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Protein Mdm4 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Nutlin-3AIC504300.0 [1], 6000.0 [2]
Nvp-cgm097IC502000.0 [1], 2100.0 [2]
Nutlin-3BIC501000.0 [1]
6-Chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acidKi36000.0 [1]
Methyl 2-[2-chloro-6-ethoxy-4-[(Z)-(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]phenoxy]acetateIC50847.4 [1]
[6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-phenylimidazol-4-yl]-1H-indol-2-yl]-[(3S)-3-[3-(dimethylamino)propyl-methylamino]pyrrolidin-1-yl]methanoneIC5019700.0 [1]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acidIC5030000.0 [1]
7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-oneIC5019320.0 [1]
2-[(2R,5R,6R)-4-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acidIC50100000.0 [1]
2-[2-[[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl]-1,3-thiazol-5-yl]acetic acidIC50100000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-amino-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoic acidIC508000.0 [1]
5-[[1-(4-Chlorophenyl)-2,5-diphenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dioneIC504200.0 [1]
5-[[1-(4-Nitrophenyl)-2,5-diphenylpyrrol-3-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dioneIC50630.0 [1]
(2S)-2-(3,3-Diphenylpropanoylamino)-3-phenylpropanoic acidIC50140.0 [1]
4-[6-[6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-(4-fluorophenyl)imidazol-4-yl]-1H-indole-2-carbonyl]oxyhexylamino]-4-oxobutanoic acidKi26300.0 [1]
Ethyl 6-chloro-3-[1-[(4-chlorophenyl)methyl]-3-phenylindol-2-yl]-1H-indole-2-carboxylateKi60000.0 [1]
2-(6-Chloro-1H-indol-3-yl)-1-[(4-chlorophenyl)methyl]-3-phenylindoleKi60000.0 [1]
Ethyl 6-chloro-3-[3-(4-chlorophenyl)-1-[(4-chlorophenyl)methyl]indol-2-yl]-1H-indole-2-carboxylateKi60000.0 [1]
Ethyl 6-chloro-3-[1-[(4-chlorophenyl)methyl]-3-(4-fluorophenyl)indol-2-yl]-1H-indole-2-carboxylateKi5000.0 [1]
6-Chloro-3-[1-[(4-chlorophenyl)methyl]-3-phenylindol-2-yl]-1H-indole-2-carboxylic acidKi200.0 [1]
6-Chloro-3-[1-[(4-chlorophenyl)methyl]-3-(4-fluorophenyl)indol-2-yl]-1H-indole-2-carboxylic acidKi1500.0 [1]
6-Chloro-3-[1-[(4-chlorophenyl)methyl]-3-phenylindol-2-yl]-N-(2-morpholin-4-ylethyl)-1H-indole-2-carboxamideKi6090.0 [1]
2-[5-[(Z)-(6-Chloro-7-methylindol-3-ylidene)methyl]-4-hydroxy-2-oxo-1H-imidazol-3-yl]-2-(3,4-difluorophenyl)-N-(1,3-dihydroxypropan-2-yl)acetamideIC5025.0 [1]
3-[3-[[4-[(2-Bromophenyl)methoxy]phenyl]methyl]-5-(4-fluorophenyl)imidazol-4-yl]-6-chloro-1H-indole-2-carboxylic acidKi4170.0 [1]
(2S)-3-[4-[3-(Pyridin-2-ylamino)propoxy]phenyl]-2-(3,3,3-triphenylpropanoylamino)propanoic acidIC504.6 [1]
(2S)-2-(3-Phenylbutanoylamino)-3-[4-[3-(pyridin-2-ylamino)propoxy]phenyl]propanoic acidIC503.3 [1]
Ethyl 6-chloro-3-[(cyclohexylmethylamino)-[1-[[4-[(2-fluorophenyl)methoxy]phenyl]methyl]tetrazol-5-yl]methyl]-1H-indole-2-carboxylateKi6990.0 [1]
(2S)-2-(3,3-Diphenylpropanoylamino)-3-(4-phenylmethoxyphenyl)propanoic acidIC5055.8 [1]
4-[[[6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-(4-fluorophenyl)imidazol-4-yl]-1H-indole-2-carbonyl]amino]methyl]benzoic acidKi14700.0 [1]
(2S)-3-(4-Aminophenyl)-2-(3,3-diphenylpropanoylamino)propanoic acidIC50207.4 [1]
6-Chloro-3-[3-[[4-[(3,5-difluorophenyl)methoxy]phenyl]methyl]-5-(4-fluorophenyl)imidazol-4-yl]-1H-indole-2-carboxylic acidKi4400.0 [1]
6-Chloro-3-[[1-(4-chlorophenyl)tetrazol-5-yl]-(cyclohexylmethylamino)methyl]-1H-indole-2-carboxylic acidKi44000.0 [1]
Ethyl 6-chloro-3-[(cyclohexylmethylamino)-[1-(4-propan-2-ylphenyl)tetrazol-5-yl]methyl]-1H-indole-2-carboxylateKi55000.0 [1]
[6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-(4-fluorophenyl)imidazol-4-yl]-1H-indol-2-yl]-(4-morpholin-4-ylpiperidin-1-yl)methanoneKi35300.0 [1]
Methyl (2S)-2-(3,3-diphenylpropanoylamino)-3-(4-hydroxyphenyl)propanoateIC5022.8 [1]
4-[6-[6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-(4-fluorophenyl)imidazol-4-yl]-1H-indole-2-carbonyl]oxyhexoxy]-4-oxobutanoic acidKi9750.0 [1]
(2S)-2-(3,3-Diphenylpropanoylamino)-3-(4-hydroxyphenyl)propanoic acidIC50214.5 [1]
6-Chloro-3-[[1-[[4-[(2-fluorophenyl)methoxy]phenyl]methyl]tetrazol-5-yl]-(pentylamino)methyl]-1H-indole-2-carboxylic acidKi4290.0 [1]
2-Morpholin-4-ylethyl 6-chloro-3-[3-[(4-chlorophenyl)methyl]-5-(4-fluorophenyl)imidazol-4-yl]-1H-indole-2-carboxylateKi40200.0 [1]
(2S)-2-(3,3-Diphenylpropanoylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acidIC50401.0 [1]
6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-(4-fluorophenyl)imidazol-4-yl]-N-[2-(diethylamino)ethyl]-1H-indole-2-carboxamideKi27400.0 [1]
6-Chloro-3-[5-(4-fluorophenyl)-3-[[4-[(3,4,5-trifluorophenyl)methoxy]phenyl]methyl]imidazol-4-yl]-1H-indole-2-carboxylic acidKi4710.0 [1]
(2S)-3-(4-Chlorophenyl)-2-(3,3-diphenylpropanoylamino)propanoic acidIC5010.7 [1]
(2S)-2-(3,3-Diphenylpropanoylamino)-3-[4-[3-(pyridin-2-ylamino)propoxy]phenyl]propanoic acidIC506.1 [1]
Methyl (2S)-3-(4-hydroxyphenyl)-2-(3,3,3-triphenylpropanoylamino)propanoateIC5010.4 [1]
(2R)-2-(3,3-Diphenylpropanoylamino)-3-(4-hydroxyphenyl)propanoic acidIC50136.4 [1]
6-Chloro-3-[3-[[4-[(3,4-dichlorophenyl)methoxy]phenyl]methyl]-5-(4-fluorophenyl)imidazol-4-yl]-1H-indole-2-carboxylic acidKi6760.0 [1]
4-[2-[6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-(4-fluorophenyl)imidazol-4-yl]-1H-indole-2-carbonyl]oxyethylamino]-4-oxobutanoic acidKi12400.0 [1]
Ethyl 6-chloro-3-[[1-(4-chlorophenyl)tetrazol-5-yl]-(cyclohexylmethylamino)methyl]-1H-indole-2-carboxylateKi46000.0 [1]
(2S)-2-(3,3-Diphenylpropanoylamino)-3-(4-nitrophenyl)propanoic acidIC5087.9 [1]
[6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-(4-fluorophenyl)imidazol-4-yl]-1H-indol-2-yl]-(4-methylpiperazin-1-yl)methanoneKi29600.0 [1]
6-Chloro-3-[3-[(3,4-difluorophenyl)methyl]-5-(4-fluorophenyl)imidazol-4-yl]-1H-indole-2-carboxylic acidKi4910.0 [1]
Ethyl 6-chloro-3-[(cyclopentylamino)-[1-(3-phenylmethoxyphenyl)tetrazol-5-yl]methyl]-1H-indole-2-carboxylateKi16170.0 [1]
(3S)-3-[[2-[[3-(Diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-oxo-4-[[(1S)-1-phenylethyl]amino]butanoic acidIC501000.0 [1]
(3S)-4-Anilino-3-[[2-[[3-(diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-oxobutanoic acidIC501000.0 [1]
(3S)-4-[(4-Chlorophenyl)methylamino]-3-[[2-[[3-(diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-oxobutanoic acidIC50302.0 [1]
(3S)-4-(Benzhydrylamino)-3-[[2-[[3-(diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-oxobutanoic acidIC5077.4 [1]
(3S)-3-[[2-[[3-(Diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-oxo-4-[(4-phenylphenyl)methylamino]butanoic acidIC501000.0 [1]
(3S)-3-[[2-[[3-(Diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-oxo-4-[(3-phenylphenyl)methylamino]butanoic acidIC501000.0 [1]
(3S)-3-[[2-[[3-(Diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-(2-naphthalen-2-ylethylamino)-4-oxobutanoic acidIC5057.5 [1]
(3S)-3-[[2-[[3-(Diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-oxo-4-[[(1R)-1-phenylethyl]amino]butanoic acidIC5012.1 [1]
(3S)-3-[[2-[[3-(Diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-[2-(1H-indol-3-yl)ethylamino]-4-oxobutanoic acidIC501000.0 [1]
(3S)-3-[[2-[[3-(Diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-[(4-methoxyphenyl)methylamino]-4-oxobutanoic acidIC501000.0 [1]
(3S)-3-[[2-[[3-(Diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-oxo-4-(2-phenylethylamino)butanoic acidIC50219.0 [1]
(3S)-4-(Benzylamino)-3-[[2-[[3-(diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-oxobutanoic acidIC50836.0 [1]
(3S)-3-[[2-[[3-(Diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-(naphthalen-1-ylamino)-4-oxobutanoic acidIC5081.9 [1]
(3S)-3-[[2-[[3-(Diaminomethylideneamino)benzoyl]amino]acetyl]amino]-4-(2,2-diphenylethylamino)-4-oxobutanoic acidIC50812.0 [1]
(5Z)-2,6-Dihydroxy-5-{[1-(4-nitrophenyl)-2,5-diphenyl-1H-pyrrol-3-yl]methylidene}pyrimidin-4(5H)-oneIC50680.0 [1]
6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-phenylimidazol-4-yl]-1H-indoleIC5022000.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-(3-phenylpropylcarbamoyl)amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-(4-methylpentylcarbamoyl)amino]-4-(carbamoylamino)pentanoic acidIC5096000.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[2-(4-bromophenyl)ethylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-(4-methylpentylcarbamoyl)amino]-4-(carbamoylamino)pentanoic acidIC5041000.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-(4-methylpentylcarbamoyl)amino]-4-(carbamoylamino)pentanoic acidIC5024000.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-methylphenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-(4-methylpentylcarbamoyl)amino]-4-(carbamoylamino)pentanoic acidIC5036000.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-nitrophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-(4-methylpentylcarbamoyl)amino]-4-(carbamoylamino)pentanoic acidIC5059000.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-methoxyphenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-(4-methylpentylcarbamoyl)amino]-4-(carbamoylamino)pentanoic acidIC50100000.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-(5-methylhexylcarbamoyl)amino]-4-(carbamoylamino)pentanoic acidIC5013000.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-(3-phenylpropylcarbamoyl)amino]-4-(carbamoylamino)pentanoic acidIC5020000.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-[3-(4-methoxyphenyl)propylcarbamoyl]amino]-4-(carbamoylamino)pentanoic acidIC5012000.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-[3-(4-nitrophenyl)propylcarbamoyl]amino]-4-(carbamoylamino)pentanoic acidIC508100.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-(carbamoylamino)pentanoic acidIC507500.0 [1]
(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-Amino-1-[[(2S)-1-[[(2S,3R)-1-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoic acidIC50100.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-[3-[1-[3-[[[6-amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-[2-(carbamoylamino)-4-carboxybutyl]carbamoyl]amino]propyl]cyclohexyl]propylcarbamoyl]amino]-4-(carbamoylamino)pentanoic acidIC506500.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-[3-[1-[3-[[[6-amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-(4-carboxybutyl)carbamoyl]amino]propyl]cyclohexyl]propylcarbamoyl]amino]-4-[(2-phenylacetyl)amino]pentanoic acidIC507600.0 [1]
4-[[6-Amino-2-[22-[6-amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-14,20-bis(2-carboxyethyl)-11,16,18,23-tetraoxo-17-prop-2-enyl-10,12,15,17,19,22,24-heptazaspiro[5.21]heptacosan-12-yl]hexyl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]-5-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]pentanoic acidIC5010000.0 [1]
4-[[6-Amino-2-[22-[6-amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-14,20-bis(2-carboxyethyl)-17-(cyclohexylmethyl)-11,16,18,23-tetraoxo-10,12,15,17,19,22,24-heptazaspiro[5.21]heptacosan-12-yl]hexyl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]-5-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]pentanoic acidIC508000.0 [1]
5-[[6-Amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-[3-[1-[3-[[[6-amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-[4-carboxy-2-[[(2S)-pyrrolidine-2-carbonyl]amino]butyl]carbamoyl]amino]propyl]cyclohexyl]propylcarbamoyl]amino]-4-formamidopentanoic acidIC5010000.0 [1]
4-[[6-Amino-2-[18-[6-amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-14,16-bis(2-carboxyethyl)-15-(4-methylpentanoyl)-11,19-dioxo-10,12,15,18,20-pentazaspiro[5.17]tricosan-12-yl]hexyl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]-5-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]pentanoic acidIC504100.0 [1]
4-[[6-Amino-2-[18-[6-amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-14,16-bis(2-carboxyethyl)-15-(3-cyclohexylpropanoyl)-11,19-dioxo-10,12,15,18,20-pentazaspiro[5.17]tricosan-12-yl]hexyl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]-5-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]pentanoic acidIC507500.0 [1]
4-[[6-Amino-2-[22-[6-amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-fluorophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-14,20-bis(2-carboxyethyl)-17-(2-methylpropyl)-11,16,18,23-tetraoxo-10,12,15,19,22,24-hexazaspiro[5.21]heptacosan-12-yl]hexyl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]-5-[(3-amino-3-oxopropyl)-(3-phenylpropylcarbamoyl)amino]pentanoic acidIC502700.0 [1]
4-[[6-Amino-2-[22-[6-amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-methylphenyl)ethylcarbamoyl]amino]hexan-2-yl]-14,20-bis(2-carboxyethyl)-17-(2-methylpropyl)-11,16,18,23-tetraoxo-10,12,15,19,22,24-hexazaspiro[5.21]heptacosan-12-yl]hexyl]-(2-phenylethylcarbamoyl)amino]-5-[(3-amino-3-oxopropyl)-[3-(4-bromophenyl)propylcarbamoyl]amino]pentanoic acidIC503200.0 [1]
4-[[6-Amino-2-[22-[6-amino-1-[[1-[(3-amino-3-oxopropyl)-[3-(4-fluorophenyl)propylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-methylphenyl)ethylcarbamoyl]amino]hexan-2-yl]-14,20-bis(2-carboxyethyl)-17-(2-methylpropyl)-11,16,18,23-tetraoxo-10,12,15,19,22,24-hexazaspiro[5.21]heptacosan-12-yl]hexyl]-(2-phenylethylcarbamoyl)amino]-5-[(3-amino-3-oxopropyl)-(3-phenylpropylcarbamoyl)amino]pentanoic acidIC505100.0 [1]
4-[[6-Amino-2-[22-[6-amino-1-[[1-[(3-amino-3-oxopropyl)-[4-(4-fluorophenyl)butylcarbamoyl]amino]-4-carboxybutan-2-yl]-[2-(4-methylphenyl)ethylcarbamoyl]amino]hexan-2-yl]-14,20-bis(2-carboxyethyl)-17-(2-methylpropyl)-11,16,18,23-tetraoxo-10,12,15,19,22,24-hexazaspiro[5.21]heptacosan-12-yl]hexyl]-(2-phenylethylcarbamoyl)amino]-5-[(3-amino-3-oxopropyl)-(propylcarbamoyl)amino]pentanoic acidIC5014000.0 [1]
(5S)-5-[[(2S)-6-Amino-2-[(20S)-12-[(2S)-6-amino-1-[1-[(3-amino-3-oxopropyl)-(3-phenylpropylcarbamoyl)amino]pentan-2-yl-[2-(4-bromophenyl)ethylcarbamoyl]amino]hexan-2-yl]-20-(3-carboxypropyl)-17-(2-methylpropyl)-11,16,18,23-tetraoxo-14-propyl-10,12,15,19,22,24-hexazaspiro[5.21]heptacosan-22-yl]hexyl]-[2-(4-bromophenyl)ethylcarbamoyl]amino]-6-[(3-amino-3-oxopropyl)-[3-(4-fluorophenyl)propylcarbamoyl]amino]hexanoic acidIC5041000.0 [1]
5-[[6-Amino-1-[[(2S)-1-[(3-amino-3-oxopropyl)-[5-(4-fluorophenyl)pentyl]amino]-4-carboxybutan-2-yl]-[4-(4-bromophenyl)butyl]amino]hexan-2-yl]-(2-spiro[5.5]undecan-3-ylethyl)amino]-4-(4-methylpentanoylamino)pentanoic acidIC50100000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamateIC50339000.0 [1]
Benzyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamateIC50348000.0 [1]
Tert-butyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-3-(1H-indol-3-yl)-1-oxo-1-[[(2S)-1-oxo-3-phenyl-1-piperidin-1-ylpropan-2-yl]amino]propan-2-yl]amino]-1-oxopentan-2-yl]carbamateIC50463000.0 [1]
2-Methylpropyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamateIC50300000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-3-(1H-indol-3-yl)-1-oxo-1-[[(2S)-1-oxo-3-phenyl-1-piperidin-1-ylpropan-2-yl]amino]propan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamateIC50192000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamateIC50307000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Protein Mdm4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/protein-mdm4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Protein Mdm4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-mdm4-inhibitors-ic50-ki.
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