2-Methoxy-6-[6-methoxy-4-[[3-(5-methoxypyrazin-2-yl)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC501.48 [1], 3.63 [2]
4-[5-[3-[[6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]phenyl]pyridin-2-yl]morpholineIC504.81 [1], 2670.0 [2]
Tert-butyl 5-[3-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]phenyl]pyridine-2-carboxylateIC504.18 [1], 81.35 [2]
2-(1,1-Difluoroethyl)-6-[6-methoxy-4-[(3-pyrimidin-5-ylphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC504.04 [1], 2426.0 [2]
2-(1,1-Difluoroethyl)-6-[4-[[3-(6-fluoropyridin-3-yl)phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC503.37 [1], 2230.0 [2]
2-Methoxy-6-[6-methoxy-4-[[3-methoxy-5-(2-methoxypyrimidin-5-yl)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC500.5 [1], 3.61 [2]
4-((3-(Furan-3-yl)benzyl)oxy)-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazoleIC5022.13 [1], 4996.0 [2]
6-[4-[[3-(3,6-Dihydro-2H-pyran-4-yl)phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC500.71 [1], 105.1 [2]
6-[4-[[2-(2-Fluoropyridin-4-yl)pyrimidin-4-yl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC500.36 [1], 2.97 [2]
4-[6-[[2-[2-[(1S)-1-Fluoroethyl]imidazo[2,1-b][1,3,4]thiadiazol-6-yl]-6-methoxy-1-benzofuran-4-yl]oxymethyl]pyridin-2-yl]oxan-4-olIC500.41 [1], 87.64 [2]
4-[4-[[6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]pyrimidin-2-yl]-N,N-dimethylbenzamideIC500.29 [1], 1.67 [2]
2-Methoxy-6-[6-methoxy-4-[[2-(4-methoxyphenyl)pyrimidin-4-yl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC500.76 [1], 1.8 [2]
2-Methoxy-6-[6-methoxy-4-[[3-[3-(trifluoromethyl)phenyl]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC504.35 [1], 4459.0 [2]
6-[4-[[3-(1,3-Benzodioxol-5-yl)phenyl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC503.5 [1], 68.19 [2]
N-[(1R)-2-[(2S)-2-[[2-(2-Methylsulfanylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1,3-benzoxazol-4-yl]oxymethyl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]benzamideIC50401.0 [1], 30000.0 [2]
6-[7-Chloro-6-methoxy-4-[(3-phenylmethoxyphenyl)methoxy]-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC50512.6 [1], 3266.0 [2]
6-[4-[(3-Chloro-5-phenylmethoxyphenyl)methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC506.2 [1], 150.8 [2]
2-Methoxy-6-[6-methoxy-4-[(3-methoxy-5-phenylmethoxyphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC502.44 [1], 22.5 [2]
2-Chloro-6-[6-methoxy-4-[(3-phenylmethoxyphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazoleIC504.69 [1], 544.3 [2]
6-(6,7-Dimethoxy-1-benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC501801.0 [1], 30000.0 [2]
2-(2-Methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1,3-benzothiazoleIC50351.2 [1], 30000.0 [2]
6-(7-Methoxy-1-benzofuran-2-yl)-2-methylsulfanylimidazo[2,1-b][1,3,4]thiadiazoleIC508.68 [1], 9436.0 [2]
6-(6,7-Dimethoxy-3-methyl-1-benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC501662.0 [1], 30000.0 [2]
2-(2-Ethylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-6-methoxy-1,3-benzoxazoleIC50220.4 [1], 30000.0 [2]
2-(2-Ethylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-5,6-difluoro-1,3-benzoxazoleIC5066.57 [1], 30000.0 [2]
6-(7-Methyl-1-benzofuran-2-yl)-2-methylsulfanylimidazo[2,1-b][1,3,4]thiadiazoleIC50216.7 [1], 8756.0 [2]
6-(7-Ethoxy-1-benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazoleIC50149.1 [1], 30000.0 [2]
6-(5-Methoxy-1-benzofuran-2-yl)-2-methylsulfanylimidazo[2,1-b][1,3,4]thiadiazoleIC50368.6 [1], 30000.0 [2]
1h-Indole-2-methanol, 1-methyl-5-nitro-3-phenyl-IC50140.0 [1]
Ethyl 4-(1-benzylindazol-3-yl)benzoateIC50130.0 [1]



References

This online tool may be cited as follows

MLA

"Quest Database™ Proteinase activated receptor 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc.21 Dec2024https://www.aatbio.com/data-sets/proteinase-activated-receptor-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024December 21). Quest Database™ Proteinase activated receptor 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/proteinase-activated-receptor-4-inhibitors-ic50-ki.
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