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Protein Wnt-3a Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
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▼
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-oneIC5078.0 [1]
8-(3-Chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-oneIC507.0 [1]
Nvp-tnks656IC503.5 [1]
2-[4-(Trifluoromethyl)phenyl]-3h-Quinazolin-4-OneIC501670.0 [1]
N-[(4-Oxo-3,4-Dihydroquinazolin-2-Yl)methyl]-3-Phenyl-N-(Thiophen-2-Ylmethyl)propanamideIC50937.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)acetamideIC503.6 [1]
2-(4-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydroquinazolin-4(3H)-oneIC501410.0 [1]
2-(4-Chlorophenyl)-7,8-dihydro-3H-pyrano[4,3-D]pyrimidin-4(5H)-oneIC504430.0 [1]
2-(4-Methoxyphenyl)-7,8-dihydro-3H-pyrano[4,3-D]pyrimidin-4(5H)-oneIC505050.0 [1]
2-(4-(Trifluoromethyl)phenyl)-5,6-dihydro-3H-pyrano[3,4-D]pyrimidin-4(8H)-oneIC5018100.0 [1]
2-(4-(Trifluoromethoxy)phenyl)-7,8-dihydro-3H-pyrano[4,3-D]pyrimidin-4(5H)-oneIC501220.0 [1]
2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-3H-pyrano[4,3-D]pyrimidin-4(5H)-oneIC502650.0 [1]
2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-3H-thiopyrano[3,2-D]pyrimidin-4(6H)-oneIC501720.0 [1]
2-(4-Bromophenyl)-7,8-dihydro-3H-pyrano[4,3-D]pyrimidin-4(5H)-oneIC504140.0 [1]
2-(Thiophen-3-YL)-7,8-dihydro-3H-pyrano[4,3-D]pyrimidin-4(5H)-oneIC508090.0 [1]
2-(4-(2-Hydroxypropan-2-YL)phenyl)-7,8-dihydro-3H-pyrano[4,3-D]pyrimidin-4(5H)-oneIC501030.0 [1]
Methyl 4-(4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-D]pyrimidin-2-YL)benzoateIC503000.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-propylacetamideIC5034.0 [1]
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenyl-N-(thiophen-2-ylmethyl)propanamideIC501920.0 [1]
2-[(Thiophen-2-ylmethylamino)methyl]-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-oneIC5050000.0 [1]
2-(P-Tolyl)-7,8-dihydro-3H-pyrano[4,3-D]pyrimidin-4(5H)-oneIC504630.0 [1]
2-[4-(Dimethylamino)phenyl]-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-oneIC504210.0 [1]
3-(4-Fluorophenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC50483.0 [1]
3-(2-Fluorophenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC50304.0 [1]
3-(3-Fluorophenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC506610.0 [1]
3-(2-Hydroxyphenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC503770.0 [1]
3-(3-Hydroxyphenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC50812.0 [1]
3-(4-Hydroxyphenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC501350.0 [1]
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-pyridin-4-yl-N-(thiophen-2-ylmethyl)propanamideIC508250.0 [1]
N-Ethyl-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenylpropanamideIC5050000.0 [1]
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenyl-N-(thiophen-3-ylmethyl)propanamideIC508540.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5040.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(pyridin-2-ylmethyl)acetamideIC5052.0 [1]
N-(Cyclopropylmethyl)-2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5017.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-(2-methylpropyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5017.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-methyl-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC50193.0 [1]
N-Benzyl-2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5065.0 [1]
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-pyridin-3-yl-N-(thiophen-2-ylmethyl)propanamideIC5041000.0 [1]
N-Ethyl-2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5070.0 [1]
2-(4-Methylsulfonylphenyl)-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-oneIC506290.0 [1]
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenylpropanamideIC5050000.0 [1]
4-Chloro-5-Cyano-N-{2-[4-(4-Fluorobenzoyl)piperidin-1-Yl]ethyl}-2-MethoxybenzamideIC501100.0 [1]
2-(4-(Trifluoromethyl)phenyl)-4A,5,7,7A-tetrahydrothieno[3,4-D]pyrimidin-4(3H)-oneIC505040.0 [1]
Items per page: 1 - 10 of 43
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References

This online tool may be cited as follows

MLA

"Quest Database™ Protein Wnt-3a Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/protein-wnt-3a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Protein Wnt-3a Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-wnt-3a-inhibitors-ic50-ki.
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