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Protein tyrosine kinase 2 beta Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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▼
Standard Values (in nM)
▲
▼
CID 11598628IC5011.0 [1], 31.0 [2], 63.0 [3]
PF-00562271 free baseIC5013.0 [1], 14.0 [2]
4-[[4-[[(1R,2R)-2-(Dimethylamino)cyclopentyl]amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-N-methylbenzenesulfonamideIC5088.0 [1], 140.0 [2], 154.0 [3]
4-N-[(1R,2R)-2-(Dimethylamino)cyclopentyl]-2-N-(4-methylsulfonylphenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamineIC5060.0 [1], 95.0 [2]
8-(4-Ethylphenyl)-5-Methyl-2,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-DioxideIC506800.0 [1], 9000.0 [2], 10000.0 [3]
DoramapimodIC50400.0 [1], 11500.0 [2]
1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[5-(pyridin-3-yloxymethyl)-1H-pyrazol-3-yl]ureaIC50637.0 [1]
1-Ethyl-8-(4-Ethylphenyl)-5-Methyl-1,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-DioxideIC5030000.0 [1]
N-[5-(6,7-Dimethoxyquinolin-4-yl)oxypyridin-2-yl]-4-(methylamino)-2-oxo-1-phenylpyridine-3-carboxamideIC5035.0 [1], 110.0 [2]
N-[5-(6,7-Dimethoxyquinolin-4-yl)oxypyridin-2-yl]-2-oxo-1-phenyl-5-thiophen-2-ylpyridine-3-carboxamideIC5053.0 [1], 1120.0 [2]
5-Benzyl-N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-2-oxo-1-phenylpyridine-3-carboxamideIC5049.0 [1], 310.0 [2]
4-N-[(1R,2R)-2-(Dimethylamino)cyclopentyl]-2-N-[4-(N,S-dimethylsulfonimidoyl)phenyl]-5-(trifluoromethyl)pyrimidine-2,4-diamineIC5067.0 [1], 98.0 [2]
4-N-[(1R,2R)-2-(Dimethylamino)cyclopentyl]-2-N-[4-(S-methyl-N-propan-2-ylsulfonimidoyl)phenyl]-5-(trifluoromethyl)pyrimidine-2,4-diamineIC5022.0 [1], 34.0 [2]
4-N-[(1R,2R)-2-(Dimethylamino)cyclopentyl]-2-N-[4-(methylsulfonimidoyl)phenyl]-5-(trifluoromethyl)pyrimidine-2,4-diamineIC5065.0 [1], 320.0 [2]
N-Cyclopropyl-4-[[4-[[(1R,2R)-2-(dimethylamino)cyclopentyl]amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzenesulfonamideIC5095.0 [1], 140.0 [2]
4-N-[(1R,2R)-2-(Dimethylamino)cyclopentyl]-2-N-[4-(N-ethyl-S-methylsulfonimidoyl)phenyl]-5-(trifluoromethyl)pyrimidine-2,4-diamineIC5037.0 [1], 63.0 [2]
CID 70692073IC5021.0 [1], 24.0 [2]
BosutinibIC50134.0 [1]
6-DimethylaminopurineKi10000.0 [1]
Tyrphostin A23Ki162.18 [1]
Met Kinase InhibitorKi10.47 [1]
LorlatinibIC5014.0 [1]
CID 11612883IC501000.0 [1]
O6-Cyclohexylmethoxy-2-(4'-sulphamoylanilino) purineKi10000.0 [1]
Cdk2 Inhibitor IIKi10000.0 [1]
7-Butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazineKi933.25 [1]
N-(4-Tert-Butylbenzyl)-1,5-Dimethyl-1,5-Dihydropyrazolo[4,3-C][2,1]benzothiazin-8-Amine 4,4-DioxideIC5010000.0 [1]
CID 59604787IC5010000.0 [1]
Unii-76pnd635L1IC5012.0 [1]
PF-562271 besylateIC5014.0 [1]
(3E)-3-[(4-Hydroxyphenyl)methylidene]-1-[(3E)-3-[(4-hydroxyphenyl)methylidene]-2-oxo-3a,4-dihydrocyclopenta[b]indol-1-yl]cyclopenta[b]indol-2-oneKi10000.0 [1]
4-N-[(1R,2R)-2-(Dimethylamino)cyclopentyl]-2-N-(2,2-dioxo-1,3-dihydro-2,1-benzothiazol-5-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamineIC5050.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
5-[[4-[[(1R,2R)-2-(Dimethylamino)cyclopentyl]amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-oneIC5053.0 [1]
5-Fluoro-2-[[(1S)-1-(5-fluoropyridin-2-yl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrileIC50129.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
N-[5-[(Z)-(5-Fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-3-(4-methylpiperazin-1-yl)propanamideKi340.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
N2-(1-Methyl-1H-indol-5-yl)-N4-(pyridin-2-ylmethyl)-5-(trifluoromethyl)pyrimidine-2,4-diamineIC501200.0 [1]
5-(4-(Benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)indolin-2-oneIC50120.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
6-(4-(Pyridin-2-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-oneIC50210.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
4-(2-Methoxyethylamino)-N-[5-(7-methoxyquinolin-4-yl)oxypyridin-2-yl]-2-oxo-1-phenylpyridine-3-carboxamideIC50120.0 [1]
16-Methylsulfonyl-26-(trifluoromethyl)-2,10,16,18,24,28,29-heptazapentacyclo[23.3.1.13,7.06,10.017,22]triaconta-1(28),3(30),4,6,17(22),18,20,25(29),26-nonaen-11-oneIC503.1 [1]
16,16-Dioxo-26-(trifluoromethyl)-16lambda6-thia-2,10,15,18,24,28,29-heptazapentacyclo[23.3.1.13,7.06,10.017,22]triaconta-1(28),3(30),4,6,17(22),18,20,25(29),26-nonaen-11-oneIC503.5 [1]
16-Ethylsulfonyl-26-(trifluoromethyl)-2,10,16,24,28,29-hexazapentacyclo[23.3.1.13,7.06,10.017,22]triaconta-1(28),3(30),4,6,17,19,21,25(29),26-nonaen-11-oneIC501.9 [1]
N-[4-[[[2-(3-Bromo-4-morpholin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-methylamino]methyl]pyridin-3-yl]-N-prop-2-enylmethanesulfonamideIC506625.0 [1]
24-Methyl-16-methylsulfonyl-26-(trifluoromethyl)-2,10,16,24,28,29-hexazapentacyclo[23.3.1.13,7.06,10.017,22]triaconta-1(28),3(30),4,6,17,19,21,25(29),26-nonaen-11-oneIC501.5 [1]
N-[3-[[[2-(3-Bromoanilino)-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]-N-prop-2-enylmethanesulfonamideIC50122.0 [1]
5-[2-[[[2-(2,3-Dihydro-1H-indol-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-yl]-methylamino]methyl]-N-methylsulfonylanilino]pentanoic acidIC50201.0 [1]
15-Methylsulfonyl-25-(trifluoromethyl)-2,10,15,17,23,27,28-heptazapentacyclo[22.3.1.13,7.06,10.016,21]nonacosa-1(27),3(29),4,6,16(21),17,19,24(28),25-nonaen-11-oneIC5030.0 [1]
16-Methylsulfonyl-6-(trifluoromethyl)-2,4,8,14,16,25-hexazatetracyclo[18.3.1.13,7.010,15]pentacosa-1(23),3,5,7(25),10(15),11,13,20(24),21-nonaeneIC500.67 [1]
5-[2-[[[2-(2,3-Dihydro-1H-indol-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]-N-ethylsulfonylanilino]pentanoic acidIC50256.0 [1]
18-Methylsulfonyl-28-(trifluoromethyl)-2,10,18,20,26,30,31-heptazahexacyclo[25.3.1.13,7.112,16.06,10.019,24]tritriaconta-1(30),3(33),4,6,12,14,16(32),19(24),20,22,27(31),28-dodecaen-11-oneIC5026.0 [1]
N-[3-[[[2-(3-Bromo-4-morpholin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]-N-prop-2-enylmethanesulfonamideIC5019.5 [1]
4-[(18E)-8-Methyl-16-methylsulfonyl-6-(trifluoromethyl)-2,4,8,13,16,25-hexazatetracyclo[18.3.1.13,7.010,15]pentacosa-1(24),3,5,7(25),10(15),11,13,18,20,22-decaen-21-yl]morpholineIC502.7 [1]
4-[(18E)-8-Methyl-16-methylsulfonyl-6-(trifluoromethyl)-2,4,8,14,16,25-hexazatetracyclo[18.3.1.13,7.010,15]pentacosa-1(24),3,5,7(25),10(15),11,13,18,20,22-decaen-21-yl]morpholineIC501.55 [1]
(18E)-16-Methylsulfonyl-6-(trifluoromethyl)-2,4,8,14,16,25-hexazatetracyclo[18.3.1.13,7.010,15]pentacosa-1(23),3,5,7(25),10(15),11,13,18,20(24),21-decaeneIC502.6 [1]
16-Methylsulfonyl-26-(trifluoromethyl)-2,10,16,24,28,29-hexazapentacyclo[23.3.1.13,7.06,10.017,22]triaconta-1(28),3(30),4,6,17,19,21,25(29),26-nonaen-11-oneIC500.9 [1]
4-[(18E)-16-Methylsulfonyl-6-(trifluoromethyl)-2,4,8,14,16,25-hexazatetracyclo[18.3.1.13,7.010,15]pentacosa-1(24),3,5,7(25),10(15),11,13,18,20,22-decaen-21-yl]morpholineIC500.84 [1]
4-[16-Methylsulfonyl-6-(trifluoromethyl)-2,4,8,14,16,25-hexazatetracyclo[18.3.1.13,7.010,15]pentacosa-1(24),3,5,7(25),10(15),11,13,20,22-nonaen-21-yl]morpholineIC501.31 [1]
1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[5-(6-oxo-1H-pyridin-3-yl)-1H-pyrazol-3-yl]ureaIC50141.0 [1]
1-[4-(6-Amino-9h-Purin-9-Yl)phenyl]-3-[3-Tert-Butyl-1-(4-Methylphenyl)-1h-Pyrazol-5-Yl]ureaIC50414.0 [1]
5-(4-(3-(Methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)indolin-2-oneIC501100.0 [1]
5-(4-(Pyridin-2-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)indolin-2-oneIC50680.0 [1]
N-Methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamideIC50190.0 [1]
5-(4-(2-(Methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)indolin-2-oneIC5015.0 [1]
N-[5-(4-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamideIC503184.0 [1]
4-N-[(1R,2R)-2-(Dimethylamino)cyclopentyl]-2-N-(1,1-dioxo-2,3-dihydro-1-benzothiophen-5-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamineIC5067.0 [1]
N2-(1H-Indazol-5-yl)-N4-(pyridin-2-ylmethyl)-5-(trifluoromethyl)pyrimidine-2,4-diamineIC50600.0 [1]
5-(4-(Pyridin-2-ylmethylamino)pyrimidin-2-ylamino)indolin-2-oneIC5010000.0 [1]
5-(5-Methyl-4-(pyridin-2-ylmethylamino)pyrimidin-2-ylamino)indolin-2-oneIC503000.0 [1]
5-(5-Chloro-4-(pyridin-2-ylmethylamino)pyrimidin-2-ylamino)indolin-2-oneIC501000.0 [1]
5-(5-Bromo-4-(pyridin-2-ylmethylamino)pyrimidin-2-ylamino)indolin-2-oneIC50580.0 [1]
2-(2-Oxoindolin-5-ylamino)-4-(pyridin-2-ylmethylamino)pyrimidine-5-carbonitrileIC501800.0 [1]
5-(4-(2-(Pyrrolidin-1-ylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)indolin-2-oneIC5017.0 [1]
5-[[4-[[(3R)-2-Oxoazepan-3-yl]amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-oneIC5049.0 [1]
7-[[4-(Cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3,4,5-tetrahydro-1-benzazepin-2-oneIC5033.0 [1]
N-Methyl-N-[2-[[[2-[(1-oxo-2,3-dihydroisoindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamideIC505.0 [1]
7-[[4-[[(1R,2R)-2-(Dimethylamino)cyclopentyl]amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2,3,4,5-tetrahydro-2-benzazepin-1-oneIC50143.0 [1]
4-N-[(1R,2R)-2-(Dimethylamino)cyclopentyl]-2-N-(2-methyl-1,1-dioxo-3H-1,2-benzothiazol-5-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamineIC5025.0 [1]
N-Methyl-N-[2-[[[2-(4-methylsulfonylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamideIC5035.0 [1]
1-[4-[[4-[[(1R,2R)-2-(Dimethylamino)cyclopentyl]amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-11-yl]ethanoneIC506.0 [1]
N-[2-[[[2-[(2,2-Dioxo-1,3-dihydro-2,1-benzothiazol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]phenyl]-N-methylmethanesulfonamideIC502.0 [1]
N-Methyl-N-[2-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide;hydrochlorideIC5031.0 [1]
1-Benzyl-N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-4-(methylamino)-2-oxopyridine-3-carboxamideIC50170.0 [1]
4-Anilino-N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-2-oxo-1-phenylpyridine-3-carboxamideIC501500.0 [1]
N-[5-(6,7-Dimethoxyquinolin-4-yl)oxypyridin-2-yl]-4-(4-methylpiperazin-1-yl)-2-oxo-1-phenylpyridine-3-carboxamideIC502800.0 [1]
N-[5-(6,7-Dimethoxyquinolin-4-yl)oxypyridin-2-yl]-4-(2-methoxyethylamino)-2-oxo-1-phenylpyridine-3-carboxamideIC5050.0 [1]
N-[5-(6,7-Dimethoxyquinolin-4-yl)oxypyridin-2-yl]-4-(oxan-4-ylamino)-2-oxo-1-phenylpyridine-3-carboxamideIC5044.0 [1]
N-[5-(6,7-Dimethoxyquinolin-4-yl)oxypyridin-2-yl]-4-(dimethylamino)-2-oxo-1-phenylpyridine-3-carboxamideIC50200.0 [1]
N-[5-(7-Methoxyquinolin-4-yl)oxypyridin-2-yl]-2-oxo-1-phenyl-5-pyridin-3-ylpyridine-3-carboxamideIC50430.0 [1]
N-[5-(6,7-Dimethoxyquinolin-4-yl)oxypyridin-2-yl]-2-oxo-1-phenyl-5-pyridin-3-ylpyridine-3-carboxamideIC5033.0 [1]
N-[5-(7-Methoxyquinolin-4-yl)oxypyridin-2-yl]-2-oxo-1-phenyl-5-pyrazin-2-ylpyridine-3-carboxamideIC501000.0 [1]
2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideIC501000.0 [1]
1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[5-(4-methoxy-2-methylphenyl)-1H-pyrazol-3-yl]ureaIC501200.0 [1]
7-[[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]-N-propan-2-yl-1H-indole-2-carboxamideIC5078.0 [1]
1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-(5-imidazo[1,2-a]pyridin-6-yl-1H-pyrazol-3-yl)ureaIC5025.0 [1]
1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-(5-quinolin-6-yl-1H-pyrazol-3-yl)ureaIC506.4 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Protein tyrosine kinase 2 beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/protein-tyrosine-kinase-2-beta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Protein tyrosine kinase 2 beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-tyrosine-kinase-2-beta-inhibitors-ic50-ki.
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