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Protein phosphatase 2C beta Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
(1R,2R,6S,7R)-4,10-Dioxatricyclo[5.2.1.02,6]decane-3,5-dioneIC50570.0 [1], 1980.0 [2], 5310.0 [3]
CantharidinIC50430.0 [1], 1780.0 [2]
Cyanoginosin LAIC500.3 [1], 3.0 [2]
(2R)-2-[[(2S,3S,4E,6E,8S,9S)-3-Acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]amino]propanoic acidIC501000.0 [1], 25000.0 [2]
Okadaic acidIC50126.0 [1]
(1R,2S,6R,7S)-5-Ethoxy-4,10-dioxatricyclo[5.2.1.02,6]decan-3-oneIC50746000.0 [1]
(1R,2S,6R,7S)-5-Propoxy-4,10-dioxatricyclo[5.2.1.02,6]decan-3-oneIC501000000.0 [1]
(1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monopropyl esterIC504820.0 [1]
(1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monomethyl esterIC504710.0 [1]
(1R,2S,6R,7S)-5-Methoxy-4,10-dioxatricyclo[5.2.1.02,6]decan-3-oneIC501000000.0 [1]
(1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monoethyl esterIC502960.0 [1]
(2S)-2-[(3As,4R,7S,7aR)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-3-(4-hydroxyphenyl)propanoic acidIC50570000.0 [1]
(2S,5R)-1-[(2S,3S,4E,6E,8S,9S)-3-Acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]pyrrolidine-2,5-dicarboxylic acidIC5050000.0 [1]
(2R)-2-[(3Ar,4S,7R,7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]propanoic acidIC501000000.0 [1]
Exo-cis-7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic acid benzyl esterIC50100000.0 [1]
[(1S,2R,6S,7R,8R)-3,5-Dioxo-4,10-dioxatricyclo[5.2.1.02,6]decan-8-yl]methyl benzoateIC5025000.0 [1]
Methyl (2S)-1-[(2S,3S,4E,6E,8S,9S)-3-acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]pyrrolidine-2-carboxylateIC50100000.0 [1]
(2S)-2-[[(2S,3S,4E,6E,8S,9S)-3-Acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]amino]propanoic acidIC50170000.0 [1]
(2S,4R)-1-[(2S,3S,4E,6E,8S,9S)-3-Acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]pyrrolidine-2,4-dicarboxylic acidIC50100000.0 [1]
(2R,4R)-1-[(2S,3S,4E,6E,8S,9S)-3-Acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]-4-tri(propan-2-yl)silyloxypyrrolidine-2-carboxylic acidIC50100000.0 [1]
(2R)-2-[[(2S,3S,4E,6E)-3-Acetamido-7-(2-benzylphenyl)-2,6-dimethylhepta-4,6-dienoyl]amino]propanoic acidIC50100000.0 [1]
N-[(2S,3S,4E,6E,8S,9S)-9-Methoxy-2,6,8-trimethyl-1-oxo-10-phenyl-1-pyrrolidin-1-yldeca-4,6-dien-3-yl]acetamideIC50100000.0 [1]
(2R,4S)-1-[(2S,3S,4E,6E,8S,9S)-3-Acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]pyrrolidine-2,4-dicarboxylic acidIC50100000.0 [1]
(2S,5S)-1-[(2S,3S,4E,6E,8S,9S)-3-Acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]pyrrolidine-2,5-dicarboxylic acidIC5050000.0 [1]
2-[[(2S,3S,4E,6E,8S,9S)-3-Acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]amino]acetic acidIC505600.0 [1]
(2S)-1-[(2S,3S,4E,6E,8S,9S)-3-Acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]pyrrolidine-2-carboxylic acidIC50100000.0 [1]
Methyl (2R)-1-[(2S,3S,4E,6E,8S,9S)-3-acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]pyrrolidine-2-carboxylateIC50100000.0 [1]
(2R,4R)-1-[(2S,3S,4E,6E,8S,9S)-3-Acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]pyrrolidine-2,4-dicarboxylic acidIC50100000.0 [1]
2-[[(2S,3S,4E,6E,8S,9S)-3-Acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]-(carboxymethyl)amino]acetic acidIC50100000.0 [1]
(2R)-1-[(2S,3S,4E,6E,8S,9S)-3-Acetamido-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl]pyrrolidine-2-carboxylic acidIC5055000.0 [1]
(2R)-2-[[(2S,3S,4E,6E)-3-Acetamido-2,6-dimethyl-7-(4-phenylphenyl)hepta-4,6-dienoyl]amino]propanoic acidIC50100000.0 [1]
(2R)-2-[[(2S,3S,4E,6E)-3-Acetamido-2,6-dimethyl-10-phenyldeca-4,6-dienoyl]amino]propanoic acidIC50100000.0 [1]
(2S)-2-[(3Ar,4S,7R,7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-3-phenylpropanoic acidIC501000000.0 [1]
(2S)-2-[(3As,4R,7S,7aR)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]propanoic acidIC501000000.0 [1]
(2R)-2-[(3Ar,4S,7R,7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-3-methylsulfanylpropanoic acidIC501000000.0 [1]
(2R)-2-[(3As,4R,7S,7aR)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]pentanedioic acidIC5095000.0 [1]
(2R)-2-[(3Ar,4S,7R,7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-3-phenylpropanoic acidIC501000000.0 [1]
(2R,3S)-2-[(3Ar,4S,7R,7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-3-methylpentanoic acidIC501000000.0 [1]
(2S)-2-[(3Ar,4S,7R,7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-4-methylpentanoic acidIC501000000.0 [1]
(2R)-2-[(3Ar,4S,7R,7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-4-methylpentanoic acidIC501000000.0 [1]
(2S)-2-[(3Ar,4S,7R,7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-3-(1H-indol-3-yl)propanoic acidIC50312000.0 [1]
(2R)-2-[(3Ar,4S,7R,7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-3-(1H-indol-3-yl)propanoic acidIC50770000.0 [1]
(2S,3S)-2-[(3Ar,4S,7R,7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-3-methylpentanoic acidIC501000000.0 [1]
(2S)-2-[(3Ar,4S,7R,7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-3-(1H-imidazol-5-yl)propanoic acidIC502820.0 [1]
(2R)-2-[(3As,4R,7S,7aR)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-3-(4-hydroxyphenyl)propanoic acidIC50101000.0 [1]
(2S,4R,4As,6R,8aR)-2-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,2'-oxolane]-4-olIC501000000.0 [1]
(1S,4R)-3-[(3-Carboxyphenyl)carbamoyl]-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acidIC5013000.0 [1]
(1S,4R)-3-[(3-Methoxycarbonylphenyl)carbamoyl]-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acidIC5060000.0 [1]
(1S,4R)-3-[(4-Ethoxycarbonylphenyl)carbamoyl]-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acidIC5076000.0 [1]
(1S,4R)-3-[(4-Ethoxycarbonylphenyl)carbamoyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acidIC5029000.0 [1]
Methyl (1S,4R)-3-[(4-chlorophenyl)carbamoyl]-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylateIC50100000.0 [1]
2-[(1R,6R,7S)-3,5-Dioxo-4,10-dioxatricyclo[5.2.1.02,6]dec-8-en-1-yl]acetonitrileIC50100000.0 [1]
N-[[(1S,2R,7R)-3,5-Dioxo-4,10-dioxatricyclo[5.2.1.02,6]decan-1-yl]methyl]acetamideIC50100000.0 [1]
N-[[(1S,2R,7R)-3,5-Dioxo-4,10-dioxatricyclo[5.2.1.02,6]dec-8-en-1-yl]methyl]acetamideIC50100000.0 [1]
(1S,4R)-3-[(3-Methoxycarbonylphenyl)carbamoyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acidIC5016000.0 [1]
(1S,4R)-3-[(4-Chlorophenyl)carbamoyl]-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acidIC5049000.0 [1]
(1S,4R)-3-(Dimethylcarbamoyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid;N-methylmethanamineIC5018000.0 [1]
Methanamine;(1S,4R)-3-(methylcarbamoyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acidIC50100000.0 [1]
(2R)-3-[(2S,6R,8S,11R)-2-[(E,2R)-4-[(2S,2'R,4R,4As,6R,8aR)-4-hydroxy-2-(hydroxymethyl)-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-11-hydroxy-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-hydroxy-2-methylpropanoic acidIC5094000.0 [1]
(2R)-2-[(3Ar,4S,7R,7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydro-4,7-epoxyisoindol-2-yl]-3-(1H-imidazol-5-yl)propanoic acidIC503220.0 [1]
Items per page: 1 - 10 of 60
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References

This online tool may be cited as follows

MLA

"Quest Database™ Protein phosphatase 2C beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/protein-phosphatase-2c-beta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Protein phosphatase 2C beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-phosphatase-2c-beta-inhibitors-ic50-ki.
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